GREMLIN Database
Q9HRB3 - Acyl-CoA dehydrogenase
UniProt: Q9HRB3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 379 (365)
Sequences: 33891 (19370)
Seq/√Len: 1013.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
147_D218_R4.1681.00
151_N216_N3.4991.00
291_K329_E3.4231.00
23_E44_A3.2691.00
143_R221_A3.0541.00
113_P118_D3.0061.00
104_A108_R2.8651.00
194_E215_D2.8471.00
30_D34_E2.8301.00
17_R75_E2.6561.00
65_D68_M2.6541.00
144_D218_R2.6141.00
113_P119_Y2.6051.00
284_T333_D2.5241.00
153_T213_S2.4041.00
263_E267_D2.3041.00
255_Q296_R2.2091.00
304_S308_A2.1341.00
18_E22_A2.1221.00
230_D233_T2.0981.00
227_E230_D2.0911.00
182_S224_L2.0641.00
274_P277_R1.9631.00
104_A107_K1.9631.00
153_T211_E1.9471.00
144_D149_V1.9441.00
166_V188_P1.9381.00
345_T350_Q1.8941.00
258_Y292_I1.8811.00
144_D147_D1.8731.00
9_H68_M1.8651.00
44_A47_D1.8631.00
56_S99_E1.8431.00
43_D47_D1.8231.00
350_Q354_R1.8211.00
170_A184_F1.8111.00
265_A337_T1.7601.00
78_R259_T1.7561.00
269_E274_P1.7561.00
103_T106_Q1.7471.00
194_E213_S1.7161.00
280_A283_N1.7071.00
75_E78_R1.7011.00
122_A166_V1.6831.00
160_A210_C1.6761.00
142_T151_N1.6751.00
74_E296_R1.6691.00
57_D63_G1.6631.00
305_K315_E1.6621.00
196_T213_S1.6621.00
148_Y184_F1.6481.00
325_E366_S1.6461.00
273_Q277_R1.6451.00
149_V216_N1.6371.00
301_R305_K1.6361.00
109_E222_D1.6261.00
173_D176_A1.6071.00
295_A323_A1.5871.00
108_R112_R1.5861.00
149_V218_R1.5831.00
255_Q259_T1.5771.00
14_E18_E1.5761.00
109_E113_P1.5631.00
187_D223_R1.5621.00
200_D345_T1.5391.00
329_E333_D1.5321.00
265_A281_V1.5251.00
220_P223_R1.5241.00
190_D217_C1.5201.00
288_M330_V1.5151.00
260_A348_A1.5111.00
11_L15_T1.5091.00
161_S210_C1.5081.00
262_S266_T1.5061.00
341_Y347_F1.5021.00
10_A13_Q1.4921.00
328_R360_E1.4851.00
143_R228_E1.4841.00
294_R322_D1.4831.00
11_L14_E1.4821.00
196_T211_E1.4781.00
39_T43_D1.4761.00
257_A331_A1.4711.00
20_C79_V1.4641.00
260_A263_E1.4631.00
143_R147_D1.4521.00
67_L304_S1.4451.00
9_H65_D1.4411.00
105_E109_E1.4291.00
256_G260_A1.4261.00
187_D190_D1.4111.00
101_F237_K1.4101.00
113_P116_E1.4021.00
221_A224_L1.3921.00
270_Q278_F1.3921.00
224_L228_E1.3901.00
151_N215_D1.3881.00
9_H71_T1.3781.00
293_E301_R1.3771.00
78_R255_Q1.3661.00
74_E255_Q1.3631.00
288_M333_D1.3621.00
261_A334_A1.3581.00
146_D221_A1.3541.00
146_D218_R1.3531.00
190_D223_R1.3521.00
281_V337_T1.3301.00
148_Y221_A1.3281.00
33_A200_D1.3281.00
59_Y107_K1.3171.00
43_D46_A1.3151.00
66_Q307_D1.3121.00
112_R116_E1.3051.00
10_A14_E1.2981.00
80_S83_I1.2871.00
147_D221_A1.2831.00
254_A292_I1.2781.00
53_V72_V1.2781.00
254_A330_V1.2751.00
332_E357_K1.2721.00
16_V50_M1.2611.00
129_T138_S1.2591.00
127_E154_K1.2551.00
143_R148_Y1.2501.00
13_Q75_E1.2461.00
289_H293_E1.2441.00
219_I223_R1.2441.00
126_T156_F1.2421.00
74_E300_R1.2401.00
105_E222_D1.2271.00
321_L366_S1.2261.00
29_G33_A1.2241.00
124_A157_I1.2211.00
240_D313_T1.2201.00
119_Y164_G1.2201.00
