GREMLIN Database
Q9HRB9 - Phosphate regulatory protein homolog
UniProt: Q9HRB9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 342 (323)
Sequences: 348 (272)
Seq/√Len: 15.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_V28_V4.5121.00
151_E170_R4.3801.00
148_M171_E4.2771.00
218_L222_N4.2651.00
217_E221_D4.2181.00
13_T17_T3.9361.00
34_V46_V3.8611.00
171_E217_E3.6170.99
148_M217_E3.1400.98
175_N221_D3.1260.98
171_E221_D3.0890.98
149_R316_S3.0760.98
175_N217_E2.8300.97
19_P22_W2.8250.97
148_M221_D2.5470.94
141_L174_A2.5240.94
152_A223_A2.5140.94
151_E218_L2.3890.92
23_A28_V2.2880.90
319_Y325_E2.2770.90
5_K14_L2.2510.90
87_V113_V2.2460.90
173_Q176_K2.2340.89
217_E325_E2.2090.89
4_R19_P2.1670.88
261_S280_Q2.1420.87
8_Q11_P2.1170.86
10_G72_R2.1080.86
153_V162_D2.0900.86
222_N325_E2.0850.86
221_D325_E2.0350.84
212_V266_A1.9710.82
4_R22_W1.9670.82
9_L12_S1.9240.81
313_L317_A1.9070.80
7_Q13_T1.8860.79
129_P180_L1.8690.78
218_L325_E1.8600.78
7_Q17_T1.8380.77
216_L276_A1.8320.77
218_L319_Y1.8300.77
155_A164_A1.8250.77
10_G20_A1.7860.75
11_P14_L1.7660.74
171_E175_N1.7540.74
315_Q322_R1.7280.73
171_E315_Q1.7250.73
127_V214_K1.7060.72
9_L218_L1.6940.71
14_L21_E1.6880.71
131_D176_K1.6600.69
180_L184_L1.6410.69
136_N140_R1.6350.68
99_N140_R1.6220.68
2_G5_K1.6190.67
4_R7_Q1.6140.67
10_G22_W1.5980.66
222_N319_Y1.5940.66
10_G31_G1.5780.65
27_D121_I1.5750.65
13_T23_A1.5690.65
12_S208_G1.5600.65
207_V210_R1.5420.64
9_L319_Y1.5420.64
312_S319_Y1.5330.63
15_A218_L1.5200.62
9_L15_A1.5200.62
164_A167_A1.5120.62
7_Q12_S1.5040.62
148_M175_N1.4730.60
9_L20_A1.4670.60
186_F208_G1.4620.59
36_V44_L1.4270.57
12_S66_D1.4240.57
18_L22_W1.4210.57
152_A164_A1.4120.57
141_L220_A1.3920.55
29_V32_D1.3890.55
9_L14_L1.3780.55
219_V316_S1.3770.55
29_V34_V1.3700.54
13_T124_R1.3680.54
121_I172_R1.3650.54
70_V177_I1.3640.54
265_A274_T1.3620.54
95_S268_N1.3610.54
32_D144_T1.3480.53
111_L278_R1.3310.52
15_A230_V1.3280.52
134_L138_L1.3100.51
115_E170_R1.3020.50
315_Q319_Y1.2880.50
4_R10_G1.2820.49
4_R13_T1.2800.49
87_V134_L1.2780.49
151_E222_N1.2780.49
4_R16_M1.2730.49
225_D311_V1.2710.49
10_G221_D1.2710.49
259_A320_S1.2700.49
74_I104_A1.2610.48
13_T43_S1.2600.48
9_L116_E1.2580.48
253_D276_A1.2500.47
62_A246_R1.2500.47
77_Q127_V1.2430.47
18_L43_S1.2290.46
153_V291_I1.2280.46
32_D329_N1.2170.46
222_N315_Q1.2170.46
113_V124_R1.2160.46
251_F310_L1.2150.46
175_N322_R1.2100.45
104_A213_A1.2090.45
20_A274_T1.2070.45
27_D270_D1.2030.45
175_N222_N1.2020.45
75_V184_L1.2010.45
68_D89_S1.2010.45
114_V279_E1.1810.44
