GREMLIN Database
Q9HRB5 - Aldehyde dehydrogenase (Retinol)
UniProt: Q9HRB5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 503 (452)
Sequences: 36333 (21678)
Seq/√Len: 1019.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
291_E399_S5.2071.00
234_R238_D3.9501.00
291_E397_E3.2581.00
263_D300_R3.1531.00
294_Y397_E3.0361.00
351_T369_G2.8211.00
378_D381_L2.8131.00
258_E290_H2.8021.00
50_D216_D2.7991.00
21_D33_T2.7871.00
326_P330_E2.6491.00
267_H304_I2.6111.00
338_I382_R2.5891.00
298_K395_L2.5881.00
337_D341_E2.5521.00
183_I186_E2.5521.00
76_K109_E2.4851.00
258_E292_D2.4481.00
78_R81_E2.4011.00
336_N368_V2.3801.00
422_S428_I2.3421.00
50_D218_D2.3121.00
21_D30_T2.3001.00
189_A195_D2.1871.00
38_T41_D2.1801.00
71_I188_F2.1721.00
79_H102_T2.1411.00
333_Q337_D2.1321.00
402_I427_Q2.0941.00
137_Q479_T2.0841.00
74_E190_D2.0731.00
323_A332_I2.0521.00
176_Q325_E2.0041.00
209_A213_D1.9941.00
413_P460_K1.9881.00
345_N376_D1.9781.00
213_D235_T1.9771.00
338_I342_E1.9581.00
254_I269_A1.9501.00
340_R346_V1.9411.00
302_V306_E1.9351.00
333_Q368_V1.9311.00
136_R473_E1.9231.00
430_Y434_N1.9061.00
81_E183_I1.9051.00
67_Y193_I1.8951.00
296_E300_R1.8921.00
43_E210_R1.8371.00
259_K427_Q1.8311.00
74_E191_A1.8011.00
436_E459_K1.7981.00
288_I408_I1.7931.00
47_A216_D1.7861.00
231_E234_R1.7861.00
402_I430_Y1.7821.00
230_E460_K1.7731.00
136_R476_T1.7721.00
80_Q98_K1.7691.00
288_I405_A1.7521.00
373_Y383_S1.7481.00
290_H398_Y1.7461.00
74_E77_D1.7441.00
78_R190_D1.7161.00
384_I396_I1.7141.00
379_P408_I1.6901.00
43_E47_A1.6791.00
305_A372_V1.6701.00
74_E187_M1.6681.00
302_V347_L1.6391.00
69_W109_E1.6331.00
269_A297_F1.6281.00
294_Y298_K1.6251.00
382_R386_E1.6201.00
404_R407_E1.6121.00
185_A200_M1.6111.00
85_V183_I1.6041.00
30_T33_T1.5971.00
274_F305_A1.5901.00
168_T197_V1.5871.00
53_E57_Q1.5851.00
108_V160_A1.5771.00
399_S404_R1.5631.00
299_Q303_E1.5501.00
76_K105_W1.5461.00
287_L393_V1.5361.00
334_T382_R1.5311.00
60_S63_D1.5301.00
295_D397_E1.5301.00
43_E214_H1.5281.00
73_H77_D1.5271.00
262_L300_R1.5271.00
346_V373_Y1.5151.00
326_P366_N1.4911.00
300_R303_E1.4841.00
70_D73_H1.4641.00
28_G364_D1.4601.00
403_E434_N1.4571.00
288_I398_Y1.4571.00
266_V300_R1.4531.00
63_D66_E1.4521.00
69_W116_R1.4471.00
418_G437_V1.4471.00
268_A421_I1.4461.00
257_T427_Q1.4411.00
186_E190_D1.4381.00
258_E427_Q1.4361.00
19_T33_T1.4191.00