327_A356_A1.2141.00
150_L184_F1.2141.00
301_R304_S1.2101.00
44_A48_L1.2101.00
70_A303_A1.1981.00
27_I31_I1.1931.00
114_L121_G1.1921.00
15_T48_L1.1911.00
273_Q278_F1.1901.00
141_A184_F1.1811.00
172_T182_S1.1811.00
70_A248_A1.1771.00
109_E223_R1.1761.00
328_R332_E1.1741.00
107_K111_L1.1701.00
260_A338_L1.1681.00
305_K310_E1.1671.00
142_T149_V1.1661.00
64_G68_M1.1651.00
188_P195_V1.1631.00
169_K183_T1.1621.00
188_P193_F1.1591.00
295_A326_A1.1511.00
291_K326_A1.1401.00
106_Q110_W1.1381.00
110_W165_S1.1371.00
258_Y262_S1.1371.00
332_E360_E1.1361.00
256_G352_F1.1351.00
248_A299_T1.1231.00
287_D370_H1.1231.00
334_A349_P1.1201.00
193_F217_C1.1191.00
100_L237_K1.1171.00
46_A51_L1.1031.00
291_K333_D1.1011.00
124_A166_V1.0981.00
317_A369_Q1.0951.00
55_I115_A1.0911.00
292_I330_V1.0911.00
168_V186_V1.0821.00
13_Q71_T1.0781.00
169_K181_I1.0781.00
121_G165_S1.0781.00
43_D118_D1.0761.00
325_E329_E1.0711.00
192_G217_C1.0701.00
284_T367_E1.0621.00
105_E108_R1.0621.00
27_I30_D1.0611.00
297_L301_R1.0601.00
266_T276_S1.0511.00
17_R21_A1.0481.00
31_I206_A1.0441.00
65_D307_D1.0431.00
326_A329_E1.0431.00
357_K360_E1.0421.00
140_T151_N1.0391.00
40_E43_D1.0291.00
58_E108_R1.0241.00
124_A214_F1.0221.00
94_G121_G1.0201.00
265_A276_S1.0161.00
15_T50_M1.0151.00
328_R353_F1.0151.00
287_D291_K1.0111.00
141_A170_A1.0061.00
251_T292_I1.0041.00
19_F44_A1.0041.00
16_V72_V1.0021.00
148_Y172_T1.0001.00
262_S285_L0.9961.00
321_L370_H0.9951.00
77_G84_G0.9881.00
232_W236_K0.9851.00
142_T216_N0.9831.00
250_S359_M0.9801.00
331_A356_A0.9751.00
101_F234_Q0.9751.00
360_E366_S0.9751.00
242_G363_E0.9751.00
166_V193_F0.9741.00
102_G106_Q0.9741.00
109_E187_D0.9691.00
155_Q211_E0.9681.00
168_V214_F0.9661.00
16_V20_C0.9651.00
67_L307_D0.9571.00
139_T150_L0.9551.00
335_V353_F0.9521.00
142_T173_D0.9401.00
165_S187_D0.9351.00
290_R318_L0.9321.00
184_F224_L0.9311.00
191_D218_R0.9301.00
133_D136_D0.9281.00
302_A319_A0.9271.00
19_F48_L0.9241.00
265_A275_I0.9161.00
251_T299_T0.9151.00
119_Y165_S0.9141.00
150_L168_V0.9131.00
55_I95_A0.9081.00
164_G189_A0.9041.00
257_A352_F0.9021.00
253_L327_A0.9001.00
287_D333_D0.8991.00
259_T263_E0.8951.00
182_S228_E0.8911.00
204_L358_L0.8891.00
193_F212_I0.8881.00
15_T18_E0.8861.00
202_M353_F0.8841.00
56_S59_Y0.8821.00
150_L219_I0.8801.00
39_T162_V0.8791.00
291_K322_D0.8791.00
366_S370_H0.8771.00
166_V212_I0.8721.00
33_A345_T0.8711.00
54_P69_Y0.8711.00
167_V183_T0.8711.00
106_Q223_R0.8701.00
253_L352_F0.8671.00
218_R221_A0.8661.00
289_H318_L0.8651.00
20_C76_L0.8641.00
58_E104_A0.8631.00
324_S366_S0.8621.00
195_V212_I0.8611.00
147_D220_P0.8551.00
160_A195_V0.8531.00
173_D180_G0.8511.00
282_R371_L0.8501.00
283_N287_D0.8501.00
359_M362_G0.8461.00
13_Q17_R0.8441.00
329_E332_E0.8421.00
94_G167_V0.8421.00
106_Q185_I0.8371.00
67_L71_T0.8361.00
283_N371_L0.8341.00
251_T295_A0.8331.00
150_L170_A0.8321.00
263_E266_T0.8321.00
358_L362_G0.8281.00
