Q9HRC2 - HALSA - GREMLIN Contacts

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Q9HRC2 - Membrane protein

UniProt:	Q9HRC2	Sequences: MTPPPAASLITPHAGTPVLNEAMVFLAERAVFLVPLVLVVLWVAPGVDRPIPVLEAALAGLGITTHDGKQKSVFVFATIVVALAISYGMGTLHSHPAPYAAGYETLLAGPPENSFPSQHTTVMFAFAWPLASLQDRWRAVVVGVAVAALVGYSRVYVGVHYPVDIAGGIAASVLGFGAVYAAQPLVTAFADRCIRVEARLLGVVFGGR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	208 (166)
Sequences:	5487 (4457)
Seq/√Len:	345.9

ECOLI - YBJG PGPB
BACSU - BCRC YODM
HALSA - Q9HRC2 Q9HNI3
SULSO - Q97VH2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
151_G	169_I	3.949	1.00
128_W	176_F	3.920	1.00
94_S	113_N	3.842	1.00
19_L	23_M	3.369	1.00
86_S	121_T	3.189	1.00
95_H	163_V	3.017	1.00
82_A	125_A	2.799	1.00
82_A	121_T	2.723	1.00
81_V	175_G	2.625	1.00
132_S	180_Y	2.586	1.00
124_F	147_A	2.542	1.00
120_T	151_G	2.451	1.00
89_M	93_H	2.444	1.00
115_F	167_G	2.429	1.00
168_G	172_S	2.278	1.00
44_A	47_V	2.074	1.00
124_F	169_I	2.048	1.00
151_G	165_I	2.021	1.00
123_M	150_V	1.956	1.00
128_W	173_V	1.874	1.00
127_A	147_A	1.742	1.00
177_G	181_A	1.645	1.00
124_F	151_G	1.639	1.00
172_S	176_F	1.596	1.00
42_W	45_P	1.588	1.00
120_T	124_F	1.549	1.00
23_M	162_P	1.542	1.00
90_G	118_Q	1.537	1.00
131_A	140_V	1.530	1.00
23_M	155_V	1.508	1.00
120_T	168_G	1.470	1.00
45_P	48_D	1.442	1.00
120_T	169_I	1.439	1.00
78_T	125_A	1.422	1.00
128_W	172_S	1.421	1.00
23_M	27_A	1.417	1.00
95_H	161_Y	1.401	1.00
19_L	22_A	1.394	1.00
61_L	65_T	1.377	1.00
20_N	24_V	1.350	1.00
41_L	45_P	1.337	1.00
175_G	179_V	1.327	1.00
127_A	146_V	1.307	1.00
120_T	165_I	1.277	1.00
153_S	157_V	1.274	1.00
74_F	179_V	1.272	1.00
78_T	129_P	1.271	1.00
116_P	167_G	1.262	1.00
121_T	171_A	1.255	1.00
42_W	46_G	1.247	1.00
127_A	143_G	1.240	1.00
87_Y	91_T	1.236	1.00
43_V	46_G	1.224	1.00
25_F	29_R	1.221	1.00
140_V	143_G	1.220	1.00
93_H	115_F	1.210	1.00
150_V	153_S	1.203	1.00
173_V	177_G	1.163	1.00
41_L	44_A	1.156	1.00
135_D	140_V	1.150	1.00
44_A	48_D	1.133	1.00
27_A	30_A	1.133	1.00
40_V	44_A	1.117	1.00
137_W	141_V	1.114	1.00
19_L	95_H	1.096	1.00
34_V	38_L	1.083	1.00
174_L	177_G	1.075	1.00
89_M	116_P	1.071	1.00
131_A	143_G	1.068	1.00
83_L	87_Y	1.066	1.00
31_V	34_V	1.062	1.00
155_V	165_I	1.055	1.00
88_G	92_L	1.052	1.00
