GREMLIN Database
Q9HRC2 - Membrane protein
UniProt: Q9HRC2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 208 (166)
Sequences: 5487 (4457)
Seq/√Len: 345.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
151_G169_I3.9491.00
128_W176_F3.9201.00
94_S113_N3.8421.00
19_L23_M3.3691.00
86_S121_T3.1891.00
95_H163_V3.0171.00
82_A125_A2.7991.00
82_A121_T2.7231.00
81_V175_G2.6251.00
132_S180_Y2.5861.00
124_F147_A2.5421.00
120_T151_G2.4511.00
89_M93_H2.4441.00
115_F167_G2.4291.00
168_G172_S2.2781.00
44_A47_V2.0741.00
124_F169_I2.0481.00
151_G165_I2.0211.00
123_M150_V1.9561.00
128_W173_V1.8741.00
127_A147_A1.7421.00
177_G181_A1.6451.00
124_F151_G1.6391.00
172_S176_F1.5961.00
42_W45_P1.5881.00
120_T124_F1.5491.00
23_M162_P1.5421.00
90_G118_Q1.5371.00
131_A140_V1.5301.00
23_M155_V1.5081.00
120_T168_G1.4701.00
45_P48_D1.4421.00
120_T169_I1.4391.00
78_T125_A1.4221.00
128_W172_S1.4211.00
23_M27_A1.4171.00
95_H161_Y1.4011.00
19_L22_A1.3941.00
61_L65_T1.3771.00
20_N24_V1.3501.00
41_L45_P1.3371.00
175_G179_V1.3271.00
127_A146_V1.3071.00
120_T165_I1.2771.00
153_S157_V1.2741.00
74_F179_V1.2721.00
78_T129_P1.2711.00
116_P167_G1.2621.00
121_T171_A1.2551.00
42_W46_G1.2471.00
127_A143_G1.2401.00
87_Y91_T1.2361.00
43_V46_G1.2241.00
25_F29_R1.2211.00
140_V143_G1.2201.00
93_H115_F1.2101.00
150_V153_S1.2031.00
173_V177_G1.1631.00
41_L44_A1.1561.00
135_D140_V1.1501.00
44_A48_D1.1331.00
27_A30_A1.1331.00
40_V44_A1.1171.00
137_W141_V1.1141.00
19_L95_H1.0961.00
34_V38_L1.0831.00
174_L177_G1.0751.00
89_M116_P1.0711.00
131_A143_G1.0681.00
83_L87_Y1.0661.00
31_V34_V1.0621.00
155_V165_I1.0551.00
88_G92_L1.0521.00
99_Y109_G1.0431.00
51_I55_E1.0411.00
116_P171_A1.0381.00
38_L42_W1.0381.00
86_S118_Q1.0351.00
38_L45_P1.0311.00
60_G64_T1.0301.00
38_L41_L1.0191.00
114_S164_D1.0191.00
124_F144_V1.0161.00
114_S161_Y1.0161.00
124_F176_F1.0051.00
155_V162_P0.9941.00
99_Y110_P0.9881.00
159_V162_P0.9871.00
33_L37_V0.9851.00
99_Y161_Y0.9851.00
64_T67_D0.9821.00
29_R32_F0.9751.00
51_I54_L0.9681.00
134_Q139_A0.9551.00
131_A144_V0.9541.00
69_K73_V0.9391.00
18_V23_M0.9321.00
35_P156_Y0.9311.00
123_M147_A0.9271.00
170_A173_V0.9171.00
115_F164_D0.9161.00
123_M127_A0.9101.00
107_L159_V0.8931.00
146_V150_V0.8921.00
147_A169_I0.8851.00
132_S176_F0.8851.00
76_F80_V0.8841.00
68_G71_K0.8821.00
26_L155_V0.8751.00
75_V129_P0.8741.00
29_R152_Y0.8721.00
119_H160_H0.8651.00
120_T123_M0.8551.00
41_L46_G0.8451.00
65_T68_G0.8321.00
144_V147_A0.8321.00
74_F129_P0.8321.00
77_A80_V0.8281.00
35_P38_L0.8271.00
95_H114_S0.8251.00
152_Y156_Y0.8251.00
141_V145_A0.8221.00
84_A88_G0.8121.00
128_W132_S0.8111.00
32_F35_P0.8091.00
89_M171_A0.8051.00
25_F28_E0.8051.00
52_P56_A0.8041.00
75_V79_I0.8021.00
74_F132_S0.8011.00
74_F78_T0.7881.00
78_T179_V0.7791.00
