Q9HRB3 - HALSA - GREMLIN Contacts

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Q9HRB3 - Acyl-CoA dehydrogenase

UniProt:	Q9HRB3	Sequences: MNHELPDEHALIQETVREFCAAEIEPIAGDIEAEHRFPTEIFDALADLDMLGVPISDEYGGLGGDQLMYATVTEELGRVSGSIGLSYAAHVSLGAKPIELFGTAEQKREWLRPLAEGDYLGAWALTEPTSGSDASDMSTTATRDGDDYVLNGTKQFITNASVAGSVVVKAVTDPDAGYDGISTFIVDPADDGFEVTAEWDKMGLNASPTCEISFDNCRIPADRLLGEEGDGWTQTKKTLDGGRISIAALSTGLAQGAYTAASEYATDREQFGQPISRFDAVRNTLVDMHRKIERARLLTRRAASKYDAGESVTRESALAKLDASEAAREVAEDAVQTLGGYGYTTDFAPQRFFRDAKLMEIGEGTSEIQHLVIGRELGL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	379 (365)
Sequences:	33891 (19370)
Seq/√Len:	1013.9

ECOLI - CAIA YDIO AIDB FADE
BACSU - ACDA ACDC ACDB FADE YDBM
HALSA - Q9HRB3 Q9HS75 Q9HRI6 Q9HPT2 Q9HQF0 Q9HMK7
SULSO - Q97UW6 Q97V73 Q97U78 Q97WQ8 Q97XW3 Q97VU6 Q97YZ6 Q97VV8 Q97YZ3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
147_D	218_R	4.168	1.00
151_N	216_N	3.499	1.00
291_K	329_E	3.423	1.00
23_E	44_A	3.269	1.00
143_R	221_A	3.054	1.00
113_P	118_D	3.006	1.00
104_A	108_R	2.865	1.00
194_E	215_D	2.847	1.00
30_D	34_E	2.830	1.00
17_R	75_E	2.656	1.00
65_D	68_M	2.654	1.00
144_D	218_R	2.614	1.00
113_P	119_Y	2.605	1.00
284_T	333_D	2.524	1.00
153_T	213_S	2.404	1.00
263_E	267_D	2.304	1.00
255_Q	296_R	2.209	1.00
304_S	308_A	2.134	1.00
18_E	22_A	2.122	1.00
230_D	233_T	2.098	1.00
227_E	230_D	2.091	1.00
182_S	224_L	2.064	1.00
274_P	277_R	1.963	1.00
104_A	107_K	1.963	1.00
153_T	211_E	1.947	1.00
144_D	149_V	1.944	1.00
166_V	188_P	1.938	1.00
345_T	350_Q	1.894	1.00
258_Y	292_I	1.881	1.00
144_D	147_D	1.873	1.00
9_H	68_M	1.865	1.00
44_A	47_D	1.863	1.00
56_S	99_E	1.843	1.00
43_D	47_D	1.823	1.00
350_Q	354_R	1.821	1.00
170_A	184_F	1.811	1.00
265_A	337_T	1.760	1.00
78_R	259_T	1.756	1.00
269_E	274_P	1.756	1.00
103_T	106_Q	1.747	1.00
194_E	213_S	1.716	1.00
280_A	283_N	1.707	1.00
75_E	78_R	1.701	1.00
122_A	166_V	1.683	1.00
160_A	210_C	1.676	1.00
142_T	151_N	1.675	1.00
74_E	296_R	1.669	1.00
57_D	63_G	1.663	1.00
305_K	315_E	1.662	1.00
196_T	213_S	1.662	1.00
148_Y	184_F	1.648	1.00
325_E	366_S	1.646	1.00
273_Q	277_R	1.645	1.00
149_V	216_N	1.637	1.00
301_R	305_K	1.636	1.00
109_E	222_D	1.626	1.00
173_D	176_A	1.607	1.00
295_A	323_A	1.587	1.00
108_R	112_R	1.586	1.00
149_V	218_R	1.583	1.00
255_Q	259_T	1.577	1.00
14_E	18_E	1.576	1.00
109_E	113_P	1.563	1.00