220_A262_A1.1790.44
134_L191_D1.1730.43
176_K213_A1.1710.43
111_L176_K1.1710.43
98_I151_E1.1660.43
172_R226_I1.1530.42
45_T87_V1.1400.41
11_P15_A1.1330.41
83_R307_R1.1310.41
112_G173_Q1.1250.41
171_E218_L1.1100.40
104_A214_K1.1090.40
156_L230_V1.1050.39
116_E275_V1.0960.39
141_L217_E1.0900.39
7_Q19_P1.0840.38
26_Q127_V1.0820.38
10_G19_P1.0810.38
166_R170_R1.0810.38
155_A265_A1.0780.38
312_S328_A1.0720.38
6_V14_L1.0620.37
195_A198_V1.0540.37
31_G108_L1.0490.36
320_S324_A1.0390.36
3_T44_L1.0380.36
7_Q11_P1.0350.36
87_V212_V1.0230.35
175_N325_E1.0190.35
10_G217_E1.0180.35
128_D131_D1.0170.35
125_C182_L1.0150.35
13_T19_P1.0140.35
7_Q16_M1.0050.34
188_A194_L1.0020.34
78_Y110_G0.9860.33
151_E163_L0.9790.33
14_L189_Y0.9740.33
112_G175_N0.9720.33
18_L120_R0.9640.32
16_M29_V0.9620.32
255_V277_V0.9600.32
9_L325_E0.9590.32
76_G175_N0.9560.32
185_I322_R0.9560.32
108_L210_R0.9560.32
221_D322_R0.9540.32
79_V179_V0.9490.31
116_E325_E0.9470.31
145_G223_A0.9300.31
153_V252_T0.9280.30
89_S116_E0.9220.30
8_Q216_L0.9200.30
13_T183_R0.9180.30
5_K12_S0.9090.30
76_G221_D0.9080.29
210_R326_I0.8980.29
36_V179_V0.8950.29
170_R218_L0.8950.29
16_M19_P0.8940.29
150_G219_V0.8930.29
43_S258_V0.8880.29
242_Q246_R0.8870.29
102_Y145_G0.8780.28
105_E177_I0.8770.28
242_Q318_Q0.8760.28
13_T33_E0.8750.28
222_N312_S0.8720.28
172_R175_N0.8700.28
180_L195_A0.8680.28
127_V176_K0.8670.28
218_L315_Q0.8630.27
325_E329_N0.8620.27
148_M325_E0.8600.27
105_E215_N0.8570.27
223_A227_A0.8560.27
246_R294_D0.8560.27
173_Q247_R0.8540.27
18_L163_L0.8540.27
46_V87_V0.8520.27
257_D283_A0.8500.27
125_C131_D0.8500.27
217_E220_A0.8490.27
32_D212_V0.8450.27
177_I221_D0.8440.27
114_V210_R0.8420.26
182_L210_R0.8400.26
183_R314_Q0.8390.26
187_T194_L0.8390.26
17_T22_W0.8370.26
62_A66_D0.8370.26
171_E322_R0.8370.26
10_G175_N0.8360.26
76_G217_E0.8360.26
311_V318_Q0.8310.26
106_T309_V0.8310.26
30_K76_G0.8270.26
8_Q13_T0.8240.26
12_S48_P0.8230.26
7_Q22_W0.8220.26
188_A198_V0.8180.25
113_V280_Q0.8180.25
7_Q10_G0.8150.25
174_A263_V0.8140.25
59_T88_E0.8130.25
13_T22_W0.8120.25
291_I299_N0.8090.25
11_P17_T0.8080.25
86_H183_R0.8030.25
18_L124_R0.7970.25
48_P137_L0.7960.25
172_R197_T0.7940.24
108_L179_V0.7940.24
168_L171_E0.7910.24
308_E311_V0.7870.24
199_G202_E0.7840.24
62_A158_H0.7830.24
240_V276_A0.7830.24
234_D262_A0.7770.24
323_N328_A0.7740.24
216_L259_A0.7740.24
273_A291_I0.7730.24
109_M179_V0.7720.24
314_Q318_Q0.7710.23
184_L188_A0.7670.23
243_A255_V0.7660.23
149_R256_D0.7640.23
200_L209_Y0.7640.23
217_E319_Y0.7620.23
241_D290_D0.7610.23
