GREMLIN Database
Q9HRC1 - Uncharacterized protein
UniProt: Q9HRC1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 358 (351)
Sequences: 337 (257)
Seq/√Len: 13.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_E33_R5.4441.00
200_D203_Q4.0791.00
203_Q206_K4.0201.00
256_V267_G4.0011.00
14_M23_T3.9721.00
59_V71_A3.7110.99
241_I314_V3.5760.99
149_A155_A3.5400.99
264_V267_G3.4590.99
294_F330_T3.2410.98
284_V294_F3.2320.98
95_R120_D3.1010.98
294_F306_I2.8930.96
256_V275_A2.8920.96
68_G72_A2.8720.96
71_A76_F2.8440.96
46_A156_G2.8380.96
242_A249_G2.7820.95
307_D335_T2.7270.95
45_T153_A2.7180.95
313_V343_Q2.6780.94
58_S79_T2.6600.94
7_V98_V2.5910.93
11_I23_T2.5730.93
134_V191_V2.4930.92
6_V43_A2.4920.92
232_L238_L2.4360.91
328_V357_V2.3950.90
62_Y82_G2.3870.90
18_V35_A2.3760.90
273_T304_A2.3460.89
169_E187_L2.3280.89
269_A302_S2.3100.88
231_V272_I2.3030.88
44_R73_A2.2830.88
3_T58_S2.2470.87
269_A305_I2.2290.87
112_V137_V2.1900.85
62_Y97_A2.1900.85
232_L242_A2.1890.85
106_V109_I2.1780.85
18_V33_R2.1460.84
227_G259_D2.0940.83
294_F311_V2.0900.83
151_Q327_R2.0850.82
122_A189_G2.0690.82
335_T338_S2.0530.81
256_V272_I1.9430.78
229_T256_V1.9260.77
68_G80_V1.8810.75
331_G336_D1.8420.74
231_V267_G1.8130.72
11_I14_M1.8070.72
171_S187_L1.7940.72
71_A78_P1.7800.71
169_E209_Y1.7400.69
11_I27_V1.7290.69
143_V148_F1.7150.68
108_V159_A1.7100.68
268_S271_E1.7090.68
7_V121_V1.7030.67
231_V256_V1.7010.67
307_D332_S1.6990.67
306_I339_L1.6760.66
74_A78_P1.6720.66
64_E108_V1.6680.66
269_A304_A1.6550.65
98_V121_V1.6430.65
30_A34_G1.6420.65
102_I124_A1.6410.64
256_V264_V1.6260.64
317_P351_E1.6130.63
143_V156_G1.6080.63
8_V70_V1.5980.62
14_M27_V1.5720.61
8_V76_F1.5680.61
171_S354_L1.5620.60
62_Y66_M1.5540.60
124_A191_V1.5150.58
44_R74_A1.5080.58
98_V126_T1.5050.58
18_V23_T1.4890.57
29_E32_K1.4810.56
229_T267_G1.4700.56
19_G268_S1.4640.55
219_G346_R1.4400.54
200_D206_K1.4300.54
342_W356_N1.4110.53
196_T285_S1.4080.52
219_G350_F1.3800.51
171_S185_T1.3780.51
92_A96_A1.3590.50
231_V301_I1.3560.50
181_G329_D1.3430.49
63_D82_G1.3360.49
50_L137_V1.3360.49
109_I132_V1.3340.48
110_L159_A1.3300.48
276_L305_I1.3210.48
151_Q220_V1.3090.47
158_V193_T1.2790.45
14_M18_V1.2770.45
63_D84_P1.2730.45
43_A137_V1.2520.44
303_P332_S1.2500.44
294_F339_L1.2350.43
178_Y292_F1.2250.43
303_P336_D1.2200.42
111_F118_A1.2190.42
89_S102_I1.2180.42
70_V74_A1.2150.42
14_M17_R1.2120.42
20_L25_G1.2090.42
18_V37_Q1.2010.41
101_F109_I1.2000.41
281_V310_E1.1910.41
25_G34_G1.1830.40
112_V146_A1.1820.40
112_V286_P1.1810.40
19_G301_I1.1760.40
100_A103_D1.1730.40
57_V76_F1.1690.40
224_V257_Y1.1550.39
307_D338_S1.1530.39
229_T258_R1.1510.39
148_F292_F1.1430.38
59_V306_I1.1390.38
188_R257_Y1.1370.38
283_Y314_V1.1320.38
17_R42_R1.1290.38
