GREMLIN Database
Q9HRE7 - Uncharacterized protein
UniProt: Q9HRE7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 189 (158)
Sequences: 876 (620)
Seq/√Len: 49.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_Q92_G3.9691.00
126_R181_T3.7381.00
95_L178_A3.3511.00
118_T175_H3.2841.00
61_A146_E2.9681.00
104_A115_V2.7291.00
59_R148_A2.7141.00
52_F126_R2.6911.00
90_V101_T2.6891.00
62_A91_L2.4271.00
94_D99_H2.3951.00
117_F154_A2.3851.00
49_L161_Y2.3131.00
128_Y159_C2.3101.00
74_E82_P2.2871.00
91_L115_V2.2251.00
91_L147_V2.1651.00
100_H178_A2.1201.00
133_Y157_P2.0601.00
65_Q90_V2.0351.00
118_T122_T2.0201.00
52_F127_T2.0001.00
92_G101_T1.9670.99
103_T173_D1.9330.99
91_L104_A1.9140.99
67_A90_V1.7880.99
134_L149_L1.7380.99
140_G146_E1.7320.99
60_V95_L1.6990.98
140_G144_G1.6570.98
92_G99_H1.6470.98
39_P42_D1.6390.98
90_V103_T1.5210.97
64_Y89_A1.5130.97
77_T83_A1.5090.97
62_A147_V1.4910.96
93_F151_F1.4790.96
135_D155_Y1.4440.96
23_R27_D1.4190.95
104_A113_L1.3860.94
31_A161_Y1.3860.94
116_P133_Y1.3710.94
159_C171_P1.3570.94
60_V93_F1.3480.94
94_D97_D1.3160.93
112_S137_D1.2950.92
67_A103_T1.2860.92
55_D181_T1.2580.91
134_L151_F1.2500.91
74_E84_E1.2150.89
98_S177_P1.2130.89
57_S95_L1.2000.89
61_A148_A1.1950.89
117_F151_F1.1690.87
130_H165_F1.1590.87
121_T171_P1.1490.87
23_R51_Y1.1310.86
64_Y104_A1.1300.86
87_R103_T1.1260.85
23_R26_K1.1240.85
126_R179_A1.1240.85
140_G145_D1.1080.84
113_L139_A1.1020.84
70_P86_T1.0940.84
50_R186_V1.0780.83
128_Y131_G1.0700.82
78_T166_S1.0680.82
33_H158_F1.0650.82
132_R154_A1.0630.82
156_N160_A1.0480.81
116_P157_P1.0340.80
129_E163_G1.0310.80
77_T81_P1.0200.79
121_T151_F1.0160.79
81_P166_S1.0140.79
26_K184_E1.0070.78
105_F116_P1.0050.78
122_T186_V0.9970.78
35_Q166_S0.9870.77
52_F130_H0.9820.77
114_F155_Y0.9790.76
36_S49_L0.9760.76
106_R109_G0.9700.76
88_A113_L0.9690.76
64_Y93_F0.9640.75
23_R184_E0.9560.75
39_P44_G0.9550.75
77_T160_A0.9520.74
58_F180_I0.9510.74
46_F49_L0.9500.74
57_S96_G0.9440.74
123_D186_V0.9390.73
128_Y171_P0.9200.72
131_G155_Y0.9180.72
151_F180_I0.9120.71
26_K29_F0.9090.71
132_R170_P0.9030.70
109_G112_S0.9000.70
93_F149_L0.8860.69
78_T162_G0.8790.68
100_H180_I0.8770.68
102_L172_A0.8740.68
58_F181_T0.8680.67
120_E177_P0.8580.66
95_L180_I0.8560.66
63_R92_G0.8540.66
120_E179_A0.8460.65
159_C169_L0.8460.65
170_P175_H0.8450.65
154_A180_I0.8360.64
117_F180_I0.8330.64
150_D154_A0.8280.64
83_A166_S0.8180.63
63_R146_E0.8170.62
89_A113_L0.8100.62
131_G159_C0.8010.61
40_P163_G0.7800.59
52_F121_T0.7800.59
53_D56_A0.7690.58
93_F139_A0.7670.58
26_K51_Y0.7660.58
128_Y157_P0.7610.57
50_R185_R0.7550.56
100_H177_P0.7460.56
129_E170_P0.7400.55
