Q9HRC4 - HALSA - GREMLIN Contacts

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Q9HRC4 - Competence-damage protein CinA-like

UniProt:	Q9HRC4	Sequences: MQVALVTVGDELLAGDTVNTNAAWLGQQLHERGATVARTIVIPDEVATIQADVAALSERYDAVIVTGGVGPTHDDVTMDAVASAFDRELTEHADAVAYFQRHDTYSAADLTTGTTHLPAGARLLENPRGVAPGAAVNNVYVLPGVPDEMKGMFETVADEFTGEQVYTEEVSVDAPESALIDTIAALQEAYDVTVGSYPGDRVRVKIQHSDADTVRAAADWFRDRVTAVSRE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	231 (223)
Sequences:	2982 (2159)
Seq/√Len:	144.6

ECOLI - CINAL
BACSU - CINA
HALSA - Q9HRC4
SULSO - Y103

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
46_V	83_S	3.856	1.00
88_E	119_A	3.184	1.00
87_R	120_G	3.045	1.00
91_E	116_H	2.990	1.00
90_T	119_A	2.875	1.00
46_V	80_A	2.820	1.00
18_V	23_A	2.798	1.00
3_V	34_A	2.630	1.00
28_Q	31_E	2.600	1.00
4_A	59_R	2.413	1.00
211_A	215_R	2.412	1.00
50_Q	83_S	2.402	1.00
28_Q	154_E	2.382	1.00
66_T	149_M	2.303	1.00
64_I	142_L	2.223	1.00
96_V	112_T	2.213	1.00
81_V	141_V	2.168	1.00
96_V	100_Q	2.124	1.00
202_V	205_K	2.123	1.00
93_A	97_A	2.016	1.00
135_A	159_E	1.979	1.00
208_H	214_V	1.971	1.00
19_N	22_A	1.966	1.00
91_E	96_V	1.952	1.00
7_T	41_V	1.882	1.00
100_Q	104_T	1.875	1.00
4_A	56_L	1.875	1.00
79_D	113_G	1.843	1.00
24_W	154_E	1.841	1.00
97_A	100_Q	1.764	1.00
91_E	112_T	1.700	1.00
25_L	153_F	1.684	1.00
97_A	101_R	1.674	1.00
45_E	48_T	1.614	1.00
92_H	95_A	1.599	1.00
87_R	119_A	1.592	1.00
57_S	139_V	1.570	1.00
24_W	153_F	1.547	1.00
140_Y	156_V	1.513	1.00
135_A	140_Y	1.498	1.00
168_E	222_R	1.492	1.00
133_G	152_M	1.483	1.00
51_A	55_A	1.477	1.00
32_R	157_A	1.474	1.00
38_R	55_A	1.473	1.00
19_N	39_T	1.468	1.00
117_L	123_L	1.466	1.00
109_D	112_T	1.450	1.00
53_V	84_A	1.446	1.00
4_A	60_Y	1.436	1.00
6_V	56_L	1.431	1.00
53_V	63_V	1.407	1.00
134_A	141_V	1.404	1.00
46_V	50_Q	1.398	1.00
28_Q	157_A	1.375	1.00
54_A	57_S	1.369	1.00
210_D	213_T	1.368	1.00
50_Q	80_A	1.367	1.00
10_D	193_T	1.364	1.00
22_A	39_T	1.350	1.00
26_G	39_T	1.348	1.00
40_I	55_A	1.335	1.00
47_A	51_A	1.325	1.00
127_P	155_T	1.315	1.00
6_V	52_D	1.307	1.00
4_A	40_I	1.303	1.00
168_E	219_D	1.285	1.00
65_V	141_V	1.277	1.00
50_Q	54_A	1.276	1.00
213_T	216_A	1.271	1.00
57_S	84_A	1.269	1.00
100_Q	112_T	1.265	1.00
114_T	130_V	1.256	1.00
49_I	80_A	1.246	1.00
2_Q	35_T	1.246	1.00
29_L	64_I	1.242	1.00
124_L	135_A	1.235	1.00
99_F	115_T	1.222	1.00
103_D	111_T	1.211	1.00
219_D	223_D	1.209	1.00
118_P	134_A	1.208	1.00
215_R	219_D	1.205	1.00
54_A	58_E	1.187	1.00
54_A	84_A	1.181	1.00
42_I	52_D	1.179	1.00
180_I	184_A	1.177	1.00
111_T	114_T	1.176	1.00
203_R	206_I	1.168	1.00
78_M	134_A	1.166	1.00
98_Y	125_E	1.162	1.00
43_P	48_T	1.160	1.00
53_V	65_V	1.158	1.00
145_V	151_G	1.144	0.99
140_Y	159_E	1.143	0.99
87_R	136_V	1.139	0.99
34_A	160_F	1.138	0.99
51_A	59_R	1.138	0.99
219_D	222_R	1.108	0.99
24_W	150_K	1.105	0.99
124_L	156_V	1.096	0.99
85_F	139_V	1.091	0.99
4_A	38_R	1.083	0.99
