Q9HRC9 - HALSA - GREMLIN Contacts

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Q9HRC9 - Uncharacterized protein

UniProt:	Q9HRC9	Sequences: MRCAVWTMVHTRIGMSMPAGVVPVGELIFAHVFPVLAVSVTPRGAGGGSVNPSRVDSLTDLAYGVLIFAAVGLILRVGTKTGVAFGFGVLAAYVLHIAWKMARFDPEWMTRTVDETVTETVEESMDEAVEQTMGETVERTVDETVGETVEQTVDETVSETVEETVKESVESTVDETVGETVEQTVDETVSETVEETVKESVEETVDETVSETVEESVKQQVEESVNETVEETVEQTVKETVDERLAAADVQPGDDDEPGDDEDGAEP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	267 (226)
Sequences:	155 (135)
Seq/√Len:	9.0

HALSA - Q9HRC9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
215_E	223_E	3.098	0.92
223_E	239_E	2.734	0.86
68_F	77_V	2.722	0.85
197_V	221_V	2.706	0.85
213_V	249_D	2.409	0.77
213_V	225_V	2.349	0.75
221_V	257_E	2.273	0.73
149_V	173_V	2.234	0.72
177_V	181_V	2.222	0.71
219_Q	243_E	2.109	0.67
225_V	245_L	2.078	0.66
92_A	98_A	2.025	0.64
235_Q	259_G	1.993	0.62
120_T	124_S	1.986	0.62
199_E	223_E	1.951	0.61
215_E	255_D	1.925	0.59
225_V	233_V	1.907	0.59
173_V	185_V	1.907	0.59
200_S	216_S	1.881	0.58
197_V	217_V	1.874	0.57
183_Q	243_E	1.867	0.57
223_E	247_A	1.844	0.56
191_E	251_Q	1.834	0.56
185_V	205_V	1.825	0.55
95_L	98_A	1.797	0.54
189_V	225_V	1.769	0.53
229_V	249_D	1.737	0.51
195_E	219_Q	1.731	0.51
162_E	180_T	1.720	0.51
227_E	243_E	1.719	0.51
114_D	118_T	1.717	0.51
174_D	214_E	1.702	0.50
114_D	120_T	1.701	0.50
209_V	245_L	1.669	0.48
64_G	72_G	1.669	0.48
189_V	193_V	1.664	0.48
219_Q	255_D	1.621	0.46
141_V	145_V	1.565	0.44
233_V	245_L	1.551	0.43
213_V	229_V	1.544	0.43
157_V	161_V	1.513	0.42
205_V	225_V	1.512	0.42
237_V	241_V	1.487	0.41
213_V	233_V	1.472	0.40
193_V	225_V	1.428	0.38
196_T	236_T	1.421	0.38
155_E	181_V	1.420	0.38
93_Y	101_M	1.413	0.38
229_V	245_L	1.400	0.37
215_E	239_E	1.392	0.37
93_Y	98_A	1.368	0.36
225_V	249_D	1.362	0.36
90_L	94_V	1.361	0.35
201_V	205_V	1.357	0.35
173_V	209_V	1.353	0.35
189_V	249_D	1.342	0.35
116_T	120_T	1.340	0.35
62_A	74_I	1.339	0.35
183_Q	255_D	1.332	0.34
161_V	173_V	1.326	0.34
190_S	198_K	1.305	0.33
127_E	135_E	1.304	0.33
155_E	179_E	1.303	0.33
214_E	234_E	1.292	0.33
42_P	58_L	1.292	0.33
128_A	142_D	1.279	0.32
153_V	165_V	1.276	0.32
202_E	238_K	1.272	0.32
217_V	241_V	1.270	0.32
150_E	172_T	1.262	0.32
169_V	181_V	1.262	0.32
157_V	177_V	1.262	0.32
234_E	252_P	1.260	0.32
241_V	249_D	1.260	0.32
163_E	179_E	1.259	0.32
248_A	252_P	1.257	0.31
176_T	232_T	1.255	0.31
91_A	101_M	1.246	0.31
149_V	161_V	1.243	0.31
175_E	187_E	1.226	0.30
209_V	213_V	1.215	0.30
165_V	169_V	1.210	0.30
171_S	243_E	1.201	0.29
229_V	241_V	1.201	0.29
79_T	92_A	1.197	0.29
219_Q	235_Q	1.186	0.29
156_T	170_E	1.185	0.29
126_D	170_E	1.171	0.28
191_E	239_E	1.170	0.28
217_V	225_V	1.165	0.28
159_E	179_E	1.165	0.28
212_T	226_N	1.157	0.28
92_A	96_H	1.155	0.28
197_V	203_E	1.154	0.28
209_V	217_V	1.152	0.28
174_D	244_R	1.141	0.27
170_E	202_E	1.135	0.27
183_Q	215_E	1.132	0.27
201_V	225_V	1.130	0.27
228_T	232_T	1.125	0.27
232_T	248_A	1.124	0.27
245_L	249_D	1.122	0.27
209_V	233_V	1.120	0.27
