GREMLIN Database
RTCA - RNA 3'-terminal phosphate cyclase
UniProt: Q9HRE8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 339 (308)
Sequences: 975 (719)
Seq/√Len: 41.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_A73_F5.0651.00
266_G270_A4.7441.00
50_V71_F3.7001.00
260_V268_N3.4321.00
292_V318_L3.3761.00
214_Q263_D3.2761.00
146_L156_A3.2041.00
283_V291_L3.1621.00
139_D163_R3.0391.00
29_R70_A2.9871.00
108_F175_L2.9241.00
18_L53_V2.8371.00
193_R245_Y2.7341.00
115_A122_I2.6811.00
319_A324_D2.6721.00
29_R72_S2.5931.00
307_V311_I2.5611.00
200_S215_Q2.5301.00
195_A244_E2.5151.00
218_A266_G2.4391.00
93_T123_T2.4331.00
215_Q237_S2.3521.00
132_A135_A2.2311.00
111_L124_A2.1891.00
282_A303_R2.1080.99
315_V325_I2.0580.99
47_C64_V2.0520.99
219_A270_A2.0410.99
144_V251_G2.0270.99
140_Y251_G2.0250.99
22_A57_C2.0140.99
98_V107_V2.0020.99
123_T174_T1.9660.99
207_A211_V1.9430.99
157_T176_T1.9390.99
21_A27_S1.9300.99
198_A241_L1.8930.99
152_H185_I1.8790.98
137_P240_V1.8650.98
316_D319_A1.8640.98
127_T172_E1.8420.98
197_T244_E1.8290.98
97_E127_T1.8150.98
22_A53_V1.7810.98
254_A269_A1.7640.98
285_S308_T1.7590.98
314_C318_L1.7230.97
216_A227_I1.6790.97
18_L50_V1.6640.97
159_S174_T1.6460.96
164_G167_P1.6380.96
150_R155_D1.6310.96
218_A267_E1.6180.96
186_T301_E1.6160.96
201_V238_A1.6110.96
116_G154_I1.6070.96
288_A311_I1.5970.96
200_S212_A1.5660.95
51_N64_V1.5480.95
148_L287_L1.5420.95
318_L321_F1.5390.95
104_I138_M1.5380.95
11_G45_Q1.5370.95
267_E271_D1.5170.94
316_D320_E1.4990.94
16_T314_C1.4650.93
309_T312_E1.4630.93
219_A266_G1.4470.93
19_T23_V1.4460.93
62_D72_S1.4420.93
189_E247_H1.4310.92
198_A225_H1.4310.92
243_A273_L1.4280.92
108_F173_A1.4270.92
131_D163_R1.4250.92
95_S127_T1.4140.92
165_F203_E1.4130.92
145_K287_L1.3880.91
219_A239_V1.3830.91
241_L273_L1.3780.91
194_E246_E1.3750.91
23_V114_L1.3730.91
58_D90_L1.3720.91
193_R243_A1.3650.90
245_Y277_E1.3630.90
112_L308_T1.3540.90
63_G68_S1.3470.90
305_P308_T1.3440.90
98_V126_L1.3280.89
123_T176_T1.3250.89
18_L47_C1.3140.89
289_D310_H1.3050.88
219_A269_A1.3050.88
138_M158_V1.2990.88
116_G156_A1.2990.88
56_I115_A1.2980.88
198_A238_A1.2960.88
89_T92_G1.2620.86
48_A51_N1.2610.86
167_P170_G1.2500.86
54_A61_T1.2500.86
143_H242_A1.2320.85
161_D172_E1.2160.84
52_A96_V1.2140.84
31_R70_A1.2090.84
209_D213_E1.1920.83
202_A212_A1.1820.83
165_F201_V1.1820.83
125_T172_E1.1790.82
152_H295_V1.1720.82
275_A285_S1.1650.82
292_V304_A1.1540.81
53_V59_A1.1520.81