112_S136_V0.7360.54
111_S137_D0.7350.54
29_F166_S0.7320.54
146_E149_L0.7250.53
114_F157_P0.7220.53
72_A86_T0.7210.53
118_T159_C0.7170.53
131_G170_P0.7130.52
161_Y184_E0.7100.52
42_D45_A0.6980.51
120_E127_T0.6950.50
58_F95_L0.6950.50
156_N165_F0.6870.50
44_G47_D0.6860.49
54_I153_L0.6860.49
25_D28_E0.6840.49
42_D162_G0.6830.49
30_L49_L0.6760.48
136_V149_L0.6660.47
106_R138_P0.6630.47
136_V147_V0.6510.46
120_E178_A0.6500.46
79_R166_S0.6470.45
33_H36_S0.6460.45
80_G83_A0.6420.45
36_S78_T0.6390.45
60_V149_L0.6370.44
133_Y155_Y0.6370.44
67_A87_R0.6330.44
105_F175_H0.6290.44
61_A149_L0.6270.43
35_Q165_F0.6220.43
89_A104_A0.6180.43
63_R112_S0.6170.42
33_H164_S0.6160.42
26_K33_H0.6150.42
95_L176_V0.6140.42
47_D66_P0.6090.42
156_N166_S0.6080.42
60_V147_V0.6080.42
33_H184_E0.6050.41
40_P162_G0.5980.41
91_L98_S0.5970.40
91_L136_V0.5960.40
56_A96_G0.5950.40
23_R32_T0.5940.40
60_V177_P0.5910.40
96_G180_I0.5900.40
24_A40_P0.5890.40
27_D48_G0.5880.40
99_H125_G0.5870.39
30_L46_F0.5860.39
95_L100_H0.5850.39
83_A157_P0.5850.39
25_D29_F0.5830.39
101_T134_L0.5820.39
107_V135_D0.5820.39
97_D100_H0.5800.39
62_A149_L0.5790.39
57_S61_A0.5740.38
94_D100_H0.5720.38
66_P89_A0.5710.38
150_D184_E0.5680.38
64_Y122_T0.5680.38
39_P48_G0.5620.37
34_D161_Y0.5620.37
77_T116_P0.5610.37
68_R76_E0.5590.37
44_G58_F0.5540.36
49_L77_T0.5530.36
30_L36_S0.5510.36
34_D39_P0.5500.36
114_F133_Y0.5480.36
44_G179_A0.5480.36
38_I51_Y0.5460.36
65_Q101_T0.5430.35
106_R112_S0.5430.35
121_T126_R0.5390.35
31_A76_E0.5390.35
56_A154_A0.5380.35
102_L177_P0.5350.35
118_T169_L0.5350.35
59_R153_L0.5350.35
44_G177_P0.5330.34
117_F122_T0.5310.34
55_D96_G0.5270.34
137_D148_A0.5250.34
71_E102_L0.5250.34
60_V113_L0.5250.34
107_V112_S0.5240.34
75_L114_F0.5240.34
162_G165_F0.5230.33
107_V110_E0.5220.33
133_Y159_C0.5210.33
60_V151_F0.5190.33
158_F164_S0.5180.33
47_D99_H0.5170.33
112_S135_D0.5170.33
138_P145_D0.5160.33
130_H159_C0.5140.33
131_G157_P0.5140.33
31_A70_P0.5110.32
58_F151_F0.5100.32
51_Y54_I0.5090.32
144_G148_A0.5070.32
39_P163_G0.5040.32
50_R157_P0.5040.32
63_R153_L0.5040.32
104_A136_V0.5040.32
39_P49_L0.5030.32
167_C183_G0.5020.32
89_A185_R0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2lokA 1 0.9947 100 0.076 Contact Map
2lnuA 1 0.9577 100 0.115 Contact Map
3wajA 1 0.7196 16.8 0.956 Contact Map
3h7hA 1 0.3175 6 0.964 Contact Map
3kd4A 3 0.7037 5.4 0.965 Contact Map
4n0rA 2 0.4974 3.9 0.967 Contact Map
3nvxA 1 0.5079 2.7 0.969 Contact Map
4av2A 3 0 2.5 0.97 Contact Map
4w60A 1 0.4497 2.4 0.97 Contact Map
3c0fB 2 0.3968 2.3 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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