GREMLIN Database
Q9HRD4 - Protein kinase
UniProt: Q9HRD4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 685 (614)
Sequences: 493 (160)
Seq/√Len: 6.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
663_S666_G10.3091.00
481_F666_G9.9561.00
481_F663_S8.5681.00
373_D428_N7.9201.00
32_T39_V7.5681.00
206_D209_S6.1561.00
167_S209_S5.7921.00
359_D459_S5.6030.99
41_R49_D5.0990.99
167_S206_D4.9190.99
47_L97_V4.9110.99
124_V408_T4.1760.96
427_Y453_E4.1750.96
23_T147_R3.8840.94
371_E374_R3.8150.93
322_I459_S3.2950.87
143_L239_A3.2880.86
392_H663_S2.7470.74
204_S467_I2.5780.69
554_I575_L2.5600.69
206_D481_F2.5490.68
178_P182_R2.5030.67
146_F232_V2.4360.65
322_I359_D2.4220.64
206_D666_G2.4180.64
204_S296_I2.4110.64
364_V641_S2.4000.63
168_P310_L2.3800.63
145_T148_W2.3770.63
134_D608_E2.3690.62
28_W402_G2.3420.61
561_D565_G2.3330.61
118_G459_S2.3120.60
550_V667_A2.2560.58
51_F94_V2.2450.58
118_G397_T2.2430.58
206_D663_S2.1390.54
300_E359_D2.1290.54
408_T672_E2.1240.53
38_T406_V2.1150.53
315_H459_S2.0450.51
438_D657_L2.0210.50
421_L424_A2.0040.49
28_W296_I1.9700.48
419_G482_L1.9670.48
134_D411_R1.9650.48
301_E356_A1.9350.46
372_Y428_N1.9310.46
265_G301_E1.9270.46
180_A655_A1.9190.46
423_K453_E1.9180.46
243_R506_V1.9170.46
180_A218_A1.9020.45
170_H323_K1.8920.45
199_L209_S1.8710.44
406_V512_V1.8660.44
102_R387_D1.8540.44
300_E459_S1.8480.43
145_T235_V1.8270.43
368_Y375_E1.8080.42
367_P379_Y1.8060.42
28_W608_E1.8000.42
103_G200_R1.7960.41
548_D552_A1.7880.41
205_L333_D1.7840.41
167_S175_V1.7580.40
613_Q646_D1.7450.40
118_G359_D1.7220.39
335_V405_G1.7170.39
424_A608_E1.7160.39
168_P592_F1.6950.38
645_V648_E1.6950.38
467_I487_V1.6930.38
435_D442_L1.6900.38
216_L231_H1.6890.38
310_L592_F1.6620.37
359_D397_T1.6620.37
364_V459_S1.6440.36
254_D319_E1.6420.36
31_D218_A1.6370.36
403_L424_A1.6260.36
509_Y590_D1.6250.35
103_G527_D1.6160.35
263_L531_A1.6140.35
246_C570_P1.6090.35
105_G329_R1.6050.35
282_A313_F1.5960.35
93_F296_I1.5940.34
609_P655_A1.5700.34
400_M484_P1.5690.34
128_V210_E1.5650.33
644_D647_E1.5650.33
326_N363_R1.5610.33
406_V661_G1.5610.33
252_P379_Y1.5590.33
569_E652_E1.5560.33
411_R452_R1.5540.33
31_D35_D1.5520.33
31_D380_E1.5440.33
133_E240_S1.5380.33
483_S555_D1.5370.33
406_V488_F1.5290.32
336_I430_E1.5220.32
31_D416_D1.5030.31
112_L303_L1.5020.31
542_Q671_L1.5010.31
252_P367_P1.4980.31
67_R406_V1.4900.31
288_A513_L1.4870.31
280_P356_A1.4850.31
141_G323_K1.4820.31
411_R456_D1.4780.31
320_Q405_G1.4710.30
176_L232_V1.4710.30
427_Y595_E1.4710.30
25_S547_M1.4650.30
103_G511_R1.4540.30
376_A380_E1.4500.30
298_S342_M1.4310.29
336_I421_L1.4290.29
30_L338_G1.4210.29
134_D655_A1.4150.29
561_D566_R1.4070.29
419_G478_D1.3980.28
528_V674_A1.3960.28
212_Y219_H1.3960.28
462_F494_N1.3940.28