99_Y	109_G	1.043	1.00
51_I	55_E	1.041	1.00
116_P	171_A	1.038	1.00
38_L	42_W	1.038	1.00
86_S	118_Q	1.035	1.00
38_L	45_P	1.031	1.00
60_G	64_T	1.030	1.00
38_L	41_L	1.019	1.00
114_S	164_D	1.019	1.00
124_F	144_V	1.016	1.00
114_S	161_Y	1.016	1.00
124_F	176_F	1.005	1.00
155_V	162_P	0.994	1.00
99_Y	110_P	0.988	1.00
159_V	162_P	0.987	1.00
33_L	37_V	0.985	1.00
99_Y	161_Y	0.985	1.00
64_T	67_D	0.982	1.00
29_R	32_F	0.975	1.00
51_I	54_L	0.968	1.00
134_Q	139_A	0.955	1.00
131_A	144_V	0.954	1.00
69_K	73_V	0.939	1.00
18_V	23_M	0.932	1.00
35_P	156_Y	0.931	1.00
123_M	147_A	0.927	1.00
170_A	173_V	0.917	1.00
115_F	164_D	0.916	1.00
123_M	127_A	0.910	1.00
107_L	159_V	0.893	1.00
146_V	150_V	0.892	1.00
147_A	169_I	0.885	1.00
132_S	176_F	0.885	1.00
76_F	80_V	0.884	1.00
68_G	71_K	0.882	1.00
26_L	155_V	0.875	1.00
75_V	129_P	0.874	1.00
29_R	152_Y	0.872	1.00
119_H	160_H	0.865	1.00
120_T	123_M	0.855	1.00
41_L	46_G	0.845	1.00
65_T	68_G	0.832	1.00
144_V	147_A	0.832	1.00
74_F	129_P	0.832	1.00
77_A	80_V	0.828	1.00
35_P	38_L	0.827	1.00
95_H	114_S	0.825	1.00
152_Y	156_Y	0.825	1.00
141_V	145_A	0.822	1.00
84_A	88_G	0.812	1.00
128_W	132_S	0.811	1.00
32_F	35_P	0.809	1.00
89_M	171_A	0.805	1.00
25_F	28_E	0.805	1.00
52_P	56_A	0.804	1.00
75_V	79_I	0.802	1.00
74_F	132_S	0.801	1.00
74_F	78_T	0.788	1.00
78_T	179_V	0.779	1.00
35_P	39_V	0.777	1.00
33_L	36_L	0.774	1.00
28_E	31_V	0.774	1.00
18_V	21_E	0.771	1.00
41_L	47_V	0.769	1.00
139_A	143_G	0.769	1.00
180_Y	184_P	0.766	1.00
22_A	162_P	0.763	1.00
129_P	176_F	0.752	1.00
121_T	125_A	0.750	1.00
37_V	40_V	0.744	1.00
30_A	34_V	0.735	0.99
138_R	142_V	0.716	0.99
148_A	169_I	0.714	0.99
39_V	44_A	0.714	0.99
158_G	162_P	0.713	0.99
151_G	155_V	0.710	0.99
118_Q	122_V	0.706	0.99
53_V	57_A	0.706	0.99
123_M	146_V	0.705	0.99
74_F	133_L	0.703	0.99
38_L	43_V	0.703	0.99
36_L	39_V	0.697	0.99
19_L	27_A	0.695	0.99
60_G	65_T	0.695	0.99
137_W	140_V	0.692	0.99
184_P	187_T	0.691	0.99
23_M	30_A	0.690	0.99
176_F	180_Y	0.684	0.99
129_P	133_L	0.679	0.99
85_I	175_G	0.678	0.99
166_A	169_I	0.674	0.99
110_P	159_V	0.671	0.99
37_V	45_P	0.669	0.99
51_I	60_G	0.665	0.99
54_L	58_L	0.663	0.99
79_I	122_V	0.661	0.99
53_V	64_T	0.658	0.99
96_P	100_A	0.653	0.99
78_T	82_A	0.650	0.99
20_N	23_M	0.650	0.99
