Q9HRE1 - HALSA - GREMLIN Contacts

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Q9HRE1 - Uncharacterized protein

UniProt:	Q9HRE1	Sequences: MRDLSHALGSGEPYPGDPPAAVTPHATMAADGYRVSAVACSTHSGTHIDAPSHLLADGRSLDAFDVSAFRFDAHVVDCTGYGPEDAIPVDRVPALDDHDMVVFNTGTAADWGRPEYYEHPHLSVAAAERCADAGCAVAVDAPSVDPTRTAPAGESSDAAAYPAHRALLGAGALIVENVTNLDGLPERVPVQAYPLPVAADGAPARVIAAP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	210 (199)
Sequences:	3763 (2665)
Seq/√Len:	188.9

HALSA - Q9HRE1
SULSO - Q97UF1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
193_Y	207_I	3.431	1.00
52_S	60_S	2.927	1.00
71_F	100_M	2.850	1.00
85_D	91_R	2.426	1.00
73_A	188_V	2.426	1.00
89_V	93_P	2.411	1.00
59_R	171_G	2.403	1.00
23_T	37_A	2.379	1.00
128_E	166_A	2.339	1.00
100_M	136_A	2.277	1.00
129_R	133_A	2.273	1.00
180_N	183_G	2.268	1.00
128_E	132_D	2.218	1.00
7_A	196_P	2.194	1.00
195_L	202_A	2.155	1.00
102_V	138_A	2.115	1.00
60_S	63_A	2.109	1.00
89_V	125_A	2.067	1.00
89_V	126_A	2.025	1.00
79_T	104_N	1.988	1.00
77_D	104_N	1.959	1.00
21_A	39_A	1.936	1.00
3_D	196_P	1.927	1.00
97_D	134_G	1.910	1.00
101_V	130_C	1.898	1.00
86_A	123_S	1.868	1.00
49_D	164_H	1.845	1.00
3_D	205_R	1.795	1.00
9_G	12_E	1.772	1.00
124_V	128_E	1.758	1.00
89_V	129_R	1.711	1.00
88_P	123_S	1.710	1.00
93_P	133_A	1.695	1.00
90_D	93_P	1.649	1.00
109_A	182_D	1.608	1.00
195_L	203_P	1.599	1.00
43_H	47_H	1.575	1.00
88_P	91_R	1.561	1.00
137_V	167_L	1.528	1.00
61_L	64_F	1.525	1.00
102_V	190_V	1.489	1.00
81_Y	91_R	1.488	1.00
84_E	118_E	1.486	1.00
92_V	103_F	1.475	1.00
82_G	85_D	1.472	1.00
48_I	69_F	1.471	1.00
93_P	129_R	1.470	1.00
123_S	126_A	1.468	1.00
96_D	99_D	1.440	1.00
108_A	182_D	1.434	1.00
191_Q	207_I	1.412	1.00
23_T	39_A	1.403	1.00
90_D	125_A	1.379	1.00
70_R	191_Q	1.366	1.00
100_M	190_V	1.359	1.00
76_V	101_V	1.333	1.00
48_I	136_A	1.333	1.00
43_H	201_G	1.325	1.00
190_V	206_V	1.324	1.00
34_R	200_D	1.316	1.00
191_Q	209_A	1.306	1.00
34_R	52_S	1.305	1.00
29_A	56_A	1.301	1.00
75_V	188_V	1.295	1.00
131_A	166_A	1.280	1.00
110_D	115_E	1.276	1.00
107_T	120_P	1.264	1.00
70_R	189_P	1.264	1.00
8_L	20_A	1.239	1.00
105_T	139_V	1.218	1.00
36_S	200_D	1.217	1.00
137_V	144_V	1.209	1.00
72_D	187_R	1.204	1.00
144_V	174_I	1.203	1.00
175_V	192_A	1.203	1.00
86_A	146_P	1.183	1.00
104_N	182_D	1.175	1.00
86_A	121_H	1.172	1.00
73_A	190_V	1.169	1.00
24_P	27_T	1.168	1.00
70_R	207_I	1.162	1.00
179_T	190_V	1.155	1.00
87_I	105_T	1.150	1.00
122_L	144_V	1.146	1.00
92_V	126_A	1.132	1.00
10_S	21_A	1.129	1.00
178_V	206_V	1.128	1.00
22_V	36_S	1.105	1.00
112_G	116_Y	1.102	1.00
138_A	178_V	1.087	1.00
17_D	35_V	1.083	1.00
