GREMLIN Database
Q9HRD0 - Anion permease
UniProt: Q9HRD0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 392 (312)
Sequences: 1349 (696)
Seq/√Len: 39.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
223_V226_G6.1821.00
45_G49_V5.9081.00
18_F247_T5.1381.00
20_V105_T4.5131.00
81_A116_L3.8421.00
252_T255_T3.2701.00
32_A203_G3.1631.00
85_V109_A2.9881.00
133_I137_V2.9861.00
167_E194_F2.9571.00
289_A294_I2.9311.00
282_L289_A2.8401.00
39_S42_T2.8351.00
132_V136_V2.7671.00
271_V295_A2.7561.00
215_I241_V2.7041.00
223_V227_V2.6981.00
36_D258_S2.6911.00
56_W235_L2.5631.00
7_G11_V2.5291.00
160_R166_T2.4741.00
112_A204_C2.3161.00
256_M296_T2.2270.99
51_F210_S2.2000.99
127_V130_E2.1930.99
243_V247_T2.1820.99
135_W139_P2.1390.99
71_L117_G2.0760.99
16_V89_I2.0750.99
18_F248_I2.0210.99
91_L95_V1.9130.98
17_G218_A1.8910.98
219_I237_G1.8630.98
138_A293_V1.8240.98
95_V99_A1.8110.98
114_A128_M1.7800.97
84_G88_F1.7690.97
256_M299_I1.7650.97
110_V131_I1.7330.97
310_P313_V1.7080.97
152_Y156_R1.6970.97
44_A246_F1.6610.96
152_Y174_D1.6550.96
148_I152_Y1.6470.96
35_A93_L1.6440.96
231_N235_L1.6370.96
15_F94_F1.6300.96
112_A283_S1.6280.96
5_L83_I1.6260.96
31_P295_A1.6110.95
291_F294_I1.6090.95
51_F245_S1.6070.95
27_P210_S1.6020.95
37_A196_V1.6010.95
107_M293_V1.5870.95
50_F204_C1.5710.95
85_V89_I1.5600.94
199_V272_A1.5330.94
146_S298_S1.5320.94
56_W238_C1.5230.94
126_A133_I1.5020.93
153_F157_L1.5000.93
199_V268_A1.4690.92
147_L305_G1.4630.92
224_G227_V1.4590.92
24_T292_V1.4440.92
46_L229_G1.4440.92
274_V298_S1.4330.92
283_S286_G1.4210.91
38_L200_I1.4190.91
123_L152_Y1.4170.91
89_I279_V1.4090.91
53_I57_T1.4070.91
31_P271_V1.4030.91
91_L243_V1.3820.90
214_N292_V1.3810.90
108_T293_V1.3720.90
66_L220_A1.3710.90
5_L79_L1.3600.89
149_I270_V1.3490.89
135_W143_F1.3460.89
6_L180_P1.3450.89
14_A81_A1.3090.87
53_I208_F1.3040.87
133_I136_V1.3030.87
234_I238_C1.3020.87
83_I176_T1.2980.87
40_K253_L1.2970.87
135_W221_P1.2870.86
18_F94_F1.2820.86
169_A173_V1.2760.86
134_W138_A1.2700.86
38_L42_T1.2560.85
19_N94_F1.2490.85
32_A272_A1.2470.85
238_C241_V1.2460.85
17_G22_G1.2440.84
150_G301_G1.2420.84
105_T216_A1.2310.84
15_F19_N1.2200.83
85_V90_G1.2150.83
43_A303_G1.2130.83
14_A240_A1.1980.82
151_R155_A1.1850.81
68_T112_A1.1840.81
11_V49_V1.1820.81
137_V287_I1.1720.81
95_V161_V1.1640.80
248_I251_R1.1570.80
271_V299_I1.1550.80
13_A216_A1.1460.79
47_M96_G1.1450.79
68_T229_G1.1380.79
50_F57_T1.1370.79
154_Y306_R1.1340.78
171_L175_R1.1250.78