322_I405_G1.3800.28
186_I619_R1.3780.28
132_F247_I1.3760.28
402_G407_L1.3680.27
291_N335_V1.3610.27
263_L319_E1.3560.27
184_Q648_E1.3520.27
111_I216_L1.3510.27
410_I592_F1.3450.27
338_G536_L1.3440.27
80_T145_T1.3440.27
171_Q175_V1.3390.27
302_L372_Y1.3370.26
269_Y359_D1.3320.26
402_G646_D1.3280.26
296_I398_L1.3240.26
15_S35_D1.3240.26
559_V657_L1.3230.26
292_A407_L1.3180.26
335_V338_G1.3180.26
323_K327_N1.3120.26
385_N620_R1.3110.26
419_G515_Q1.3050.26
182_R246_C1.3040.26
482_L509_Y1.3010.25
397_T459_S1.3000.25
315_H359_D1.2990.25
527_D574_F1.2960.25
180_A408_T1.2950.25
331_D484_P1.2920.25
302_L529_R1.2890.25
434_I439_P1.2820.25
299_G342_M1.2770.25
375_E409_R1.2730.25
373_D513_L1.2720.25
402_G573_T1.2670.24
293_N333_D1.2630.24
320_Q608_E1.2540.24
32_T493_D1.2520.24
511_R651_N1.2440.24
187_D408_T1.2410.24
44_H539_I1.2360.24
574_F635_N1.2340.24
209_S481_F1.2260.23
458_V552_A1.2210.23
81_F99_S1.2160.23
552_A625_K1.2120.23
179_E389_P1.2090.23
338_G383_L1.2000.23
576_R600_V1.1880.22
118_G315_H1.1870.22
23_T28_W1.1760.22
223_D231_H1.1750.22
220_Y421_L1.1720.22
364_V603_R1.1700.22
72_D387_D1.1660.22
115_G173_P1.1650.22
115_G579_E1.1650.22
115_G593_R1.1650.22
134_D380_E1.1650.22
379_Y623_E1.1650.22
408_T552_A1.1590.22
173_P579_E1.1570.22
173_P593_R1.1570.22
493_D531_A1.1570.22
579_E593_R1.1570.22
49_D399_T1.1530.22
388_V467_I1.1450.21
303_L460_P1.1430.21
310_L356_A1.1400.21
24_Q202_S1.1350.21
349_R379_Y1.1350.21
118_G429_G1.1340.21
290_C530_H1.1320.21
440_E444_E1.1320.21
648_E655_A1.1290.21
129_R339_R1.1270.21
248_E280_P1.1240.21
408_T509_Y1.1230.21
73_P651_N1.1120.21
280_P661_G1.1110.20
27_Q664_E1.1100.20
219_H232_V1.1100.20
133_E378_I1.1080.20
320_Q595_E1.1070.20
44_H277_E1.1060.20
646_D655_A1.1010.20
14_E18_A1.1010.20
397_T484_P1.0950.20
168_P263_L1.0940.20
61_D366_F1.0940.20
408_T466_E1.0940.20
51_F657_L1.0930.20
300_E315_H1.0930.20
28_W218_A1.0870.20
19_D31_D1.0860.20
482_L527_D1.0850.20
645_V654_V1.0840.20
42_N45_Q1.0830.20
92_E512_V1.0810.20
417_A466_E1.0800.20
254_D310_L1.0790.20
532_L636_F1.0760.20
397_T511_R1.0760.20
246_C375_E1.0760.20
525_I674_A1.0750.20
19_D611_D1.0720.20
171_Q209_S1.0710.20
561_D568_Q1.0700.20
117_V257_N1.0670.19
214_D419_G1.0670.19
293_N368_Y1.0650.19
116_P423_K1.0610.19
121_K454_G1.0590.19
341_N454_G1.0590.19
360_R454_G1.0590.19
395_P454_G1.0590.19
454_G546_Y1.0590.19
122_S375_E1.0580.19
350_A560_A1.0570.19
184_Q218_A1.0540.19
408_T659_D1.0530.19
561_D564_T1.0530.19
186_I523_R1.0530.19
658_V664_E1.0450.19
396_H399_T1.0430.19
413_P598_N1.0390.19
397_T556_D1.0360.19
408_T416_D1.0350.19
265_G356_A1.0340.19
412_E440_E1.0310.19
442_L445_E1.0280.19
300_E405_G1.0280.19
121_K341_N1.0280.19
121_K360_R1.0280.19
121_K395_P1.0280.19
121_K546_Y1.0280.19