73_H109_E1.4151.00
58_S434_N1.4131.00
80_Q84_E1.4021.00
269_A287_L1.4021.00
114_D117_H1.4011.00
289_V297_F1.4001.00
304_I307_S1.3941.00
296_E299_Q1.3921.00
84_E88_K1.3921.00
337_D340_R1.3861.00
108_V156_F1.3841.00
72_Y109_E1.3831.00
144_C169_V1.3751.00
335_Y388_V1.3701.00
257_T398_Y1.3681.00
59_L63_D1.3601.00
135_R433_D1.3591.00
404_R408_I1.3561.00
87_T97_G1.3541.00
78_R183_I1.3471.00
23_R30_T1.3411.00
233_A463_N1.3391.00
332_I390_G1.3291.00
41_D44_A1.3281.00
84_E314_L1.3181.00
219_T245_A1.3161.00
329_V368_V1.3151.00
401_D404_R1.3091.00
29_E364_D1.3061.00
309_A317_E1.3051.00
209_A235_T1.3011.00
398_Y408_I1.2981.00
329_V333_Q1.2931.00
18_E36_R1.2911.00
330_E334_T1.2911.00
53_E168_T1.2851.00
24_N27_N1.2851.00
344_E373_Y1.2851.00
185_A198_F1.2831.00
155_P171_W1.2751.00
257_T431_Y1.2721.00
46_I214_H1.2681.00
342_E382_R1.2551.00
94_I98_K1.2541.00
303_E306_E1.2491.00
306_E348_V1.2481.00
406_V431_Y1.2441.00
295_D299_Q1.2371.00
42_V207_A1.2331.00
188_F198_F1.2311.00
298_K302_V1.2231.00
213_D238_D1.2181.00
255_V405_A1.2141.00
326_P329_V1.2141.00
72_Y76_K1.2111.00
290_H293_L1.2001.00
290_H401_D1.1921.00
209_A231_E1.1921.00
82_L183_I1.1841.00
46_I216_D1.1801.00
293_L296_E1.1801.00
175_E204_F1.1791.00
470_E473_E1.1791.00
309_A319_F1.1771.00
39_T210_R1.1721.00
36_R204_F1.1691.00
301_F393_V1.1611.00
339_A373_Y1.1601.00
379_P411_D1.1581.00
87_T313_P1.1581.00
380_D385_T1.1581.00
136_R478_R1.1571.00
47_A51_D1.1541.00
334_T338_I1.1531.00
297_F301_F1.1531.00
311_D318_T1.1531.00
84_E94_I1.1491.00
71_I187_M1.1481.00
133_Y429_N1.1481.00
418_G440_A1.1441.00
469_R473_E1.1401.00
300_R304_I1.1371.00
46_I217_I1.1371.00
228_V231_E1.1311.00
59_L67_Y1.1301.00
196_G199_N1.1271.00
403_E430_Y1.1271.00
298_K347_L1.1251.00
71_I193_I1.1211.00
70_D74_E1.1141.00
432_R481_W1.1141.00
385_T411_D1.1091.00
175_E205_G1.1081.00
144_C221_L1.1041.00
71_I108_V1.1041.00
159_M198_F1.1021.00
385_T413_P1.1001.00
254_I284_S1.0951.00
24_N312_D1.0931.00
233_A244_A1.0921.00
303_E307_S1.0921.00
231_E235_T1.0911.00
251_K285_E1.0851.00
210_R214_H1.0831.00
428_I442_G1.0821.00
139_R219_T1.0801.00
121_D469_R1.0801.00
143_G211_I1.0801.00
79_H98_K1.0791.00
26_A313_P1.0771.00
398_Y401_D1.0761.00
255_V431_Y1.0731.00
308_V320_M1.0721.00
48_A199_N1.0711.00
227_E231_E1.0671.00
69_W113_G1.0651.00
403_E407_E1.0651.00
182_Q202_Q1.0641.00
20_F36_R1.0631.00
302_V348_V1.0621.00