148_Y228_E0.8271.00
40_E44_A0.8251.00
265_A285_L0.8251.00
82_S206_A0.8251.00
171_V181_I0.8241.00
325_E360_E0.8231.00
32_E354_R0.8231.00
165_S185_I0.8231.00
21_A25_E0.8191.00
27_I40_E0.8171.00
325_E370_H0.8171.00
18_E21_A0.8161.00
156_F341_Y0.8161.00
122_A163_A0.8151.00
322_D326_A0.8131.00
67_L300_R0.8121.00
312_V315_E0.8121.00
331_A352_F0.8111.00
103_T107_K0.8091.00
332_E353_F0.8071.00
293_E296_R0.8041.00
287_D329_E0.8041.00
156_F344_T0.8041.00
353_F357_K0.8031.00
71_T300_R0.8011.00
258_Y289_H0.7991.00
261_A337_T0.7981.00
184_F219_I0.7981.00
214_F217_C0.7971.00
164_G188_P0.7931.00
261_A338_L0.7891.00
298_L319_A0.7851.00
137_M169_K0.7831.00
148_Y224_L0.7821.00
328_R357_K0.7791.00
202_M350_Q0.7751.00
9_H67_L0.7731.00
335_V349_P0.7721.00
264_Y341_Y0.7681.00
21_A79_V0.7661.00
257_A334_A0.7651.00
255_Q289_H0.7611.00
205_N345_T0.7611.00
246_I363_E0.7591.00
21_A78_R0.7591.00
71_T75_E0.7571.00
122_A188_P0.7571.00
293_E297_L0.7571.00
290_R321_L0.7571.00
30_D33_A0.7541.00
288_M334_A0.7511.00
124_A168_V0.7511.00
254_A326_A0.7511.00
59_Y104_A0.7501.00
124_A212_I0.7461.00
141_A148_Y0.7441.00
19_F45_L0.7421.00
247_A299_T0.7421.00
203_G355_D0.7411.00
224_L227_E0.7391.00
290_R322_D0.7381.00
284_T287_D0.7361.00
132_S368_I0.7361.00
161_S208_P0.7351.00
39_T164_G0.7341.00
260_A352_F0.7331.00
298_L318_L0.7321.00
326_A330_V0.7291.00
19_F23_E0.7271.00
41_I83_I0.7261.00
182_S229_G0.7241.00
20_C24_I0.7241.00
58_E107_K0.7221.00
284_T337_T0.7201.00
247_A319_A0.7201.00
95_A114_L0.7201.00
78_R256_G0.7191.00
110_W223_R0.7191.00
190_D193_F0.7161.00
125_L239_L0.7151.00
294_R298_L0.7131.00
331_A353_F0.7121.00
173_D229_G0.7091.00
335_V342_G0.7091.00
29_G351_R0.7071.00
284_T336_Q0.7041.00
153_T196_T0.7031.00
53_V64_G0.7011.00
230_D234_Q0.6971.00
369_Q372_V0.6971.00
17_R78_R0.6951.00
296_R300_R0.6931.00
110_W185_I0.6921.00
338_L349_P0.6911.00
141_A172_T0.6871.00
279_D283_N0.6861.00
55_I59_Y0.6831.00
253_L356_A0.6831.00
147_D222_D0.6831.00
278_F282_R0.6801.00
137_M181_I0.6791.00
261_A265_A0.6761.00
247_A323_A0.6731.00
143_R146_D0.6731.00
35_H205_N0.6711.00
275_I278_F0.6701.00
311_S315_E0.6701.00
171_V180_G0.6701.00
25_E28_A0.6691.00
351_R355_D0.6691.00
58_E61_G0.6641.00
291_K294_R0.6621.00
204_L362_G0.6621.00
171_V174_P0.6601.00
24_I41_I0.6601.00
140_T173_D0.6551.00
299_T323_A0.6551.00
102_G107_K0.6531.00
186_V214_F0.6521.00
189_A193_F0.6481.00
331_A349_P0.6471.00
256_G259_T0.6461.00
39_T120_L0.6461.00
298_L322_D0.6461.00
291_K325_E0.6451.00
35_H200_D0.6441.00
250_S324_S0.6431.00
303_A307_D0.6421.00
139_T154_K0.6401.00
128_P153_T0.6391.00
282_R374_G0.6371.00
31_I36_R0.6361.00
97_P238_T0.6341.00
172_T180_G0.6331.00
254_A295_A0.6331.00
140_T174_P0.6331.00
255_Q292_I0.6311.00
110_W119_Y0.6301.00
171_V176_A0.6281.00
301_R315_E0.6271.00
261_A288_M0.6221.00
13_Q74_E0.6201.00
200_D205_N0.6171.00
123_W235_T0.6171.00
145_G218_R0.6161.00
41_I44_A0.6151.00