252_P461_R1.0280.19
341_N360_R1.0280.19
341_N395_P1.0280.19
341_N546_Y1.0280.19
360_R395_P1.0280.19
360_R546_Y1.0280.19
395_P546_Y1.0280.19
251_E357_F1.0270.19
34_Y185_V1.0250.19
270_S506_V1.0250.19
331_D459_S1.0240.18
249_T460_P1.0240.18
64_V187_D1.0240.18
28_W609_P1.0220.18
223_D440_E1.0160.18
25_S609_P1.0160.18
425_K430_E1.0160.18
15_S18_A1.0140.18
55_G205_L1.0140.18
133_E459_S1.0120.18
512_V620_R1.0050.18
67_R467_I1.0030.18
388_V522_E1.0030.18
133_E252_P1.0000.18
261_T484_P0.9980.18
221_D613_Q0.9960.18
583_G663_S0.9960.18
134_D180_A0.9960.18
88_E380_E0.9950.18
406_V609_P0.9910.18
387_D566_R0.9900.18
296_I646_D0.9820.18
134_D187_D0.9810.18
237_L506_V0.9800.18
289_F583_G0.9790.18
209_S666_G0.9780.17
363_R679_A0.9760.17
254_D263_L0.9680.17
245_D657_L0.9670.17
147_R380_E0.9660.17
27_Q655_A0.9640.17
41_R311_Y0.9630.17
15_S679_A0.9620.17
394_E484_P0.9610.17
32_T456_D0.9580.17
324_P338_G0.9540.17
247_I254_D0.9540.17
222_D342_M0.9520.17
103_G586_G0.9510.17
115_G409_R0.9510.17
600_V618_L0.9500.17
110_I336_I0.9500.17
123_D167_S0.9490.17
303_L340_T0.9480.17
73_P76_E0.9460.17
14_E180_A0.9460.17
269_Y459_S0.9450.17
58_T61_D0.9440.17
252_P378_I0.9430.17
429_G442_L0.9420.17
88_E402_G0.9410.17
27_Q406_V0.9410.17
177_L648_E0.9380.17
442_L646_D0.9360.17
410_I510_Q0.9350.17
245_D292_A0.9350.17
339_R627_W0.9350.17
559_V590_D0.9350.17
171_Q252_P0.9340.17
483_S665_D0.9330.17
92_E335_V0.9330.17
319_E595_E0.9330.17
322_I331_D0.9320.17
209_S663_S0.9300.16
207_P552_A0.9280.16
97_V124_V0.9270.16
102_R406_V0.9270.16
49_D408_T0.9270.16
122_S368_Y0.9250.16
533_A673_F0.9250.16
548_D644_D0.9250.16
471_I575_L0.9230.16
656_A659_D0.9200.16
25_S184_Q0.9190.16
665_D669_E0.9190.16
31_D648_E0.9160.16
408_T606_E0.9140.16
539_I622_L0.9100.16
171_Q666_G0.9100.16
302_L308_E0.9070.16
168_P356_A0.9050.16
117_V258_Q0.9020.16
282_A301_E0.9020.16
212_Y232_V0.9010.16
130_R380_E0.8980.16
118_G211_F0.8960.16
396_H530_H0.8950.16
534_Y567_E0.8940.16
72_D293_N0.8930.16
272_L285_Y0.8930.16
349_R405_G0.8920.16
45_Q487_V0.8920.16
331_D359_D0.8910.16
97_V651_N0.8910.16
113_L379_Y0.8900.16
172_D666_G0.8900.16
541_R550_V0.8890.16
116_P457_G0.8890.16
12_Y15_S0.8880.16
331_D467_I0.8880.16
222_D348_K0.8880.16
609_P645_V0.8880.16
408_T482_L0.8850.16
182_R205_L0.8850.16
93_F384_G0.8830.16
397_T400_M0.8830.16
288_A460_P0.8820.16
141_G182_R0.8800.15
131_Y210_E0.8790.15
298_S339_R0.8780.15
67_R394_E0.8780.15
364_V651_N0.8780.15
236_R327_N0.8770.15
338_G622_L0.8770.15
38_T49_D0.8760.15
398_L648_E0.8740.15
42_N296_I0.8730.15
462_F594_Q0.8700.15
61_D180_A0.8690.15
276_G301_E0.8690.15
133_E279_D0.8670.15
28_W180_A0.8650.15
133_E368_Y0.8650.15
326_N483_S0.8640.15
326_N660_R0.8640.15
596_V663_S0.8640.15
288_A404_F0.8640.15
278_S288_A0.8590.15
466_E630_K0.8580.15
