GREMLIN Database
TFE - Transcription factor E
UniProt: Q9HRC7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 172 (160)
Sequences: 164 (118)
Seq/√Len: 9.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
112_L158_D4.2230.99
105_V165_R4.1990.99
94_R168_L3.8130.98
23_K45_L3.0800.92
101_L161_I2.9840.91
110_Y116_F2.9000.90
60_Y65_A2.8410.89
35_E68_R2.7260.86
110_Y114_N2.5030.81
37_T72_D2.4930.81
87_E164_L2.4690.80
126_F130_E2.3530.77
105_V135_G2.1610.70
27_V47_L2.1380.69
57_F78_L2.0770.67
15_Y160_R2.0750.67
104_L107_R2.0170.65
104_L161_I1.8400.57
107_R116_F1.8210.56
150_N154_V1.7910.55
9_D89_V1.7200.52
9_D44_R1.7180.52
102_E106_D1.6960.51
64_L117_Y1.6460.49
46_G93_L1.6220.48
41_L168_L1.6000.47
46_G139_P1.5680.45
18_E27_V1.5500.44
84_F140_E1.5390.44
41_L154_V1.4800.41
21_G117_Y1.4600.41
39_E52_V1.4550.40
108_R129_G1.4270.39
52_V65_A1.4130.39
21_G76_G1.3950.38
58_I112_L1.3720.37
101_L159_D1.3710.37
45_L73_E1.3680.37
113_E120_E1.3560.36
61_E71_R1.3530.36
99_R127_E1.3470.36
52_V136_F1.3390.36
12_V16_L1.3290.35
19_L93_L1.3130.35
67_Y74_D1.3020.34
134_L145_V1.2900.34
151_T158_D1.2570.32
16_L20_V1.2410.32
38_D133_D1.2260.31
19_L58_I1.2140.31
72_D77_W1.2120.31
107_R110_Y1.2050.30
15_Y81_L1.2000.30
45_L137_E1.1920.30
135_G153_L1.1790.29
75_S100_L1.1780.29
69_R150_N1.1760.29
35_E61_E1.1530.28
63_D67_Y1.1520.28
22_P164_L1.1470.28
57_F80_Y1.1380.28
37_T54_R1.1030.27
42_A80_Y1.1010.27
80_Y141_C1.0800.26
22_P163_R1.0780.26
35_E42_A1.0760.26
38_D101_L1.0650.25
38_D43_E1.0550.25
108_R154_V1.0550.25
45_L118_L1.0500.25
120_E124_I1.0400.25
108_R111_E1.0390.25
108_R139_P1.0350.24
64_L80_Y1.0300.24
20_V25_M1.0300.24
104_L111_E1.0300.24
57_F77_W1.0110.24
75_S127_E1.0100.24
64_L133_D1.0080.24
92_N109_E1.0030.23
10_P34_G0.9970.23
69_R72_D0.9850.23
135_G163_R0.9800.23
162_E166_S0.9750.22
87_E126_F0.9730.22
69_R80_Y0.9510.22
71_R76_G0.9490.22
111_E150_N0.9460.22
65_A69_R0.9350.21
98_D134_L0.9350.21
72_D76_G0.9310.21
106_D143_S0.9250.21
112_L123_S0.9180.21
49_L81_L0.9120.21
158_D162_E0.9110.21
81_L96_E0.8960.20
50_N77_W0.8920.20
90_P150_N0.8880.20
69_R77_W0.8880.20
16_L81_L0.8850.20
35_E93_L0.8810.20
38_D58_I0.8810.20
9_D157_M0.8790.20
39_E151_T0.8780.20
69_R111_E0.8710.19
46_G157_M0.8710.19
125_R148_M0.8680.19
53_R138_C0.8660.19
35_E64_L0.8590.19
120_E126_F0.8580.19
16_L28_A0.8560.19
78_L96_E0.8520.19
28_A129_G0.8470.19
37_T133_D0.8460.19
62_N75_S0.8380.19
52_V60_Y0.8380.19
71_R115_E0.8360.18
30_A85_Q0.8320.18
15_Y32_P0.8290.18
49_L77_W0.8220.18
54_R78_L0.8150.18
9_D28_A0.8120.18
34_G149_E0.8110.18
33_D142_G0.8070.18
155_D162_E0.8050.18
53_R119_C0.8020.18
119_C138_C0.8020.18
89_V130_E0.7980.17