32_G179_W1.0611.00
306_E369_G1.0581.00
349_D371_F1.0541.00
255_V409_H1.0541.00
402_I431_Y1.0471.00
470_E478_R1.0461.00
150_F280_R1.0431.00
329_V366_N1.0381.00
261_D423_E1.0361.00
159_M169_V1.0351.00
82_L187_M1.0341.00
406_V434_N1.0311.00
332_I392_H1.0151.00
312_D315_D1.0141.00
424_D427_Q1.0141.00
121_D470_E1.0131.00
52_A168_T1.0131.00
143_G217_I1.0091.00
398_Y405_A1.0061.00
342_E381_L1.0031.00
28_G366_N1.0001.00
349_D369_G0.9951.00
78_R187_M0.9951.00
456_G465_Y0.9941.00
54_D407_E0.9851.00
77_D190_D0.9831.00
182_Q200_M0.9811.00
419_A445_P0.9771.00
54_D436_E0.9751.00
135_R481_W0.9741.00
253_G418_G0.9721.00
465_Y477_E0.9681.00
261_D264_I0.9681.00
139_R243_L0.9611.00
104_A156_F0.9611.00
15_D44_A0.9591.00
65_A116_R0.9561.00
115_A164_V0.9531.00
218_D436_E0.9421.00
36_R206_D0.9411.00
272_S284_S0.9401.00
230_E240_P0.9381.00
458_M477_E0.9371.00
141_V168_T0.9371.00
78_R186_E0.9351.00
377_Y381_L0.9311.00
335_Y338_I0.9311.00
233_A237_A0.9281.00
141_V217_I0.9271.00
88_K314_L0.9261.00
186_E189_A0.9251.00
273_S285_E0.9251.00
50_D54_D0.9251.00
24_N88_K0.9221.00
81_E84_E0.9201.00
295_D298_K0.9181.00
263_D296_E0.9181.00
338_I341_E0.9161.00
57_Q436_E0.9151.00
92_K100_D0.9141.00
132_A453_L0.9131.00
257_T402_I0.9121.00
243_L477_E0.9121.00
54_D58_S0.9111.00
270_V304_I0.9101.00
294_Y395_L0.9101.00
264_I268_A0.9081.00
407_E411_D0.9061.00
39_T43_E0.9011.00
142_V219_T0.8991.00
137_Q433_D0.8991.00
266_V301_F0.8961.00
343_A381_L0.8951.00
340_R373_Y0.8921.00
225_S228_V0.8891.00
69_W112_A0.8871.00
24_N29_E0.8861.00
332_I388_V0.8841.00
254_I421_I0.8821.00
344_E381_L0.8811.00
262_L266_V0.8801.00
137_Q458_M0.8791.00
90_C177_T0.8751.00
266_V304_I0.8741.00
61_R65_A0.8741.00
42_V143_G0.8741.00
66_E70_D0.8731.00
65_A69_W0.8701.00
405_A408_I0.8641.00
257_T422_S0.8631.00
396_I408_I0.8631.00
133_Y483_L0.8631.00
72_Y112_A0.8621.00
14_G41_D0.8601.00
74_E78_R0.8581.00
429_N433_D0.8581.00
233_A236_V0.8571.00
350_R371_F0.8561.00
52_A197_V0.8531.00
334_T337_D0.8501.00
176_Q327_A0.8481.00
23_R366_N0.8461.00
335_Y382_R0.8451.00
398_Y404_R0.8451.00
104_A152_V0.8441.00
418_G435_A0.8441.00
75_L104_A0.8421.00
39_T206_D0.8421.00
203_G207_A0.8411.00
220_V232_V0.8381.00
230_E234_R0.8381.00
453_L480_A0.8351.00
139_R167_N0.8341.00
65_A112_A0.8341.00
139_R477_E0.8331.00
44_A48_A0.8321.00
143_G208_G0.8321.00
220_V236_V0.8321.00
420_V431_Y0.8311.00