258_Q356_A0.8560.15
380_E389_P0.8550.15
214_D550_V0.8550.15
453_E595_E0.8520.15
573_T651_N0.8520.15
109_R377_K0.8510.15
296_I537_D0.8510.15
133_E370_L0.8490.15
43_A336_I0.8490.15
434_I526_E0.8460.15
392_H481_F0.8450.15
170_H376_A0.8450.15
459_S484_P0.8440.15
283_F424_A0.8440.15
79_N411_R0.8410.15
15_S372_Y0.8410.15
468_A627_W0.8400.15
82_F572_E0.8360.15
315_H366_F0.8360.15
483_S527_D0.8360.15
303_L309_F0.8320.15
92_E506_V0.8300.15
98_K308_E0.8260.14
300_E322_I0.8250.14
350_A550_V0.8210.14
56_K399_T0.8210.14
313_F375_E0.8200.14
117_V345_Y0.8170.14
278_S323_K0.8170.14
483_S598_N0.8170.14
301_E318_Q0.8130.14
290_C542_Q0.8130.14
172_D199_L0.8120.14
118_G262_E0.8120.14
113_L367_P0.8110.14
250_F524_A0.8110.14
116_P378_I0.8100.14
118_G403_L0.8090.14
645_V655_A0.8060.14
257_N316_A0.8050.14
110_I289_F0.8050.14
295_G409_R0.8040.14
35_D507_A0.8030.14
491_V656_A0.8020.14
49_D59_D0.8010.14
587_D633_N0.8010.14
53_Y514_E0.8000.14
543_G633_N0.8000.14
114_L561_D0.8000.14
368_Y409_R0.7980.14
43_A187_D0.7980.14
269_Y338_G0.7970.14
521_K679_A0.7950.14
36_D591_D0.7950.14
123_D366_F0.7950.14
335_V383_L0.7940.14
513_L527_D0.7940.14
222_D560_A0.7940.14
25_S180_A0.7920.14
383_L631_K0.7920.14
289_F308_E0.7920.14
89_S560_A0.7910.14
236_R309_F0.7900.14
50_M626_L0.7890.14
185_V385_N0.7890.14
309_F323_K0.7880.14
313_F402_G0.7860.14
347_D649_Q0.7860.14
101_A488_F0.7850.14
184_Q513_L0.7850.14
272_L615_N0.7830.14
340_T468_A0.7820.14
141_G303_L0.7810.14
120_G404_F0.7800.14
39_V559_V0.7790.14
148_W213_M0.7770.14
428_N619_R0.7760.14
14_E214_D0.7760.14
58_T366_F0.7760.14
376_A390_D0.7760.14
39_V93_F0.7730.14
178_P375_E0.7730.14
241_E292_A0.7730.14
597_S600_V0.7730.14
362_K372_Y0.7730.14
59_D65_E0.7720.14
58_T185_V0.7710.14
256_K345_Y0.7710.14
141_G313_F0.7710.14
109_R340_T0.7690.13
179_E225_Q0.7690.13
173_P409_R0.7680.13
409_R579_E0.7680.13
409_R593_R0.7680.13
373_D398_L0.7660.13
483_S566_R0.7650.13
15_S458_V0.7640.13
182_R375_E0.7640.13
280_P301_E0.7630.13
122_S379_Y0.7630.13
110_I556_D0.7610.13
480_G665_D0.7580.13
35_D390_D0.7570.13
313_F357_F0.7570.13
15_S39_V0.7540.13
93_F144_Y0.7530.13
167_S666_G0.7500.13
312_D359_D0.7460.13
402_G641_S0.7450.13
493_D565_G0.7450.13
141_G528_V0.7440.13
285_Y399_T0.7440.13
263_L355_E0.7420.13
174_L365_D0.7420.13
174_L607_G0.7410.13
93_F527_D0.7400.13
132_F570_P0.7400.13
49_D670_V0.7390.13
24_Q51_F0.7380.13
257_N271_K0.7370.13
333_D517_R0.7360.13
175_V206_D0.7360.13
118_G300_E0.7350.13
58_T68_L0.7340.13
312_D459_S0.7330.13
68_L383_L0.7330.13
513_L646_D0.7280.13
266_D583_G0.7280.13
272_L500_S0.7270.13
172_D663_S0.7230.13
46_R258_Q0.7210.13
174_L280_P0.7200.13
109_R256_K0.7190.13
276_G323_K0.7190.13
124_V446_A0.7180.13
133_E379_Y0.7180.13
349_R357_F0.7170.13
408_T654_V0.7160.13