98_V125_V1.1280.38
167_T320_L1.1200.37
6_V137_V1.1190.37
151_Q238_L1.1180.37
103_D313_V1.1140.37
119_T188_R1.1090.37
20_L35_A1.1080.37
18_V34_G1.1060.37
29_E120_D1.1050.36
272_I276_L1.0940.36
98_V101_F1.0830.35
191_V327_R1.0780.35
96_A103_D1.0770.35
178_Y234_P1.0710.35
18_V30_A1.0640.34
25_G302_S1.0550.34
44_R70_V1.0390.33
217_A245_L1.0370.33
342_W354_L1.0310.33
266_D300_Q1.0290.33
220_V283_Y1.0160.32
232_L283_Y1.0110.32
121_V134_V1.0100.32
178_Y285_S1.0100.32
327_R355_V1.0060.32
154_A205_A1.0050.32
23_T27_V1.0030.32
248_S265_R1.0010.31
8_V74_A1.0000.31
276_L293_V0.9870.31
89_S316_S0.9850.31
3_T308_R0.9830.31
59_V339_L0.9810.31
19_G112_V0.9790.30
166_T195_V0.9780.30
69_G100_A0.9770.30
134_V170_V0.9620.30
20_L34_G0.9600.30
176_G180_D0.9540.29
156_G196_T0.9480.29
311_V354_L0.9440.29
325_V355_V0.9440.29
23_T162_F0.9390.29
3_T195_V0.9380.29
125_V189_G0.9380.29
234_P301_I0.9360.29
306_I328_V0.9320.28
137_V238_L0.9310.28
187_L190_V0.9310.28
72_A78_P0.9120.27
51_R54_A0.9120.27
96_A100_A0.9120.27
228_V281_V0.9060.27
222_D354_L0.9020.27
25_G30_A0.9010.27
272_I336_D0.8980.27
236_G248_S0.8910.27
19_G234_P0.8890.27
141_V234_P0.8860.26
38_R42_R0.8830.26
181_G348_G0.8820.26
282_V301_I0.8780.26
332_S336_D0.8780.26
43_A112_V0.8770.26
51_R74_A0.8760.26
52_D76_F0.8740.26
98_V320_L0.8730.26
342_W357_V0.8730.26
66_M97_A0.8710.26
46_A143_V0.8710.26
303_P335_T0.8700.26
207_Q211_G0.8690.26
40_P70_V0.8680.26
4_V59_V0.8670.26
293_V313_V0.8670.26
186_T337_A0.8650.26
304_A308_R0.8600.25
91_A95_R0.8580.25
305_I330_T0.8570.25
165_T284_V0.8570.25
224_V230_Y0.8550.25
216_L221_A0.8530.25
82_G149_A0.8530.25
282_V285_S0.8480.25
46_A110_L0.8440.25
291_G326_L0.8440.25
347_T353_R0.8420.25
23_T35_A0.8360.24
135_L313_V0.8350.24
103_D334_D0.8350.24
109_I259_D0.8310.24
28_A49_A0.8300.24
69_G73_A0.8270.24
307_D315_A0.8220.24
249_G286_P0.8200.24
27_V90_T0.8190.24
277_G308_R0.8180.24
344_R356_N0.8090.23
84_P89_S0.8080.23
6_V208_A0.8050.23
100_A104_H0.7970.23
185_T272_I0.7960.23
4_V58_S0.7950.23
109_I133_P0.7900.23
330_T339_L0.7890.23
12_A15_G0.7810.22
225_R259_D0.7800.22
156_G347_T0.7790.22
120_D293_V0.7760.22
231_V282_V0.7740.22
213_T286_P0.7740.22
234_P268_S0.7730.22
121_V218_A0.7710.22
242_A247_V0.7660.22
99_E131_S0.7650.22
287_I329_D0.7620.22
95_R123_T0.7610.22
10_P15_G0.7580.21
10_P13_G0.7580.21
236_G285_S0.7550.21
52_D57_V0.7530.21
306_I335_T0.7510.21
272_I275_A0.7480.21
156_G185_T0.7480.21
8_V40_P0.7470.21
221_A224_V0.7470.21
224_V316_S0.7450.21
80_V312_R0.7430.21
27_V45_T0.7380.21
254_V339_L0.7370.21
178_Y351_E0.7350.21
146_A213_T0.7350.21
232_L269_A0.7320.20
23_T249_G0.7320.20
207_Q317_P0.7290.20
192_A331_G0.7280.20
211_G215_A0.7260.20
170_V316_S0.7250.20
121_V159_A0.7250.20
46_A139_A0.7240.20
130_A257_Y0.7230.20