291_L302_V1.1420.80
105_P141_F1.1400.80
204_S235_A1.1290.80
215_Q265_V1.1280.79
200_S237_S1.1230.79
276_F285_S1.1170.79
161_D174_T1.1170.79
71_F321_F1.1170.79
131_D137_P1.1160.79
53_V73_F1.1030.78
53_V110_S1.1020.78
218_A270_A1.1020.78
124_A175_L1.1010.78
48_A96_V1.0940.77
164_G169_G1.0930.77
140_Y287_L1.0830.77
269_A273_L1.0810.76
148_L187_L1.0800.76
140_Y144_V1.0770.76
319_A325_I1.0760.76
39_N43_Q1.0690.76
106_L109_D1.0560.75
38_S43_Q1.0500.74
11_G37_R1.0380.74
46_H102_G1.0370.73
101_A129_G1.0360.73
281_G305_P1.0310.73
21_A28_F1.0230.72
239_V266_G1.0130.72
15_R109_D1.0120.72
129_G289_D1.0080.71
256_G259_G1.0020.71
198_A216_A1.0010.71
34_R41_G0.9990.71
28_F71_F0.9970.70
314_C317_L0.9960.70
95_S125_T0.9960.70
169_G236_G0.9950.70
310_H313_T0.9890.70
117_A180_S0.9890.70
104_I173_A0.9840.69
56_I111_L0.9820.69
40_P170_G0.9770.69
160_V199_Y0.9770.69
129_G136_P0.9760.69
224_A227_I0.9730.69
310_H317_L0.9710.68
12_Q310_H0.9700.68
24_S321_F0.9680.68
311_I315_V0.9590.67
40_P169_G0.9550.67
101_A136_P0.9520.67
307_V315_V0.9500.67
12_Q101_A0.9470.66
136_P289_D0.9460.66
101_A106_L0.9420.66
145_K149_L0.9390.66
141_F158_V0.9360.66
125_T161_D0.9350.65
18_L28_F0.9330.65
37_R46_H0.9310.65
130_T171_G0.9290.65
112_L154_I0.9280.65
195_A222_D0.9270.65
162_R190_R0.9240.65
121_P178_E0.9220.64
288_A308_T0.9190.64
52_A107_V0.9170.64
270_A274_A0.9080.63
56_I122_I0.9040.63
60_A76_E0.8990.62
94_T124_A0.8960.62
118_L122_I0.8950.62
184_P298_A0.8930.62
295_V302_V0.8900.62
37_R63_G0.8890.61
37_R101_A0.8880.61
52_A126_L0.8880.61
129_G310_H0.8870.61
137_P165_F0.8860.61
45_Q101_A0.8840.61
117_A152_H0.8820.61
245_Y282_A0.8770.60
138_M160_V0.8740.60
61_T64_V0.8690.60
239_V270_A0.8680.60
204_S232_A0.8660.59
215_Q239_V0.8600.59
283_V287_L0.8580.59
28_F321_F0.8570.59
315_V327_I0.8520.58
11_G129_G0.8500.58
53_V96_V0.8330.56
262_A265_V0.8300.56
152_H184_P0.8290.56
140_Y284_D0.8290.56
292_V315_V0.8280.56
37_R43_Q0.8250.56
12_Q106_L0.8240.56
101_A167_P0.8210.55
312_E316_D0.8190.55
101_A169_G0.8130.55
167_P234_S0.8130.55
34_R42_L0.8130.55
200_S219_A0.8090.54
100_T310_H0.8080.54
146_L158_V0.8060.54
98_V104_I0.8060.54
37_R103_S0.8060.54
30_M173_A0.8060.54
57_C76_E0.8010.54
170_G236_G0.7950.53
196_L243_A0.7940.53
37_R45_Q0.7940.53
57_C74_E0.7930.53
57_C60_A0.7910.53
99_G107_V0.7910.53
49_A110_S0.7900.52
138_M238_A0.7900.52
136_P310_H0.7880.52
288_A305_P0.7870.52
60_A74_E0.7860.52
109_D290_Q0.7850.52
252_F276_F0.7830.52
282_A295_V0.7820.52