246_C410_I0.7150.13
622_L670_V0.7120.13
671_L675_G0.7110.13
300_E484_P0.7110.13
216_L539_I0.7100.12
57_T502_P0.7090.12
83_G174_L0.7090.12
19_D28_W0.7080.12
36_D39_V0.7050.12
418_I482_L0.7050.12
566_R673_F0.7050.12
168_P254_D0.7040.12
405_G459_S0.7040.12
108_K300_E0.7020.12
31_D408_T0.7000.12
258_Q355_E0.6990.12
379_Y459_S0.6980.12
482_L569_E0.6980.12
262_E516_V0.6970.12
128_V131_Y0.6970.12
67_R70_S0.6970.12
233_E547_M0.6970.12
392_H666_G0.6960.12
384_G530_H0.6960.12
444_E664_E0.6920.12
120_G566_R0.6910.12
22_D309_F0.6910.12
437_V563_L0.6900.12
35_D184_Q0.6900.12
66_Y70_S0.6890.12
145_T283_F0.6880.12
270_S591_D0.6880.12
39_V49_D0.6880.12
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367_P644_D0.6840.12
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29_Y33_L0.6820.12
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243_R416_D0.6810.12
298_S379_Y0.6790.12
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320_Q459_S0.6780.12
653_W670_V0.6780.12
180_A547_M0.6780.12
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130_R408_T0.6770.12
109_R141_G0.6770.12
388_V559_V0.6750.12
340_T543_G0.6730.12
558_T582_L0.6730.12
324_P363_R0.6720.12
399_T508_D0.6720.12
276_G282_A0.6700.12
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408_T570_P0.6690.12
563_L660_R0.6670.12
300_E331_D0.6670.12
310_L319_E0.6660.12
552_A647_E0.6660.12
42_N467_I0.6640.12
336_I428_N0.6630.12
42_N61_D0.6620.12
147_R235_V0.6610.12
237_L641_S0.6610.12
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141_G178_P0.6600.12
14_E497_Q0.6590.12
41_R45_Q0.6580.12
22_D188_D0.6580.12
259_D356_A0.6570.12
340_T637_S0.6560.12
441_K445_E0.6560.12
413_P440_E0.6560.12
454_G457_G0.6550.12
470_A548_D0.6540.12
112_L340_T0.6520.12
103_G114_L0.6510.12
72_D309_F0.6510.12
276_G356_A0.6480.12
146_F220_Y0.6460.11
130_R406_V0.6460.11
221_D619_R0.6460.11
496_P664_E0.6460.11
318_Q344_E0.6440.11
175_V209_S0.6420.11
100_G301_E0.6410.11
406_V426_A0.6410.11
34_Y113_L0.6410.11
622_L636_F0.6410.11
574_F673_F0.6400.11
104_L108_K0.6380.11
171_Q174_L0.6380.11
259_D381_K0.6380.11
220_Y231_H0.6370.11
88_E544_E0.6370.11
128_V313_F0.6370.11
378_I459_S0.6360.11
29_Y89_S0.6350.11
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346_Q373_D0.6340.11
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18_A59_D0.6320.11
292_A297_F0.6320.11
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44_H605_R0.6310.11
619_R672_E0.6300.11
177_L549_H0.6290.11
70_S538_E0.6290.11
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466_E489_N0.6280.11
38_T238_V0.6270.11
541_R642_N0.6260.11
121_K457_G0.6250.11
341_N457_G0.6250.11
360_R457_G0.6250.11
395_P457_G0.6250.11
457_G546_Y0.6250.11
103_G453_E0.6250.11
607_G623_E0.6250.11
