Q9HRD9 - HALSA - GREMLIN Contacts

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Q9HRD9 - Uncharacterized protein

UniProt:	Q9HRD9	Sequences: MSLRHLMAEVRGREKALTVYAPAGDGVVTAVREYFSSQHVAIEHEPTEDALRAVLADADGTQLASVDAPALRELASRDLHKVGDEAPYSPLLEHLDHTTFTSYDRRQMTMASREIEDRAWRANSGQLHTGFQRLSNVRKERDTYEQLAACDLSVHVYGVPDAELGDTSFAVHAPESDELAVSWFVLYDGGTDRAQSSALLAEERADGGFYGFWTYDPALVQRALEAVTGYQQPA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	234 (227)
Sequences:	115 (92)
Seq/√Len:	6.1

HALSA - Q9HRD9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
196_S	221_Q	4.744	0.98
155_H	172_H	3.982	0.94
134_L	158_G	3.898	0.93
135_S	161_D	3.319	0.85
108_M	111_A	3.251	0.84
193_R	196_S	3.000	0.79
135_S	158_G	2.696	0.70
7_M	16_A	2.587	0.67
193_R	200_L	2.378	0.60
17_L	92_L	2.369	0.60
67_D	105_R	2.356	0.59
114_E	121_R	2.319	0.58
103_Y	108_M	2.278	0.57
60_G	179_L	2.213	0.54
158_G	161_D	2.192	0.54
128_H	157_Y	2.068	0.49
96_D	223_A	1.997	0.47
2_S	212_F	1.993	0.46
157_Y	172_H	1.975	0.46
98_T	188_D	1.966	0.45
128_H	224_L	1.910	0.43
200_L	214_T	1.861	0.42
40_V	223_A	1.860	0.42
100_F	201_A	1.852	0.41
84_D	145_E	1.852	0.41
111_A	210_Y	1.746	0.38
186_L	220_V	1.725	0.37
82_V	140_E	1.709	0.37
197_S	215_Y	1.677	0.36
153_S	223_A	1.639	0.34
17_L	185_V	1.635	0.34
184_F	198_A	1.621	0.34
134_L	161_D	1.584	0.33
102_S	204_R	1.577	0.32
119_A	127_L	1.574	0.32
3_L	35_F	1.554	0.32
104_D	208_G	1.539	0.31
108_M	168_S	1.472	0.29
25_D	149_A	1.469	0.29
64_A	182_S	1.449	0.28
16_A	151_D	1.445	0.28
10_V	36_S	1.443	0.28
2_S	33_E	1.404	0.27
156_V	226_A	1.385	0.27
121_R	197_S	1.384	0.27
178_E	227_V	1.384	0.27
82_V	136_N	1.380	0.26
62_Q	65_S	1.379	0.26
17_L	182_S	1.378	0.26
148_A	151_D	1.368	0.26
100_F	221_Q	1.367	0.26
95_L	226_A	1.359	0.26
10_V	227_V	1.347	0.26
108_M	210_Y	1.346	0.26
29_T	69_P	1.344	0.25
122_A	165_G	1.343	0.25
87_P	162_A	1.318	0.25
25_D	48_E	1.309	0.25
212_F	217_P	1.307	0.24
104_D	226_A	1.295	0.24
103_Y	185_V	1.289	0.24
191_T	196_S	1.280	0.24
180_A	223_A	1.280	0.24
189_G	209_F	1.261	0.23
49_D	52_R	1.256	0.23
17_L	21_A	1.256	0.23
2_S	169_F	1.255	0.23
107_Q	209_F	1.254	0.23
134_L	157_Y	1.253	0.23
102_S	179_L	1.227	0.22
153_S	169_F	1.227	0.22
123_N	150_C	1.224	0.22
138_R	193_R	1.215	0.22
119_A	125_G	1.214	0.22
68_A	192_D	1.213	0.22
108_M	128_H	1.213	0.22
114_E	197_S	1.208	0.22
141_R	219_L	1.191	0.22
76_S	89_S	1.190	0.22
77_R	152_L	1.190	0.22
61_T	186_L	1.185	0.21
170_A	190_G	1.179	0.21
2_S	137_V	1.174	0.21
50_A	55_L	1.155	0.21
102_S	209_F	1.148	0.21
56_A	97_H	1.146	0.20
53_A	123_N	1.144	0.20
21_A	100_F	1.142	0.20
84_D	112_S	1.140	0.20
145_E	214_T	1.122	0.20
28_V	160_P	1.118	0.20
114_E	118_R	1.115	0.20
124_S	142_D	1.114	0.20
21_A	56_A	1.105	0.20
18_T	157_Y	1.105	0.20
114_E	202_E	1.101	0.19
202_E	210_Y	1.099	0.19
111_A	212_F	1.099	0.19
120_W	205_A	1.098	0.19
137_V	229_G	1.098	0.19
56_A	185_V	1.091	0.19
135_S	159_V	1.091	0.19
12_G	187_Y	1.088	0.19
49_D	145_E	1.084	0.19
