GREMLIN Database
Q9HRD9 - Uncharacterized protein
UniProt: Q9HRD9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 234 (227)
Sequences: 115 (92)
Seq/√Len: 6.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
196_S221_Q4.7440.98
155_H172_H3.9820.94
134_L158_G3.8980.93
135_S161_D3.3190.85
108_M111_A3.2510.84
193_R196_S3.0000.79
135_S158_G2.6960.70
7_M16_A2.5870.67
193_R200_L2.3780.60
17_L92_L2.3690.60
67_D105_R2.3560.59
114_E121_R2.3190.58
103_Y108_M2.2780.57
60_G179_L2.2130.54
158_G161_D2.1920.54
128_H157_Y2.0680.49
96_D223_A1.9970.47
2_S212_F1.9930.46
157_Y172_H1.9750.46
98_T188_D1.9660.45
128_H224_L1.9100.43
200_L214_T1.8610.42
40_V223_A1.8600.42
100_F201_A1.8520.41
84_D145_E1.8520.41
111_A210_Y1.7460.38
186_L220_V1.7250.37
82_V140_E1.7090.37
197_S215_Y1.6770.36
153_S223_A1.6390.34
17_L185_V1.6350.34
184_F198_A1.6210.34
134_L161_D1.5840.33
102_S204_R1.5770.32
119_A127_L1.5740.32
3_L35_F1.5540.32
104_D208_G1.5390.31
108_M168_S1.4720.29
25_D149_A1.4690.29
64_A182_S1.4490.28
16_A151_D1.4450.28
10_V36_S1.4430.28
2_S33_E1.4040.27
156_V226_A1.3850.27
121_R197_S1.3840.27
178_E227_V1.3840.27
82_V136_N1.3800.26
62_Q65_S1.3790.26
17_L182_S1.3780.26
148_A151_D1.3680.26
100_F221_Q1.3670.26
95_L226_A1.3590.26
10_V227_V1.3470.26
108_M210_Y1.3460.26
29_T69_P1.3440.25
122_A165_G1.3430.25
87_P162_A1.3180.25
25_D48_E1.3090.25
212_F217_P1.3070.24
104_D226_A1.2950.24
103_Y185_V1.2890.24
191_T196_S1.2800.24
180_A223_A1.2800.24
189_G209_F1.2610.23
49_D52_R1.2560.23
17_L21_A1.2560.23
2_S169_F1.2550.23
107_Q209_F1.2540.23
134_L157_Y1.2530.23
102_S179_L1.2270.22
153_S169_F1.2270.22
123_N150_C1.2240.22
138_R193_R1.2150.22
119_A125_G1.2140.22
68_A192_D1.2130.22
108_M128_H1.2130.22
114_E197_S1.2080.22
141_R219_L1.1910.22
76_S89_S1.1900.22
77_R152_L1.1900.22
61_T186_L1.1850.21
170_A190_G1.1790.21
2_S137_V1.1740.21
50_A55_L1.1550.21
102_S209_F1.1480.21
56_A97_H1.1460.20
53_A123_N1.1440.20
21_A100_F1.1420.20
84_D112_S1.1400.20
145_E214_T1.1220.20
28_V160_P1.1180.20
114_E118_R1.1150.20
124_S142_D1.1140.20
21_A56_A1.1050.20
18_T157_Y1.1050.20
114_E202_E1.1010.19
202_E210_Y1.0990.19
111_A212_F1.0990.19
120_W205_A1.0980.19
137_V229_G1.0980.19
56_A185_V1.0910.19
135_S159_V1.0910.19
12_G187_Y1.0880.19
49_D145_E1.0840.19
130_G178_E1.0790.19
78_D110_M1.0740.19
110_M136_N1.0700.19
82_V105_R1.0660.19
78_D140_E1.0650.19
124_S156_V1.0590.19
106_R152_L1.0590.19
66_V105_R1.0580.18
181_V226_A1.0560.18
129_T185_V1.0530.18
