GREMLIN Database
Q9HRE1 - Uncharacterized protein
UniProt: Q9HRE1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 210 (199)
Sequences: 3763 (2665)
Seq/√Len: 188.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
193_Y207_I3.4311.00
52_S60_S2.9271.00
71_F100_M2.8501.00
85_D91_R2.4261.00
73_A188_V2.4261.00
89_V93_P2.4111.00
59_R171_G2.4031.00
23_T37_A2.3791.00
128_E166_A2.3391.00
100_M136_A2.2771.00
129_R133_A2.2731.00
180_N183_G2.2681.00
128_E132_D2.2181.00
7_A196_P2.1941.00
195_L202_A2.1551.00
102_V138_A2.1151.00
60_S63_A2.1091.00
89_V125_A2.0671.00
89_V126_A2.0251.00
79_T104_N1.9881.00
77_D104_N1.9591.00
21_A39_A1.9361.00
3_D196_P1.9271.00
97_D134_G1.9101.00
101_V130_C1.8981.00
86_A123_S1.8681.00
49_D164_H1.8451.00
3_D205_R1.7951.00
9_G12_E1.7721.00
124_V128_E1.7581.00
89_V129_R1.7111.00
88_P123_S1.7101.00
93_P133_A1.6951.00
90_D93_P1.6491.00
109_A182_D1.6081.00
195_L203_P1.5991.00
43_H47_H1.5751.00
88_P91_R1.5611.00
137_V167_L1.5281.00
61_L64_F1.5251.00
102_V190_V1.4891.00
81_Y91_R1.4881.00
84_E118_E1.4861.00
92_V103_F1.4751.00
82_G85_D1.4721.00
48_I69_F1.4711.00
93_P129_R1.4701.00
123_S126_A1.4681.00
96_D99_D1.4401.00
108_A182_D1.4341.00
191_Q207_I1.4121.00
23_T39_A1.4031.00
90_D125_A1.3791.00
70_R191_Q1.3661.00
100_M190_V1.3591.00
76_V101_V1.3331.00
48_I136_A1.3331.00
43_H201_G1.3251.00
190_V206_V1.3241.00
34_R200_D1.3161.00
191_Q209_A1.3061.00
34_R52_S1.3051.00
29_A56_A1.3011.00
75_V188_V1.2951.00
131_A166_A1.2801.00
110_D115_E1.2761.00
107_T120_P1.2641.00
70_R189_P1.2641.00
8_L20_A1.2391.00
105_T139_V1.2181.00
36_S200_D1.2171.00
137_V144_V1.2091.00
72_D187_R1.2041.00
144_V174_I1.2031.00
175_V192_A1.2031.00
86_A146_P1.1831.00
104_N182_D1.1751.00
86_A121_H1.1721.00
73_A190_V1.1691.00
24_P27_T1.1681.00
70_R207_I1.1621.00
179_T190_V1.1551.00
87_I105_T1.1501.00
122_L144_V1.1461.00
92_V126_A1.1321.00
10_S21_A1.1291.00
178_V206_V1.1281.00
22_V36_S1.1051.00
112_G116_Y1.1021.00
138_A178_V1.0871.00
17_D35_V1.0831.00
36_S42_T1.0811.00
48_I61_L1.0791.00
92_V129_R1.0681.00
192_A204_A1.0611.00
139_V144_V1.0601.00
42_T199_A1.0551.00
72_D99_D1.0511.00
49_D53_H1.0511.00
74_H95_L1.0481.00
78_C91_R1.0431.00
136_A175_V1.0421.00
102_V181_L1.0411.00
62_D198_A1.0401.00
132_D170_A1.0391.00
75_V104_N1.0301.00
89_V92_V1.0281.00
53_H164_H1.0261.00
20_A197_V1.0251.00
145_D163_A1.0171.00
138_A181_L1.0061.00
78_C103_F0.9920.99
176_E179_T0.9900.99
127_A166_A0.9840.99
136_A190_V0.9730.99
124_V163_A0.9730.99
70_R193_Y0.9660.99
175_V190_V0.9600.99
50_A201_G0.9550.99
113_R116_Y0.9540.99
172_A176_E0.9530.99
4_L208_A0.9500.99
28_M34_R0.9500.99
40_C44_S0.9250.99
103_F122_L0.9240.99
48_I192_A0.9220.99
73_A102_V0.9080.99
167_L172_A0.9080.99
40_C203_P0.9040.99
145_D161_Y0.9030.99
54_L161_Y0.9000.99
59_R63_A0.9000.99
75_V102_V0.8990.99
189_P209_A0.8990.99
163_A166_A0.8990.99
42_T200_D0.8950.99
59_R65_D0.8900.99
59_R68_A0.8840.99
64_F69_F0.8800.99
88_P126_A0.8780.99
104_N108_A0.8720.99
113_R117_Y0.8580.98
48_I204_A0.8530.98
127_A163_A0.8520.98
125_A128_E0.8520.98
18_P21_A0.8510.98
72_D189_P0.8480.98
66_V207_I0.8450.98
95_L99_D0.8450.98
145_D177_N0.8370.98
65_D68_A0.8370.98
131_A170_A0.8330.98
6_H46_T0.8320.98
4_L206_V0.8290.98
71_F189_P0.8270.98
104_N185_P0.8260.98
