GREMLIN Database
Q9HRA8 - Uncharacterized protein
UniProt: Q9HRA8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 433 (340)
Sequences: 104 (68)
Seq/√Len: 3.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
234_W242_M3.5010.70
94_V267_V3.2200.63
94_V248_E2.7460.50
348_S381_S2.6850.48
259_H357_I2.6220.47
285_P312_S2.5970.46
250_L305_E2.5360.44
234_W239_N2.5350.44
304_E331_S2.5300.44
165_I183_V2.4600.42
247_M257_Q2.4240.41
347_R351_A2.3780.40
120_R211_E2.3260.39
129_L142_D2.3240.39
351_A366_L2.2990.38
145_G193_V2.2980.38
109_V262_D2.2380.36
287_A331_S2.1870.35
154_L163_E2.1340.34
129_L145_G2.1080.33
203_S335_V2.1050.33
157_D398_A2.0910.33
279_L282_R2.0730.32
367_V386_L2.0090.31
294_I387_V2.0010.30
107_E263_A1.9920.30
131_A141_G1.9890.30
201_D208_L1.9690.30
351_A358_G1.9660.30
397_A404_D1.9590.30
273_L277_G1.9560.29
200_D274_D1.9400.29
307_V331_S1.9080.28
312_S345_D1.8740.28
109_V165_I1.8590.27
219_D348_S1.8480.27
367_V397_A1.8420.27
351_A412_E1.8110.26
123_D126_E1.8020.26
320_L335_V1.7990.26
110_D406_A1.7980.26
99_G206_Q1.7930.26
369_I381_S1.7830.26
77_E264_L1.7610.25
219_D233_Q1.7590.25
300_L331_S1.7550.25
132_V137_R1.7520.25
303_I331_S1.7480.25
294_I348_S1.7440.25
101_Y350_A1.7030.24
359_D365_P1.7030.24
242_M245_L1.6910.24
229_T275_A1.6890.24
302_H415_K1.6790.23
145_G157_D1.6560.23
150_E153_D1.6210.22
226_P398_A1.6210.22
317_T378_V1.6200.22
385_A412_E1.6200.22
370_L383_A1.6030.22
260_C357_I1.5970.22
347_R366_L1.5930.22
348_S369_I1.5910.22
250_L271_A1.5860.22
322_A351_A1.5640.21
322_A347_R1.5560.21
358_G366_L1.5230.21
85_D174_A1.5180.20
258_R269_K1.4990.20
312_S318_T1.4970.20
112_A160_A1.4930.20
219_D294_I1.4910.20
228_W282_R1.4900.20
324_G351_A1.4870.20
165_I332_T1.4770.20
81_A85_D1.4680.20
348_S387_V1.4590.19
347_R358_G1.4510.19
357_I402_A1.4370.19
132_V192_G1.4360.19
178_T198_E1.4330.19
351_A385_A1.4290.19
213_Y231_L1.4220.19
105_A332_T1.4180.19
365_P412_E1.4110.19
219_D338_Q1.4080.19
88_A161_V1.4070.18
144_L148_F1.4060.18
331_S335_V1.3990.18
173_D253_S1.3970.18
239_N242_M1.3880.18
242_M249_H1.3880.18
89_E183_V1.3750.18
251_D365_P1.3700.18
324_G378_V1.3690.18
163_E183_V1.3610.18
396_E399_A1.3600.18
304_E335_V1.3540.18
100_P208_L1.3520.18
355_G384_W1.3510.18
303_I316_R1.3480.18
234_W265_L1.3450.17
129_L132_V1.3440.17
296_V369_I1.3410.17
147_T156_A1.3400.17
255_F326_I1.3340.17
324_G380_A1.3310.17
219_D296_V1.3250.17
374_D402_A1.3170.17
195_D202_L1.3000.17
81_A174_A1.3000.17
352_R355_G1.2940.17
219_D387_V1.2910.17
284_D288_I1.2900.17
375_S406_A1.2850.17
219_D229_T1.2810.16
171_D189_L1.2800.16
213_Y357_I1.2790.16
230_A253_S1.2760.16
95_D188_S1.2750.16
112_A211_E1.2660.16
77_E301_E1.2650.16
324_G352_R1.2580.16
112_A131_A1.2570.16
135_Q140_A1.2520.16
234_W249_H1.2520.16
