GREMLIN Database
Q9HRC9 - Uncharacterized protein
UniProt: Q9HRC9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 267 (226)
Sequences: 155 (135)
Seq/√Len: 9.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
215_E223_E3.0980.92
223_E239_E2.7340.86
68_F77_V2.7220.85
197_V221_V2.7060.85
213_V249_D2.4090.77
213_V225_V2.3490.75
221_V257_E2.2730.73
149_V173_V2.2340.72
177_V181_V2.2220.71
219_Q243_E2.1090.67
225_V245_L2.0780.66
92_A98_A2.0250.64
235_Q259_G1.9930.62
120_T124_S1.9860.62
199_E223_E1.9510.61
215_E255_D1.9250.59
225_V233_V1.9070.59
173_V185_V1.9070.59
200_S216_S1.8810.58
197_V217_V1.8740.57
183_Q243_E1.8670.57
223_E247_A1.8440.56
191_E251_Q1.8340.56
185_V205_V1.8250.55
95_L98_A1.7970.54
189_V225_V1.7690.53
229_V249_D1.7370.51
195_E219_Q1.7310.51
162_E180_T1.7200.51
227_E243_E1.7190.51
114_D118_T1.7170.51
174_D214_E1.7020.50
114_D120_T1.7010.50
209_V245_L1.6690.48
64_G72_G1.6690.48
189_V193_V1.6640.48
219_Q255_D1.6210.46
141_V145_V1.5650.44
233_V245_L1.5510.43
213_V229_V1.5440.43
157_V161_V1.5130.42
205_V225_V1.5120.42
237_V241_V1.4870.41
213_V233_V1.4720.40
193_V225_V1.4280.38
196_T236_T1.4210.38
155_E181_V1.4200.38
93_Y101_M1.4130.38
229_V245_L1.4000.37
215_E239_E1.3920.37
93_Y98_A1.3680.36
225_V249_D1.3620.36
90_L94_V1.3610.35
201_V205_V1.3570.35
173_V209_V1.3530.35
189_V249_D1.3420.35
116_T120_T1.3400.35
62_A74_I1.3390.35
183_Q255_D1.3320.34
161_V173_V1.3260.34
190_S198_K1.3050.33
127_E135_E1.3040.33
155_E179_E1.3030.33
214_E234_E1.2920.33
42_P58_L1.2920.33
128_A142_D1.2790.32
153_V165_V1.2760.32
202_E238_K1.2720.32
217_V241_V1.2700.32
150_E172_T1.2620.32
169_V181_V1.2620.32
157_V177_V1.2620.32
234_E252_P1.2600.32
241_V249_D1.2600.32
163_E179_E1.2590.32
248_A252_P1.2570.31
176_T232_T1.2550.31
91_A101_M1.2460.31
149_V161_V1.2430.31
175_E187_E1.2260.30
209_V213_V1.2150.30
165_V169_V1.2100.30
171_S243_E1.2010.29
229_V241_V1.2010.29
79_T92_A1.1970.29
219_Q235_Q1.1860.29
156_T170_E1.1850.29
126_D170_E1.1710.28
191_E239_E1.1700.28
217_V225_V1.1650.28
159_E179_E1.1650.28
212_T226_N1.1570.28
92_A96_H1.1550.28
197_V203_E1.1540.28
209_V217_V1.1520.28
174_D244_R1.1410.27
170_E202_E1.1350.27
183_Q215_E1.1320.27
201_V225_V1.1300.27
228_T232_T1.1250.27
232_T248_A1.1240.27
245_L249_D1.1220.27
209_V233_V1.1200.27
34_P47_G1.1170.26
135_E147_E1.1160.26
185_V209_V1.1130.26
156_T184_T1.1100.26
80_K90_L1.1090.26
226_N244_R1.1010.26
39_S43_R1.0990.26
37_A41_T1.0990.26
233_V249_D1.0940.26
197_V233_V1.0830.25
231_E239_E1.0790.25