169_K235_T0.6121.00
12_I68_M0.6111.00
69_Y245_S0.6111.00
328_R356_A0.6101.00
32_E205_N0.6091.00
157_I212_I0.6081.00
127_E139_T0.6081.00
143_R149_V0.6061.00
96_K100_L0.6051.00
45_L50_M0.6021.00
139_T152_G0.6021.00
167_V225_L0.5971.00
99_E107_K0.5961.00
295_A322_D0.5961.00
327_A331_A0.5961.00
66_Q306_Y0.5941.00
193_F214_F0.5901.00
114_L165_S0.5901.00
256_G348_A0.5901.00
365_T368_I0.5891.00
58_E63_G0.5881.00
240_D316_S0.5861.00
144_D221_A0.5851.00
12_I16_V0.5831.00
45_L83_I0.5821.00
176_A179_D0.5801.00
137_M171_V0.5791.00
290_R294_R0.5771.00
145_G149_V0.5771.00
29_G348_A0.5771.00
125_L134_A0.5761.00
12_I72_V0.5761.00
162_V208_P0.5751.00
17_R79_V0.5741.00
52_G115_A0.5721.00
71_T74_E0.5721.00
248_A252_G0.5701.00
281_V285_L0.5691.00
172_T228_E0.5691.00
195_V210_C0.5681.00
298_L302_A0.5671.00
287_D325_E0.5661.00
23_E26_P0.5651.00
165_S223_R0.5651.00
125_L169_K0.5641.00
306_Y312_V0.5641.00
318_L373_I0.5641.00
278_F281_V0.5641.00
186_V217_C0.5621.00
270_Q275_I0.5611.00
37_F40_E0.5601.00
85_L204_L0.5591.00
251_T255_Q0.5581.00
139_T168_V0.5571.00
97_P101_F0.5561.00
106_Q109_E0.5561.00
268_R271_F0.5551.00
336_Q357_K0.5531.00
109_E112_R0.5521.00
348_A352_F0.5521.00
244_I303_A0.5521.00
293_E298_L0.5511.00
15_T62_L0.5511.00
182_S226_G0.5471.00
52_G62_L0.5461.00
281_V284_T0.5451.00
173_D177_G0.5441.00
269_E277_R0.5421.00
171_V178_Y0.5421.00
81_G253_L0.5411.00
244_I306_Y0.5401.00
198_E211_E0.5401.00
202_M354_R0.5391.00
170_A182_S0.5381.00
139_T170_A0.5371.00
341_Y344_T0.5371.00
130_S138_S0.5371.00
321_L325_E0.5361.00
150_L186_V0.5361.00
203_G343_Y0.5341.00
56_S61_G0.5321.00
36_R39_T0.5321.00
275_I281_V0.5321.00
28_A351_R0.5311.00
340_G343_Y0.5301.00
241_G306_Y0.5291.00
35_H345_T0.5291.00
94_G97_P0.5291.00
321_L373_I0.5281.00
95_A111_L0.5271.00
96_K99_E0.5271.00
244_I299_T0.5251.00
160_A212_I0.5241.00
200_D346_D0.5241.00
168_V217_C0.5231.00
143_R173_D0.5221.00
25_E79_V0.5211.00
139_T214_F0.5211.00
97_P234_Q0.5181.00
280_A284_T0.5171.00
254_A327_A0.5171.00
189_A195_V0.5161.00
73_T77_G0.5161.00
348_A351_R0.5141.00
227_E234_Q0.5141.00
98_I102_G0.5121.00
264_Y347_F0.5111.00
324_S359_M0.5101.00
287_D290_R0.5091.00
221_A228_E0.5081.00
271_F278_F0.5071.00
31_I80_S0.5071.00
254_A257_A0.5061.00
233_T237_K0.5061.00
27_I41_I0.5061.00
368_I371_L0.5051.00
157_I160_A0.5021.00
175_D180_G0.5021.00
291_K295_A0.5021.00
94_G114_L0.5011.00
185_I225_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4irnA 4 0.9921 100 0.07 Contact Map
4m9aA 4 0.9921 100 0.075 Contact Map
2d29A 4 1 100 0.078 Contact Map
4l1fA 4 1 100 0.078 Contact Map
3r7kA 4 0.9974 100 0.079 Contact Map
3p4tA 4 0.9947 100 0.079 Contact Map
1bucA 4 1 100 0.081 Contact Map
1ukwA 4 0.9974 100 0.085 Contact Map
2jifA 4 0.9974 100 0.086 Contact Map
3mpiA 4 0.9947 100 0.087 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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