9_D12_V0.7890.17
66_T78_L0.7870.17
19_L143_S0.7820.17
63_D160_R0.7800.17
67_Y88_N0.7730.17
93_L96_E0.7630.17
103_A117_Y0.7550.16
88_N117_Y0.7550.16
27_V36_V0.7540.16
64_L69_R0.7400.16
26_P91_G0.7380.16
29_A129_G0.7370.16
145_V151_T0.7310.16
106_D154_V0.7300.16
13_Q87_E0.7260.16
109_E113_E0.7230.16
52_V69_R0.7170.16
143_S155_D0.7150.15
44_R159_D0.7140.15
16_L161_I0.7110.15
40_E52_V0.7100.15
78_L81_L0.7070.15
140_E158_D0.7040.15
98_D107_R0.7030.15
38_D168_L0.7020.15
88_N107_R0.7010.15
108_R153_L0.6980.15
77_W80_Y0.6960.15
15_Y78_L0.6950.15
23_K107_R0.6940.15
61_E96_E0.6870.15
54_R66_T0.6810.15
128_F136_F0.6790.15
18_E36_V0.6720.15
126_F132_M0.6690.14
15_Y39_E0.6660.14
52_V128_F0.6570.14
56_L138_C0.6490.14
53_R56_L0.6490.14
129_G166_S0.6450.14
21_G107_R0.6440.14
17_H22_P0.6430.14
42_A68_R0.6410.14
14_K62_N0.6410.14
151_T154_V0.6410.14
30_A114_N0.6380.14
37_T52_V0.6300.14
109_E133_D0.6240.13
26_P94_R0.6240.13
104_L108_R0.6240.13
14_K107_R0.6200.13
110_Y128_F0.6200.13
48_E65_A0.6180.13
11_V22_P0.6170.13
24_G55_A0.6160.13
31_P39_E0.6100.13
101_L164_L0.6050.13
162_E165_R0.6010.13
56_L59_L0.6000.13
27_V50_N0.5980.13
85_Q168_L0.5960.13
119_C141_C0.5940.13
111_E128_F0.5910.13
41_L141_C0.5870.13
117_Y156_A0.5860.13
102_E143_S0.5860.13
83_T113_E0.5800.13
97_M167_E0.5800.13
76_G160_R0.5780.13
76_G81_L0.5740.12
56_L119_C0.5730.12
110_Y125_R0.5710.12
76_G115_E0.5690.12
49_L116_F0.5630.12
23_K105_V0.5630.12
142_G152_D0.5630.12
110_Y166_S0.5620.12
95_E143_S0.5610.12
50_N136_F0.5610.12
100_L116_F0.5550.12
39_E75_S0.5550.12
137_E142_G0.5520.12
133_D145_V0.5450.12
144_A154_V0.5440.12
12_V34_G0.5430.12
40_E157_M0.5420.12
155_D161_I0.5400.12
101_L157_M0.5400.12
15_Y116_F0.5400.12
49_L79_T0.5390.12
27_V135_G0.5380.12
156_A162_E0.5380.12
61_E156_A0.5380.12
134_L144_A0.5370.12
91_G133_D0.5320.12
133_D136_F0.5290.12
61_E70_V0.5280.12
108_R113_E0.5270.12
152_D155_D0.5260.12
41_L135_G0.5240.12
147_A167_E0.5230.12
125_R152_D0.5230.12
16_L95_E0.5210.11
22_P99_R0.5210.11
75_S132_M0.5200.11
43_E74_D0.5200.11
117_Y126_F0.5170.11
72_D78_L0.5150.11
46_G94_R0.5090.11
39_E110_Y0.5050.11
52_V75_S0.5050.11
132_M166_S0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xubA 1 0.7965 99.9 0.65 Contact Map
1q1hA 1 0.4826 98.9 0.81 Contact Map
1vd4A 1 0.3256 98 0.856 Contact Map
4qiwP 1 0.2442 97.1 0.881 Contact Map
4aybP 1 0.25 96.5 0.889 Contact Map
3mwmA 2 0.5756 95.8 0.896 Contact Map
3pwfA 4 0.8081 95.6 0.897 Contact Map
2o03A 2 0.5872 95.6 0.898 Contact Map
1vziA 2 0.3488 95.4 0.899 Contact Map
2oqgA 4 0.5988 95.3 0.899 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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