137_V141_V1.0780.25
173_V193_V1.0770.25
229_V233_V1.0680.25
33_F38_V1.0670.25
72_G75_L1.0670.25
136_T140_T1.0650.25
247_A255_D1.0630.25
225_V229_V1.0620.25
127_E131_Q1.0620.25
128_A148_T1.0610.25
83_V99_W1.0590.25
236_T240_T1.0590.25
217_V237_V1.0510.24
236_T250_V1.0490.24
195_E255_D1.0470.24
86_G99_W1.0410.24
237_V249_D1.0380.24
230_E238_K1.0320.24
137_V145_V1.0310.24
176_T206_D1.0310.24
194_E226_N1.0310.24
198_K238_K1.0300.24
59_T84_A1.0270.24
90_L102_A1.0270.24
37_A40_V1.0210.23
41_T93_Y1.0210.23
171_S195_E1.0160.23
250_V254_D1.0140.23
167_E183_Q1.0050.23
203_E239_E1.0010.23
170_E178_G0.9970.23
215_E247_A0.9940.23
167_E231_E0.9880.22
195_E203_E0.9860.22
198_K212_T0.9850.22
129_V133_M0.9830.22
214_E244_R0.9780.22
185_V189_V0.9680.22
33_F37_A0.9680.22
213_V245_L0.9670.22
151_Q163_E0.9670.22
161_V181_V0.9500.21
173_V177_V0.9460.21
196_T222_E0.9380.21
225_V237_V0.9370.21
201_V209_V0.9340.21
173_V245_L0.9310.21
49_S57_S0.9200.20
237_V245_L0.9180.20
161_V185_V0.9170.20
201_V221_V0.9140.20
149_V153_V0.9070.20
160_T174_D0.9050.20
212_T242_D0.9040.20
171_S187_E0.9000.20
204_T224_S0.8960.20
203_E251_Q0.8930.20
218_K246_A0.8920.20
110_T115_E0.8920.20
209_V249_D0.8900.20
217_V233_V0.8890.19
131_Q135_E0.8800.19
214_E254_D0.8750.19
202_E220_Q0.8700.19
169_V177_V0.8670.19
141_V153_V0.8640.19
224_S244_R0.8580.19
164_T184_T0.8570.19
169_V229_V0.8480.18
40_V58_L0.8450.18
164_T174_D0.8440.18
171_S251_Q0.8430.18
59_T67_I0.8410.18
157_V181_V0.8330.18
168_S172_T0.8260.18
204_T220_Q0.8230.18
53_S67_I0.8140.18
33_F36_L0.8120.17
77_V85_F0.8100.17
201_V241_V0.8100.17
63_Y73_L0.8070.17
227_E251_Q0.8060.17
163_E223_E0.8040.17
160_T202_E0.8010.17
147_E171_S0.7930.17
231_E255_D0.7920.17
163_E195_E0.7840.17
238_K246_A0.7840.17
177_V189_V0.7840.17
172_T180_T0.7800.17
240_T244_R0.7790.17
130_E176_T0.7710.16
156_T188_T0.7690.16
61_L67_I0.7690.16
35_V62_A0.7650.16
222_E232_T0.7630.16
154_D170_E0.7550.16
211_E231_E0.7540.16
142_D172_T0.7500.16
163_E171_S0.7500.16
194_E244_R0.7490.16
205_V209_V0.7480.16
190_S212_T0.7480.16
198_K216_S0.7460.16
196_T232_T0.7450.16
210_S250_V0.7440.16
207_E231_E0.7420.16
221_V245_L0.7400.16
212_T244_R0.7350.16
160_T172_T0.7340.16
231_E247_A0.7310.16
234_E254_D0.7300.16
191_E223_E0.7220.15
192_T242_D0.7130.15
221_V233_V0.7100.15
201_V213_V0.7100.15
201_V217_V0.7080.15
201_V237_V0.7050.15
221_V241_V0.7050.15
165_V185_V0.7040.15
159_E199_E0.7000.15
169_V185_V0.6970.15
169_V193_V0.6970.15
248_A258_P0.6940.15
145_V169_V0.6940.15