119_T299_D0.7220.20
14_M37_Q0.7180.20
120_D282_V0.7160.20
207_Q215_A0.7150.20
42_R120_D0.7110.20
177_A184_Q0.7110.20
77_T186_T0.7100.20
234_P238_L0.7080.20
100_A275_A0.7080.20
6_V101_F0.7050.20
109_I277_G0.7020.19
63_D81_V0.7010.19
30_A35_A0.7010.19
14_M141_V0.7000.19
253_G266_D0.7000.19
234_P249_G0.6960.19
112_V289_G0.6950.19
51_R301_I0.6930.19
144_Y290_Q0.6920.19
62_Y81_V0.6920.19
163_E262_L0.6920.19
14_M35_A0.6910.19
259_D301_I0.6900.19
141_V328_V0.6890.19
216_L224_V0.6890.19
94_T345_V0.6870.19
11_I313_V0.6850.19
89_S274_A0.6850.19
219_G250_S0.6840.19
9_N13_G0.6820.19
9_N15_G0.6820.19
157_R241_I0.6790.19
14_M356_N0.6780.19
194_P266_D0.6770.19
206_K327_R0.6760.19
194_P348_G0.6760.19
23_T195_V0.6760.19
188_R224_V0.6750.19
173_I178_Y0.6750.19
6_V71_A0.6720.18
279_D344_R0.6710.18
5_G9_N0.6680.18
79_T220_V0.6670.18
47_L181_G0.6660.18
139_A143_V0.6660.18
77_T223_S0.6650.18
28_A307_D0.6650.18
149_A267_G0.6640.18
270_S274_A0.6630.18
293_V312_R0.6600.18
259_D345_V0.6590.18
65_P69_G0.6590.18
238_L339_L0.6590.18
46_A159_A0.6540.18
257_Y316_S0.6540.18
53_A169_E0.6540.18
3_T40_P0.6530.18
222_D349_R0.6530.18
216_L222_D0.6530.18
281_V312_R0.6530.18
158_V170_V0.6510.18
112_V185_T0.6460.18
341_G347_T0.6440.18
150_V202_L0.6440.18
238_L283_Y0.6410.17
42_R329_D0.6400.17
158_V322_Q0.6380.17
196_T249_G0.6370.17
121_V125_V0.6370.17
9_N12_A0.6360.17
158_V190_V0.6360.17
226_D334_D0.6350.17
66_M290_Q0.6340.17
14_M34_G0.6340.17
6_V289_G0.6340.17
31_R131_S0.6310.17
229_T278_T0.6310.17
90_T333_E0.6290.17
344_R352_K0.6290.17
267_G273_T0.6290.17
38_R41_Q0.6280.17
267_G305_I0.6260.17
32_K248_S0.6260.17
7_V350_F0.6250.17
120_D267_G0.6250.17
175_E179_R0.6230.17
195_V320_L0.6220.17
270_S335_T0.6210.17
264_V271_E0.6210.17
303_P307_D0.6200.17
214_G269_A0.6190.17
285_S315_A0.6170.17
144_Y335_T0.6170.17
227_G261_A0.6170.17
311_V339_L0.6150.17
20_L302_S0.6140.17
343_Q357_V0.6140.17
59_V269_A0.6140.17
200_D205_A0.6120.17
112_V156_G0.6090.17
326_L348_G0.6080.16
285_S323_T0.6060.16
31_R88_A0.6050.16
119_T171_S0.6040.16
3_T240_E0.6040.16
256_V285_S0.6030.16
60_V81_V0.6020.16
53_A226_D0.6020.16
250_S316_S0.6020.16
148_F191_V0.6020.16
281_V346_R0.6010.16
11_I356_N0.6010.16
276_L308_R0.6000.16
162_F330_T0.6000.16
126_T137_V0.5980.16
14_M88_A0.5980.16
301_I351_E0.5970.16
28_A59_V0.5960.16
54_A109_I0.5960.16
173_I301_I0.5960.16
285_S292_F0.5960.16
63_D121_V0.5950.16
247_V257_Y0.5940.16
330_T336_D0.5920.16
59_V130_A0.5890.16
60_V65_P0.5890.16
229_T279_D0.5890.16
131_S334_D0.5880.16
50_L343_Q0.5870.16
197_E294_F0.5860.16
159_A186_T0.5850.16
37_Q65_P0.5850.16
231_V342_W0.5820.16
31_R134_V0.5800.16
256_V336_D0.5780.16
62_Y313_V0.5770.16
151_Q177_A0.5770.16
171_S311_V0.5760.16
229_T277_G0.5750.16
269_A273_T0.5730.15