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533_A539_I0.6230.11
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180_A456_D0.6210.11
241_E327_N0.6210.11
64_V508_D0.6210.11
518_E534_Y0.6200.11
317_T504_D0.6200.11
68_L516_V0.6200.11
167_S663_S0.6170.11
92_E320_Q0.6170.11
236_R249_T0.6160.11
259_D301_E0.6150.11
27_Q661_G0.6150.11
177_L421_L0.6140.11
42_N331_D0.6130.11
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256_K340_T0.6100.11
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61_D387_D0.6010.11
26_F411_R0.6010.11
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100_G344_E0.6000.11
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263_L595_E0.5990.11
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305_L312_D0.5920.11
463_V491_V0.5920.11
336_I356_A0.5920.11
171_Q206_D0.5910.11
547_M657_L0.5910.11
173_P454_G0.5900.11
292_A548_D0.5900.11
454_G579_E0.5900.11
454_G593_R0.5900.11
252_P429_G0.5890.11
100_G304_K0.5880.11
115_G375_E0.5880.11
21_R408_T0.5870.11
643_A652_E0.5870.11
182_R570_P0.5870.11
129_R298_S0.5870.11
170_H291_N0.5870.11
324_P335_V0.5860.11
39_V89_S0.5860.11
513_L651_N0.5860.11
36_D179_E0.5830.11
322_I329_R0.5820.11
172_D209_S0.5810.11
647_E665_D0.5810.11
60_D377_K0.5810.11
263_L339_R0.5800.11
351_D596_V0.5800.11
496_P560_A0.5790.11
527_D637_S0.5790.11
329_R359_D0.5790.11
401_A516_V0.5790.11
276_G528_V0.5790.11
180_A482_L0.5780.11
141_G236_R0.5780.11
17_P419_G0.5780.11
184_Q613_Q0.5780.11
31_D412_E0.5770.10
108_K356_A0.5770.10
124_V296_I0.5770.10
249_T303_L0.5760.10
629_D665_D0.5760.10
178_P205_L0.5740.10
28_W204_S0.5730.10
247_I319_E0.5730.10
616_D619_R0.5720.10
247_I310_L0.5720.10
65_E657_L0.5700.10
319_E467_I0.5690.10
44_H466_E0.5680.10
269_Y329_R0.5660.10
35_D380_E0.5660.10
638_A678_V0.5650.10
171_Q344_E0.5650.10
336_I374_R0.5650.10
547_M605_R0.5640.10
74_L119_S0.5630.10
386_A622_L0.5630.10
185_V350_A0.5620.10
205_L570_P0.5610.10
517_R535_D0.5610.10
338_G535_D0.5610.10
503_E566_R0.5610.10
496_P506_V0.5600.10
238_V420_L0.5590.10
367_P564_T0.5590.10
121_K173_P0.5590.10
121_K579_E0.5590.10
121_K593_R0.5590.10
173_P341_N0.5590.10
173_P360_R0.5590.10
173_P395_P0.5590.10
173_P546_Y0.5590.10
341_N579_E0.5590.10
341_N593_R0.5590.10
360_R579_E0.5590.10
360_R593_R0.5590.10
395_P579_E0.5590.10
395_P593_R0.5590.10
546_Y579_E0.5590.10
546_Y593_R0.5590.10
101_A469_A0.5580.10
378_I461_R0.5580.10
336_I584_V0.5580.10
652_E661_G0.5570.10
115_G454_G0.5570.10
513_L663_S0.5570.10
132_F246_C0.5570.10
35_D218_A0.5560.10
145_T167_S0.5560.10
15_S655_A0.5560.10
368_Y459_S0.5560.10
294_R333_D0.5550.10
180_A406_V0.5550.10
209_S376_A0.5550.10
231_H369_V0.5550.10
367_P378_I0.5550.10
167_S212_Y0.5540.10
129_R355_E0.5530.10
289_F428_N0.5530.10
96_K111_I0.5500.10