36_S218_A1.0520.18
108_M196_S1.0510.18
98_T216_D1.0510.18
40_V100_F1.0480.18
48_E165_G1.0390.18
11_R68_A1.0390.18
178_E226_A1.0350.18
160_P177_D1.0340.18
203_E206_D1.0330.18
113_R144_Y1.0290.18
2_S206_D1.0250.18
32_R92_L1.0250.18
80_H117_D1.0190.18
5_H127_L1.0150.18
178_E188_D1.0140.18
117_D121_R1.0080.17
14_E101_T1.0040.17
111_A215_Y0.9980.17
17_L100_F0.9970.17
136_N140_E0.9970.17
34_Y187_Y0.9920.17
77_R83_G0.9900.17
26_G79_L0.9820.17
40_V201_A0.9800.17
15_K128_H0.9730.17
96_D216_D0.9720.17
128_H155_H0.9680.17
73_E138_R0.9670.17
82_V110_M0.9630.17
145_E225_E0.9590.16
19_V203_E0.9590.16
45_E200_L0.9560.16
67_D77_R0.9530.16
48_E96_D0.9520.16
163_E179_L0.9480.16
69_P175_E0.9420.16
199_L213_W0.9380.16
77_R136_N0.9310.16
36_S150_C0.9300.16
18_T94_H0.9240.16
52_R164_L0.9230.16
21_A44_H0.9230.16
178_E216_D0.9230.16
11_R191_T0.9200.16
17_L184_F0.9090.15
134_L164_L0.9090.15
60_G218_A0.9040.15
59_D79_L0.9000.15
168_S181_V0.8910.15
35_F65_S0.8840.15
45_E48_E0.8820.15
149_A166_D0.8800.15
64_A140_E0.8770.15
120_W187_Y0.8740.15
207_G229_G0.8740.15
30_A181_V0.8700.15
50_A148_A0.8670.15
186_L224_L0.8550.15
114_E117_D0.8510.14
16_A178_E0.8500.14
198_A223_A0.8410.14
108_M221_Q0.8390.14
102_S130_G0.8360.14
21_A24_G0.8210.14
55_L65_S0.8180.14
134_L159_V0.8150.14
153_S170_A0.8120.14
152_L203_E0.8090.14
161_D229_G0.8070.14
75_A83_G0.7970.14
118_R121_R0.7920.13
97_H154_V0.7900.13
123_N151_D0.7840.13
62_Q201_A0.7830.13
38_Q42_I0.7810.13
78_D107_Q0.7810.13
140_E217_P0.7800.13
58_A229_G0.7800.13
4_R156_V0.7780.13
144_Y201_A0.7750.13
95_L217_P0.7750.13
78_D185_V0.7720.13
148_A175_E0.7690.13
185_V206_D0.7670.13
48_E149_A0.7630.13
45_E225_E0.7610.13
140_E174_P0.7600.13
89_S110_M0.7580.13
58_A128_H0.7560.13
45_E55_L0.7520.13
39_H227_V0.7510.13
10_V212_F0.7460.13
26_G193_R0.7440.13
72_R148_A0.7400.13
39_H154_V0.7390.13
107_Q136_N0.7290.12
204_R210_Y0.7280.12
152_L186_L0.7210.12
112_S199_L0.7210.12
54_V162_A0.7200.12
12_G142_D0.7180.12
104_D174_P0.7090.12
189_G202_E0.7070.12
76_S80_H0.7060.12
43_E205_A0.7060.12
107_Q111_A0.7000.12
48_E195_Q0.6940.12
101_T210_Y0.6940.12
9_E65_S0.6930.12
189_G204_R0.6920.12
135_S214_T0.6900.12
50_A223_A0.6890.12
112_S134_L0.6870.12
90_P169_F0.6850.12
76_S110_M0.6830.12
110_M197_S0.6810.12
77_R82_V0.6800.12
75_A110_M0.6790.12
36_S43_E0.6780.12
43_E161_D0.6750.12
126_Q210_Y0.6730.12
19_V40_V0.6660.11
85_E126_Q0.6650.11
126_Q153_S0.6640.11
120_W143_T0.6640.11
144_Y220_V0.6590.11