187_D	223_R	1.562	1.00
200_D	345_T	1.539	1.00
329_E	333_D	1.532	1.00
265_A	281_V	1.525	1.00
220_P	223_R	1.524	1.00
190_D	217_C	1.520	1.00
288_M	330_V	1.515	1.00
260_A	348_A	1.511	1.00
11_L	15_T	1.509	1.00
161_S	210_C	1.508	1.00
262_S	266_T	1.506	1.00
341_Y	347_F	1.502	1.00
10_A	13_Q	1.492	1.00
328_R	360_E	1.485	1.00
143_R	228_E	1.484	1.00
294_R	322_D	1.483	1.00
11_L	14_E	1.482	1.00
196_T	211_E	1.478	1.00
39_T	43_D	1.476	1.00
257_A	331_A	1.471	1.00
20_C	79_V	1.464	1.00
260_A	263_E	1.463	1.00
143_R	147_D	1.452	1.00
67_L	304_S	1.445	1.00
9_H	65_D	1.441	1.00
105_E	109_E	1.429	1.00
256_G	260_A	1.426	1.00
187_D	190_D	1.411	1.00
101_F	237_K	1.410	1.00
113_P	116_E	1.402	1.00
221_A	224_L	1.392	1.00
270_Q	278_F	1.392	1.00
224_L	228_E	1.390	1.00
151_N	215_D	1.388	1.00
9_H	71_T	1.378	1.00
293_E	301_R	1.377	1.00
78_R	255_Q	1.366	1.00
74_E	255_Q	1.363	1.00
288_M	333_D	1.362	1.00
261_A	334_A	1.358	1.00
146_D	221_A	1.354	1.00
146_D	218_R	1.353	1.00
190_D	223_R	1.352	1.00
281_V	337_T	1.330	1.00
148_Y	221_A	1.328	1.00
33_A	200_D	1.328	1.00
59_Y	107_K	1.317	1.00
43_D	46_A	1.315	1.00
66_Q	307_D	1.312	1.00
112_R	116_E	1.305	1.00
10_A	14_E	1.298	1.00
80_S	83_I	1.287	1.00
147_D	221_A	1.283	1.00
254_A	292_I	1.278	1.00
53_V	72_V	1.278	1.00
254_A	330_V	1.275	1.00
332_E	357_K	1.272	1.00
16_V	50_M	1.261	1.00
129_T	138_S	1.259	1.00
127_E	154_K	1.255	1.00
143_R	148_Y	1.250	1.00
13_Q	75_E	1.246	1.00
289_H	293_E	1.244	1.00
219_I	223_R	1.244	1.00
126_T	156_F	1.242	1.00
74_E	300_R	1.240	1.00
105_E	222_D	1.227	1.00
321_L	366_S	1.226	1.00
29_G	33_A	1.224	1.00
124_A	157_I	1.221	1.00
240_D	313_T	1.220	1.00
119_Y	164_G	1.220	1.00
327_A	356_A	1.214	1.00
150_L	184_F	1.214	1.00
301_R	304_S	1.210	1.00
44_A	48_L	1.210	1.00
70_A	303_A	1.198	1.00
27_I	31_I	1.193	1.00
114_L	121_G	1.192	1.00
15_T	48_L	1.191	1.00
273_Q	278_F	1.190	1.00
141_A	184_F	1.181	1.00
172_T	182_S	1.181	1.00
70_A	248_A	1.177	1.00
109_E	223_R	1.176	1.00
328_R	332_E	1.174	1.00
107_K	111_L	1.170	1.00
260_A	338_L	1.168	1.00
305_K	310_E	1.167	1.00
142_T	149_V	1.166	1.00
64_G	68_M	1.165	1.00
188_P	195_V	1.163	1.00
169_K	183_T	1.162	1.00
188_P	193_F	1.159	1.00
295_A	326_A	1.151	1.00
291_K	326_A	1.140	1.00
106_Q	110_W	1.138	1.00
110_W	165_S	1.137	1.00
258_Y	262_S	1.137	1.00
332_E	360_E	1.136	1.00
256_G	352_F	1.135	1.00
