GREMLIN Database
Q9HRC4 - Competence-damage protein CinA-like
UniProt: Q9HRC4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 231 (223)
Sequences: 2982 (2159)
Seq/√Len: 144.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_V83_S3.8561.00
88_E119_A3.1841.00
87_R120_G3.0451.00
91_E116_H2.9901.00
90_T119_A2.8751.00
46_V80_A2.8201.00
18_V23_A2.7981.00
3_V34_A2.6301.00
28_Q31_E2.6001.00
4_A59_R2.4131.00
211_A215_R2.4121.00
50_Q83_S2.4021.00
28_Q154_E2.3821.00
66_T149_M2.3031.00
64_I142_L2.2231.00
96_V112_T2.2131.00
81_V141_V2.1681.00
96_V100_Q2.1241.00
202_V205_K2.1231.00
93_A97_A2.0161.00
135_A159_E1.9791.00
208_H214_V1.9711.00
19_N22_A1.9661.00
91_E96_V1.9521.00
7_T41_V1.8821.00
100_Q104_T1.8751.00
4_A56_L1.8751.00
79_D113_G1.8431.00
24_W154_E1.8411.00
97_A100_Q1.7641.00
91_E112_T1.7001.00
25_L153_F1.6841.00
97_A101_R1.6741.00
45_E48_T1.6141.00
92_H95_A1.5991.00
87_R119_A1.5921.00
57_S139_V1.5701.00
24_W153_F1.5471.00
140_Y156_V1.5131.00
135_A140_Y1.4981.00
168_E222_R1.4921.00
133_G152_M1.4831.00
51_A55_A1.4771.00
32_R157_A1.4741.00
38_R55_A1.4731.00
19_N39_T1.4681.00
117_L123_L1.4661.00
109_D112_T1.4501.00
53_V84_A1.4461.00
4_A60_Y1.4361.00
6_V56_L1.4311.00
53_V63_V1.4071.00
134_A141_V1.4041.00
46_V50_Q1.3981.00
28_Q157_A1.3751.00
54_A57_S1.3691.00
210_D213_T1.3681.00
50_Q80_A1.3671.00
10_D193_T1.3641.00
22_A39_T1.3501.00
26_G39_T1.3481.00
40_I55_A1.3351.00
47_A51_A1.3251.00
127_P155_T1.3151.00
6_V52_D1.3071.00
4_A40_I1.3031.00
168_E219_D1.2851.00
65_V141_V1.2771.00
50_Q54_A1.2761.00
213_T216_A1.2711.00
57_S84_A1.2691.00
100_Q112_T1.2651.00
114_T130_V1.2561.00
49_I80_A1.2461.00
2_Q35_T1.2461.00
29_L64_I1.2421.00
124_L135_A1.2351.00
99_F115_T1.2221.00
103_D111_T1.2111.00
219_D223_D1.2091.00
118_P134_A1.2081.00
215_R219_D1.2051.00
54_A58_E1.1871.00
54_A84_A1.1811.00
42_I52_D1.1791.00
180_I184_A1.1771.00
111_T114_T1.1761.00
203_R206_I1.1681.00
78_M134_A1.1661.00
98_Y125_E1.1621.00
43_P48_T1.1601.00
53_V65_V1.1581.00
145_V151_G1.1440.99
140_Y159_E1.1430.99
87_R136_V1.1390.99
34_A160_F1.1380.99
51_A59_R1.1380.99
219_D222_R1.1080.99
24_W150_K1.1050.99
124_L156_V1.0960.99
85_F139_V1.0910.99
4_A38_R1.0830.99
189_A220_W1.0810.99
153_F157_A1.0750.99
122_R159_E1.0730.99
7_T12_L1.0720.99
185_A189_A1.0630.99
178_A182_T1.0630.99
5_L66_T1.0580.99
40_I52_D1.0520.99
26_G36_V1.0440.99
102_H106_S1.0420.99
65_V81_V1.0420.99