204_R209_F0.6580.11
162_A165_G0.6560.11
118_R191_T0.6540.11
58_A138_R0.6520.11
38_Q133_R0.6490.11
58_A193_R0.6450.11
34_Y96_D0.6430.11
50_A122_A0.6420.11
4_R84_D0.6420.11
6_L117_D0.6370.11
154_V181_V0.6370.11
104_D178_E0.6360.11
11_R204_R0.6350.11
38_Q105_R0.6310.11
130_G227_V0.6310.11
103_Y111_A0.6290.11
34_Y38_Q0.6290.11
122_A213_W0.6290.11
146_Q162_A0.6270.11
59_D96_D0.6260.11
117_D202_E0.6210.11
117_D209_F0.6210.11
42_I49_D0.6210.11
66_V83_G0.6190.11
43_E216_D0.6160.11
84_D142_D0.6130.11
15_K228_T0.6120.11
92_L147_L0.6070.11
137_V177_D0.6050.11
56_A172_H0.6050.11
28_V55_L0.6020.11
29_T193_R0.6000.11
104_D191_T0.5950.10
66_V89_S0.5950.10
60_G151_D0.5940.10
102_S178_E0.5930.10
142_D229_G0.5910.10
42_I142_D0.5880.10
102_S117_D0.5860.10
17_L198_A0.5850.10
77_R105_R0.5850.10
197_S226_A0.5810.10
6_L24_G0.5770.10
198_A202_E0.5740.10
13_R169_F0.5720.10
202_E215_Y0.5700.10
48_E145_E0.5690.10
125_G214_T0.5690.10
103_Y140_E0.5690.10
116_E183_W0.5680.10
116_E131_F0.5680.10
131_F183_W0.5680.10
16_A156_V0.5640.10
74_L83_G0.5640.10
50_A153_S0.5640.10
119_A187_Y0.5640.10
24_G36_S0.5630.10
82_V89_S0.5610.10
111_A204_R0.5600.10
34_Y63_L0.5560.10
18_T104_D0.5560.10
149_A163_E0.5550.10
112_S135_S0.5540.10
22_P44_H0.5540.10
117_D197_S0.5540.10
193_R221_Q0.5520.10
3_L216_D0.5510.10
101_T168_S0.5490.10
141_R169_F0.5480.10
48_E129_T0.5450.10
28_V177_D0.5420.10
120_W211_G0.5410.10
111_A209_F0.5320.10
9_E219_L0.5320.10
47_T165_G0.5320.10
69_P163_E0.5300.10
114_E204_R0.5300.10
75_A228_T0.5290.10
115_I185_V0.5250.10
152_L197_S0.5240.10
112_S143_T0.5230.10
92_L96_D0.5210.10
101_T184_F0.5200.09
2_S13_R0.5190.09
202_E217_P0.5180.09
37_S43_E0.5140.09
77_R109_T0.5140.09
17_L81_K0.5130.09
65_S75_A0.5130.09
66_V143_T0.5090.09
9_E72_R0.5090.09
35_F45_E0.5090.09
118_R188_D0.5070.09
104_D190_G0.5060.09
191_T215_Y0.5050.09
98_T114_E0.5030.09
155_H174_P0.5030.09
36_S212_F0.5020.09
101_T202_E0.5010.09
163_E229_G0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1we0A 3 0.4017 25.4 0.967 Contact Map
3hf7A 2 0.2778 16.5 0.969 Contact Map
3lv9A 2 0.3376 16 0.969 Contact Map
2v8qE 1 0.2906 14.7 0.97 Contact Map
2uv4A 2 0.2735 14.4 0.97 Contact Map
3jtfA 2 0.3376 14.1 0.97 Contact Map
4kceA 2 0.4316 13.9 0.97 Contact Map
4f0hA 4 0.3034 13 0.971 Contact Map
4nasA 2 0.2564 12.8 0.971 Contact Map
3ocoA 2 0.3291 12.7 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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