294_I381_S1.2510.16
90_V103_S1.2510.16
324_G355_G1.2290.16
351_A355_G1.2150.15
107_E249_H1.2140.15
128_D135_Q1.2120.15
260_C263_A1.2060.15
128_D141_G1.2050.15
103_S262_D1.2050.15
351_A356_L1.1950.15
93_G128_D1.1940.15
154_L158_L1.1920.15
324_G388_Q1.1860.15
332_T360_T1.1820.15
224_F332_T1.1770.15
180_E187_D1.1650.15
221_H242_M1.1540.15
351_A380_A1.1450.15
269_K387_V1.1390.14
274_D312_S1.1290.14
191_E211_E1.1290.14
217_M267_V1.1290.14
83_L130_A1.1280.14
262_D267_V1.1260.14
167_A335_V1.1230.14
228_W257_Q1.1110.14
177_D198_E1.1100.14
401_Y419_A1.1090.14
141_G148_F1.1080.14
200_D238_G1.0910.14
128_D134_A1.0870.14
324_G366_L1.0830.14
386_L403_D1.0820.14
294_I369_I1.0730.14
352_R378_V1.0710.14
105_A165_I1.0690.13
78_S135_Q1.0680.13
324_G356_L1.0610.13
105_A183_V1.0610.13
109_V393_A1.0600.13
94_V163_E1.0570.13
188_S195_D1.0520.13
219_D320_L1.0470.13
352_R356_L1.0430.13
95_D103_S1.0400.13
296_V348_S1.0390.13
179_I323_V1.0390.13
257_Q279_L1.0340.13
285_P318_T1.0310.13
272_A381_S1.0310.13
386_L394_A1.0250.13
143_A200_D1.0230.13
92_D131_A1.0230.13
204_V224_F1.0200.13
325_E346_V1.0170.13
139_A142_D1.0120.13
231_L234_W1.0070.13
324_G347_R1.0070.13
221_H348_S1.0020.13
358_G385_A1.0000.13
287_A304_E0.9980.13
335_V338_Q0.9970.13
102_A172_A0.9930.13
96_D400_E0.9860.12
307_V338_Q0.9860.12
186_T307_V0.9850.12
171_D322_A0.9820.12
231_L263_A0.9750.12
94_V383_A0.9730.12
213_Y277_G0.9700.12
94_V402_A0.9690.12
183_V323_V0.9690.12
157_D239_N0.9660.12
304_E307_V0.9650.12
77_E117_G0.9640.12
324_G327_G0.9610.12
119_T154_L0.9610.12
137_R172_A0.9610.12
223_D253_S0.9600.12
229_T239_N0.9560.12
78_S128_D0.9540.12
351_A388_Q0.9540.12
347_R412_E0.9530.12
347_R352_R0.9530.12
128_D375_S0.9480.12
95_D270_P0.9470.12
152_G167_A0.9450.12
345_D349_Q0.9320.12
352_R384_W0.9300.12
95_D190_D0.9290.12
173_D230_A0.9260.12
108_T261_L0.9230.12
221_H229_T0.9150.12
349_Q377_T0.9120.12
297_E414_T0.9030.11
246_C323_V0.9020.11
325_E343_R0.9010.11
231_L259_H0.9010.11
213_Y303_I0.8990.11
121_W125_G0.8930.11
195_D204_V0.8930.11
207_K406_A0.8910.11
218_G348_S0.8850.11
166_S194_A0.8820.11
253_S323_V0.8770.11
173_D187_D0.8760.11
102_A178_T0.8730.11
366_L412_E0.8690.11
195_D198_E0.8680.11
265_L349_Q0.8660.11
137_R413_A0.8630.11
95_D105_A0.8570.11
292_G416_A0.8550.11
380_A388_Q0.8540.11
355_G378_V0.8520.11
171_D347_R0.8510.11
228_W279_L0.8480.11
381_S404_D0.8450.11
184_A194_A0.8450.11
157_D193_V0.8440.11
109_V390_G0.8430.11
275_A353_A0.8430.11
117_G414_T0.8430.11
200_D203_S0.8380.11
108_T300_L0.8370.11
297_E335_V0.8370.11
356_L380_A0.8370.11
355_G412_E0.8360.11
221_H319_A0.8310.11
84_T174_A0.8310.11
270_P323_V0.8280.11
352_R381_S0.8250.11
162_S166_S0.8240.11
173_D208_L0.8230.11
264_L276_V0.8230.11
327_G356_L0.8210.11
92_D114_S0.8200.11