130_G	178_E	1.079	0.19
78_D	110_M	1.074	0.19
110_M	136_N	1.070	0.19
82_V	105_R	1.066	0.19
78_D	140_E	1.065	0.19
124_S	156_V	1.059	0.19
106_R	152_L	1.059	0.19
66_V	105_R	1.058	0.18
181_V	226_A	1.056	0.18
129_T	185_V	1.053	0.18
36_S	218_A	1.052	0.18
108_M	196_S	1.051	0.18
98_T	216_D	1.051	0.18
40_V	100_F	1.048	0.18
48_E	165_G	1.039	0.18
11_R	68_A	1.039	0.18
178_E	226_A	1.035	0.18
160_P	177_D	1.034	0.18
203_E	206_D	1.033	0.18
113_R	144_Y	1.029	0.18
2_S	206_D	1.025	0.18
32_R	92_L	1.025	0.18
80_H	117_D	1.019	0.18
5_H	127_L	1.015	0.18
178_E	188_D	1.014	0.18
117_D	121_R	1.008	0.17
14_E	101_T	1.004	0.17
111_A	215_Y	0.998	0.17
17_L	100_F	0.997	0.17
136_N	140_E	0.997	0.17
34_Y	187_Y	0.992	0.17
77_R	83_G	0.990	0.17
26_G	79_L	0.982	0.17
40_V	201_A	0.980	0.17
15_K	128_H	0.973	0.17
96_D	216_D	0.972	0.17
128_H	155_H	0.968	0.17
73_E	138_R	0.967	0.17
82_V	110_M	0.963	0.17
145_E	225_E	0.959	0.16
19_V	203_E	0.959	0.16
45_E	200_L	0.956	0.16
67_D	77_R	0.953	0.16
48_E	96_D	0.952	0.16
163_E	179_L	0.948	0.16
69_P	175_E	0.942	0.16
199_L	213_W	0.938	0.16
77_R	136_N	0.931	0.16
36_S	150_C	0.930	0.16
18_T	94_H	0.924	0.16
52_R	164_L	0.923	0.16
21_A	44_H	0.923	0.16
178_E	216_D	0.923	0.16
11_R	191_T	0.920	0.16
17_L	184_F	0.909	0.15
134_L	164_L	0.909	0.15
60_G	218_A	0.904	0.15
59_D	79_L	0.900	0.15
168_S	181_V	0.891	0.15
35_F	65_S	0.884	0.15
45_E	48_E	0.882	0.15
149_A	166_D	0.880	0.15
64_A	140_E	0.877	0.15
120_W	187_Y	0.874	0.15
207_G	229_G	0.874	0.15
30_A	181_V	0.870	0.15
50_A	148_A	0.867	0.15
186_L	224_L	0.855	0.15
114_E	117_D	0.851	0.14
16_A	178_E	0.850	0.14
198_A	223_A	0.841	0.14
108_M	221_Q	0.839	0.14
102_S	130_G	0.836	0.14
21_A	24_G	0.821	0.14
55_L	65_S	0.818	0.14
134_L	159_V	0.815	0.14
153_S	170_A	0.812	0.14
152_L	203_E	0.809	0.14
161_D	229_G	0.807	0.14
75_A	83_G	0.797	0.14
118_R	121_R	0.792	0.13
97_H	154_V	0.790	0.13
123_N	151_D	0.784	0.13
62_Q	201_A	0.783	0.13
38_Q	42_I	0.781	0.13
78_D	107_Q	0.781	0.13
140_E	217_P	0.780	0.13
58_A	229_G	0.780	0.13
4_R	156_V	0.778	0.13
144_Y	201_A	0.775	0.13
95_L	217_P	0.775	0.13
78_D	185_V	0.772	0.13
148_A	175_E	0.769	0.13
185_V	206_D	0.767	0.13
48_E	149_A	0.763	0.13
45_E	225_E	0.761	0.13
140_E	174_P	0.760	0.13
89_S	110_M	0.758	0.13
58_A	128_H	0.756	0.13
45_E	55_L	0.752	0.13
39_H	227_V	0.751	0.13
10_V	212_F	0.746	0.13
26_G	193_R	0.744	0.13
72_R	148_A	0.740	0.13
39_H	154_V	0.739	0.13
107_Q	136_N	0.729	0.12
204_R	210_Y	0.728	0.12
152_L	186_L	0.721	0.12
112_S	199_L	0.721	0.12
54_V	162_A	0.720	0.12
12_G	142_D	0.718	0.12
104_D	174_P	0.709	0.12
189_G	202_E	0.707	0.12
76_S	80_H	0.706	0.12
43_E	205_A	0.706	0.12
107_Q	111_A	0.700	0.12
48_E	195_Q	0.694	0.12
101_T	210_Y	0.694	0.12
9_E	65_S	0.693	0.12
189_G	204_R	0.692	0.12
135_S	214_T	0.690	0.12
50_A	223_A	0.689	0.12
112_S	134_L	0.687	0.12
90_P	169_F	0.685	0.12
76_S	110_M	0.683	0.12
110_M	197_S	0.681	0.12
77_R	82_V	0.680	0.12
75_A	110_M	0.679	0.12
36_S	43_E	0.678	0.12
43_E	161_D	0.675	0.12