128_M131_I1.1160.77
56_W231_N1.1150.77
149_I201_T1.1090.77
24_T210_S1.1080.77
263_L282_L1.1080.77
16_V34_G1.1060.77
151_R305_G1.0930.76
68_T157_L1.0900.76
36_D165_R1.0870.75
172_R183_R1.0790.75
129_G133_I1.0790.75
7_G228_V1.0740.75
148_I177_G1.0610.74
85_V220_A1.0600.74
136_V140_V1.0570.73
69_E286_G1.0540.73
268_A272_A1.0510.73
24_T107_M1.0290.71
142_G198_T1.0270.71
31_P150_G1.0230.71
52_F56_W1.0090.70
108_T119_A1.0050.69
92_A103_A1.0020.69
215_I237_G0.9970.69
172_R177_G0.9950.69
80_E280_I0.9950.69
58_L238_C0.9920.68
206_M263_L0.9920.68
247_T250_R0.9920.68
9_G250_R0.9900.68
35_A76_I0.9840.68
213_S291_F0.9830.68
179_I182_V0.9770.67
217_N221_P0.9740.67
168_G175_R0.9730.67
192_E265_L0.9680.67
38_L146_S0.9650.66
31_P272_A0.9630.66
149_I277_T0.9580.66
70_L220_A0.9580.66
24_T27_P0.9570.66
261_T279_V0.9560.66
33_V43_A0.9550.65
15_F90_G0.9530.65
11_V14_A0.9460.65
158_H188_T0.9430.64
112_A116_L0.9420.64
172_R181_T0.9390.64
52_F192_E0.9320.64
47_M245_S0.9270.63
200_I289_A0.9250.63
200_I279_V0.9240.63
15_F253_L0.9220.63
4_A7_G0.9210.63
41_P45_G0.9150.62
100_G301_G0.9130.62
24_T213_S0.9130.62
267_A306_R0.9050.61
35_A63_V0.9010.61
14_A236_L0.8980.61
204_C277_T0.8960.60
162_A165_R0.8930.60
108_T202_I0.8930.60
117_G121_D0.8920.60
184_P190_R0.8920.60
89_I269_I0.8870.60
85_V120_R0.8820.59
15_F248_I0.8810.59
68_T132_V0.8810.59
136_V181_T0.8810.59
23_S103_A0.8800.59
230_M281_F0.8800.59
98_Y248_I0.8700.58
109_A216_A0.8700.58
71_L80_E0.8660.58
180_P183_R0.8640.58
187_N190_R0.8630.58
215_I221_P0.8630.58
128_M132_V0.8600.57
25_T241_V0.8490.56
66_L85_V0.8490.56
30_G34_G0.8460.56
31_P202_I0.8450.56
169_A172_R0.8450.56
106_S292_V0.8440.56
214_N217_N0.8440.56
14_A179_I0.8400.56
312_S315_S0.8400.56
10_L236_L0.8390.55
23_S97_N0.8380.55
34_G240_A0.8380.55
122_A241_V0.8370.55
27_P51_F0.8370.55
104_S138_A0.8370.55
206_M294_I0.8350.55
204_C254_E0.8340.55
12_V280_I0.8310.55
158_H266_T0.8310.55
124_D236_L0.8280.54
29_F57_T0.8280.54
68_T127_V0.8270.54
158_H163_M0.8250.54
140_V228_V0.8240.54
311_V315_S0.8240.54
24_T214_N0.8200.54
46_L49_V0.8180.54
66_L110_V0.8180.54
6_L189_N0.8140.53
94_F209_S0.8140.53
114_A118_L0.8110.53
210_S214_N0.8100.53
152_Y155_A0.8100.53
35_A251_R0.8060.52
9_G83_I0.8060.52
65_T69_E0.8050.52
38_L272_A0.8010.52
95_V162_A0.7970.52
29_F38_L0.7970.52
27_P214_N0.7960.52
11_V165_R0.7890.51
168_G183_R0.7890.51
154_Y159_R0.7870.51
121_D142_G0.7850.51
118_L136_V0.7840.50
146_S270_V0.7820.50
96_G103_A0.7820.50