248_A	299_T	1.123	1.00
287_D	370_H	1.123	1.00
334_A	349_P	1.120	1.00
193_F	217_C	1.119	1.00
100_L	237_K	1.117	1.00
46_A	51_L	1.103	1.00
291_K	333_D	1.101	1.00
124_A	166_V	1.098	1.00
317_A	369_Q	1.095	1.00
55_I	115_A	1.091	1.00
292_I	330_V	1.091	1.00
168_V	186_V	1.082	1.00
13_Q	71_T	1.078	1.00
169_K	181_I	1.078	1.00
121_G	165_S	1.078	1.00
43_D	118_D	1.076	1.00
325_E	329_E	1.071	1.00
192_G	217_C	1.070	1.00
284_T	367_E	1.062	1.00
105_E	108_R	1.062	1.00
27_I	30_D	1.061	1.00
297_L	301_R	1.060	1.00
266_T	276_S	1.051	1.00
17_R	21_A	1.048	1.00
31_I	206_A	1.044	1.00
65_D	307_D	1.043	1.00
326_A	329_E	1.043	1.00
357_K	360_E	1.042	1.00
140_T	151_N	1.039	1.00
40_E	43_D	1.029	1.00
58_E	108_R	1.024	1.00
124_A	214_F	1.022	1.00
94_G	121_G	1.020	1.00
265_A	276_S	1.016	1.00
15_T	50_M	1.015	1.00
328_R	353_F	1.015	1.00
287_D	291_K	1.011	1.00
141_A	170_A	1.006	1.00
251_T	292_I	1.004	1.00
19_F	44_A	1.004	1.00
16_V	72_V	1.002	1.00
148_Y	172_T	1.000	1.00
262_S	285_L	0.996	1.00
321_L	370_H	0.995	1.00
77_G	84_G	0.988	1.00
232_W	236_K	0.985	1.00
142_T	216_N	0.983	1.00
250_S	359_M	0.980	1.00
331_A	356_A	0.975	1.00
101_F	234_Q	0.975	1.00
360_E	366_S	0.975	1.00
242_G	363_E	0.975	1.00
166_V	193_F	0.974	1.00
102_G	106_Q	0.974	1.00
109_E	187_D	0.969	1.00
155_Q	211_E	0.968	1.00
168_V	214_F	0.966	1.00
16_V	20_C	0.965	1.00
67_L	307_D	0.957	1.00
139_T	150_L	0.955	1.00
335_V	353_F	0.952	1.00
142_T	173_D	0.940	1.00
165_S	187_D	0.935	1.00
290_R	318_L	0.932	1.00
184_F	224_L	0.931	1.00
191_D	218_R	0.930	1.00
133_D	136_D	0.928	1.00
302_A	319_A	0.927	1.00
19_F	48_L	0.924	1.00
265_A	275_I	0.916	1.00
251_T	299_T	0.915	1.00
119_Y	165_S	0.914	1.00
150_L	168_V	0.913	1.00
55_I	95_A	0.908	1.00
164_G	189_A	0.904	1.00
257_A	352_F	0.902	1.00
253_L	327_A	0.900	1.00
287_D	333_D	0.899	1.00
259_T	263_E	0.895	1.00
182_S	228_E	0.891	1.00
204_L	358_L	0.889	1.00
193_F	212_I	0.888	1.00
15_T	18_E	0.886	1.00
202_M	353_F	0.884	1.00
56_S	59_Y	0.882	1.00
150_L	219_I	0.880	1.00
39_T	162_V	0.879	1.00
291_K	322_D	0.879	1.00
366_S	370_H	0.877	1.00
166_V	212_I	0.872	1.00
33_A	345_T	0.871	1.00
54_P	69_Y	0.871	1.00
167_V	183_T	0.871	1.00
106_Q	223_R	0.870	1.00
253_L	352_F	0.867	1.00
218_R	221_A	0.866	1.00
289_H	318_L	0.865	1.00
20_C	76_L	0.864	1.00
58_E	104_A	0.863	1.00
324_S	366_S	0.862	1.00
195_V	212_I	0.861	1.00
147_D	220_P	0.855	1.00