228_T240_T0.6910.15
222_E258_P0.6880.15
199_E211_E0.6860.15
42_P69_A0.6850.15
187_E235_Q0.6830.14
191_E215_E0.6790.14
84_A91_A0.6780.14
155_E183_Q0.6630.14
95_L109_M0.6630.14
155_E163_E0.6590.14
196_T208_T0.6580.14
241_V245_L0.6560.14
161_V193_V0.6550.14
199_E235_Q0.6540.14
214_E224_S0.6540.14
197_V241_V0.6530.14
228_T236_T0.6530.14
204_T214_E0.6470.14
206_D236_T0.6470.14
229_V253_G0.6450.14
208_T228_T0.6440.14
92_A95_L0.6410.14
59_T75_L0.6390.14
201_V249_D0.6310.13
209_V221_V0.6290.13
141_V173_V0.6260.13
211_E251_Q0.6190.13
61_L84_A0.6170.13
155_E195_E0.6170.13
166_K184_T0.6160.13
207_E239_E0.6160.13
95_L107_E0.6130.13
166_K208_T0.6130.13
48_G57_S0.6120.13
60_D76_R0.6110.13
193_V205_V0.6100.13
204_T208_T0.6070.13
175_E235_Q0.6050.13
233_V257_E0.6050.13
200_S228_T0.6030.13
189_V213_V0.6020.13
183_Q207_E0.6000.13
238_K252_P0.5940.13
207_E243_E0.5930.13
232_T236_T0.5910.13
218_K230_E0.5880.13
205_V227_E0.5870.13
171_S191_E0.5850.12
37_A49_S0.5810.12
139_R175_E0.5810.12
127_E163_E0.5800.12
75_L91_A0.5800.12
233_V237_V0.5750.12
193_V253_G0.5740.12
64_G86_G0.5710.12
152_T188_T0.5680.12
159_E183_Q0.5680.12
166_K206_D0.5640.12
219_Q227_E0.5590.12
174_D234_E0.5590.12
76_R85_F0.5560.12
34_P38_V0.5560.12
151_Q167_E0.5540.12
197_V237_V0.5460.12
182_E218_K0.5460.12
160_T186_D0.5450.12
122_E132_T0.5430.12
36_L41_T0.5420.12
183_Q231_E0.5420.12
239_E247_A0.5390.12
238_K256_D0.5370.12
178_G210_S0.5370.12
236_T246_A0.5370.12
34_P37_A0.5350.12
35_V54_R0.5340.12
228_T250_V0.5260.11
203_E221_V0.5240.11
220_Q240_T0.5230.11
82_G87_F0.5230.11
165_V181_V0.5200.11
149_V185_V0.5200.11
141_V161_V0.5190.11
121_V125_M0.5180.11
185_V201_V0.5170.11
204_T240_T0.5160.11
122_E162_E0.5150.11
143_E215_E0.5130.11
164_T186_D0.5110.11
165_V189_V0.5110.11
122_E146_G0.5110.11
69_A102_A0.5100.11
215_E227_E0.5080.11
219_Q241_V0.5070.11
197_V201_V0.5070.11
170_E184_T0.5050.11
200_S224_S0.5030.11
166_K212_T0.5010.11
184_T200_S0.5010.11
136_T144_T0.5010.11
249_D257_E0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qc5X 1 0.4045 94.1 0.874 Contact Map
4m00A 1 0.412 87.1 0.894 Contact Map
4m03A 2 0.4045 85.8 0.896 Contact Map
2kpnA 1 0.1685 72.7 0.908 Contact Map
4jguA 1 0.1236 68.6 0.911 Contact Map
4u6tA 1 0.1236 67 0.912 Contact Map
4l9dA 1 0.1273 63.9 0.914 Contact Map
2yrlA 1 0.1498 63.2 0.914 Contact Map
4aqoA 1 0.1236 61.2 0.915 Contact Map
4m02A 1 0.4157 58.5 0.916 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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