117_G218_A0.7810.50
175_R182_V0.7810.50
205_L212_T0.7790.50
136_V301_G0.7760.50
165_R173_V0.7740.50
68_T275_S0.7740.50
10_L222_L0.7690.49
24_T51_F0.7670.49
107_M292_V0.7660.49
74_P77_F0.7650.49
200_I238_C0.7650.49
176_T242_G0.7620.48
124_D141_I0.7580.48
263_L271_V0.7570.48
32_A125_V0.7560.48
107_M111_G0.7530.48
62_V253_L0.7510.47
50_F53_I0.7450.47
129_G132_V0.7450.47
113_I222_L0.7440.47
111_G135_W0.7420.47
184_P256_M0.7410.47
162_A169_A0.7410.47
6_L233_A0.7400.46
179_I183_R0.7330.46
25_T245_S0.7320.46
48_T242_G0.7300.46
146_S274_V0.7280.45
16_V30_G0.7270.45
71_L154_Y0.7250.45
166_T169_A0.7250.45
176_T229_G0.7240.45
28_A279_V0.7240.45
215_I240_A0.7220.45
180_P274_V0.7190.45
17_G287_I0.7140.44
13_A70_L0.7140.44
141_I287_I0.7100.44
50_F256_M0.7080.44
142_G294_I0.7070.43
132_V151_R0.7060.43
201_T266_T0.7060.43
233_A238_C0.7060.43
191_R266_T0.7050.43
66_L73_Q0.7040.43
30_G113_I0.7020.43
171_L273_S0.7010.43
38_L46_L0.6980.43
206_M216_A0.6980.43
8_V160_R0.6940.42
138_A141_I0.6940.42
37_A50_F0.6940.42
148_I201_T0.6920.42
27_P292_V0.6920.42
77_F114_A0.6910.42
96_G245_S0.6910.42
208_F211_G0.6900.42
252_T296_T0.6890.42
155_A173_V0.6870.42
91_L233_A0.6870.42
279_V283_S0.6860.42
270_V274_V0.6840.41
228_V231_N0.6840.41
137_V282_L0.6800.41
19_N91_L0.6790.41
17_G213_S0.6780.41
222_L306_R0.6780.41
172_R175_R0.6760.41
60_R301_G0.6750.41
155_A313_V0.6720.40
160_R251_R0.6710.40
116_L307_A0.6660.40
105_T136_V0.6640.40
82_S113_I0.6640.40
97_N251_R0.6640.40
29_F196_V0.6630.40
25_T249_A0.6620.40
36_D64_D0.6610.39
212_T300_V0.6610.39
156_R160_R0.6590.39
14_A311_V0.6570.39
158_H310_P0.6560.39
221_P237_G0.6540.39
254_E259_D0.6520.39
30_G208_F0.6510.39
242_G245_S0.6500.38
37_A219_I0.6450.38
153_F294_I0.6430.38
84_G256_M0.6400.38
229_G285_I0.6370.37
79_L227_V0.6330.37
6_L79_L0.6330.37
22_G35_A0.6330.37
11_V228_V0.6320.37
189_N192_E0.6300.37
214_N291_F0.6300.37
252_T256_M0.6290.37
178_A182_V0.6290.37
20_V216_A0.6280.37
263_L299_I0.6280.37
216_A292_V0.6270.37
277_T294_I0.6250.36
71_L116_L0.6230.36
87_F129_G0.6210.36
191_R222_L0.6200.36
56_W262_E0.6200.36
36_D164_N0.6150.35
51_F93_L0.6110.35
137_V187_N0.6100.35
95_V298_S0.6090.35
36_D282_L0.6060.35
141_I173_V0.6060.35
93_L105_T0.6060.35
60_R284_A0.6060.35
215_I282_L0.6060.35
12_V90_G0.6050.35
27_P245_S0.6050.35
175_R179_I0.6050.35
31_P201_T0.6030.35
121_D291_F0.6030.35
154_Y181_T0.6010.34
18_F76_I0.5980.34
48_T142_G0.5970.34
52_F242_G0.5930.34
102_P292_V0.5920.34
147_L207_A0.5880.33