181_S363_I0.8200.11
243_I364_A0.8190.11
122_T208_L0.8160.11
322_A366_L0.8130.10
106_A394_A0.8120.10
170_L266_H0.8100.10
105_A268_A0.8040.10
135_Q143_A0.8010.10
351_A381_S0.8010.10
187_D239_N0.8000.10
350_A383_A0.7980.10
287_A338_Q0.7970.10
195_D395_L0.7950.10
347_R355_G0.7940.10
262_D367_V0.7940.10
129_L271_A0.7880.10
324_G381_S0.7870.10
258_R393_A0.7870.10
358_G363_I0.7870.10
213_Y263_A0.7860.10
275_A381_S0.7840.10
296_V304_E0.7830.10
117_G400_E0.7820.10
139_A204_V0.7820.10
233_Q242_M0.7800.10
152_G166_S0.7790.10
338_Q345_D0.7790.10
160_A261_L0.7720.10
242_M307_V0.7690.10
342_E364_A0.7690.10
290_V294_I0.7690.10
102_A107_E0.7680.10
175_D196_A0.7660.10
322_A412_E0.7650.10
376_E404_D0.7650.10
218_G221_H0.7610.10
126_E337_D0.7610.10
140_A148_F0.7600.10
352_R358_G0.7560.10
347_R388_Q0.7550.10
87_L97_Q0.7540.10
216_V257_Q0.7530.10
275_A369_I0.7500.10
212_G361_R0.7490.10
106_A166_S0.7480.10
218_G269_K0.7470.10
160_A167_A0.7420.10
94_V394_A0.7410.10
146_E415_K0.7390.10
265_L269_K0.7370.10
91_R118_E0.7360.10
365_P394_A0.7350.10
115_T118_E0.7350.10
110_D177_D0.7340.10
103_S368_D0.7320.10
197_Q210_A0.7310.10
232_K236_Q0.7290.10
148_F165_I0.7280.10
117_G155_G0.7270.10
99_G280_A0.7270.10
178_T184_A0.7260.10
312_S328_S0.7240.10
221_H239_N0.7230.10
305_E348_S0.7220.10
301_E356_L0.7220.10
83_L87_L0.7190.10
276_V363_I0.7190.10
108_T234_W0.7190.10
123_D254_E0.7190.10
106_A159_A0.7160.10
322_A358_G0.7160.10
123_D205_R0.7140.10
202_L395_L0.7140.10
358_G412_E0.7120.09
149_D334_V0.7110.09
141_G146_E0.7110.09
384_W409_V0.7080.09
314_N347_R0.7080.09
234_W261_L0.7070.09
116_I235_E0.7070.09
120_R144_L0.7050.09
324_G384_W0.7040.09
231_L242_M0.7010.09
194_A319_A0.7010.09
261_L265_L0.7010.09
155_G185_A0.6960.09
338_Q381_S0.6930.09
150_E286_K0.6910.09
219_D381_S0.6900.09
327_G385_A0.6850.09
207_K332_T0.6850.09
184_A187_D0.6830.09
168_A260_C0.6760.09
149_D156_A0.6750.09
263_A349_Q0.6730.09
125_G368_D0.6730.09
118_E269_K0.6720.09
329_R375_S0.6720.09
78_S330_E0.6710.09
169_G404_D0.6700.09
94_V99_G0.6700.09
161_V264_L0.6700.09
114_S207_K0.6690.09
374_D397_A0.6690.09
77_E268_A0.6670.09
249_H307_V0.6660.09
356_L378_V0.6640.09
352_R380_A0.6620.09
340_V415_K0.6610.09
288_I347_R0.6610.09
309_E406_A0.6600.09
365_P385_A0.6590.09
116_I154_L0.6590.09
327_G351_A0.6580.09
325_E351_A0.6560.09
296_V317_T0.6560.09
264_L382_A0.6560.09
228_W259_H0.6560.09
356_L410_E0.6530.09
288_I319_A0.6530.09
265_L331_S0.6520.09
231_L284_D0.6510.09
217_M307_V0.6490.09
378_V381_S0.6460.09
99_G201_D0.6450.09
81_A155_G0.6450.09
86_H96_D0.6430.09
111_A264_L0.6430.09
347_R385_A0.6420.09
240_V397_A0.6410.09
181_S194_A0.6400.09
328_S392_E0.6380.09
327_G379_R0.6370.09
176_A181_S0.6360.09
128_D142_D0.6350.09
221_H234_W0.6290.09