189_A	220_W	1.081	0.99
153_F	157_A	1.075	0.99
122_R	159_E	1.073	0.99
7_T	12_L	1.072	0.99
185_A	189_A	1.063	0.99
178_A	182_T	1.063	0.99
5_L	66_T	1.058	0.99
40_I	52_D	1.052	0.99
26_G	36_V	1.044	0.99
102_H	106_S	1.042	0.99
65_V	81_V	1.042	0.99
128_R	151_G	1.041	0.99
151_G	155_T	1.039	0.99
73_H	184_A	1.036	0.99
56_L	60_Y	1.033	0.99
17_T	23_A	1.033	0.99
92_H	117_L	1.026	0.99
101_R	105_Y	1.020	0.99
202_V	206_I	1.020	0.99
175_P	178_A	1.011	0.99
25_L	149_M	1.009	0.99
89_L	116_H	1.003	0.99
42_I	48_T	0.992	0.99
201_R	205_K	0.988	0.98
156_V	160_F	0.984	0.98
202_V	207_Q	0.979	0.98
149_M	153_F	0.975	0.98
57_S	138_N	0.974	0.98
127_P	151_G	0.970	0.98
46_V	76_V	0.969	0.98
174_A	179_L	0.965	0.98
3_V	62_A	0.965	0.98
53_V	81_V	0.960	0.98
62_A	140_Y	0.958	0.98
81_V	139_V	0.957	0.98
212_D	216_A	0.955	0.98
111_T	177_S	0.948	0.98
191_D	213_T	0.946	0.98
191_D	217_A	0.943	0.98
221_F	224_R	0.940	0.98
216_A	220_W	0.935	0.98
63_V	139_V	0.928	0.98
50_Q	84_A	0.919	0.98
218_A	222_R	0.915	0.97
28_Q	153_F	0.913	0.97
8_V	197_Y	0.907	0.97
170_V	222_R	0.907	0.97
23_A	27_Q	0.887	0.97
7_T	22_A	0.885	0.97
123_L	132_P	0.885	0.97
129_G	148_E	0.884	0.97
8_V	65_V	0.884	0.97
82_A	89_L	0.883	0.97
183_I	194_V	0.878	0.97
40_I	59_R	0.872	0.97
117_L	134_A	0.872	0.97
5_L	25_L	0.865	0.96
180_I	196_S	0.857	0.96
142_L	153_F	0.857	0.96
6_V	63_V	0.856	0.96
94_D	97_A	0.853	0.96
16_D	197_Y	0.849	0.96
93_A	96_V	0.848	0.96
85_F	136_V	0.847	0.96
168_E	218_A	0.836	0.96
117_L	132_P	0.829	0.95
51_A	58_E	0.826	0.95
122_R	137_N	0.825	0.95
190_Y	194_V	0.817	0.95
124_L	159_E	0.816	0.95
73_H	196_S	0.811	0.95
52_D	56_L	0.809	0.95
101_R	104_T	0.803	0.95
179_L	202_V	0.802	0.95
203_R	207_Q	0.800	0.95
190_Y	220_W	0.799	0.95
8_V	49_I	0.791	0.94
93_A	100_Q	0.789	0.94
141_V	145_V	0.787	0.94
78_M	197_Y	0.785	0.94
87_R	118_P	0.781	0.94
168_E	215_R	0.781	0.94
171_S	201_R	0.777	0.94
5_L	36_V	0.776	0.94
126_N	129_G	0.768	0.93
56_L	63_V	0.768	0.93
153_F	156_V	0.765	0.93
92_H	123_L	0.764	0.93
208_H	217_A	0.762	0.93
37_A	48_T	0.758	0.93
217_A	221_F	0.748	0.92
128_R	147_D	0.745	0.92
22_A	26_G	0.741	0.92
187_Q	194_V	0.735	0.92
142_L	149_M	0.734	0.92
124_L	152_M	0.733	0.92
40_I	56_L	0.732	0.92
19_N	41_V	0.728	0.91
131_A	148_E	0.728	0.91
32_R	158_D	0.723	0.91
179_L	204_V	0.723	0.91
85_F	118_P	0.720	0.91
49_I	53_V	0.720	0.91
51_A	54_A	0.717	0.91
206_I	214_V	0.717	0.91
46_V	79_D	0.711	0.90
210_D	214_V	0.709	0.90
7_T	19_N	0.708	0.90
87_R	137_N	0.705	0.90
196_S	202_V	0.695	0.89
104_T	107_A	0.693	0.89
45_E	193_T	0.686	0.89
23_A	26_G	0.684	0.89
98_Y	101_R	0.684	0.89
95_A	117_L	0.682	0.88
16_D	205_K	0.682	0.88
220_W	224_R	0.681	0.88
122_R	135_A	0.678	0.88
13_L	197_Y	0.674	0.88
10_D	198_P	0.674	0.88
212_D	223_D	0.671	0.88
94_D	125_E	0.669	0.87
220_W	223_D	0.669	0.87
24_W	149_M	0.661	0.87
186_L	221_F	0.657	0.86
110_L	181_D	0.657	0.86
142_L	152_M	0.656	0.86