128_R151_G1.0410.99
151_G155_T1.0390.99
73_H184_A1.0360.99
56_L60_Y1.0330.99
17_T23_A1.0330.99
92_H117_L1.0260.99
101_R105_Y1.0200.99
202_V206_I1.0200.99
175_P178_A1.0110.99
25_L149_M1.0090.99
89_L116_H1.0030.99
42_I48_T0.9920.99
201_R205_K0.9880.98
156_V160_F0.9840.98
202_V207_Q0.9790.98
149_M153_F0.9750.98
57_S138_N0.9740.98
127_P151_G0.9700.98
46_V76_V0.9690.98
174_A179_L0.9650.98
3_V62_A0.9650.98
53_V81_V0.9600.98
62_A140_Y0.9580.98
81_V139_V0.9570.98
212_D216_A0.9550.98
111_T177_S0.9480.98
191_D213_T0.9460.98
191_D217_A0.9430.98
221_F224_R0.9400.98
216_A220_W0.9350.98
63_V139_V0.9280.98
50_Q84_A0.9190.98
218_A222_R0.9150.97
28_Q153_F0.9130.97
8_V197_Y0.9070.97
170_V222_R0.9070.97
23_A27_Q0.8870.97
7_T22_A0.8850.97
123_L132_P0.8850.97
129_G148_E0.8840.97
8_V65_V0.8840.97
82_A89_L0.8830.97
183_I194_V0.8780.97
40_I59_R0.8720.97
117_L134_A0.8720.97
5_L25_L0.8650.96
180_I196_S0.8570.96
142_L153_F0.8570.96
6_V63_V0.8560.96
94_D97_A0.8530.96
16_D197_Y0.8490.96
93_A96_V0.8480.96
85_F136_V0.8470.96
168_E218_A0.8360.96
117_L132_P0.8290.95
51_A58_E0.8260.95
122_R137_N0.8250.95
190_Y194_V0.8170.95
124_L159_E0.8160.95
73_H196_S0.8110.95
52_D56_L0.8090.95
101_R104_T0.8030.95
179_L202_V0.8020.95
203_R207_Q0.8000.95
190_Y220_W0.7990.95
8_V49_I0.7910.94
93_A100_Q0.7890.94
141_V145_V0.7870.94
78_M197_Y0.7850.94
87_R118_P0.7810.94
168_E215_R0.7810.94
171_S201_R0.7770.94
5_L36_V0.7760.94
126_N129_G0.7680.93
56_L63_V0.7680.93
153_F156_V0.7650.93
92_H123_L0.7640.93
208_H217_A0.7620.93
37_A48_T0.7580.93
217_A221_F0.7480.92
128_R147_D0.7450.92
22_A26_G0.7410.92
187_Q194_V0.7350.92
142_L149_M0.7340.92
124_L152_M0.7330.92
40_I56_L0.7320.92
19_N41_V0.7280.91
131_A148_E0.7280.91
32_R158_D0.7230.91
179_L204_V0.7230.91
85_F118_P0.7200.91
49_I53_V0.7200.91
51_A54_A0.7170.91
206_I214_V0.7170.91
46_V79_D0.7110.90
210_D214_V0.7090.90
7_T19_N0.7080.90
87_R137_N0.7050.90
196_S202_V0.6950.89
104_T107_A0.6930.89
45_E193_T0.6860.89
23_A26_G0.6840.89
98_Y101_R0.6840.89
95_A117_L0.6820.88
16_D205_K0.6820.88
220_W224_R0.6810.88
122_R135_A0.6780.88
13_L197_Y0.6740.88
10_D198_P0.6740.88
212_D223_D0.6710.88
94_D125_E0.6690.87
220_W223_D0.6690.87
24_W149_M0.6610.87
186_L221_F0.6570.86
110_L181_D0.6570.86
142_L152_M0.6560.86
73_H188_E0.6550.86
217_A220_W0.6550.86
185_A188_E0.6500.86
78_M141_V0.6460.86
113_G116_H0.6460.86
52_D55_A0.6450.85
69_V148_E0.6440.85
