GREMLIN Database
Q9HRD1 - UDP-glucose 4-epimerase
UniProt: Q9HRD1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 314 (287)
Sequences: 59783 (41778)
Seq/√Len: 2466.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
249_L295_D2.8851.00
13_G33_V2.8791.00
7_R30_D2.6411.00
24_A216_D2.5341.00
217_A235_L2.4681.00
92_E96_A2.4341.00
72_I222_I2.3781.00
231_N282_K2.3521.00
116_T218_M2.3191.00
24_A219_T2.2641.00
253_E299_R2.2191.00
86_Q89_Q2.1721.00
63_A107_A2.1301.00
7_R32_L2.0401.00
34_A54_R2.0291.00
233_F285_A2.0251.00
252_D295_D1.9771.00
112_R163_T1.9761.00
216_D291_T1.9701.00
24_A27_G1.9571.00
74_F222_I1.9271.00
293_A296_E1.9191.00
75_H115_F1.9181.00
244_T248_D1.9121.00
32_L70_V1.8971.00
54_R61_D1.8641.00
32_L50_E1.8491.00
242_S245_A1.8491.00
169_F218_M1.8471.00
249_L252_D1.8441.00
58_D61_D1.8201.00
99_Y152_L1.7991.00
9_V70_V1.7761.00
153_I164_S1.7651.00
32_L52_R1.7641.00
11_T75_H1.7491.00
216_D220_H1.7491.00
27_G219_T1.7451.00
212_E300_T1.7431.00
167_Y221_V1.7411.00
238_R284_A1.7061.00
284_A289_E1.6991.00
30_D50_E1.6831.00
147_L151_G1.6651.00
195_T261_E1.6341.00
219_T223_E1.6231.00
27_G223_E1.6211.00
10_V22_A1.6161.00
63_A104_R1.6121.00
91_F148_A1.6111.00
187_Q191_A1.6071.00
21_A215_V1.5981.00
8_I29_N1.5921.00
173_V297_A1.5831.00
99_Y103_E1.5511.00
220_H224_H1.5181.00
96_A99_Y1.5131.00
57_C92_E1.5131.00
21_A74_F1.5121.00
280_I284_A1.5071.00
98_T149_D1.5051.00
106_A160_H1.5021.00
21_A76_F1.4991.00
59_P103_E1.4981.00
210_H300_T1.4871.00
249_L253_E1.4761.00
24_A215_V1.4671.00
112_R165_W1.4421.00
197_T261_E1.4321.00
88_R92_E1.4311.00
283_L286_L1.4241.00
59_P100_N1.4211.00
17_V172_I1.4031.00
299_R303_A1.3881.00
169_F214_C1.3741.00
73_V105_M1.3661.00
61_D64_D1.3651.00
37_L51_F1.3581.00
191_A194_E1.3501.00
71_D111_D1.3481.00
136_L147_L1.3481.00
63_A108_V1.3421.00
205_E240_T1.3231.00
209_L214_C1.3121.00
22_A33_V1.3071.00
292_R300_T1.3061.00
117_S121_V1.3021.00
76_F116_T1.2951.00
29_N223_E1.2951.00
151_G154_S1.2901.00
210_H297_A1.2801.00
154_S166_V1.2721.00
13_G22_A1.2651.00
59_P63_A1.2571.00
170_A278_L1.2531.00
74_F218_M1.2511.00
23_G176_R1.2451.00
116_T169_F1.2401.00
7_R71_D1.2371.00
167_Y218_M1.2301.00
245_A248_D1.2261.00
115_F149_D1.2171.00
244_T262_Y1.2121.00
142_Y146_K1.2061.00
211_V215_V1.1911.00
131_E134_A1.1901.00
25_L219_T1.1891.00
132_D282_K1.1881.00
152_L155_T1.1841.00
144_A148_A1.1811.00
157_A164_S1.1771.00
296_E299_R1.1751.00
66_I70_V1.1621.00
20_H212_E1.1591.00
282_K285_A1.1561.00
188_K194_E1.1561.00
296_E300_T1.1551.00
64_D68_P1.1541.00
75_H98_T1.1451.00
103_E106_A1.1431.00
8_I25_L1.1401.00
203_R242_S1.1391.00
127_M131_E1.1391.00
9_V34_A1.1331.00
122_Y234_N1.1121.00
56_M97_M1.0981.00
103_E107_A1.0971.00
94_N145_S1.0961.00
154_S232_V1.0941.00
102_L156_Y1.0921.00
195_T259_A1.0911.00
24_A212_E1.0871.00
115_F166_V1.0851.00
26_A48_G1.0811.00
231_N285_A1.0771.00
155_T159_A1.0741.00
168_R232_V1.0721.00
26_A49_V1.0721.00
20_H211_V1.0701.00
33_V49_V1.0661.00
217_A283_L1.0661.00
203_R244_T1.0631.00
241_T294_S1.0551.00
248_D251_S1.0461.00
241_T245_A1.0451.00