34_P	47_G	1.117	0.26
135_E	147_E	1.116	0.26
185_V	209_V	1.113	0.26
156_T	184_T	1.110	0.26
80_K	90_L	1.109	0.26
226_N	244_R	1.101	0.26
39_S	43_R	1.099	0.26
37_A	41_T	1.099	0.26
233_V	249_D	1.094	0.26
197_V	233_V	1.083	0.25
231_E	239_E	1.079	0.25
137_V	141_V	1.078	0.25
173_V	193_V	1.077	0.25
229_V	233_V	1.068	0.25
33_F	38_V	1.067	0.25
72_G	75_L	1.067	0.25
136_T	140_T	1.065	0.25
247_A	255_D	1.063	0.25
225_V	229_V	1.062	0.25
127_E	131_Q	1.062	0.25
128_A	148_T	1.061	0.25
83_V	99_W	1.059	0.25
236_T	240_T	1.059	0.25
217_V	237_V	1.051	0.24
236_T	250_V	1.049	0.24
195_E	255_D	1.047	0.24
86_G	99_W	1.041	0.24
237_V	249_D	1.038	0.24
230_E	238_K	1.032	0.24
137_V	145_V	1.031	0.24
176_T	206_D	1.031	0.24
194_E	226_N	1.031	0.24
198_K	238_K	1.030	0.24
59_T	84_A	1.027	0.24
90_L	102_A	1.027	0.24
37_A	40_V	1.021	0.23
41_T	93_Y	1.021	0.23
171_S	195_E	1.016	0.23
250_V	254_D	1.014	0.23
167_E	183_Q	1.005	0.23
203_E	239_E	1.001	0.23
170_E	178_G	0.997	0.23
215_E	247_A	0.994	0.23
167_E	231_E	0.988	0.22
195_E	203_E	0.986	0.22
198_K	212_T	0.985	0.22
129_V	133_M	0.983	0.22
214_E	244_R	0.978	0.22
185_V	189_V	0.968	0.22
33_F	37_A	0.968	0.22
213_V	245_L	0.967	0.22
151_Q	163_E	0.967	0.22
161_V	181_V	0.950	0.21
173_V	177_V	0.946	0.21
196_T	222_E	0.938	0.21
225_V	237_V	0.937	0.21
201_V	209_V	0.934	0.21
173_V	245_L	0.931	0.21
49_S	57_S	0.920	0.20
237_V	245_L	0.918	0.20
161_V	185_V	0.917	0.20
201_V	221_V	0.914	0.20
149_V	153_V	0.907	0.20
160_T	174_D	0.905	0.20
212_T	242_D	0.904	0.20
171_S	187_E	0.900	0.20
204_T	224_S	0.896	0.20
203_E	251_Q	0.893	0.20
218_K	246_A	0.892	0.20
110_T	115_E	0.892	0.20
209_V	249_D	0.890	0.20
217_V	233_V	0.889	0.19
131_Q	135_E	0.880	0.19
214_E	254_D	0.875	0.19
202_E	220_Q	0.870	0.19
169_V	177_V	0.867	0.19
141_V	153_V	0.864	0.19
224_S	244_R	0.858	0.19
164_T	184_T	0.857	0.19
169_V	229_V	0.848	0.18
40_V	58_L	0.845	0.18
164_T	174_D	0.844	0.18
171_S	251_Q	0.843	0.18
59_T	67_I	0.841	0.18
157_V	181_V	0.833	0.18
168_S	172_T	0.826	0.18
204_T	220_Q	0.823	0.18
53_S	67_I	0.814	0.18
33_F	36_L	0.812	0.17
77_V	85_F	0.810	0.17
201_V	241_V	0.810	0.17
63_Y	73_L	0.807	0.17
227_E	251_Q	0.806	0.17
163_E	223_E	0.804	0.17
160_T	202_E	0.801	0.17
147_E	171_S	0.793	0.17
231_E	255_D	0.792	0.17
163_E	195_E	0.784	0.17
238_K	246_A	0.784	0.17
177_V	189_V	0.784	0.17
172_T	180_T	0.780	0.17
240_T	244_R	0.779	0.17
130_E	176_T	0.771	0.16
156_T	188_T	0.769	0.16
61_L	67_I	0.769	0.16
35_V	62_A	0.765	0.16
222_E	232_T	0.763	0.16
154_D	170_E	0.755	0.16
211_E	231_E	0.754	0.16
142_D	172_T	0.750	0.16
163_E	171_S	0.750	0.16
194_E	244_R	0.749	0.16
205_V	209_V	0.748	0.16
190_S	212_T	0.748	0.16
198_K	216_S	0.746	0.16
196_T	232_T	0.745	0.16
210_S	250_V	0.744	0.16
207_E	231_E	0.742	0.16
221_V	245_L	0.740	0.16
212_T	244_R	0.735	0.16
160_T	172_T	0.734	0.16
231_E	247_A	0.731	0.16
234_E	254_D	0.730	0.16
191_E	223_E	0.722	0.15
192_T	242_D	0.713	0.15
221_V	233_V	0.710	0.15
201_V	213_V	0.710	0.15
201_V	217_V	0.708	0.15
201_V	237_V	0.705	0.15
221_V	241_V	0.705	0.15
