GREMLIN Database
Q9HRD8 - Uncharacterized protein
UniProt: Q9HRD8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 169 (136)
Sequences: 19421 (15379)
Seq/√Len: 1318.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
54_L112_V3.0001.00
24_R54_L2.8421.00
26_I131_A2.5931.00
119_G155_R2.5821.00
52_D110_T2.5231.00
24_R52_D2.5161.00
41_E165_T2.3371.00
133_H165_T2.3071.00
112_V125_L2.2521.00
125_L129_R2.0761.00
116_G121_E2.0121.00
136_I156_I1.9891.00
154_Q158_L1.9151.00
126_A134_I1.8671.00
54_L110_T1.8471.00
134_I162_G1.8281.00
54_L129_R1.8221.00
114_R121_E1.7441.00
54_L131_A1.7411.00
28_V136_I1.7411.00
58_V121_E1.7081.00
54_L125_L1.6731.00
56_L125_L1.6461.00
40_E101_V1.6411.00
27_A42_A1.6031.00
24_R132_D1.5851.00
28_V122_I1.5681.00
121_E124_A1.5371.00
87_T91_R1.5371.00
127_D161_D1.4831.00
45_L49_V1.4431.00
155_R159_E1.4011.00
51_A132_D1.3881.00
52_D108_E1.3821.00
134_I160_F1.3811.00
91_R95_S1.3651.00
57_H90_A1.3631.00
123_L159_E1.3611.00
114_R125_L1.2851.00
27_A39_V1.2811.00
126_A161_D1.2631.00
112_V129_R1.2611.00
42_A46_A1.2591.00
36_K101_V1.2521.00
134_I156_I1.2351.00
160_F164_V1.2011.00
90_A93_F1.2001.00
22_M163_A1.1631.00
125_L128_D1.1461.00
56_L114_R1.1381.00
93_F97_I1.1371.00
101_V104_D1.1251.00
118_K152_V1.0791.00
29_V97_I1.0601.00
47_A105_V1.0491.00
138_G168_T1.0481.00
138_G166_V1.0481.00
56_L122_I1.0421.00
95_S111_S1.0331.00
157_I166_V1.0301.00
144_T148_I1.0201.00
24_R131_A1.0181.00
126_A162_G1.0171.00
22_M41_E1.0121.00
41_E167_I1.0101.00
25_A133_H1.0081.00
146_K154_Q1.0071.00
39_V55_L0.9981.00
58_V118_K0.9981.00
88_D92_K0.9961.00
83_I87_T0.9941.00
39_V97_I0.9901.00
35_A38_L0.9771.00
114_R128_D0.9741.00
124_A128_D0.9671.00
59_T115_V0.9651.00
126_A131_A0.9621.00
55_L109_P0.9451.00
93_F96_D0.9441.00
86_A89_G0.9361.00
44_E48_G0.9331.00
84_D88_D0.9321.00
136_I153_T0.9321.00
97_I101_V0.9221.00
41_E45_L0.9171.00
24_R129_R0.9101.00
41_E44_E0.9031.00
31_A57_H0.9021.00
42_A135_F0.8881.00
29_V55_L0.8821.00
49_V132_D0.8791.00
153_T166_V0.8721.00
26_I56_L0.8591.00
42_A53_L0.8581.00
89_G93_F0.8551.00
59_T113_G0.8521.00
43_G105_V0.8521.00
46_A53_L0.8441.00
90_A94_A0.8431.00
43_G107_I0.8421.00
123_L126_A0.8381.00
143_P146_K0.8371.00
32_S35_A0.8331.00
29_V38_L0.8311.00
100_D103_S0.8211.00
89_G92_K0.8201.00
94_A111_S0.8201.00
26_I134_I0.8181.00
141_R145_G0.8151.00
29_V39_V0.8041.00
86_A90_A0.8041.00
43_G102_L0.8031.00
123_L156_I0.8021.00
90_A113_G0.7981.00
26_I125_L0.7931.00
110_T129_R0.7931.00
41_E163_A0.7931.00
100_D104_D0.7921.00
102_L109_P0.7871.00
92_K96_D0.7801.00
39_V43_G0.7791.00
37_Q40_E0.7781.00
31_A93_F0.7761.00
123_L160_F0.7741.00
85_E89_G0.7701.00
22_M132_D0.7671.00
125_L131_A0.7671.00
36_K40_E0.7641.00
27_A53_L0.7621.00
135_F165_T0.7571.00
46_A49_V0.7571.00
44_E47_A0.7541.00
36_K96_D0.7501.00
88_D91_R0.7491.00
31_A97_I0.7461.00
32_S140_K0.7421.00
117_D120_D0.7391.00
47_A106_D0.7351.00
28_V137_A0.7231.00
23_D51_A0.7221.00
85_E88_D0.7211.00
122_I156_I0.7181.00
27_A38_L0.7111.00
57_H93_F0.7051.00
144_T147_A0.7031.00
22_M133_H0.6951.00
23_D132_D0.6951.00
46_A51_A0.6921.00
138_G153_T0.6911.00
143_P147_A0.6891.00
55_L97_I0.6751.00
29_V36_K0.6731.00
24_R51_A0.6701.00
97_I102_L0.6681.00
95_S100_D0.6641.00
42_A51_A0.6641.00
136_I166_V0.6641.00
140_K149_F0.6641.00
91_R111_S0.6641.00
45_L48_G0.6631.00
119_G123_L0.6581.00
119_G156_I0.6561.00
36_K97_I0.6551.00
87_T115_V0.6551.00
96_D100_D0.6441.00
25_A46_A0.6401.00
121_E125_L0.6381.00
94_A113_G0.6371.00
22_M51_A0.6351.00
29_V35_A0.6311.00
59_T90_A0.6311.00
43_G47_A0.6291.00
130_D162_G0.6261.00
38_L135_F0.6231.00
65_G69_E0.6171.00
55_L102_L0.6151.00
56_L121_E0.6131.00
84_D87_T0.6031.00
119_G152_V0.5991.00
34_S37_Q0.5981.00
120_D124_A0.5871.00
96_D101_V0.5831.00
45_L135_F0.5791.00
25_A135_F0.5771.00
55_L111_S0.5761.00
59_T87_T0.5761.00
33_D36_K0.5681.00
138_G148_I0.5661.00
149_F153_T0.5631.00
137_A167_I0.5571.00
156_I164_V0.5521.00
127_D162_G0.5511.00
112_V115_V0.5431.00
119_G159_E0.5421.00
22_M165_T0.5351.00
92_K95_S0.5321.00
116_G124_A0.5261.00
30_E35_A0.5181.00
43_G53_L0.5151.00
61_E115_V0.5071.00
123_L155_R0.5061.00
140_K150_G0.5061.00
58_V116_G0.5011.00
83_I115_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mt0A 1 0.8698 99.9 0.239 Contact Map
4r2kA 2 0.9527 99.9 0.24 Contact Map
4wy2A 2 0.9408 99.9 0.253 Contact Map
2gm3A 2 0.7515 99.9 0.254 Contact Map
3s3tA 4 0.8462 99.9 0.261 Contact Map
5ahwA 4 0.8521 99.9 0.262 Contact Map
3cisA 4 0.9172 99.9 0.262 Contact Map
4wnyA 2 0.7692 99.9 0.263 Contact Map
3hgmA 2 0.8521 99.9 0.27 Contact Map
1mjhA 2 0.8343 99.9 0.271 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0069 seconds.