95_A98_Y0.6420.85
73_H180_I0.6400.85
126_N133_G0.6380.85
166_Y211_A0.6370.85
24_W28_Q0.6360.85
10_D43_P0.6350.85
212_D215_R0.6330.84
126_N131_A0.6320.84
204_V218_A0.6320.84
32_R153_F0.6300.84
187_Q190_Y0.6260.84
3_V29_L0.6260.84
145_V152_M0.6240.84
95_A126_N0.6230.83
204_V222_R0.6210.83
36_V39_T0.6200.83
91_E115_T0.6200.83
124_L133_G0.6190.83
216_A219_D0.6150.83
98_Y102_H0.6110.82
47_A83_S0.6080.82
206_I209_S0.6060.82
35_T209_S0.6040.82
97_A104_T0.6030.81
95_A123_L0.6020.81
38_R52_D0.6020.81
8_V198_P0.6010.81
142_L156_V0.6010.81
183_I187_Q0.5990.81
121_A136_V0.5980.81
130_V148_E0.5950.81
27_Q31_E0.5950.81
78_M195_G0.5940.80
189_A224_R0.5890.80
206_I218_A0.5870.80
10_D196_S0.5860.80
73_H187_Q0.5860.80
80_A84_A0.5850.79
37_A45_E0.5830.79
20_T150_K0.5810.79
6_V65_V0.5810.79
71_P177_S0.5790.79
2_Q37_A0.5760.78
81_V136_V0.5730.78
13_L41_V0.5680.77
21_N149_M0.5650.77
95_A99_F0.5620.77
21_N145_V0.5620.77
54_A86_D0.5600.76
95_A132_P0.5590.76
44_D72_T0.5590.76
163_E209_S0.5580.76
71_P111_T0.5550.76
7_T149_M0.5550.76
69_V129_G0.5540.76
131_A152_M0.5540.76
12_L17_T0.5520.75
56_L59_R0.5510.75
25_L64_I0.5510.75
145_V198_P0.5500.75
118_P139_V0.5500.75
48_T52_D0.5490.75
186_L194_V0.5470.75
34_A62_A0.5470.75
97_A223_D0.5470.75
29_L34_A0.5470.75
118_P130_V0.5450.75
82_A88_E0.5430.74
192_V206_I0.5430.74
117_L121_A0.5380.74
118_P141_V0.5380.74
120_G136_V0.5380.74
18_V27_Q0.5360.73
114_T131_A0.5320.73
50_Q53_V0.5310.73
81_V134_A0.5310.73
8_V196_S0.5310.73
205_K208_H0.5300.72
8_V77_T0.5290.72
23_A150_K0.5280.72
41_V196_S0.5260.72
53_V139_V0.5260.72
98_Y130_V0.5240.72
181_D184_A0.5230.71
25_L157_A0.5200.71
34_A162_G0.5100.70
178_A181_D0.5090.69
126_N152_M0.5090.69
48_T167_T0.5090.69
172_V179_L0.5080.69
67_G70_G0.5050.69
147_D150_K0.5050.69
95_A134_A0.5030.69
3_V8_V0.5010.68
122_R215_R0.5000.68
95_A152_M0.5000.68
118_P136_V0.5000.68
76_V80_A0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4uuwA 2 0.9957 100 0.29 Contact Map
3kbqA 2 0.697 100 0.456 Contact Map
2is8A 3 0.671 100 0.599 Contact Map
3rfqA 5 0.6537 100 0.604 Contact Map
2g2cA 1 0.6364 100 0.606 Contact Map
3iwtA 4 0.6364 100 0.607 Contact Map
1y5eA 4 0.658 100 0.608 Contact Map
4lhbA 4 0.6494 100 0.608 Contact Map
1mkzA 2 0.6883 100 0.615 Contact Map
3pzyA 3 0.6364 100 0.619 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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