213_Y326_I0.6270.09
84_T90_V0.6260.09
90_V375_S0.6220.09
235_E401_Y0.6210.09
100_P394_A0.6200.09
287_A307_V0.6190.09
153_D167_A0.6170.09
186_T281_A0.6150.09
234_W307_V0.6130.09
365_P391_T0.6120.09
217_M276_V0.6120.09
328_S356_L0.6100.09
124_Q167_A0.6080.09
347_R356_L0.6080.09
304_E309_E0.6070.09
261_L276_V0.6060.09
234_W411_Q0.6060.09
355_G380_A0.6030.09
296_V381_S0.6020.08
249_H374_D0.6010.08
82_A209_R0.6010.08
100_P337_D0.5990.08
173_D211_E0.5950.08
339_L385_A0.5930.08
218_G338_Q0.5920.08
282_R318_T0.5890.08
146_E198_E0.5890.08
123_D131_A0.5890.08
264_L272_A0.5850.08
80_E149_D0.5820.08
177_D364_A0.5780.08
197_Q206_Q0.5770.08
261_L353_A0.5760.08
83_L91_R0.5730.08
175_D199_W0.5730.08
116_I211_E0.5730.08
291_V299_G0.5690.08
249_H265_L0.5670.08
123_D203_S0.5670.08
129_L143_A0.5660.08
105_A400_E0.5660.08
97_Q144_L0.5650.08
319_A392_E0.5650.08
307_V357_I0.5650.08
355_G391_T0.5640.08
141_G144_L0.5640.08
103_S161_V0.5640.08
226_P340_V0.5600.08
97_Q282_R0.5590.08
262_D386_L0.5590.08
77_E300_L0.5580.08
351_A384_W0.5580.08
325_E352_R0.5580.08
123_D127_D0.5570.08
247_M261_L0.5560.08
113_Q341_A0.5550.08
298_D335_V0.5550.08
355_G381_S0.5540.08
338_Q351_A0.5510.08
140_A203_S0.5510.08
293_K372_S0.5490.08
83_L94_V0.5490.08
231_L249_H0.5470.08
234_W298_D0.5470.08
78_S149_D0.5470.08
322_A356_L0.5460.08
97_Q226_P0.5450.08
352_R388_Q0.5450.08
183_V312_S0.5430.08
328_S351_A0.5420.08
81_A383_A0.5420.08
229_T294_I0.5420.08
336_A361_R0.5410.08
81_A107_E0.5390.08
131_A134_A0.5380.08
229_T276_V0.5370.08
245_L298_D0.5350.08
294_I320_L0.5330.08
335_V381_S0.5320.08
241_E247_M0.5320.08
102_A183_V0.5260.08
106_A122_T0.5260.08
299_G312_S0.5250.08
177_D183_V0.5250.08
236_Q310_D0.5240.08
77_E392_E0.5230.08
322_A380_A0.5220.08
139_A149_D0.5220.08
366_L385_A0.5180.08
77_E213_Y0.5180.08
374_D388_Q0.5170.08
309_E331_S0.5150.08
135_Q145_G0.5140.08
269_K300_L0.5140.08
131_A337_D0.5140.08
355_G388_Q0.5110.08
221_H294_I0.5110.08
177_D243_I0.5100.08
317_T335_V0.5100.08
217_M234_W0.5100.08
124_Q144_L0.5090.08
221_H269_K0.5060.08
158_L165_I0.5050.08
138_E159_A0.5050.08
116_I400_E0.5050.08
192_G195_D0.5040.08
191_E364_A0.5030.08
279_L302_H0.5020.08
394_A416_A0.5020.08
356_L381_S0.5000.08
327_G391_T0.5000.08
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2z6gA 1 0.3533 100 0.82 Contact Map
4uadA 1 0.3857 99.8 0.878 Contact Map
3grlA 2 0.3903 99.8 0.878 Contact Map
3ltmA 1 0.418 99.8 0.879 Contact Map
3ltjA 2 0.4319 99.8 0.88 Contact Map
4r0zA 1 0.4018 99.8 0.882 Contact Map
2jdqA 2 0.4688 99.7 0.882 Contact Map
4db6A 1 0.3533 99.7 0.884 Contact Map
4uaeA 1 0.4758 99.7 0.884 Contact Map
1xm9A 1 0.4827 99.7 0.887 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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