GREMLIN Database
Q9HRB1 - Uncharacterized protein
UniProt: Q9HRB1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 161 (124)
Sequences: 102 (77)
Seq/√Len: 6.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_G57_V4.0260.96
28_H118_Y2.7070.76
20_A87_I2.6700.75
127_D131_E2.4740.68
13_A34_G2.3550.64
19_F57_V2.3000.62
22_E73_G2.2720.61
13_A57_V2.2500.61
14_E120_P2.2450.60
93_G126_F2.2120.59
84_V107_K2.0810.54
37_R80_D2.0090.52
82_R87_I1.9600.50
119_G122_C1.9540.50
21_R114_L1.9380.49
110_L125_A1.9010.48
19_F34_G1.8380.45
37_R59_V1.8100.44
16_A139_D1.7410.42
32_Y126_F1.7000.40
76_Q112_I1.6910.40
54_V84_V1.6870.40
52_Y87_I1.6340.38
114_L129_E1.6290.38
92_N95_L1.6110.37
62_G86_S1.5860.36
84_V136_T1.5730.36
53_V139_D1.5640.35
50_D131_E1.5560.35
21_R102_R1.5320.34
12_I112_I1.4710.32
13_A19_F1.4390.31
35_L102_R1.4380.31
100_A103_S1.4240.31
14_E114_L1.4190.30
19_F79_N1.4120.30
19_F135_T1.3940.30
63_T123_W1.3840.29
8_S24_A1.3530.28
16_A34_G1.3370.28
14_E18_E1.3360.28
13_A16_A1.3300.28
18_E27_S1.2960.27
33_L104_M1.2320.25
37_R69_S1.2240.24
38_A102_R1.1970.24
13_A135_T1.1710.23
28_H94_V1.1470.22
121_D131_E1.1430.22
26_D87_I1.1310.22
50_D128_S1.1170.22
20_A38_A1.1140.22
76_Q96_A1.1000.21
10_L38_A1.0930.21
11_G86_S1.0870.21
10_L125_A1.0840.21
116_H132_P1.0580.20
22_E35_L1.0410.20
9_V76_Q1.0220.19
14_E25_Q1.0190.19
112_I123_W1.0170.19
70_A105_F1.0110.19
22_E25_Q1.0030.19
64_E136_T0.9980.19
107_K128_S0.9830.18
35_L133_R0.9810.18
107_K114_L0.9760.18
71_T92_N0.9640.18
8_S127_D0.9470.18
28_H95_L0.9400.17
115_G119_G0.9240.17
53_V106_G0.9180.17
35_L138_L0.9120.17
70_A87_I0.9040.17
80_D125_A0.9030.17
18_E35_L0.8990.17
120_P126_F0.8890.16
28_H116_H0.8890.16
13_A63_T0.8860.16
7_P25_Q0.8850.16
16_A19_F0.8830.16
35_L86_S0.8790.16
124_R136_T0.8760.16
8_S134_T0.8690.16
114_L133_R0.8630.16
68_V131_E0.8580.16
68_V127_D0.8530.16
60_I77_V0.8510.16
72_F76_Q0.8490.15
59_V66_N0.8440.15
68_V74_S0.8440.15
28_H68_V0.8330.15
82_R138_L0.8330.15
8_S131_E0.8220.15
72_F80_D0.8030.15
9_V17_L0.7930.14
124_R132_P0.7890.14
94_V115_G0.7860.14
71_T139_D0.7780.14
11_G63_T0.7770.14
15_D124_R0.7710.14
134_T138_L0.7520.14
9_V136_T0.7510.14
124_R138_L0.7500.14
12_I69_S0.7500.14
22_E81_M0.7480.14
32_Y67_P0.7470.14
13_A55_T0.7440.14
58_L82_R0.7270.13
36_L97_P0.7240.13
95_L115_G0.7240.13
18_E30_D0.7210.13
102_R111_H0.7200.13
84_V87_I0.7180.13
92_N129_E0.7170.13
16_A119_G0.7110.13
14_E76_Q0.7080.13
77_V86_S0.7020.13
77_V102_R0.7000.13
112_I135_T0.6980.13
65_T112_I0.6980.13
62_G123_W0.6970.13
97_P102_R0.6950.13
21_R24_A0.6940.13
114_L137_V0.6930.13
122_C138_L0.6890.13
92_N118_Y0.6880.13
48_A75_T0.6870.13
100_A107_K0.6850.12
20_A24_A0.6750.12
32_Y111_H0.6710.12
38_A118_Y0.6600.12
18_E120_P0.6540.12
10_L30_D0.6530.12
64_E112_I0.6520.12
64_E138_L0.6340.12
8_S102_R0.6310.12
81_M114_L0.6310.12
75_T81_M0.6290.12
92_N126_F0.6270.12
9_V137_V0.6270.12
58_L106_G0.6180.11
9_V135_T0.6150.11
119_G134_T0.6150.11
18_E139_D0.5940.11
103_S129_E0.5930.11
76_Q109_Q0.5820.11
121_D137_V0.5810.11
18_E82_R0.5790.11
14_E20_A0.5780.11
50_D73_G0.5740.11
63_T86_S0.5740.11
51_G69_S0.5700.11
11_G51_G0.5660.11
10_L132_P0.5540.10
56_D122_C0.5530.10
105_F111_H0.5520.10
60_I111_H0.5510.10
37_R75_T0.5510.10
97_P111_H0.5470.10
27_S96_A0.5450.10
9_V51_G0.5410.10
21_R107_K0.5340.10
82_R128_S0.5340.10
52_Y120_P0.5320.10
24_A96_A0.5280.10
77_V83_N0.5270.10
50_D86_S0.5250.10
73_G133_R0.5230.10
65_T70_A0.5220.10
14_E118_Y0.5170.10
55_T127_D0.5150.10
79_N115_G0.5140.10
59_V137_V0.5140.10
84_V134_T0.5130.10
34_G139_D0.5120.10
26_D53_V0.5120.10
66_N103_S0.5120.10
66_N72_F0.5090.10
34_G79_N0.5090.10
78_P108_G0.5090.10
131_E134_T0.5070.10
14_E134_T0.5060.10
86_S100_A0.5030.10
77_V120_P0.5020.10
25_Q104_M0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1oi0A 1 0.6894 99.9 0.669 Contact Map
2kksA 1 0.795 99.7 0.75 Contact Map
2kcqA 1 0.8137 99.6 0.76 Contact Map
3rzvA 1 0.9379 99.5 0.783 Contact Map
2znrA 1 0.9068 99.5 0.789 Contact Map
4nqlA 1 0.9317 99.4 0.792 Contact Map
4jxeA 1 0.9379 99.4 0.797 Contact Map
4d10E 1 0.9193 99.1 0.819 Contact Map
4o8yB 1 0.7826 99.1 0.822 Contact Map
4f7oA 3 0.8696 99 0.826 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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