35_P39_V0.7771.00
33_L36_L0.7741.00
28_E31_V0.7741.00
18_V21_E0.7711.00
41_L47_V0.7691.00
139_A143_G0.7691.00
180_Y184_P0.7661.00
22_A162_P0.7631.00
129_P176_F0.7521.00
121_T125_A0.7501.00
37_V40_V0.7441.00
30_A34_V0.7350.99
138_R142_V0.7160.99
148_A169_I0.7140.99
39_V44_A0.7140.99
158_G162_P0.7130.99
151_G155_V0.7100.99
118_Q122_V0.7060.99
53_V57_A0.7060.99
123_M146_V0.7050.99
74_F133_L0.7030.99
38_L43_V0.7030.99
36_L39_V0.6970.99
19_L27_A0.6950.99
60_G65_T0.6950.99
137_W140_V0.6920.99
184_P187_T0.6910.99
23_M30_A0.6900.99
176_F180_Y0.6840.99
129_P133_L0.6790.99
85_I175_G0.6780.99
166_A169_I0.6740.99
110_P159_V0.6710.99
37_V45_P0.6690.99
51_I60_G0.6650.99
54_L58_L0.6630.99
79_I122_V0.6610.99
53_V64_T0.6580.99
96_P100_A0.6530.99
78_T82_A0.6500.99
20_N23_M0.6500.99
121_T175_G0.6440.99
79_I83_L0.6440.99
44_A146_V0.6430.99
102_G109_G0.6410.99
37_V44_A0.6380.99
81_V179_V0.6350.99
171_A175_G0.6290.98
86_S171_A0.6220.98
82_A175_G0.6180.98
162_P166_A0.6150.98
64_T69_K0.6140.98
35_P40_V0.6070.98
167_G170_A0.6050.98
74_F183_Q0.6030.98
78_T176_F0.6030.98
127_A176_F0.6020.98
131_A137_W0.6020.98
128_W144_V0.6010.98
99_Y159_V0.6000.98
112_E118_Q0.5980.98
90_G97_A0.5940.98
86_S110_P0.5930.98
121_T168_G0.5900.98
82_A122_V0.5890.98
27_A31_V0.5880.98
30_A35_P0.5860.98
129_P132_S0.5860.98
24_V28_E0.5790.97
38_L152_Y0.5770.97
125_A129_P0.5760.97
86_S112_E0.5760.97
95_H164_D0.5750.97
42_W48_D0.5740.97
179_V183_Q0.5730.97
21_E24_V0.5730.97
80_V83_L0.5710.97
82_A86_S0.5700.97
64_T68_G0.5690.97
41_L149_L0.5660.97
124_F173_V0.5650.97
85_I88_G0.5600.97
130_L143_G0.5600.97
96_P101_A0.5590.97
56_A126_F0.5580.97
55_E62_G0.5570.97
92_L96_P0.5560.97
106_L157_V0.5540.97
73_V77_A0.5490.96
71_K133_L0.5480.96
58_L62_G0.5480.96
79_I126_F0.5470.96
166_A170_A0.5460.96
126_F130_L0.5450.96
18_V22_A0.5430.96
100_A111_P0.5400.96
41_L48_D0.5380.96
34_V37_V0.5370.96
40_V156_Y0.5300.96
63_I67_D0.5270.95
136_R140_V0.5270.95
19_L163_V0.5240.95
83_L86_S0.5240.95
95_H115_F0.5230.95
78_T81_V0.5230.95
145_A149_L0.5210.95
62_G66_H0.5210.95
132_S184_P0.5200.95
129_P180_Y0.5170.95
101_A161_Y0.5140.95
60_G76_F0.5130.95
19_L24_V0.5120.95
83_L122_V0.5100.95
148_A152_Y0.5090.94
43_V47_V0.5080.94
110_P122_V0.5080.94
36_L40_V0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4px7A 1 0.9231 100 0.404 Contact Map
1d2tA 5 0.9471 99.9 0.467 Contact Map
1qi9A 2 0.9615 99.9 0.487 Contact Map
4citA 1 0.8558 99.9 0.487 Contact Map
1up8A 9 0.9183 99.9 0.512 Contact Map
2ipbA 2 0.9519 99.9 0.512 Contact Map
3w36A 2 0.8846 99.9 0.519 Contact Map
3bb0A 1 0.9567 99.8 0.55 Contact Map
2kluA 1 0.2308 8.2 0.945 Contact Map
3j01B 1 0.3654 6.8 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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