36_S	42_T	1.081	1.00
48_I	61_L	1.079	1.00
92_V	129_R	1.068	1.00
192_A	204_A	1.061	1.00
139_V	144_V	1.060	1.00
42_T	199_A	1.055	1.00
72_D	99_D	1.051	1.00
49_D	53_H	1.051	1.00
74_H	95_L	1.048	1.00
78_C	91_R	1.043	1.00
136_A	175_V	1.042	1.00
102_V	181_L	1.041	1.00
62_D	198_A	1.040	1.00
132_D	170_A	1.039	1.00
75_V	104_N	1.030	1.00
89_V	92_V	1.028	1.00
53_H	164_H	1.026	1.00
20_A	197_V	1.025	1.00
145_D	163_A	1.017	1.00
138_A	181_L	1.006	1.00
78_C	103_F	0.992	0.99
176_E	179_T	0.990	0.99
127_A	166_A	0.984	0.99
136_A	190_V	0.973	0.99
124_V	163_A	0.973	0.99
70_R	193_Y	0.966	0.99
175_V	190_V	0.960	0.99
50_A	201_G	0.955	0.99
113_R	116_Y	0.954	0.99
172_A	176_E	0.953	0.99
4_L	208_A	0.950	0.99
28_M	34_R	0.950	0.99
40_C	44_S	0.925	0.99
103_F	122_L	0.924	0.99
48_I	192_A	0.922	0.99
73_A	102_V	0.908	0.99
167_L	172_A	0.908	0.99
40_C	203_P	0.904	0.99
145_D	161_Y	0.903	0.99
54_L	161_Y	0.900	0.99
59_R	63_A	0.900	0.99
75_V	102_V	0.899	0.99
189_P	209_A	0.899	0.99
163_A	166_A	0.899	0.99
42_T	200_D	0.895	0.99
59_R	65_D	0.890	0.99
59_R	68_A	0.884	0.99
64_F	69_F	0.880	0.99
88_P	126_A	0.878	0.99
104_N	108_A	0.872	0.99
113_R	117_Y	0.858	0.98
48_I	204_A	0.853	0.98
127_A	163_A	0.852	0.98
125_A	128_E	0.852	0.98
18_P	21_A	0.851	0.98
72_D	189_P	0.848	0.98
66_V	207_I	0.845	0.98
95_L	99_D	0.845	0.98
145_D	177_N	0.837	0.98
65_D	68_A	0.837	0.98
131_A	170_A	0.833	0.98
6_H	46_T	0.832	0.98
4_L	206_V	0.829	0.98
71_F	189_P	0.827	0.98
104_N	185_P	0.826	0.98
108_A	179_T	0.820	0.98
97_D	133_A	0.819	0.98
15_P	18_P	0.816	0.98
138_A	179_T	0.815	0.98
43_H	164_H	0.814	0.98
73_A	184_L	0.809	0.98
18_P	37_A	0.802	0.98
131_A	172_A	0.795	0.97
37_A	41_S	0.788	0.97
144_V	175_V	0.784	0.97
119_H	147_T	0.781	0.97
8_L	12_E	0.776	0.97
6_H	111_W	0.771	0.97
64_F	173_L	0.770	0.97
78_C	81_Y	0.770	0.97
24_P	34_R	0.767	0.97
38_V	42_T	0.765	0.97
81_Y	85_D	0.761	0.97
5_S	206_V	0.751	0.96
172_A	177_N	0.750	0.96
138_A	176_E	0.740	0.96
142_P	177_N	0.739	0.96
119_H	142_P	0.738	0.96
24_P	36_S	0.737	0.96
74_H	187_R	0.737	0.96
95_L	101_V	0.736	0.96
18_P	41_S	0.735	0.96
121_H	129_R	0.731	0.96
112_G	117_Y	0.730	0.96
68_A	171_G	0.724	0.96
35_V	41_S	0.720	0.95
34_R	56_A	0.720	0.95
95_L	135_C	0.717	0.95
85_D	88_P	0.717	0.95
128_E	169_G	0.709	0.95
17_D	41_S	0.706	0.95
38_V	197_V	0.706	0.95
95_L	98_H	0.706	0.95
74_H	99_D	0.698	0.95
124_V	162_P	0.694	0.94
122_L	126_A	0.693	0.94
2_R	186_E	0.691	0.94
8_L	195_L	0.690	0.94
43_H	200_D	0.684	0.94
196_P	205_R	0.680	0.94
106_G	109_A	0.680	0.94
48_I	175_V	0.678	0.94
121_H	199_A	0.675	0.94
47_H	200_D	0.667	0.93
127_A	167_L	0.659	0.93