121_T	175_G	0.644	0.99
79_I	83_L	0.644	0.99
44_A	146_V	0.643	0.99
102_G	109_G	0.641	0.99
37_V	44_A	0.638	0.99
81_V	179_V	0.635	0.99
171_A	175_G	0.629	0.98
86_S	171_A	0.622	0.98
82_A	175_G	0.618	0.98
162_P	166_A	0.615	0.98
64_T	69_K	0.614	0.98
35_P	40_V	0.607	0.98
167_G	170_A	0.605	0.98
74_F	183_Q	0.603	0.98
78_T	176_F	0.603	0.98
127_A	176_F	0.602	0.98
131_A	137_W	0.602	0.98
128_W	144_V	0.601	0.98
99_Y	159_V	0.600	0.98
112_E	118_Q	0.598	0.98
90_G	97_A	0.594	0.98
86_S	110_P	0.593	0.98
121_T	168_G	0.590	0.98
82_A	122_V	0.589	0.98
27_A	31_V	0.588	0.98
30_A	35_P	0.586	0.98
129_P	132_S	0.586	0.98
24_V	28_E	0.579	0.97
38_L	152_Y	0.577	0.97
125_A	129_P	0.576	0.97
86_S	112_E	0.576	0.97
95_H	164_D	0.575	0.97
42_W	48_D	0.574	0.97
179_V	183_Q	0.573	0.97
21_E	24_V	0.573	0.97
80_V	83_L	0.571	0.97
82_A	86_S	0.570	0.97
64_T	68_G	0.569	0.97
41_L	149_L	0.566	0.97
124_F	173_V	0.565	0.97
85_I	88_G	0.560	0.97
130_L	143_G	0.560	0.97
96_P	101_A	0.559	0.97
56_A	126_F	0.558	0.97
55_E	62_G	0.557	0.97
92_L	96_P	0.556	0.97
106_L	157_V	0.554	0.97
73_V	77_A	0.549	0.96
71_K	133_L	0.548	0.96
58_L	62_G	0.548	0.96
79_I	126_F	0.547	0.96
166_A	170_A	0.546	0.96
126_F	130_L	0.545	0.96
18_V	22_A	0.543	0.96
100_A	111_P	0.540	0.96
41_L	48_D	0.538	0.96
34_V	37_V	0.537	0.96
40_V	156_Y	0.530	0.96
63_I	67_D	0.527	0.95
136_R	140_V	0.527	0.95
19_L	163_V	0.524	0.95
83_L	86_S	0.524	0.95
95_H	115_F	0.523	0.95
78_T	81_V	0.523	0.95
145_A	149_L	0.521	0.95
62_G	66_H	0.521	0.95
132_S	184_P	0.520	0.95
129_P	180_Y	0.517	0.95
101_A	161_Y	0.514	0.95
60_G	76_F	0.513	0.95
19_L	24_V	0.512	0.95
83_L	122_V	0.510	0.95
148_A	152_Y	0.509	0.94
43_V	47_V	0.508	0.94
110_P	122_V	0.508	0.94
36_L	40_V	0.500	0.94

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4px7A	1	0.9231	100	0.404	Contact Map
1d2tA	5	0.9471	99.9	0.467	Contact Map
1qi9A	2	0.9615	99.9	0.487	Contact Map
4citA	1	0.8558	99.9	0.487	Contact Map
1up8A	9	0.9183	99.9	0.512	Contact Map
2ipbA	2	0.9519	99.9	0.512	Contact Map
3w36A	2	0.8846	99.9	0.519	Contact Map
3bb0A	1	0.9567	99.8	0.55	Contact Map
2kluA	1	0.2308	8.2	0.945	Contact Map
3j01B	1	0.3654	6.8	0.947	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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