73_H	188_E	0.655	0.86
217_A	220_W	0.655	0.86
185_A	188_E	0.650	0.86
78_M	141_V	0.646	0.86
113_G	116_H	0.646	0.86
52_D	55_A	0.645	0.85
69_V	148_E	0.644	0.85
95_A	98_Y	0.642	0.85
73_H	180_I	0.640	0.85
126_N	133_G	0.638	0.85
166_Y	211_A	0.637	0.85
24_W	28_Q	0.636	0.85
10_D	43_P	0.635	0.85
212_D	215_R	0.633	0.84
126_N	131_A	0.632	0.84
204_V	218_A	0.632	0.84
32_R	153_F	0.630	0.84
187_Q	190_Y	0.626	0.84
3_V	29_L	0.626	0.84
145_V	152_M	0.624	0.84
95_A	126_N	0.623	0.83
204_V	222_R	0.621	0.83
36_V	39_T	0.620	0.83
91_E	115_T	0.620	0.83
124_L	133_G	0.619	0.83
216_A	219_D	0.615	0.83
98_Y	102_H	0.611	0.82
47_A	83_S	0.608	0.82
206_I	209_S	0.606	0.82
35_T	209_S	0.604	0.82
97_A	104_T	0.603	0.81
95_A	123_L	0.602	0.81
38_R	52_D	0.602	0.81
8_V	198_P	0.601	0.81
142_L	156_V	0.601	0.81
183_I	187_Q	0.599	0.81
121_A	136_V	0.598	0.81
130_V	148_E	0.595	0.81
27_Q	31_E	0.595	0.81
78_M	195_G	0.594	0.80
189_A	224_R	0.589	0.80
206_I	218_A	0.587	0.80
10_D	196_S	0.586	0.80
73_H	187_Q	0.586	0.80
80_A	84_A	0.585	0.79
37_A	45_E	0.583	0.79
20_T	150_K	0.581	0.79
6_V	65_V	0.581	0.79
71_P	177_S	0.579	0.79
2_Q	37_A	0.576	0.78
81_V	136_V	0.573	0.78
13_L	41_V	0.568	0.77
21_N	149_M	0.565	0.77
95_A	99_F	0.562	0.77
21_N	145_V	0.562	0.77
54_A	86_D	0.560	0.76
95_A	132_P	0.559	0.76
44_D	72_T	0.559	0.76
163_E	209_S	0.558	0.76
71_P	111_T	0.555	0.76
7_T	149_M	0.555	0.76
69_V	129_G	0.554	0.76
131_A	152_M	0.554	0.76
12_L	17_T	0.552	0.75
56_L	59_R	0.551	0.75
25_L	64_I	0.551	0.75
145_V	198_P	0.550	0.75
118_P	139_V	0.550	0.75
48_T	52_D	0.549	0.75
186_L	194_V	0.547	0.75
34_A	62_A	0.547	0.75
97_A	223_D	0.547	0.75
29_L	34_A	0.547	0.75
118_P	130_V	0.545	0.75
82_A	88_E	0.543	0.74
192_V	206_I	0.543	0.74
117_L	121_A	0.538	0.74
118_P	141_V	0.538	0.74
120_G	136_V	0.538	0.74
18_V	27_Q	0.536	0.73
114_T	131_A	0.532	0.73
50_Q	53_V	0.531	0.73
81_V	134_A	0.531	0.73
8_V	196_S	0.531	0.73
205_K	208_H	0.530	0.72
8_V	77_T	0.529	0.72
23_A	150_K	0.528	0.72
41_V	196_S	0.526	0.72
53_V	139_V	0.526	0.72
98_Y	130_V	0.524	0.72
181_D	184_A	0.523	0.71
25_L	157_A	0.520	0.71
34_A	162_G	0.510	0.70
178_A	181_D	0.509	0.69
126_N	152_M	0.509	0.69
48_T	167_T	0.509	0.69
172_V	179_L	0.508	0.69
67_G	70_G	0.505	0.69
147_D	150_K	0.505	0.69
95_A	134_A	0.503	0.69
3_V	8_V	0.501	0.68
122_R	215_R	0.500	0.68
95_A	152_M	0.500	0.68
118_P	136_V	0.500	0.68
76_V	80_A	0.500	0.68

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4uuwA	2	0.9957	100	0.29	Contact Map
3kbqA	2	0.697	100	0.456	Contact Map
2is8A	3	0.671	100	0.599	Contact Map
3rfqA	5	0.6537	100	0.604	Contact Map
2g2cA	1	0.6364	100	0.606	Contact Map
3iwtA	4	0.6364	100	0.607	Contact Map
1y5eA	4	0.658	100	0.608	Contact Map
4lhbA	4	0.6494	100	0.608	Contact Map
1mkzA	2	0.6883	100	0.615	Contact Map
3pzyA	3	0.6364	100	0.619	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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