160_A	195_V	0.853	1.00
173_D	180_G	0.851	1.00
282_R	371_L	0.850	1.00
283_N	287_D	0.850	1.00
359_M	362_G	0.846	1.00
13_Q	17_R	0.844	1.00
329_E	332_E	0.842	1.00
94_G	167_V	0.842	1.00
106_Q	185_I	0.837	1.00
67_L	71_T	0.836	1.00
283_N	371_L	0.834	1.00
251_T	295_A	0.833	1.00
150_L	170_A	0.832	1.00
263_E	266_T	0.832	1.00
358_L	362_G	0.828	1.00
148_Y	228_E	0.827	1.00
40_E	44_A	0.825	1.00
265_A	285_L	0.825	1.00
82_S	206_A	0.825	1.00
171_V	181_I	0.824	1.00
325_E	360_E	0.823	1.00
32_E	354_R	0.823	1.00
165_S	185_I	0.823	1.00
21_A	25_E	0.819	1.00
27_I	40_E	0.817	1.00
325_E	370_H	0.817	1.00
18_E	21_A	0.816	1.00
156_F	341_Y	0.816	1.00
122_A	163_A	0.815	1.00
322_D	326_A	0.813	1.00
67_L	300_R	0.812	1.00
312_V	315_E	0.812	1.00
331_A	352_F	0.811	1.00
103_T	107_K	0.809	1.00
332_E	353_F	0.807	1.00
293_E	296_R	0.804	1.00
287_D	329_E	0.804	1.00
156_F	344_T	0.804	1.00
353_F	357_K	0.803	1.00
71_T	300_R	0.801	1.00
258_Y	289_H	0.799	1.00
261_A	337_T	0.798	1.00
184_F	219_I	0.798	1.00
214_F	217_C	0.797	1.00
164_G	188_P	0.793	1.00
261_A	338_L	0.789	1.00
298_L	319_A	0.785	1.00
137_M	169_K	0.783	1.00
148_Y	224_L	0.782	1.00
328_R	357_K	0.779	1.00
202_M	350_Q	0.775	1.00
9_H	67_L	0.773	1.00
335_V	349_P	0.772	1.00
264_Y	341_Y	0.768	1.00
21_A	79_V	0.766	1.00
257_A	334_A	0.765	1.00
255_Q	289_H	0.761	1.00
205_N	345_T	0.761	1.00
246_I	363_E	0.759	1.00
21_A	78_R	0.759	1.00
71_T	75_E	0.757	1.00
122_A	188_P	0.757	1.00
293_E	297_L	0.757	1.00
290_R	321_L	0.757	1.00
30_D	33_A	0.754	1.00
288_M	334_A	0.751	1.00
124_A	168_V	0.751	1.00
254_A	326_A	0.751	1.00
59_Y	104_A	0.750	1.00
124_A	212_I	0.746	1.00
141_A	148_Y	0.744	1.00
19_F	45_L	0.742	1.00
247_A	299_T	0.742	1.00
203_G	355_D	0.741	1.00
224_L	227_E	0.739	1.00
290_R	322_D	0.738	1.00
284_T	287_D	0.736	1.00
132_S	368_I	0.736	1.00
161_S	208_P	0.735	1.00
39_T	164_G	0.734	1.00
260_A	352_F	0.733	1.00
298_L	318_L	0.732	1.00
326_A	330_V	0.729	1.00
19_F	23_E	0.727	1.00
41_I	83_I	0.726	1.00
182_S	229_G	0.724	1.00
20_C	24_I	0.724	1.00
58_E	107_K	0.722	1.00
284_T	337_T	0.720	1.00
247_A	319_A	0.720	1.00
95_A	114_L	0.720	1.00
78_R	256_G	0.719	1.00
110_W	223_R	0.719	1.00
190_D	193_F	0.716	1.00
125_L	239_L	0.715	1.00
294_R	298_L	0.713	1.00
331_A	353_F	0.712	1.00
173_D	229_G	0.709	1.00
335_V	342_G	0.709	1.00
29_G	351_R	0.707	1.00
284_T	336_Q	0.704	1.00