8_I72_I1.0451.00
115_F153_I1.0301.00
105_M113_F1.0291.00
236_G278_L1.0291.00
154_S164_S1.0271.00
114_A167_Y1.0241.00
207_S238_R1.0181.00
14_A35_D1.0181.00
104_R108_V1.0151.00
240_T277_R1.0151.00
101_V113_F1.0091.00
56_M77_A1.0071.00
100_N103_E1.0051.00
79_Y93_E1.0011.00
240_T275_R0.9941.00
42_R46_P0.9911.00
280_I290_P0.9901.00
102_L113_F0.9891.00
154_S158_H0.9861.00
19_S176_R0.9811.00
205_E242_S0.9811.00
96_A100_N0.9781.00
295_D299_R0.9771.00
224_H227_S0.9741.00
251_S257_D0.9731.00
165_W221_V0.9721.00
205_E275_R0.9671.00
130_P133_Y0.9671.00
220_H286_L0.9651.00
91_F95_G0.9621.00
216_D288_W0.9581.00
254_L302_A0.9541.00
253_E302_A0.9531.00
163_T229_P0.9511.00
16_L174_G0.9451.00
210_H292_R0.9431.00
104_R107_A0.9421.00
20_H23_G0.9381.00
184_D188_K0.9361.00
220_H223_E0.9351.00
216_D292_R0.9321.00
172_I214_C0.9321.00
34_A61_D0.9321.00
150_E168_R0.9311.00
7_R70_V0.9271.00
61_D65_V0.9231.00
76_F218_M0.9211.00
102_L153_I0.9201.00
11_T101_V0.9191.00
106_A162_I0.9171.00
105_M110_V0.9151.00
66_I104_R0.9151.00
37_L40_G0.9141.00
62_V104_R0.9111.00
95_G148_A0.9111.00
16_L211_V0.9101.00
113_F153_I0.9101.00
90_L145_S0.9081.00
187_Q190_R0.9071.00
233_F282_K0.9031.00
168_R234_N0.9021.00
35_D51_F0.9001.00
212_E292_R0.8991.00
91_F96_A0.8981.00
253_E295_D0.8981.00
72_I112_R0.8961.00
181_V185_F0.8911.00
66_I73_V0.8891.00
166_V232_V0.8831.00
52_R65_V0.8811.00
300_T303_A0.8791.00
167_Y235_L0.8781.00
180_T183_P0.8771.00
93_E97_M0.8771.00
210_H213_D0.8761.00
148_A151_G0.8721.00
217_A288_W0.8701.00
236_G280_I0.8681.00
251_S256_V0.8651.00
216_D219_T0.8631.00
21_A25_L0.8511.00
292_R296_E0.8511.00
184_D187_Q0.8511.00
38_S53_R0.8501.00
228_R231_N0.8351.00
245_A249_L0.8331.00
22_A31_V0.8331.00
8_I74_F0.8321.00
98_T153_I0.8291.00
37_L53_R0.8271.00
197_T263_T0.8261.00
100_N104_R0.8251.00
251_S258_P0.8231.00
193_P196_L0.8221.00
79_Y89_Q0.8211.00
59_P107_A0.8201.00
20_H24_A0.8201.00
66_I108_V0.8191.00
73_V101_V0.8171.00
60_D63_A0.8101.00
7_R29_N0.8091.00
173_V210_H0.8091.00
213_D237_T0.8091.00
34_A62_V0.8031.00
202_G244_T0.8011.00
253_E303_A0.7981.00
11_T77_A0.7971.00
34_A65_V0.7961.00
129_T132_D0.7961.00
117_S150_E0.7941.00
87_P144_A0.7901.00
172_I209_L0.7881.00
26_A31_V0.7861.00
89_Q93_E0.7851.00
260_Y263_T0.7821.00
186_I190_R0.7801.00
111_D163_T0.7781.00
131_E279_S0.7771.00
57_C93_E0.7751.00
8_I222_I0.7741.00
151_G155_T0.7691.00
156_Y160_H0.7691.00
17_V214_C0.7671.00
221_V283_L0.7671.00
32_L69_D0.7671.00
89_Q92_E0.7671.00
20_H215_V0.7631.00
60_D64_D0.7621.00
281_E284_A0.7621.00
238_R280_I0.7591.00
62_V66_I0.7591.00
36_D55_D0.7561.00
102_L152_L0.7541.00
21_A218_M0.7501.00
106_A161_G0.7501.00
128_P131_E0.7491.00
79_Y90_L0.7481.00
253_E298_V0.7461.00
119_S170_A0.7461.00
224_H228_R0.7461.00
220_H288_W0.7461.00
188_K191_A0.7351.00
239_T293_A0.7331.00
75_H101_V0.7291.00
98_T102_L0.7281.00
148_A152_L0.7231.00
19_S23_G0.7181.00
119_S278_L0.7171.00
292_R297_A0.7171.00
175_P300_T0.7151.00
215_V219_T0.7101.00
262_Y265_G0.7091.00
58_D62_V0.7051.00
103_E156_Y0.7051.00
221_V286_L0.7031.00
249_L294_S0.7001.00