305_L535_D0.5490.10
141_G276_G0.5490.10
259_D355_E0.5480.10
216_L369_V0.5480.10
497_Q609_P0.5480.10
364_V618_L0.5460.10
486_T580_E0.5460.10
59_D657_L0.5440.10
461_R564_T0.5440.10
559_V565_G0.5440.10
111_I427_Y0.5430.10
178_P246_C0.5430.10
380_E646_D0.5420.10
118_G322_I0.5420.10
308_E586_G0.5410.10
169_M309_F0.5400.10
331_D465_D0.5400.10
308_E583_G0.5390.10
379_Y461_R0.5390.10
183_Q511_R0.5390.10
284_D340_T0.5390.10
249_T426_A0.5370.10
298_S348_K0.5370.10
74_L611_D0.5360.10
517_R576_R0.5360.10
171_Q663_S0.5360.10
503_E559_V0.5350.10
353_K524_A0.5350.10
485_L517_R0.5340.10
338_G590_D0.5330.10
240_S491_V0.5320.10
644_D665_D0.5320.10
21_R467_I0.5320.10
397_T417_A0.5310.10
141_G550_V0.5310.10
95_N134_D0.5310.10
106_P112_L0.5310.10
498_H501_I0.5300.10
326_N365_D0.5300.10
401_A570_P0.5290.10
323_K401_A0.5290.10
182_R206_D0.5290.10
120_G361_T0.5280.10
269_Y300_E0.5280.10
544_E559_V0.5280.10
34_Y373_D0.5280.10
411_R440_E0.5270.10
184_Q199_L0.5270.10
58_T642_N0.5270.10
115_G121_K0.5270.10
115_G341_N0.5270.10
115_G360_R0.5270.10
115_G395_P0.5270.10
115_G546_Y0.5270.10
211_F397_T0.5270.10
44_H381_K0.5260.10
404_F607_G0.5250.10
566_R641_S0.5240.10
50_M241_E0.5240.10
306_Q342_M0.5230.10
236_R303_L0.5220.10
533_A619_R0.5220.10
59_D185_V0.5220.10
263_L301_E0.5210.10
317_T335_V0.5210.10
412_E496_P0.5190.10
105_G335_V0.5190.10
556_D646_D0.5190.10
61_D563_L0.5180.10
467_I631_K0.5180.10
92_E405_G0.5170.10
127_Q241_E0.5170.10
32_T644_D0.5160.10
571_D580_E0.5160.10
602_R663_S0.5160.10
130_R664_E0.5150.10
248_E275_Y0.5150.10
323_K674_A0.5140.10
232_V613_Q0.5130.10
36_D350_A0.5130.10
129_R334_Q0.5130.10
134_D179_E0.5130.10
81_F428_N0.5120.10
412_E416_D0.5120.10
253_K325_K0.5120.10
308_E317_T0.5120.10
105_G359_D0.5120.10
555_D598_N0.5110.10
199_L504_D0.5110.10
283_F297_F0.5110.10
188_D372_Y0.5110.10
148_W326_N0.5100.10
182_R669_E0.5100.10
577_A621_A0.5100.10
91_H347_D0.5100.10
180_A225_Q0.5100.10
36_D607_G0.5080.10
167_S481_F0.5070.10
105_G146_F0.5070.10
272_L277_E0.5050.10
47_L238_V0.5040.10
122_S319_E0.5040.10
18_A646_D0.5040.10
258_Q289_F0.5030.10
552_A560_A0.5020.10
44_H50_M0.5020.10
28_W547_M0.5020.10
214_D654_V0.5020.10
132_F357_F0.5010.09
514_E518_E0.5010.09
72_D148_W0.5010.09
501_I573_T0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1g8pA 1 0.4628 99.5 0.933 Contact Map
2r44A 1 0.4423 99.4 0.938 Contact Map
4ww4B 2 0.5591 99.3 0.941 Contact Map
2c9oA 3 0.4496 99.2 0.944 Contact Map
1in4A 1 0.4292 99.1 0.945 Contact Map
1hqcA 1 0.4423 99.1 0.945 Contact Map
3pxiA 3 0.4263 99.1 0.945 Contact Map
3k1jA 4 0.654 99.1 0.946 Contact Map
1g41A 3 0.4234 99.1 0.946 Contact Map
4r7yA 3 0.4891 99.1 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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