173_V177_G0.5880.33
153_F174_D0.5880.33
55_A86_L0.5880.33
101_V199_V0.5870.33
144_W298_S0.5870.33
275_S302_L0.5870.33
45_G169_A0.5860.33
167_E175_R0.5860.33
167_E279_V0.5860.33
30_G131_I0.5850.33
120_R128_M0.5790.33
35_A255_T0.5780.32
17_G118_L0.5770.32
260_I279_V0.5770.32
36_D173_V0.5760.32
36_D68_T0.5750.32
205_L277_T0.5730.32
195_G269_I0.5720.32
28_A197_V0.5700.32
9_G298_S0.5690.32
298_S314_Q0.5680.32
283_S293_V0.5670.32
29_F260_I0.5660.32
69_E72_R0.5660.32
251_R254_E0.5650.31
50_F198_T0.5650.31
22_G278_L0.5610.31
224_G281_F0.5610.31
212_T259_D0.5610.31
147_L307_A0.5600.31
66_L284_A0.5600.31
149_I310_P0.5590.31
93_L233_A0.5590.31
78_T243_V0.5570.31
129_G209_S0.5570.31
269_I291_F0.5530.31
23_S51_F0.5530.31
16_V86_L0.5520.30
93_L97_N0.5490.30
116_L119_A0.5470.30
58_L199_V0.5450.30
157_L195_G0.5450.30
37_A260_I0.5440.30
7_G193_L0.5420.30
307_A312_S0.5420.30
53_I131_I0.5420.30
36_D262_E0.5410.30
71_L109_A0.5410.30
309_R313_V0.5400.30
135_W237_G0.5390.29
209_S212_T0.5380.29
30_G299_I0.5370.29
89_I282_L0.5370.29
68_T241_V0.5350.29
110_V286_G0.5350.29
38_L242_G0.5350.29
31_P199_V0.5340.29
198_T269_I0.5340.29
51_F96_G0.5340.29
232_P270_V0.5340.29
94_F198_T0.5330.29
135_W217_N0.5320.29
143_F301_G0.5310.29
85_V166_T0.5310.29
45_G173_V0.5310.29
104_S195_G0.5310.29
171_L182_V0.5300.29
64_D67_G0.5290.29
203_G276_A0.5270.29
30_G256_M0.5270.29
13_A83_I0.5260.28
119_A165_R0.5260.28
71_L123_L0.5240.28
164_N259_D0.5220.28
145_V162_A0.5210.28
250_R254_E0.5210.28
19_N32_A0.5200.28
272_A295_A0.5200.28
208_F222_L0.5200.28
249_A257_G0.5180.28
206_M280_I0.5170.28
165_R168_G0.5170.28
192_E267_A0.5160.28
108_T280_I0.5150.28
261_T303_G0.5130.28
237_G241_V0.5120.27
45_G165_R0.5120.27
59_G135_W0.5110.27
153_F230_M0.5100.27
158_H313_V0.5090.27
28_A94_F0.5090.27
73_Q114_A0.5080.27
252_T291_F0.5080.27
52_F206_M0.5080.27
235_L243_V0.5070.27
9_G171_L0.5040.27
165_R177_G0.5030.27
70_L243_V0.5020.27
130_E285_I0.5000.27
5_L11_V0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ldfA 3 0.5995 77.4 0.964 Contact Map
2b6oA 6 0.5893 75.8 0.965 Contact Map
3d9sA 3 0.5816 65.5 0.967 Contact Map
4oj2X 3 0.6122 63.7 0.968 Contact Map
3c02A 3 0.5867 54.5 0.97 Contact Map
1j4nA 4 0.6224 44.1 0.971 Contact Map
4c7rA 3 0.7781 43.1 0.972 Contact Map
4nefA 4 0.4235 24.5 0.975 Contact Map
3pe5A 1 0 23.2 0.975 Contact Map
3fymA 1 0.1837 21.9 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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