GREMLIN Database
RIBL - FAD synthase
UniProt: Q9HRB2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 146 (127)
Sequences: 3057 (1854)
Seq/√Len: 164.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_V28_G3.9571.00
51_N69_I3.0111.00
43_H73_E2.6141.00
25_A65_D2.4571.00
9_T41_V2.3691.00
19_H56_D2.3451.00
53_Q128_L2.2191.00
77_A80_E2.1561.00
22_E63_P2.1191.00
30_E66_H2.1091.00
5_V34_I2.0891.00
101_E105_A2.0371.00
35_L55_R1.9521.00
23_D26_A1.8671.00
102_A106_D1.8551.00
24_A88_A1.8541.00
37_R69_I1.8511.00
50_P53_Q1.8101.00
55_R59_A1.7921.00
3_R30_E1.7861.00
55_R67_A1.7861.00
19_H22_E1.7771.00
13_I61_L1.7591.00
22_E56_D1.7221.00
114_E118_P1.7111.00
51_N55_R1.7071.00
115_R118_P1.7001.00
55_R69_I1.6621.00
95_H105_A1.5801.00
103_E107_R1.5451.00
42_T46_P1.5331.00
37_R71_H1.5181.00
83_D107_R1.4841.00
12_L49_L1.4771.00
56_D59_A1.4761.00
13_I57_V1.4711.00
94_H97_A1.4651.00
19_H23_D1.4381.00
25_A30_E1.3771.00
15_P128_L1.3601.00
18_V57_V1.3421.00
49_L53_Q1.3341.00
13_I18_V1.3191.00
15_P53_Q1.3121.00
24_A31_L1.2791.00
72_P77_A1.2751.00
39_E43_H1.2721.00
48_V134_A1.2441.00
10_F20_Y1.2421.00
39_E71_H1.2101.00
91_F114_E1.1801.00
15_P57_V1.1801.00
104_L109_L1.1661.00
132_D135_D1.1421.00
76_F103_E1.1421.00
4_V88_A1.1401.00
87_I100_I1.0911.00
75_I87_I1.0680.99
99_A103_E1.0610.99
13_I58_V1.0520.99
27_M88_A1.0170.99
2_T110_D1.0110.99
22_E26_A1.0110.99
36_A40_N0.9900.99
35_L58_V0.9680.99
2_T86_V0.9650.99
27_M86_V0.9600.99
110_D114_E0.9360.99
34_I78_P0.9340.99
113_V116_A0.9280.99
34_I68_R0.9160.98
130_S134_A0.9120.98
114_E117_S0.9060.98
37_R51_N0.8920.98
21_L24_A0.8900.98
80_E106_D0.8890.98
80_E103_E0.8770.98
100_I104_L0.8750.98
25_A62_D0.8710.98
99_A102_A0.8580.98
99_A104_L0.8540.97
32_H82_I0.8530.97
33_V58_V0.8470.97
79_I87_I0.8420.97
15_P19_H0.8410.97
28_G88_A0.8410.97
128_L132_D0.8250.97
132_D136_R0.8210.97
42_T45_D0.8110.96
80_E107_R0.8060.96
49_L133_I0.8000.96
18_V60_A0.7960.96
60_A63_P0.7900.96
36_A70_G0.7880.96
129_S132_D0.7870.96
6_A20_Y0.7790.96
21_L63_P0.7780.96
59_A66_H0.7750.95
15_P56_D0.7730.95
64_V67_A0.7590.95
22_E62_D0.7560.95
112_A115_R0.7550.95
100_I103_E0.7530.95
6_A10_F0.7480.95
4_V27_M0.7480.95
22_E60_A0.7410.94
7_Q34_I0.7390.94
77_A81_A0.7270.94
87_I99_A0.7240.94
35_L67_A0.7230.93
7_Q87_I0.7150.93
3_R66_H0.7100.93
37_R70_G0.7020.92
76_F80_E0.7000.92
76_F79_I0.6980.92
58_V67_A0.6980.92
40_N70_G0.6980.92
103_E106_D0.6940.92
98_A102_A0.6930.92
39_E69_I0.6930.92
23_D115_R0.6920.92
95_H101_E0.6890.92
56_D60_A0.6870.92
18_V63_P0.6850.92
7_Q70_G0.6790.91
42_T47_P0.6760.91
39_E42_T0.6740.91
33_V82_I0.6730.91
15_P18_V0.6720.91
66_H69_I0.6660.90
5_V87_I0.6640.90
105_A110_D0.6470.89
33_V64_V0.6360.88
99_A107_R0.6310.88
90_G93_Q0.6290.88
96_D101_E0.6280.88
3_R85_D0.6280.88
50_P128_L0.6250.87
76_F102_A0.6220.87
91_F94_H0.6200.87
6_A21_L0.6200.87
45_D49_L0.6190.87
89_L93_Q0.6160.87
70_G93_Q0.6140.86
39_E51_N0.6110.86
49_L57_V0.6100.86
18_V61_L0.6100.86
95_H99_A0.6070.86
104_L107_R0.6000.85
7_Q89_L0.5950.85
40_N43_H0.5940.85
98_A113_V0.5820.83
22_E59_A0.5770.83
38_R51_N0.5770.83
80_E83_D0.5770.83
3_R84_P0.5720.82
110_D115_R0.5710.82
99_A105_A0.5690.82
102_A105_A0.5680.82
93_Q113_V0.5630.81
28_G86_V0.5590.81
19_H116_A0.5590.81
52_R69_I0.5570.81
25_A31_L0.5560.81
98_A101_E0.5560.81
76_F99_A0.5560.81
79_I84_P0.5550.80
9_T36_A0.5510.80
39_E50_P0.5470.79
15_P49_L0.5460.79
101_E104_L0.5410.79
134_A137_V0.5390.78
15_P50_P0.5380.78
27_M112_A0.5370.78
4_V86_V0.5370.78
83_D106_D0.5370.78
43_H47_P0.5360.78
109_L114_E0.5340.78
97_A101_E0.5340.78
110_D113_V0.5290.77
6_A36_A0.5230.76
32_H84_P0.5110.75
23_D114_E0.5110.75
87_I98_A0.5110.75
93_Q98_A0.5100.75
68_R78_P0.5070.74
2_T29_D0.5070.74
21_L61_L0.5020.73
59_A136_R0.5010.73
78_P82_I0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3elbA 2 0.8904 100 0.365 Contact Map
4mvcA 2 0.9384 99.9 0.445 Contact Map
3hl4A 2 0.9247 99.9 0.475 Contact Map
3glvA 2 0.8219 99.9 0.531 Contact Map
2b7lA 2 0.774 99.9 0.534 Contact Map
1cozA 2 0.8493 99.9 0.547 Contact Map
3do8A 2 0.8425 99.7 0.624 Contact Map
3k9wA 5 0.9315 99.6 0.65 Contact Map
1mrzA 2 0.9452 99.6 0.656 Contact Map
3op1A 4 0.9452 99.5 0.664 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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