83_N90_L0.7001.00
55_D58_D0.7001.00
52_R68_P0.6991.00
130_P134_A0.6991.00
248_D252_D0.6961.00
73_V113_F0.6911.00
127_M130_P0.6901.00
261_E265_G0.6851.00
213_D216_D0.6811.00
180_T184_D0.6791.00
97_M100_N0.6791.00
175_P210_H0.6781.00
164_S230_L0.6781.00
129_T133_Y0.6751.00
140_S143_G0.6751.00
220_H287_G0.6731.00
284_A290_P0.6701.00
189_L251_S0.6681.00
141_V144_A0.6681.00
144_A151_G0.6671.00
170_A236_G0.6661.00
91_F145_S0.6631.00
114_A222_I0.6621.00
66_I105_M0.6551.00
235_L283_L0.6541.00
185_F189_L0.6511.00
106_A156_Y0.6501.00
179_G182_V0.6491.00
228_R285_A0.6441.00
29_N71_D0.6401.00
241_T246_I0.6381.00
123_G137_E0.6301.00
25_L222_I0.6291.00
205_E277_R0.6291.00
138_P143_G0.6261.00
75_H113_F0.6251.00
183_P187_Q0.6231.00
22_A26_A0.6221.00
9_V54_R0.6221.00
247_A251_S0.6181.00
91_F144_A0.6181.00
7_R69_D0.6151.00
165_W233_F0.6141.00
62_V100_N0.6131.00
246_I294_S0.6121.00
27_G220_H0.6111.00
121_V150_E0.6111.00
204_Q243_V0.6101.00
114_A218_M0.6101.00
169_F172_I0.6091.00
33_V51_F0.6081.00
193_P256_V0.6051.00
27_G216_D0.6051.00
155_T158_H0.6051.00
120_T143_G0.6041.00
20_H176_R0.6031.00
131_E282_K0.6021.00
291_T296_E0.6021.00
10_V25_L0.6011.00
29_N72_I0.6001.00
84_Y141_V0.6001.00
193_P197_T0.5981.00
30_D48_G0.5951.00
251_S254_L0.5931.00
52_R61_D0.5911.00
68_P108_V0.5901.00
145_S149_D0.5891.00
21_A219_T0.5881.00
241_T249_L0.5871.00
152_L156_Y0.5871.00
167_Y217_A0.5861.00
72_I111_D0.5861.00
72_I114_A0.5841.00
9_V73_V0.5841.00
62_V65_V0.5831.00
186_I302_A0.5831.00
207_S240_T0.5831.00
87_P141_V0.5811.00
171_N206_K0.5791.00
149_D153_I0.5771.00
28_D31_V0.5721.00
78_A94_N0.5701.00
144_A155_T0.5691.00
207_S237_T0.5681.00
9_V66_I0.5671.00
214_C235_L0.5611.00
166_V230_L0.5601.00
95_G99_Y0.5581.00
213_D291_T0.5581.00
114_A221_V0.5571.00
59_P104_R0.5511.00
133_Y282_K0.5501.00
175_P212_E0.5501.00
127_M134_A0.5501.00
14_A37_L0.5481.00
141_V145_S0.5461.00
219_T222_I0.5461.00
79_Y94_N0.5431.00
9_V65_V0.5391.00
283_L290_P0.5381.00
153_I166_V0.5351.00
181_V189_L0.5351.00
163_T228_R0.5321.00
118_S146_K0.5321.00
249_L298_V0.5311.00
239_T295_D0.5301.00
156_Y162_I0.5291.00
261_E264_G0.5281.00
260_Y265_G0.5271.00
179_G183_P0.5261.00
32_L65_V0.5241.00
210_H301_A0.5221.00
283_L288_W0.5221.00
186_I250_V0.5211.00
73_V110_V0.5211.00
229_P233_F0.5181.00
128_P132_D0.5171.00
273_V276_M0.5151.00
280_I283_L0.5151.00
157_A162_I0.5151.00
260_Y264_G0.5121.00
87_P91_F0.5111.00
157_A230_L0.5111.00
37_L41_S0.5101.00
233_F283_L0.5091.00
105_M108_V0.5071.00
121_V168_R0.5071.00
23_G212_E0.5061.00
249_L299_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sb8A 2 0.9713 100 0.194 Contact Map
3rufA 2 0.965 100 0.197 Contact Map
3sxpA 3 0.9331 100 0.219 Contact Map
1rkxA 3 0.9713 100 0.221 Contact Map
2q1sA 2 0.9427 100 0.221 Contact Map
3slgA 4 0.9618 100 0.225 Contact Map
2c5aA 2 0.9745 100 0.228 Contact Map
2c20A 2 0.9713 100 0.228 Contact Map
3eheA 2 0.9172 100 0.23 Contact Map
4wkgA 5 0.9777 100 0.232 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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