GREMLIN Database
Q9HRD2 - Uncharacterized protein
UniProt: Q9HRD2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 104 (89)
Sequences: 292 (134)
Seq/√Len: 14.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_G45_P2.6930.95
82_R85_E2.4480.92
38_I52_D2.2720.89
24_L30_L2.2350.88
40_H43_L2.1690.86
73_R77_E2.1380.85
31_E38_I2.0670.83
22_N25_D2.0430.82
59_T67_H2.0030.81
81_R85_E1.9990.81
19_D87_Q1.9740.80
73_R76_R1.8630.76
61_A67_H1.8110.74
5_T74_G1.7770.72
53_K76_R1.6360.66
6_G9_R1.6090.64
5_T42_R1.6040.64
45_P58_K1.5950.64
36_G89_V1.5770.63
15_A70_L1.5530.62
45_P74_G1.5270.60
21_P67_H1.5040.59
15_A28_S1.4790.58
13_V81_R1.4170.54
41_G58_K1.3950.53
29_D41_G1.3790.52
15_A56_L1.3690.52
6_G10_D1.3470.51
38_I73_R1.3440.50
20_T69_L1.3180.49
33_Y84_W1.3050.48
56_L75_K1.2340.44
22_N30_L1.2260.44
60_K72_D1.1880.42
58_K84_W1.1650.41
11_L49_T1.1460.40
22_N61_A1.1430.40
10_D81_R1.1300.39
20_T67_H1.1300.39
54_G73_R1.1090.38
78_L86_D1.1050.38
33_Y71_T1.0800.36
9_R49_T1.0730.36
15_A21_P1.0610.35
35_T48_D1.0480.35
61_A90_P1.0470.35
29_D55_L1.0310.34
4_L8_Q0.9960.32
4_L31_E0.9900.32
16_A26_I0.9610.31
29_D80_S0.9600.30
45_P49_T0.9550.30
3_D34_Y0.9440.30
61_A75_K0.9380.29
8_Q27_K0.9150.28
53_K88_Y0.8980.28
29_D88_Y0.8910.27
3_D85_E0.8830.27
39_N63_E0.8770.27
7_F64_R0.8770.27
45_P48_D0.8600.26
5_T8_Q0.8450.25
77_E80_S0.8440.25
20_T70_L0.8410.25
41_G51_V0.8360.25
18_L56_L0.8320.25
6_G21_P0.8270.25
81_R84_W0.8260.25
39_N62_D0.8260.25
51_V65_T0.8230.25
17_G21_P0.8170.24
8_Q50_L0.8150.24
26_I79_Q0.8110.24
23_G66_N0.8040.24
20_T24_L0.7980.24
80_S85_E0.7880.23
34_Y38_I0.7870.23
9_R21_P0.7720.23
41_G65_T0.7700.22
2_D74_G0.7700.22
18_L21_P0.7680.22
20_T30_L0.7630.22
17_G85_E0.7600.22
40_H55_L0.7560.22
17_G84_W0.7430.21
48_D74_G0.7360.21
29_D33_Y0.7100.20
74_G79_Q0.6980.20
35_T78_L0.6970.20
17_G88_Y0.6900.20
68_Y71_T0.6820.19
3_D40_H0.6800.19
28_S79_Q0.6670.19
58_K81_R0.6650.19
7_F39_N0.6640.19
51_V58_K0.6640.19
40_H62_D0.6610.19
34_Y39_N0.6520.18
19_D49_T0.6480.18
27_K62_D0.6480.18
3_D87_Q0.6370.18
58_K66_N0.6360.18
28_S76_R0.6320.18
45_P60_K0.6310.18
29_D53_K0.6220.17
60_K63_E0.6210.17
56_L69_L0.6160.17
23_G64_R0.6060.17
15_A18_L0.6040.17
11_L37_N0.6010.17
16_A71_T0.5920.16
13_V85_E0.5900.16
55_L77_E0.5890.16
82_R89_V0.5850.16
10_D42_R0.5810.16
5_T46_N0.5720.16
2_D35_T0.5710.16
3_D56_L0.5710.16
14_V71_T0.5630.16
24_L34_Y0.5550.15
47_L65_T0.5430.15
15_A90_P0.5410.15
38_I80_S0.5370.15
41_G66_N0.5370.15
5_T73_R0.5310.15
84_W88_Y0.5300.15
85_E89_V0.5270.15
25_D39_N0.5260.15
9_R79_Q0.5250.14
73_R85_E0.5150.14
51_V83_E0.5140.14
32_T35_T0.5020.14
7_F41_G0.5010.14
26_I47_L0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2co5A 2 0.875 98.8 0.762 Contact Map
3l9fA 2 0.9135 98.6 0.778 Contact Map
1yg2A 2 0.8654 98.3 0.791 Contact Map
1xmaA 2 0.8654 98.3 0.793 Contact Map
2e1nA 2 0.8365 98.2 0.798 Contact Map
2dqlA 2 0.8846 98.2 0.798 Contact Map
4ejoA 2 0.9231 98.2 0.799 Contact Map
3elkA 3 0.9135 98.2 0.8 Contact Map
2eshA 2 0.9615 98.2 0.8 Contact Map
3f8bA 2 0.8846 98.2 0.801 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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