265_A269_A0.8301.00
256_V297_F0.8301.00
266_V297_F0.8271.00
294_Y376_D0.8271.00
15_D38_T0.8271.00
185_A189_A0.8251.00
330_E333_Q0.8251.00
26_A367_W0.8231.00
229_G248_M0.8191.00
252_N285_E0.8181.00
58_S433_D0.8181.00
20_F204_F0.8141.00
171_W181_G0.8131.00
161_V471_V0.8101.00
56_W197_V0.8071.00
379_P396_I0.8071.00
40_T43_E0.8031.00
165_E476_T0.8031.00
15_D40_T0.7981.00
49_A199_N0.7961.00
40_T44_A0.7931.00
212_V232_V0.7921.00
406_V410_N0.7911.00
155_P159_M0.7901.00
48_A196_G0.7901.00
336_N392_H0.7891.00
14_G19_T0.7891.00
162_A169_V0.7881.00
182_Q186_E0.7861.00
265_A297_F0.7821.00
68_L164_V0.7811.00
51_D54_D0.7811.00
83_G98_K0.7791.00
425_Y428_I0.7791.00
266_V270_V0.7751.00
44_A47_A0.7751.00
14_G35_Q0.7731.00
69_W73_H0.7701.00
193_I198_F0.7691.00
229_G246_C0.7681.00
156_F184_I0.7681.00
233_A240_P0.7651.00
144_C158_H0.7641.00
437_V440_A0.7611.00
253_G409_H0.7611.00
299_Q302_V0.7611.00
222_F228_V0.7601.00
31_L88_K0.7601.00
87_T94_I0.7591.00
327_A330_E0.7581.00
37_G41_D0.7581.00
90_C324_I0.7571.00
332_I368_V0.7571.00
67_Y191_A0.7571.00
143_G220_V0.7571.00
173_P202_Q0.7561.00
301_F372_V0.7551.00
95_S319_F0.7541.00
15_D41_D0.7531.00
203_G208_G0.7531.00
75_L105_W0.7471.00
51_D55_E0.7471.00
70_D191_A0.7461.00
152_V180_C0.7421.00
94_I314_L0.7411.00
83_G87_T0.7391.00
37_G45_A0.7381.00
270_V301_F0.7371.00
290_H402_I0.7341.00
308_V319_F0.7311.00
212_V235_T0.7301.00
262_L293_L0.7301.00
257_T290_H0.7271.00
193_I197_V0.7271.00
54_D57_Q0.7221.00
212_V220_V0.7221.00
88_K179_W0.7221.00
289_V293_L0.7221.00
339_A388_V0.7211.00
62_I116_R0.7201.00
335_Y386_E0.7191.00
305_A348_V0.7191.00
76_K79_H0.7151.00
24_N314_L0.7141.00
83_G94_I0.7141.00
236_V244_A0.7131.00
226_A460_K0.7121.00
98_K102_T0.7111.00
55_E59_L0.7111.00
208_G212_V0.7081.00
132_A480_A0.7071.00
425_Y483_L0.7051.00
315_D318_T0.7031.00
175_E331_K0.7031.00
86_V89_E0.7011.00
171_W198_F0.6991.00
263_D304_I0.6961.00
167_N476_T0.6951.00
92_K96_E0.6941.00
155_P181_G0.6931.00
368_V371_F0.6931.00
230_E238_D0.6911.00
42_V210_R0.6881.00
302_V305_A0.6851.00
423_E426_R0.6841.00
259_K422_S0.6831.00
49_A168_T0.6831.00
23_R28_G0.6821.00
442_G483_L0.6821.00
340_R351_T0.6811.00
158_H466_P0.6811.00
328_H331_K0.6801.00
82_L152_V0.6791.00
42_V46_I0.6781.00
139_R218_D0.6781.00
76_K102_T0.6781.00
176_Q324_I0.6781.00
56_W67_Y0.6761.00
350_R369_G0.6761.00
287_L297_F0.6761.00
