GREMLIN Database
Q9HRB7 - Uncharacterized protein
UniProt: Q9HRB7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 74 (68)
Sequences: 138 (67)
Seq/√Len: 8.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_T13_D2.5660.78
35_L64_S2.4070.73
44_V66_S2.4060.73
57_D72_E2.3370.71
10_R60_K1.9730.57
6_D72_E1.8540.53
37_L51_E1.8050.50
27_R63_R1.7230.47
5_T14_Y1.7020.46
9_R72_E1.6850.46
13_D20_D1.6490.44
13_D51_E1.6260.43
10_R33_D1.4930.38
46_L65_K1.4910.38
41_Q65_K1.4380.36
7_E41_Q1.4340.36
46_L58_I1.4120.35
29_K70_R1.4080.35
38_S55_E1.4060.34
26_F36_G1.3730.33
33_D58_I1.3230.31
29_K62_S1.2990.31
53_S58_I1.2620.29
36_G66_S1.2540.29
20_D72_E1.2360.28
16_R55_E1.2330.28
42_V45_R1.2210.28
42_V64_S1.2140.28
27_R41_Q1.2110.28
56_V70_R1.1550.26
26_F31_I1.1240.25
8_E41_Q1.1240.25
45_R64_S1.1230.25
19_V55_E1.0700.23
25_Y61_W1.0650.23
13_D60_K1.0550.23
8_E45_R1.0540.23
6_D9_R1.0540.23
35_L42_V1.0280.22
11_I42_V1.0200.22
60_K65_K1.0020.21
8_E48_E0.9990.21
27_R34_H0.9970.21
32_A66_S0.9770.21
32_A44_V0.9740.20
24_R65_K0.9170.19
8_E52_K0.9150.19
22_G29_K0.9090.19
34_H70_R0.9090.19
27_R45_R0.9060.19
51_E57_D0.8970.18
42_V66_S0.8940.18
17_E38_S0.8670.18
30_N62_S0.8610.18
6_D54_E0.8200.17
14_Y57_D0.8030.16
11_I45_R0.7980.16
49_L58_I0.7950.16
22_G49_L0.7880.16
9_R51_E0.7640.15
4_Y29_K0.7610.15
34_H63_R0.7490.15
9_R60_K0.7480.15
41_Q63_R0.7460.15
4_Y30_N0.7420.15
13_D57_D0.7310.15
7_E27_R0.6860.14
9_R32_A0.6820.14
31_I40_K0.6810.14
41_Q45_R0.6810.14
23_E57_D0.6790.14
5_T12_L0.6780.14
25_Y50_A0.6570.13
18_S36_G0.6550.13
7_E55_E0.6550.13
30_N65_K0.6510.13
58_I65_K0.6450.13
35_L52_K0.6380.13
51_E54_E0.6270.13
30_N64_S0.6160.12
15_L26_F0.6080.12
34_H72_E0.5930.12
7_E63_R0.5910.12
10_R25_Y0.5900.12
46_L51_E0.5860.12
28_S56_V0.5810.12
17_E59_E0.5690.12
55_E71_V0.5600.11
27_R65_K0.5580.11
62_S70_R0.5570.11
29_K41_Q0.5560.11
28_S48_E0.5550.11
30_N42_V0.5550.11
9_R13_D0.5530.11
10_R37_L0.5340.11
31_I36_G0.5330.11
35_L45_R0.5310.11
26_F60_K0.5260.11
20_D34_H0.5220.11
56_V63_R0.5180.11
10_R59_E0.5130.11
11_I71_V0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qgpA 1 0.9189 93.9 0.838 Contact Map
1qbjA 1 0.8784 90.9 0.853 Contact Map
3lmmA 1 0.8784 86 0.865 Contact Map
1xmkA 1 0.8784 85.4 0.866 Contact Map
4ou0A 1 0.8784 84.3 0.868 Contact Map
4un1B 1 0.9595 83.1 0.87 Contact Map
4ch7A 1 0.8784 82.2 0.871 Contact Map
1oyiA 1 0.8378 81.3 0.872 Contact Map
3eyiA 1 0.8378 80.1 0.874 Contact Map
2ia0A 2 0.8919 74.1 0.88 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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