44_L321_M0.7600.23
247_R294_D0.7580.23
84_I124_R0.7580.23
138_L256_D0.7580.23
90_E279_E0.7500.23
14_L219_V0.7460.22
167_A220_A0.7410.22
169_N191_D0.7410.22
175_N218_L0.7400.22
105_E214_K0.7400.22
72_R221_D0.7390.22
270_D273_A0.7370.22
176_K278_R0.7370.22
121_I306_A0.7360.22
188_A266_A0.7320.22
31_G104_A0.7290.22
278_R281_F0.7280.22
98_I166_R0.7260.22
20_A218_L0.7260.22
10_G13_T0.7240.22
207_V267_V0.7230.22
2_G108_L0.7220.22
246_R287_R0.7190.21
112_G218_L0.7160.21
137_L167_A0.7150.21
148_M220_A0.7150.21
94_D134_L0.7150.21
52_R290_D0.7150.21
121_I167_A0.7150.21
135_N209_Y0.7130.21
4_R17_T0.7130.21
74_I158_H0.7110.21
116_E170_R0.7100.21
100_A155_A0.7080.21
26_Q42_G0.7060.21
121_I140_R0.7050.21
130_A242_Q0.7040.21
140_R143_N0.7040.21
156_L240_V0.7020.21
90_E286_D0.6990.21
70_V193_G0.6990.21
264_S273_A0.6980.21
94_D290_D0.6940.21
36_V93_L0.6940.21
284_I317_A0.6940.21
78_Y325_E0.6940.21
47_T76_G0.6910.20
246_R253_D0.6900.20
61_H168_L0.6900.20
171_E325_E0.6890.20
215_N322_R0.6860.20
79_V182_L0.6860.20
18_L114_V0.6860.20
107_Q180_L0.6840.20
51_A276_A0.6830.20
11_P123_I0.6820.20
6_V26_Q0.6810.20
175_N315_Q0.6780.20
181_L198_V0.6770.20
97_H165_Q0.6760.20
126_S144_T0.6760.20
219_V259_A0.6740.20
56_T200_L0.6740.20
50_S286_D0.6730.20
46_V257_D0.6720.20
137_L205_P0.6690.20
126_S171_E0.6670.20
28_V36_V0.6660.20
118_P124_R0.6630.19
207_V214_K0.6570.19
18_L44_L0.6560.19
12_S87_V0.6530.19
32_D322_R0.6520.19
6_V325_E0.6520.19
13_T327_A0.6520.19
72_R176_K0.6510.19
113_V290_D0.6510.19
134_L312_S0.6500.19
319_Y329_N0.6480.19
290_D297_E0.6470.19
16_M22_W0.6460.19
60_I314_Q0.6460.19
217_E322_R0.6460.19
105_E185_I0.6440.19
219_V324_A0.6420.19
137_L197_T0.6420.19
4_R18_L0.6420.19
57_E84_I0.6410.19
185_I207_V0.6410.19
154_K163_L0.6390.19
42_G234_D0.6390.19
13_T125_C0.6370.18
105_E112_G0.6370.18
72_R131_D0.6360.18
36_V46_V0.6350.18
8_Q25_S0.6330.18
254_A284_I0.6320.18
145_G220_A0.6310.18
232_A294_D0.6310.18
17_T202_E0.6290.18
46_V253_D0.6280.18
172_R180_L0.6270.18
34_V104_A0.6270.18
309_V316_S0.6240.18
128_D194_L0.6230.18
138_L200_L0.6230.18
305_E309_V0.6220.18
96_A286_D0.6220.18
5_K152_A0.6200.18
133_D176_K0.6180.18
54_G87_V0.6180.18
157_A277_V0.6180.18
212_V261_S0.6170.18
153_V249_R0.6160.18
119_A251_F0.6150.18
122_T199_G0.6140.18
14_L23_A0.6130.18
10_G148_M0.6120.18
74_I328_A0.6090.18
197_T220_A0.6090.18
59_T322_R0.6070.17
126_S223_A0.6070.17
23_A144_T0.6070.17
154_K158_H0.6050.17
6_V148_M0.6050.17
39_G128_D0.6030.17
89_S219_V0.6010.17
262_A320_S0.6010.17
235_G302_D0.6010.17
126_S226_I0.6000.17