153_T	196_T	0.703	1.00
53_V	64_G	0.701	1.00
230_D	234_Q	0.697	1.00
369_Q	372_V	0.697	1.00
17_R	78_R	0.695	1.00
296_R	300_R	0.693	1.00
110_W	185_I	0.692	1.00
338_L	349_P	0.691	1.00
141_A	172_T	0.687	1.00
279_D	283_N	0.686	1.00
55_I	59_Y	0.683	1.00
253_L	356_A	0.683	1.00
147_D	222_D	0.683	1.00
278_F	282_R	0.680	1.00
137_M	181_I	0.679	1.00
261_A	265_A	0.676	1.00
247_A	323_A	0.673	1.00
143_R	146_D	0.673	1.00
35_H	205_N	0.671	1.00
275_I	278_F	0.670	1.00
311_S	315_E	0.670	1.00
171_V	180_G	0.670	1.00
25_E	28_A	0.669	1.00
351_R	355_D	0.669	1.00
58_E	61_G	0.664	1.00
291_K	294_R	0.662	1.00
204_L	362_G	0.662	1.00
171_V	174_P	0.660	1.00
24_I	41_I	0.660	1.00
140_T	173_D	0.655	1.00
299_T	323_A	0.655	1.00
102_G	107_K	0.653	1.00
186_V	214_F	0.652	1.00
189_A	193_F	0.648	1.00
331_A	349_P	0.647	1.00
256_G	259_T	0.646	1.00
39_T	120_L	0.646	1.00
298_L	322_D	0.646	1.00
291_K	325_E	0.645	1.00
35_H	200_D	0.644	1.00
250_S	324_S	0.643	1.00
303_A	307_D	0.642	1.00
139_T	154_K	0.640	1.00
128_P	153_T	0.639	1.00
282_R	374_G	0.637	1.00
31_I	36_R	0.636	1.00
97_P	238_T	0.634	1.00
172_T	180_G	0.633	1.00
254_A	295_A	0.633	1.00
140_T	174_P	0.633	1.00
255_Q	292_I	0.631	1.00
110_W	119_Y	0.630	1.00
171_V	176_A	0.628	1.00
301_R	315_E	0.627	1.00
261_A	288_M	0.622	1.00
13_Q	74_E	0.620	1.00
200_D	205_N	0.617	1.00
123_W	235_T	0.617	1.00
145_G	218_R	0.616	1.00
41_I	44_A	0.615	1.00
169_K	235_T	0.612	1.00
12_I	68_M	0.611	1.00
69_Y	245_S	0.611	1.00
328_R	356_A	0.610	1.00
32_E	205_N	0.609	1.00
157_I	212_I	0.608	1.00
127_E	139_T	0.608	1.00
143_R	149_V	0.606	1.00
96_K	100_L	0.605	1.00
45_L	50_M	0.602	1.00
139_T	152_G	0.602	1.00
167_V	225_L	0.597	1.00
99_E	107_K	0.596	1.00
295_A	322_D	0.596	1.00
327_A	331_A	0.596	1.00
66_Q	306_Y	0.594	1.00
193_F	214_F	0.590	1.00
114_L	165_S	0.590	1.00
256_G	348_A	0.590	1.00
365_T	368_I	0.589	1.00
58_E	63_G	0.588	1.00
240_D	316_S	0.586	1.00
144_D	221_A	0.585	1.00
12_I	16_V	0.583	1.00
45_L	83_I	0.582	1.00
176_A	179_D	0.580	1.00
137_M	171_V	0.579	1.00
290_R	294_R	0.577	1.00
145_G	149_V	0.577	1.00
29_G	348_A	0.577	1.00
125_L	134_A	0.576	1.00
12_I	72_V	0.576	1.00
162_V	208_P	0.575	1.00
17_R	79_V	0.574	1.00
52_G	115_A	0.572	1.00
71_T	74_E	0.572	1.00
248_A	252_G	0.570	1.00
281_V	285_L	0.569	1.00
172_T	228_E	0.569	1.00
195_V	210_C	0.568	1.00
298_L	302_A	0.567	1.00