310_V320_M0.6751.00
43_E216_D0.6751.00
325_E328_H0.6731.00
243_L474_A0.6711.00
379_P384_I0.6711.00
348_V372_V0.6691.00
277_T320_M0.6691.00
234_R237_A0.6691.00
85_V179_W0.6681.00
336_N373_Y0.6661.00
206_D209_A0.6651.00
305_A308_V0.6651.00
347_L376_D0.6641.00
288_I384_I0.6641.00
57_Q434_N0.6621.00
146_T155_P0.6611.00
401_D407_E0.6611.00
210_R213_D0.6601.00
312_D318_T0.6581.00
346_V349_D0.6581.00
402_I406_V0.6571.00
170_V199_N0.6561.00
61_R115_A0.6551.00
73_H76_K0.6531.00
81_E186_E0.6521.00
50_D53_E0.6521.00
37_G201_V0.6491.00
57_Q137_Q0.6481.00
288_I379_P0.6481.00
269_A301_F0.6441.00
331_K334_T0.6431.00
80_Q94_I0.6431.00
408_I411_D0.6431.00
436_E458_M0.6421.00
155_P184_I0.6421.00
131_D429_N0.6401.00
132_A482_T0.6391.00
56_W163_L0.6381.00
158_H221_L0.6381.00
35_Q202_Q0.6351.00
28_G326_P0.6351.00
55_E58_S0.6331.00
301_F395_L0.6321.00
473_E476_T0.6321.00
57_Q138_P0.6321.00
270_V308_V0.6311.00
133_Y481_W0.6311.00
422_S427_Q0.6301.00
183_I187_M0.6301.00
256_V265_A0.6291.00
92_K150_F0.6281.00
235_T238_D0.6271.00
18_E206_D0.6271.00
101_V105_W0.6261.00
425_Y429_N0.6251.00
432_R442_G0.6251.00
168_T199_N0.6231.00
245_A474_A0.6231.00
188_F193_I0.6231.00
175_E231_E0.6211.00
428_I432_R0.6211.00
429_N483_L0.6201.00
54_D434_N0.6191.00
262_L296_E0.6191.00
377_Y384_I0.6181.00
34_F178_P0.6181.00
282_V449_A0.6171.00
376_D397_E0.6171.00
233_A246_C0.6161.00
118_P476_T0.6161.00
87_T314_L0.6161.00
204_F207_A0.6161.00
19_T35_Q0.6141.00
327_A331_K0.6121.00
72_Y105_W0.6101.00
47_A50_D0.6091.00
86_V180_C0.6081.00
388_V392_H0.6071.00
259_K424_D0.6051.00
346_V371_F0.6051.00
377_Y383_S0.6051.00
75_L108_V0.6041.00
22_S32_G0.6031.00
52_A55_E0.6021.00
264_I267_H0.6011.00
118_P472_I0.5991.00
63_D67_Y0.5991.00
473_E478_R0.5981.00
159_M171_W0.5981.00
22_S89_E0.5971.00
135_R479_T0.5961.00
323_A328_H0.5951.00
333_Q336_N0.5951.00
264_I423_E0.5941.00
61_R164_V0.5931.00
406_V430_Y0.5921.00
45_A201_V0.5921.00
84_E87_T0.5911.00
152_V184_I0.5911.00
289_V395_L0.5911.00
426_R429_N0.5901.00
86_V100_D0.5901.00
302_V372_V0.5891.00
205_G208_G0.5891.00
39_T213_D0.5881.00
272_S445_P0.5881.00
254_I287_L0.5851.00
142_V167_N0.5851.00
100_D150_F0.5851.00
333_Q340_R0.5841.00
219_T474_A0.5821.00
86_V97_G0.5811.00
426_R430_Y0.5811.00
280_R283_S0.5801.00
79_H83_G0.5801.00
420_V428_I0.5791.00
75_L152_V0.5781.00
440_A479_T0.5761.00
289_V294_Y0.5751.00