126_Q	210_Y	0.673	0.12
19_V	40_V	0.666	0.11
85_E	126_Q	0.665	0.11
126_Q	153_S	0.664	0.11
120_W	143_T	0.664	0.11
144_Y	220_V	0.659	0.11
204_R	209_F	0.658	0.11
162_A	165_G	0.656	0.11
118_R	191_T	0.654	0.11
58_A	138_R	0.652	0.11
38_Q	133_R	0.649	0.11
58_A	193_R	0.645	0.11
34_Y	96_D	0.643	0.11
50_A	122_A	0.642	0.11
4_R	84_D	0.642	0.11
6_L	117_D	0.637	0.11
154_V	181_V	0.637	0.11
104_D	178_E	0.636	0.11
11_R	204_R	0.635	0.11
38_Q	105_R	0.631	0.11
130_G	227_V	0.631	0.11
103_Y	111_A	0.629	0.11
34_Y	38_Q	0.629	0.11
122_A	213_W	0.629	0.11
146_Q	162_A	0.627	0.11
59_D	96_D	0.626	0.11
117_D	202_E	0.621	0.11
117_D	209_F	0.621	0.11
42_I	49_D	0.621	0.11
66_V	83_G	0.619	0.11
43_E	216_D	0.616	0.11
84_D	142_D	0.613	0.11
15_K	228_T	0.612	0.11
92_L	147_L	0.607	0.11
137_V	177_D	0.605	0.11
56_A	172_H	0.605	0.11
28_V	55_L	0.602	0.11
29_T	193_R	0.600	0.11
104_D	191_T	0.595	0.10
66_V	89_S	0.595	0.10
60_G	151_D	0.594	0.10
102_S	178_E	0.593	0.10
142_D	229_G	0.591	0.10
42_I	142_D	0.588	0.10
102_S	117_D	0.586	0.10
17_L	198_A	0.585	0.10
77_R	105_R	0.585	0.10
197_S	226_A	0.581	0.10
6_L	24_G	0.577	0.10
198_A	202_E	0.574	0.10
13_R	169_F	0.572	0.10
202_E	215_Y	0.570	0.10
48_E	145_E	0.569	0.10
125_G	214_T	0.569	0.10
103_Y	140_E	0.569	0.10
116_E	183_W	0.568	0.10
116_E	131_F	0.568	0.10
131_F	183_W	0.568	0.10
16_A	156_V	0.564	0.10
74_L	83_G	0.564	0.10
50_A	153_S	0.564	0.10
119_A	187_Y	0.564	0.10
24_G	36_S	0.563	0.10
82_V	89_S	0.561	0.10
111_A	204_R	0.560	0.10
34_Y	63_L	0.556	0.10
18_T	104_D	0.556	0.10
149_A	163_E	0.555	0.10
112_S	135_S	0.554	0.10
22_P	44_H	0.554	0.10
117_D	197_S	0.554	0.10
193_R	221_Q	0.552	0.10
3_L	216_D	0.551	0.10
101_T	168_S	0.549	0.10
141_R	169_F	0.548	0.10
48_E	129_T	0.545	0.10
28_V	177_D	0.542	0.10
120_W	211_G	0.541	0.10
111_A	209_F	0.532	0.10
9_E	219_L	0.532	0.10
47_T	165_G	0.532	0.10
69_P	163_E	0.530	0.10
114_E	204_R	0.530	0.10
75_A	228_T	0.529	0.10
115_I	185_V	0.525	0.10
152_L	197_S	0.524	0.10
112_S	143_T	0.523	0.10
92_L	96_D	0.521	0.10
101_T	184_F	0.520	0.09
2_S	13_R	0.519	0.09
202_E	217_P	0.518	0.09
37_S	43_E	0.514	0.09
77_R	109_T	0.514	0.09
17_L	81_K	0.513	0.09
65_S	75_A	0.513	0.09
66_V	143_T	0.509	0.09
9_E	72_R	0.509	0.09
35_F	45_E	0.509	0.09
118_R	188_D	0.507	0.09
104_D	190_G	0.506	0.09
191_T	215_Y	0.505	0.09
98_T	114_E	0.503	0.09
155_H	174_P	0.503	0.09
36_S	212_F	0.502	0.09
101_T	202_E	0.501	0.09
163_E	229_G	0.500	0.09

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1we0A	3	0.4017	25.4	0.967	Contact Map
3hf7A	2	0.2778	16.5	0.969	Contact Map
3lv9A	2	0.3376	16	0.969	Contact Map
2v8qE	1	0.2906	14.7	0.97	Contact Map
2uv4A	2	0.2735	14.4	0.97	Contact Map
3jtfA	2	0.3376	14.1	0.97	Contact Map
4kceA	2	0.4316	13.9	0.97	Contact Map
4f0hA	4	0.3034	13	0.971	Contact Map
4nasA	2	0.2564	12.8	0.971	Contact Map
3ocoA	2	0.3291	12.7	0.971	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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