165_V	185_V	0.704	0.15
159_E	199_E	0.700	0.15
169_V	185_V	0.697	0.15
169_V	193_V	0.697	0.15
248_A	258_P	0.694	0.15
145_V	169_V	0.694	0.15
228_T	240_T	0.691	0.15
222_E	258_P	0.688	0.15
199_E	211_E	0.686	0.15
42_P	69_A	0.685	0.15
187_E	235_Q	0.683	0.14
191_E	215_E	0.679	0.14
84_A	91_A	0.678	0.14
155_E	183_Q	0.663	0.14
95_L	109_M	0.663	0.14
155_E	163_E	0.659	0.14
196_T	208_T	0.658	0.14
241_V	245_L	0.656	0.14
161_V	193_V	0.655	0.14
199_E	235_Q	0.654	0.14
214_E	224_S	0.654	0.14
197_V	241_V	0.653	0.14
228_T	236_T	0.653	0.14
204_T	214_E	0.647	0.14
206_D	236_T	0.647	0.14
229_V	253_G	0.645	0.14
208_T	228_T	0.644	0.14
92_A	95_L	0.641	0.14
59_T	75_L	0.639	0.14
201_V	249_D	0.631	0.13
209_V	221_V	0.629	0.13
141_V	173_V	0.626	0.13
211_E	251_Q	0.619	0.13
61_L	84_A	0.617	0.13
155_E	195_E	0.617	0.13
166_K	184_T	0.616	0.13
207_E	239_E	0.616	0.13
95_L	107_E	0.613	0.13
166_K	208_T	0.613	0.13
48_G	57_S	0.612	0.13
60_D	76_R	0.611	0.13
193_V	205_V	0.610	0.13
204_T	208_T	0.607	0.13
175_E	235_Q	0.605	0.13
233_V	257_E	0.605	0.13
200_S	228_T	0.603	0.13
189_V	213_V	0.602	0.13
183_Q	207_E	0.600	0.13
238_K	252_P	0.594	0.13
207_E	243_E	0.593	0.13
232_T	236_T	0.591	0.13
218_K	230_E	0.588	0.13
205_V	227_E	0.587	0.13
171_S	191_E	0.585	0.12
37_A	49_S	0.581	0.12
139_R	175_E	0.581	0.12
127_E	163_E	0.580	0.12
75_L	91_A	0.580	0.12
233_V	237_V	0.575	0.12
193_V	253_G	0.574	0.12
64_G	86_G	0.571	0.12
152_T	188_T	0.568	0.12
159_E	183_Q	0.568	0.12
166_K	206_D	0.564	0.12
219_Q	227_E	0.559	0.12
174_D	234_E	0.559	0.12
76_R	85_F	0.556	0.12
34_P	38_V	0.556	0.12
151_Q	167_E	0.554	0.12
197_V	237_V	0.546	0.12
182_E	218_K	0.546	0.12
160_T	186_D	0.545	0.12
122_E	132_T	0.543	0.12
36_L	41_T	0.542	0.12
183_Q	231_E	0.542	0.12
239_E	247_A	0.539	0.12
238_K	256_D	0.537	0.12
178_G	210_S	0.537	0.12
236_T	246_A	0.537	0.12
34_P	37_A	0.535	0.12
35_V	54_R	0.534	0.12
228_T	250_V	0.526	0.11
203_E	221_V	0.524	0.11
220_Q	240_T	0.523	0.11
82_G	87_F	0.523	0.11
165_V	181_V	0.520	0.11
149_V	185_V	0.520	0.11
141_V	161_V	0.519	0.11
121_V	125_M	0.518	0.11
185_V	201_V	0.517	0.11
204_T	240_T	0.516	0.11
122_E	162_E	0.515	0.11
143_E	215_E	0.513	0.11
164_T	186_D	0.511	0.11
165_V	189_V	0.511	0.11
122_E	146_G	0.511	0.11
69_A	102_A	0.510	0.11
215_E	227_E	0.508	0.11
219_Q	241_V	0.507	0.11
197_V	201_V	0.507	0.11
170_E	184_T	0.505	0.11
200_S	224_S	0.503	0.11
166_K	212_T	0.501	0.11
184_T	200_S	0.501	0.11
136_T	144_T	0.501	0.11
249_D	257_E	0.500	0.11

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3qc5X	1	0.4045	94.1	0.874	Contact Map
4m00A	1	0.412	87.1	0.894	Contact Map
4m03A	2	0.4045	85.8	0.896	Contact Map
2kpnA	1	0.1685	72.7	0.908	Contact Map
4jguA	1	0.1236	68.6	0.911	Contact Map
4u6tA	1	0.1236	67	0.912	Contact Map
4l9dA	1	0.1273	63.9	0.914	Contact Map
2yrlA	1	0.1498	63.2	0.914	Contact Map
4aqoA	1	0.1236	61.2	0.915	Contact Map
4m02A	1	0.4157	58.5	0.916	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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