229_T264_V0.5730.15
18_V27_V0.5720.15
120_D123_T0.5700.15
94_T141_V0.5700.15
7_V81_V0.5690.15
143_V183_V0.5690.15
6_V213_T0.5680.15
156_G299_D0.5680.15
224_V232_L0.5670.15
287_I293_V0.5670.15
144_Y200_D0.5660.15
209_Y258_R0.5650.15
169_E190_V0.5640.15
194_P253_G0.5630.15
60_V104_H0.5630.15
99_E223_S0.5620.15
72_A131_S0.5610.15
32_K158_V0.5600.15
234_P286_P0.5600.15
231_V309_S0.5600.15
13_G22_G0.5600.15
15_G22_G0.5600.15
207_Q212_T0.5590.15
89_S265_R0.5590.15
330_T341_G0.5590.15
105_G139_A0.5580.15
154_A269_A0.5580.15
193_T271_E0.5560.15
192_A328_V0.5560.15
57_V149_A0.5560.15
209_Y349_R0.5550.15
299_D331_G0.5530.15
97_A105_G0.5530.15
264_V315_A0.5530.15
307_D357_V0.5490.15
292_F351_E0.5480.15
125_V135_L0.5480.15
224_V259_D0.5480.15
121_V271_E0.5470.15
105_G220_V0.5470.15
60_V105_G0.5450.15
59_V78_P0.5450.15
210_A231_V0.5440.15
109_I263_V0.5430.15
238_L327_R0.5420.15
201_A206_K0.5410.15
102_I307_D0.5390.15
171_S197_E0.5390.15
148_F249_G0.5390.15
158_V186_T0.5390.15
6_V62_Y0.5370.14
3_T60_V0.5370.14
183_V289_G0.5370.14
232_L286_P0.5370.14
281_V285_S0.5360.14
312_R346_R0.5360.14
109_I189_G0.5350.14
178_Y323_T0.5340.14
103_D241_I0.5330.14
301_I335_T0.5330.14
141_V198_G0.5320.14
119_T186_T0.5310.14
293_V308_R0.5310.14
224_V262_L0.5310.14
280_N309_S0.5290.14
101_F289_G0.5280.14
157_R355_V0.5280.14
170_V289_G0.5260.14
165_T314_V0.5250.14
293_V330_T0.5250.14
323_T341_G0.5250.14
208_A213_T0.5230.14
99_E226_D0.5230.14
268_S306_I0.5230.14
284_V330_T0.5230.14
16_G19_G0.5230.14
8_V130_A0.5230.14
221_A241_I0.5230.14
183_V355_V0.5220.14
221_A230_Y0.5220.14
38_R292_F0.5210.14
97_A157_R0.5200.14
23_T190_V0.5200.14
130_A191_V0.5190.14
80_V354_L0.5190.14
91_A218_A0.5190.14
156_G183_V0.5170.14
157_R206_K0.5170.14
143_V159_A0.5170.14
50_L220_V0.5170.14
12_A22_G0.5160.14
346_R349_R0.5160.14
173_I242_A0.5150.14
253_G302_S0.5140.14
7_V101_F0.5130.14
151_Q267_G0.5120.14
61_T225_R0.5100.14
157_R169_E0.5100.14
144_Y251_P0.5100.14
79_T103_D0.5090.14
27_V91_A0.5080.14
148_F232_L0.5070.14
230_Y337_A0.5070.14
51_R72_A0.5060.14
303_P338_S0.5060.14
8_V357_V0.5040.14
31_R226_D0.5020.14
146_A190_V0.5020.14
148_F325_V0.5010.14
10_P22_G0.5010.14
223_S230_Y0.5010.14
326_L329_D0.5000.14
135_L292_F0.5000.14
23_T207_Q0.5000.14
273_T305_I0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qv7A 2 0.6788 98.9 0.922 Contact Map
4werA 2 0.6955 98.7 0.927 Contact Map
3s40A 3 0.6955 98.5 0.933 Contact Map
2an1A 4 0.6788 98.5 0.933 Contact Map
1u0tA 4 0.6313 98.3 0.937 Contact Map
1yt5A 4 0.648 98.2 0.937 Contact Map
1z0sA 4 0.6369 98.2 0.938 Contact Map
2bonA 1 0.6508 98 0.941 Contact Map
2i2cA 3 0.6201 97.6 0.947 Contact Map
4v24A 1 0.7626 96.8 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0105 seconds.