54_G317_A0.5990.17
290_D294_D0.5990.17
216_L295_L0.5970.17
67_A301_A0.5970.17
54_G276_A0.5970.17
55_E87_V0.5950.17
148_M312_S0.5950.17
148_M174_A0.5940.17
9_L266_A0.5930.17
102_Y177_I0.5920.17
186_F322_R0.5910.17
141_L221_D0.5910.17
184_L187_T0.5910.17
217_E222_N0.5910.17
134_L243_A0.5900.17
171_E208_G0.5900.17
194_L219_V0.5900.17
214_K263_V0.5890.17
246_R249_R0.5880.17
30_K215_N0.5880.17
167_A171_E0.5870.17
115_E248_I0.5860.17
38_E185_I0.5860.17
40_G265_A0.5840.17
51_A250_E0.5830.17
246_R277_V0.5830.17
234_D277_V0.5820.17
11_P170_R0.5810.17
34_V310_L0.5790.17
134_L147_T0.5760.17
225_D314_Q0.5750.16
75_V329_N0.5750.16
177_I217_E0.5740.16
289_A293_A0.5730.16
173_Q316_S0.5720.16
57_E86_H0.5690.16
54_G63_T0.5660.16
54_G313_L0.5650.16
86_H147_T0.5600.16
261_S272_D0.5600.16
89_S180_L0.5600.16
31_G72_R0.5600.16
311_V319_Y0.5570.16
89_S93_L0.5570.16
191_D197_T0.5570.16
79_V187_T0.5570.16
296_P304_L0.5530.16
109_M127_V0.5520.16
5_K22_W0.5520.16
109_M328_A0.5520.16
127_V131_D0.5520.16
28_V165_Q0.5510.16
134_L193_G0.5500.16
42_G263_V0.5500.16
49_A86_H0.5500.16
44_L109_M0.5490.16
117_T249_R0.5470.16
235_G243_A0.5450.16
44_L171_E0.5450.16
184_L284_I0.5440.16
137_L284_I0.5440.16
249_R257_D0.5430.16
133_D320_S0.5420.15
112_G140_R0.5410.15
186_F330_L0.5410.15
156_L257_D0.5400.15
107_Q313_L0.5400.15
17_T114_V0.5380.15
122_T287_R0.5380.15
116_E312_S0.5370.15
104_A108_L0.5360.15
12_S47_T0.5320.15
117_T120_R0.5320.15
86_H155_A0.5300.15
8_Q34_V0.5290.15
181_L207_V0.5280.15
113_V116_E0.5280.15
284_I306_A0.5270.15
102_Y173_Q0.5260.15
13_T115_E0.5250.15
201_D302_D0.5240.15
108_L183_R0.5240.15
180_L282_S0.5230.15
12_S148_M0.5210.15
6_V18_L0.5210.15
101_V121_I0.5210.15
16_M55_E0.5190.15
76_G278_R0.5180.15
171_E174_A0.5180.15
168_L319_Y0.5180.15
96_A287_R0.5160.15
312_S325_E0.5160.15
5_K13_T0.5120.15
222_N323_N0.5120.15
275_V328_A0.5090.15
26_Q129_P0.5080.15
19_P28_V0.5080.15
54_G100_A0.5040.14
9_L222_N0.5040.14
279_E284_I0.5040.14
20_A177_I0.5030.14
45_T220_A0.5030.14
101_V241_D0.5010.14
2_G271_Y0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sumB 2 0.617 99.9 0.738 Contact Map
1xwmA 2 0.5994 99.9 0.741 Contact Map
2i0mA 2 0.5848 99.9 0.743 Contact Map
1t72A 5 0.6082 99.9 0.746 Contact Map
4q25A 2 0.5965 99.9 0.754 Contact Map
2oltA 5 0.5673 99.7 0.8 Contact Map
3l39A 3 0.576 98.7 0.881 Contact Map
2mrnA 2 0.1462 98.6 0.887 Contact Map
3o27A 2 0.152 98.1 0.9 Contact Map
1mvfD 1 0.1287 98 0.902 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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