108_A179_T0.8200.98
97_D133_A0.8190.98
15_P18_P0.8160.98
138_A179_T0.8150.98
43_H164_H0.8140.98
73_A184_L0.8090.98
18_P37_A0.8020.98
131_A172_A0.7950.97
37_A41_S0.7880.97
144_V175_V0.7840.97
119_H147_T0.7810.97
8_L12_E0.7760.97
6_H111_W0.7710.97
64_F173_L0.7700.97
78_C81_Y0.7700.97
24_P34_R0.7670.97
38_V42_T0.7650.97
81_Y85_D0.7610.97
5_S206_V0.7510.96
172_A177_N0.7500.96
138_A176_E0.7400.96
142_P177_N0.7390.96
119_H142_P0.7380.96
24_P36_S0.7370.96
74_H187_R0.7370.96
95_L101_V0.7360.96
18_P41_S0.7350.96
121_H129_R0.7310.96
112_G117_Y0.7300.96
68_A171_G0.7240.96
35_V41_S0.7200.95
34_R56_A0.7200.95
95_L135_C0.7170.95
85_D88_P0.7170.95
128_E169_G0.7090.95
17_D41_S0.7060.95
38_V197_V0.7060.95
95_L98_H0.7060.95
74_H99_D0.6980.95
124_V162_P0.6940.94
122_L126_A0.6930.94
2_R186_E0.6910.94
8_L195_L0.6900.94
43_H200_D0.6840.94
196_P205_R0.6800.94
106_G109_A0.6800.94
48_I175_V0.6780.94
121_H199_A0.6750.94
47_H200_D0.6670.93
127_A167_L0.6590.93
124_V166_A0.6560.93
8_L44_S0.6520.92
174_I177_N0.6500.92
71_F98_H0.6480.92
78_C87_I0.6470.92
72_D98_H0.6460.92
78_C85_D0.6440.92
40_C197_V0.6370.91
130_C135_C0.6360.91
101_V135_C0.6350.91
119_H143_S0.6260.91
141_A144_V0.6250.91
60_S64_F0.6230.91
42_T201_G0.6190.90
188_V208_A0.6190.90
95_L133_A0.6110.90
111_W177_N0.6100.90
164_H194_P0.6100.90
171_G177_N0.6090.90
94_A133_A0.6080.89
103_F137_V0.6030.89
13_P111_W0.6020.89
35_V42_T0.5960.89
143_S158_A0.5960.89
8_L40_C0.5950.88
144_V167_L0.5950.88
175_V204_A0.5910.88
6_H177_N0.5880.88
57_D63_A0.5880.88
26_A33_Y0.5860.88
119_H141_A0.5840.88
136_A168_L0.5820.87
46_T181_L0.5810.87
49_D201_G0.5800.87
79_T109_A0.5800.87
89_V133_A0.5790.87
72_D96_D0.5770.87
17_D20_A0.5770.87
108_A180_N0.5770.87
96_D133_A0.5760.87
114_P117_Y0.5750.87
171_G176_E0.5750.87
131_A135_C0.5730.87
17_D22_V0.5720.86
100_M138_A0.5720.86
122_L127_A0.5720.86
5_S8_L0.5700.86
122_L137_V0.5690.86
175_V206_V0.5680.86
80_G91_R0.5670.86
116_Y177_N0.5640.86
126_A129_R0.5640.86
82_G91_R0.5620.85
107_T141_A0.5610.85
106_G120_P0.5590.85
59_R64_F0.5590.85
14_Y17_D0.5590.85
24_P31_D0.5570.85
63_A198_A0.5550.85
4_L180_N0.5550.85
16_G19_P0.5470.84
110_D120_P0.5440.84
6_H180_N0.5420.83
127_A131_A0.5380.83
18_P25_H0.5340.83
62_D196_P0.5320.82
38_V203_P0.5310.82
47_H50_A0.5310.82
50_A202_A0.5310.82
79_T82_G0.5300.82
35_V200_D0.5280.82
129_R132_D0.5270.82
50_A61_L0.5270.82
175_V178_V0.5250.81
80_G85_D0.5250.81
107_T142_P0.5240.81
78_C92_V0.5230.81
59_R62_D0.5230.81
89_V123_S0.5200.81
106_G110_D0.5180.81
97_D135_C0.5180.81
145_D162_P0.5170.80
88_P125_A0.5130.80
33_Y54_L0.5100.80
4_L106_G0.5080.79
28_M31_D0.5070.79
43_H176_E0.5070.79
105_T141_A0.5070.79
77_D202_A0.5070.79
144_V163_A0.5040.79
194_P197_V0.5020.79
6_H108_A0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4m8dA 4 0.9762 100 0.191 Contact Map
4cogA 3 0.9333 100 0.207 Contact Map
4co9A 2 0.9286 100 0.212 Contact Map
1r61A 3 0.9143 100 0.214 Contact Map
4cobA 2 0.9286 100 0.215 Contact Map
2b0aA 2 0.8381 100 0.281 Contact Map
3cpkA 1 0.5476 17.1 0.954 Contact Map
2ab1A 1 0.5333 14.8 0.955 Contact Map
2cyjA 1 0.519 12.7 0.957 Contact Map
2fi9A 1 0.5429 11.6 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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