124_V	166_A	0.656	0.93
8_L	44_S	0.652	0.92
174_I	177_N	0.650	0.92
71_F	98_H	0.648	0.92
78_C	87_I	0.647	0.92
72_D	98_H	0.646	0.92
78_C	85_D	0.644	0.92
40_C	197_V	0.637	0.91
130_C	135_C	0.636	0.91
101_V	135_C	0.635	0.91
119_H	143_S	0.626	0.91
141_A	144_V	0.625	0.91
60_S	64_F	0.623	0.91
42_T	201_G	0.619	0.90
188_V	208_A	0.619	0.90
95_L	133_A	0.611	0.90
111_W	177_N	0.610	0.90
164_H	194_P	0.610	0.90
171_G	177_N	0.609	0.90
94_A	133_A	0.608	0.89
103_F	137_V	0.603	0.89
13_P	111_W	0.602	0.89
35_V	42_T	0.596	0.89
143_S	158_A	0.596	0.89
8_L	40_C	0.595	0.88
144_V	167_L	0.595	0.88
175_V	204_A	0.591	0.88
6_H	177_N	0.588	0.88
57_D	63_A	0.588	0.88
26_A	33_Y	0.586	0.88
119_H	141_A	0.584	0.88
136_A	168_L	0.582	0.87
46_T	181_L	0.581	0.87
49_D	201_G	0.580	0.87
79_T	109_A	0.580	0.87
89_V	133_A	0.579	0.87
72_D	96_D	0.577	0.87
17_D	20_A	0.577	0.87
108_A	180_N	0.577	0.87
96_D	133_A	0.576	0.87
114_P	117_Y	0.575	0.87
171_G	176_E	0.575	0.87
131_A	135_C	0.573	0.87
17_D	22_V	0.572	0.86
100_M	138_A	0.572	0.86
122_L	127_A	0.572	0.86
5_S	8_L	0.570	0.86
122_L	137_V	0.569	0.86
175_V	206_V	0.568	0.86
80_G	91_R	0.567	0.86
116_Y	177_N	0.564	0.86
126_A	129_R	0.564	0.86
82_G	91_R	0.562	0.85
107_T	141_A	0.561	0.85
106_G	120_P	0.559	0.85
59_R	64_F	0.559	0.85
14_Y	17_D	0.559	0.85
24_P	31_D	0.557	0.85
63_A	198_A	0.555	0.85
4_L	180_N	0.555	0.85
16_G	19_P	0.547	0.84
110_D	120_P	0.544	0.84
6_H	180_N	0.542	0.83
127_A	131_A	0.538	0.83
18_P	25_H	0.534	0.83
62_D	196_P	0.532	0.82
38_V	203_P	0.531	0.82
47_H	50_A	0.531	0.82
50_A	202_A	0.531	0.82
79_T	82_G	0.530	0.82
35_V	200_D	0.528	0.82
129_R	132_D	0.527	0.82
50_A	61_L	0.527	0.82
175_V	178_V	0.525	0.81
80_G	85_D	0.525	0.81
107_T	142_P	0.524	0.81
78_C	92_V	0.523	0.81
59_R	62_D	0.523	0.81
89_V	123_S	0.520	0.81
106_G	110_D	0.518	0.81
97_D	135_C	0.518	0.81
145_D	162_P	0.517	0.80
88_P	125_A	0.513	0.80
33_Y	54_L	0.510	0.80
4_L	106_G	0.508	0.79
28_M	31_D	0.507	0.79
43_H	176_E	0.507	0.79
105_T	141_A	0.507	0.79
77_D	202_A	0.507	0.79
144_V	163_A	0.504	0.79
194_P	197_V	0.502	0.79
6_H	108_A	0.500	0.78

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4m8dA	4	0.9762	100	0.191	Contact Map
4cogA	3	0.9333	100	0.207	Contact Map
4co9A	2	0.9286	100	0.212	Contact Map
1r61A	3	0.9143	100	0.214	Contact Map
4cobA	2	0.9286	100	0.215	Contact Map
2b0aA	2	0.8381	100	0.281	Contact Map
3cpkA	1	0.5476	17.1	0.954	Contact Map
2ab1A	1	0.5333	14.8	0.955	Contact Map
2cyjA	1	0.519	12.7	0.957	Contact Map
2fi9A	1	0.5429	11.6	0.957	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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