101_V152_V0.5741.00
254_I419_A0.5741.00
406_V435_A0.5731.00
72_Y108_V0.5731.00
48_A195_D0.5731.00
75_L184_I0.5721.00
31_L179_W0.5691.00
336_N371_F0.5671.00
98_K316_E0.5671.00
342_E380_D0.5661.00
258_E398_Y0.5641.00
184_I188_F0.5631.00
252_N417_A0.5621.00
71_I74_E0.5601.00
175_E227_E0.5591.00
309_A315_D0.5591.00
373_Y377_Y0.5571.00
111_A161_V0.5561.00
82_L101_V0.5541.00
226_A230_E0.5521.00
110_W114_D0.5501.00
409_H435_A0.5471.00
153_A157_W0.5461.00
405_A409_H0.5461.00
383_S388_V0.5451.00
323_A368_V0.5441.00
273_S393_V0.5441.00
113_G116_R0.5431.00
22_S178_P0.5421.00
441_Y444_L0.5421.00
379_P407_E0.5411.00
291_E294_Y0.5411.00
436_E477_E0.5401.00
50_D141_V0.5401.00
67_Y71_I0.5401.00
83_G101_V0.5401.00
75_L82_L0.5381.00
284_S419_A0.5371.00
420_V442_G0.5361.00
287_L395_L0.5351.00
141_V218_D0.5341.00
335_Y339_A0.5341.00
262_L265_A0.5331.00
310_V319_F0.5331.00
260_A265_A0.5331.00
103_E153_A0.5321.00
49_A170_V0.5311.00
402_I434_N0.5311.00
144_C159_M0.5301.00
142_V169_V0.5301.00
384_I408_I0.5291.00
274_F308_V0.5291.00
83_G97_G0.5291.00
212_V239_D0.5281.00
417_A441_Y0.5281.00
143_G170_V0.5271.00
90_C276_T0.5271.00
221_L475_V0.5261.00
342_E378_D0.5261.00
227_E327_A0.5261.00
103_E449_A0.5241.00
262_L297_F0.5241.00
137_Q436_E0.5241.00
165_E472_I0.5231.00
143_G212_V0.5231.00
18_E38_T0.5221.00
205_G209_A0.5211.00
114_D469_R0.5201.00
34_F179_W0.5201.00
48_A52_A0.5201.00
266_V293_L0.5201.00
435_A440_A0.5191.00
49_A141_V0.5181.00
247_E416_L0.5181.00
62_I66_E0.5171.00
276_T280_R0.5151.00
157_W467_S0.5151.00
263_D303_E0.5151.00
61_R119_K0.5131.00
431_Y435_A0.5121.00
142_V221_L0.5111.00
79_H105_W0.5101.00
189_A196_G0.5091.00
22_S31_L0.5081.00
244_A463_N0.5081.00
102_T105_W0.5071.00
45_A199_N0.5061.00
130_K444_L0.5051.00
45_A170_V0.5041.00
163_L198_F0.5031.00
253_G437_V0.5021.00
407_E434_N0.5001.00
418_G431_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4o5hA 4 0.9423 100 0.073 Contact Map
3ek1A 5 0.9404 100 0.073 Contact Map
4iymA 6 0.9642 100 0.075 Contact Map
4yweA 5 0.9404 100 0.075 Contact Map
4lihA 5 0.9423 100 0.076 Contact Map
4qf6A 4 0.9404 100 0.076 Contact Map
1a4sA 4 0.9642 100 0.076 Contact Map
4pxlA 4 0.9503 100 0.076 Contact Map
4pz2A 4 0.9543 100 0.077 Contact Map
1wndA 4 0.9364 100 0.08 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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