46_H106_L0.7820.52
45_Q106_L0.7810.52
199_Y228_A0.7790.51
249_R253_A0.7770.51
295_V315_V0.7770.51
262_A266_G0.7770.51
69_E295_V0.7770.51
257_E260_V0.7760.51
286_H290_Q0.7680.50
17_A142_Q0.7670.50
11_G289_D0.7660.50
113_P300_G0.7630.50
131_D201_V0.7630.50
172_E318_L0.7620.50
196_L225_H0.7600.50
45_Q310_H0.7570.49
196_L273_L0.7560.49
56_I94_T0.7530.49
139_D199_Y0.7490.49
12_Q45_Q0.7450.48
131_D238_A0.7440.48
51_N178_E0.7420.48
17_A21_A0.7420.48
91_G120_E0.7390.48
55_D217_T0.7360.47
198_A243_A0.7360.47
18_L73_F0.7350.47
275_A278_S0.7350.47
202_A211_V0.7350.47
250_A284_D0.7290.47
289_D313_T0.7260.47
252_F273_L0.7210.46
100_T136_P0.7210.46
102_G106_L0.7170.46
215_Q266_G0.7160.46
107_V124_A0.7090.45
37_R290_Q0.7080.45
12_Q289_D0.7060.45
125_T174_T0.7060.45
148_L291_L0.7050.45
312_E317_L0.7000.44
160_V173_A0.7000.44
119_D217_T0.6980.44
10_G130_T0.6910.43
297_V310_H0.6850.43
167_P236_G0.6830.43
309_T313_T0.6810.42
89_T118_L0.6760.42
108_F112_L0.6760.42
32_Y36_A0.6730.42
110_S113_P0.6730.42
12_Q37_R0.6710.42
37_R310_H0.6710.42
37_R289_D0.6700.41
241_L323_Y0.6690.41
17_A328_E0.6690.41
238_A266_G0.6690.41
17_A68_S0.6650.41
140_Y289_D0.6640.41
106_L129_G0.6640.41
48_A107_V0.6640.41
139_D142_Q0.6620.41
103_S132_A0.6620.41
281_G303_R0.6600.41
141_F323_Y0.6590.40
71_F270_A0.6570.40
23_V197_T0.6570.40
117_A138_M0.6570.40
195_A224_A0.6560.40
64_V68_S0.6550.40
259_G265_V0.6550.40
295_V325_I0.6540.40
115_A147_P0.6540.40
91_G119_D0.6510.40
23_V123_T0.6510.40
181_T278_S0.6510.40
10_G34_R0.6480.39
158_V172_E0.6450.39
10_G15_R0.6420.39
43_Q66_V0.6420.39
52_A111_L0.6390.39
219_A238_A0.6380.39
304_A307_V0.6360.38
166_Y259_G0.6330.38
69_E104_I0.6320.38
101_A289_D0.6320.38
168_R294_V0.6320.38
104_I124_A0.6320.38
18_L61_T0.6290.38
96_V111_L0.6280.38
113_P289_D0.6280.38
145_K311_I0.6260.38
143_H240_V0.6250.37
219_A241_L0.6240.37
35_R47_C0.6240.37
45_Q109_D0.6240.37
284_D308_T0.6240.37
103_S113_P0.6210.37
14_V28_F0.6170.37
315_V318_L0.6160.37
254_A265_V0.6160.37
95_S172_E0.6140.37
146_L157_T0.6130.36
163_R171_G0.6130.36
70_A175_L0.6100.36
290_Q310_H0.6090.36
137_P253_A0.6070.36
132_A140_Y0.6070.36
45_Q289_D0.6060.36
37_R313_T0.6050.36
131_D139_D0.6030.36
165_F252_F0.6020.35
76_E173_A0.6020.35
14_V33_V0.6010.35
142_Q202_A0.5980.35
102_G135_A0.5970.35
11_G15_R0.5950.35
236_G266_G0.5940.35
45_Q287_L0.5940.35
202_A210_E0.5920.35
285_S306_E0.5910.35
89_T117_A0.5910.35
37_R136_P0.5900.34
16_T293_P0.5890.34
304_A311_I0.5890.34