287_D	325_E	0.566	1.00
23_E	26_P	0.565	1.00
165_S	223_R	0.565	1.00
125_L	169_K	0.564	1.00
306_Y	312_V	0.564	1.00
318_L	373_I	0.564	1.00
278_F	281_V	0.564	1.00
186_V	217_C	0.562	1.00
270_Q	275_I	0.561	1.00
37_F	40_E	0.560	1.00
85_L	204_L	0.559	1.00
251_T	255_Q	0.558	1.00
139_T	168_V	0.557	1.00
97_P	101_F	0.556	1.00
106_Q	109_E	0.556	1.00
268_R	271_F	0.555	1.00
336_Q	357_K	0.553	1.00
109_E	112_R	0.552	1.00
348_A	352_F	0.552	1.00
244_I	303_A	0.552	1.00
293_E	298_L	0.551	1.00
15_T	62_L	0.551	1.00
182_S	226_G	0.547	1.00
52_G	62_L	0.546	1.00
281_V	284_T	0.545	1.00
173_D	177_G	0.544	1.00
269_E	277_R	0.542	1.00
171_V	178_Y	0.542	1.00
81_G	253_L	0.541	1.00
244_I	306_Y	0.540	1.00
198_E	211_E	0.540	1.00
202_M	354_R	0.539	1.00
170_A	182_S	0.538	1.00
139_T	170_A	0.537	1.00
341_Y	344_T	0.537	1.00
130_S	138_S	0.537	1.00
321_L	325_E	0.536	1.00
150_L	186_V	0.536	1.00
203_G	343_Y	0.534	1.00
56_S	61_G	0.532	1.00
36_R	39_T	0.532	1.00
275_I	281_V	0.532	1.00
28_A	351_R	0.531	1.00
340_G	343_Y	0.530	1.00
241_G	306_Y	0.529	1.00
35_H	345_T	0.529	1.00
94_G	97_P	0.529	1.00
321_L	373_I	0.528	1.00
95_A	111_L	0.527	1.00
96_K	99_E	0.527	1.00
244_I	299_T	0.525	1.00
160_A	212_I	0.524	1.00
200_D	346_D	0.524	1.00
168_V	217_C	0.523	1.00
143_R	173_D	0.522	1.00
25_E	79_V	0.521	1.00
139_T	214_F	0.521	1.00
97_P	234_Q	0.518	1.00
280_A	284_T	0.517	1.00
254_A	327_A	0.517	1.00
189_A	195_V	0.516	1.00
73_T	77_G	0.516	1.00
348_A	351_R	0.514	1.00
227_E	234_Q	0.514	1.00
98_I	102_G	0.512	1.00
264_Y	347_F	0.511	1.00
324_S	359_M	0.510	1.00
287_D	290_R	0.509	1.00
221_A	228_E	0.508	1.00
271_F	278_F	0.507	1.00
31_I	80_S	0.507	1.00
254_A	257_A	0.506	1.00
233_T	237_K	0.506	1.00
27_I	41_I	0.506	1.00
368_I	371_L	0.505	1.00
157_I	160_A	0.502	1.00
175_D	180_G	0.502	1.00
291_K	295_A	0.502	1.00
94_G	114_L	0.501	1.00
185_I	225_L	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4irnA	4	0.9921	100	0.07	Contact Map
4m9aA	4	0.9921	100	0.075	Contact Map
2d29A	4	1	100	0.078	Contact Map
4l1fA	4	1	100	0.078	Contact Map
3r7kA	4	0.9974	100	0.079	Contact Map
3p4tA	4	0.9947	100	0.079	Contact Map
1bucA	4	1	100	0.081	Contact Map
1ukwA	4	0.9974	100	0.085	Contact Map
2jifA	4	0.9974	100	0.086	Contact Map
3mpiA	4	0.9947	100	0.087	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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