169_G234_S0.5880.34
103_S203_E0.5880.34
37_R106_L0.5870.34
145_K308_T0.5870.34
106_L310_H0.5860.34
170_G234_S0.5840.34
129_G313_T0.5840.34
250_A255_L0.5830.34
96_V276_F0.5830.34
37_R129_G0.5810.34
45_Q129_G0.5800.34
46_H49_A0.5800.34
126_L175_L0.5730.33
158_V175_L0.5730.33
104_I198_A0.5710.33
18_L64_V0.5710.33
94_T122_I0.5700.33
112_L149_L0.5700.33
77_V217_T0.5680.33
107_V110_S0.5670.33
191_G245_Y0.5660.32
108_F138_M0.5630.32
211_V237_S0.5620.32
141_F175_L0.5610.32
293_P314_C0.5600.32
162_R172_E0.5590.32
29_R177_V0.5590.32
305_P311_I0.5580.32
101_A310_H0.5580.32
248_S276_F0.5580.32
200_S239_V0.5570.32
117_A244_E0.5570.32
272_A290_Q0.5560.32
133_K257_E0.5560.32
99_G265_V0.5560.32
77_V89_T0.5550.32
141_F190_R0.5540.32
201_V242_A0.5530.31
129_G132_A0.5530.31
28_F53_V0.5520.31
164_G171_G0.5510.31
275_A306_E0.5500.31
140_Y240_V0.5480.31
41_G171_G0.5470.31
106_L289_D0.5460.31
11_G101_A0.5460.31
193_R196_L0.5430.31
324_D327_I0.5430.31
21_A309_T0.5430.31
218_A221_P0.5420.31
236_G269_A0.5420.31
103_S121_P0.5380.30
145_K294_V0.5370.30
136_P169_G0.5370.30
13_L109_D0.5360.30
162_R229_Y0.5350.30
116_G294_V0.5350.30
149_L154_I0.5340.30
29_R325_I0.5340.30
253_A304_A0.5320.30
139_D281_G0.5280.29
245_Y276_F0.5270.29
245_Y248_S0.5260.29
257_E265_V0.5260.29
49_A177_V0.5250.29
252_F269_A0.5230.29
131_D240_V0.5220.29
168_R252_F0.5220.29
177_V261_S0.5210.29
203_E232_A0.5190.29
11_G106_L0.5190.29
96_V126_L0.5170.29
276_F305_P0.5170.29
40_P167_P0.5160.29
242_A249_R0.5140.28
147_P253_A0.5140.28
23_V178_E0.5130.28
261_S264_A0.5120.28
14_V40_P0.5110.28
267_E270_A0.5110.28
33_V40_P0.5100.28
25_G42_L0.5100.28
46_H129_G0.5100.28
263_D266_G0.5090.28
159_S184_P0.5080.28
162_R217_T0.5060.28
92_G122_I0.5060.28
19_T22_A0.5050.28
61_T177_V0.5040.28
17_A317_L0.5040.28
16_T318_L0.5040.28
23_V172_E0.5030.28
59_A74_E0.5030.28
105_P239_V0.5030.28
222_D227_I0.5020.28
241_L244_E0.5020.28
53_V114_L0.5010.27
151_E308_T0.5010.27
231_D234_S0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4o89A 1 0.9617 100 0.071 Contact Map
3tutA 1 0.9587 100 0.113 Contact Map
4clqA 1 0.9499 100 0.145 Contact Map
2o0bA 1 0.8083 97 0.932 Contact Map
3r38A 2 0.5752 91.8 0.95 Contact Map
3rmtA 4 0.8024 91 0.951 Contact Map
3nvsA 1 0.8289 90.8 0.951 Contact Map
2yvwA 1 0.7699 86.4 0.955 Contact Map
1ejdA 4 0.2094 39.9 0.968 Contact Map
2pqcA 1 0.2183 32.2 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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