GREMLIN Database
Q9HRA7 - CDP-diacylglycerol-serine O-phosphatidyltransferase
UniProt: Q9HRA7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 225 (207)
Sequences: 2182 (1423)
Seq/√Len: 98.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
113_A135_T8.0421.00
44_A75_S4.9431.00
17_T67_L4.0461.00
15_V54_V3.9581.00
26_A79_A3.5801.00
113_A167_M3.3951.00
73_V114_V2.9021.00
62_P66_H2.8811.00
74_A78_V2.7331.00
19_N75_S2.5631.00
20_A71_A2.3001.00
162_V166_L2.2941.00
30_A83_I2.1561.00
19_N47_A2.1531.00
65_K124_D2.1471.00
22_L47_A2.1181.00
108_G164_A2.1121.00
31_P82_C2.0371.00
77_G113_A2.0141.00
109_F138_A2.0111.00
33_N36_L1.9801.00
21_A107_A1.9771.00
22_L40_I1.9371.00
26_A83_I1.9211.00
17_T111_A1.9041.00
81_A110_V1.9021.00
66_H122_A1.8541.00
19_N44_A1.8151.00
180_D185_G1.8021.00
138_A167_M1.7811.00
84_V160_A1.7791.00
31_P86_A1.7501.00
46_I50_L1.7451.00
27_V79_A1.7171.00
105_V161_G1.7121.00
45_A140_T1.6981.00
173_Y217_A1.6931.00
112_S168_V1.6801.00
20_A74_A1.6751.00
205_A209_W1.6341.00
201_A204_K1.6321.00
138_A163_L1.5531.00
24_F107_A1.5371.00
69_S121_T1.5361.00
89_G102_A1.4911.00
70_L118_G1.4851.00
148_A207_F1.4771.00
26_A30_A1.4581.00
20_A114_V1.4541.00
88_T102_A1.4421.00
41_V143_A1.4311.00
14_A18_A1.4111.00
174_P216_F1.3830.99
18_A47_A1.3780.99
62_P65_K1.3680.99
66_H121_T1.3480.99
142_L160_A1.3160.99
92_W157_V1.2960.99
119_L169_S1.2870.99
24_F110_V1.2850.99
125_T131_E1.2790.99
27_V78_V1.2750.99
144_A207_F1.2730.99
161_G165_V1.2670.99
25_L29_T1.2470.99
88_T91_T1.2390.99
131_E170_T1.2200.99
182_L185_G1.2090.99
11_V58_L1.1980.98
70_L121_T1.1970.98
109_F113_A1.1880.98
154_T158_G1.1690.98
39_R43_V1.1650.98
53_V176_L1.1510.98
81_A106_G1.1500.98
123_Y131_E1.1500.98
19_N23_G1.1430.98
112_S164_A1.1410.98
18_A22_L1.1380.98
15_V18_A1.1190.98
73_V135_T1.1180.98
30_A86_A1.1060.97
63_A122_A1.0960.97
8_R11_V1.0930.97
136_T139_A1.0830.97
208_G212_A1.0810.97
161_G189_A1.0620.97
189_A193_V1.0570.97
11_V54_V1.0550.97
34_P86_A1.0550.97
125_T170_T1.0410.96
85_V89_G1.0360.96
140_T210_A1.0360.96
202_F218_P1.0320.96
200_G204_K1.0190.96
28_V107_A1.0180.96
141_L214_L1.0160.96
12_A58_L1.0070.95
109_F142_L0.9960.95
84_V156_I0.9780.95
133_V173_Y0.9770.95
47_A75_S0.9710.94
38_A147_L0.9580.94
212_A216_F0.9580.94
133_V141_L0.9580.94
78_V110_V0.9520.94
24_F28_V0.9460.94
84_V142_L0.9460.94
22_L44_A0.9410.94
106_G110_V0.9340.93
51_D72_D0.9270.93
51_D68_D0.9240.93
141_L210_A0.9230.93
68_D72_D0.9210.93
129_H172_E0.9200.93
186_V190_G0.9180.93
190_G209_W0.9150.93
77_G135_T0.9100.92
194_A209_W0.9040.92
113_A138_A0.8930.92
102_A105_V0.8900.91
40_I43_V0.8790.91
20_A75_S0.8770.91
63_A66_H0.8750.91
30_A82_C0.8710.91
21_A24_F0.8670.90
202_F205_A0.8620.90
133_V137_L0.8530.90
196_A200_G0.8530.90
28_V82_C0.8470.89
141_L205_A0.8450.89
24_F106_G0.8440.89
79_A83_I0.8440.89
141_L163_L0.8390.89
174_P178_V0.8360.89
127_H131_E0.8330.89
205_A214_L0.8200.88
69_S118_G0.8200.88
23_G44_A0.8180.88
158_G162_V0.8140.87
108_G189_A0.8080.87
29_T36_L0.8040.87
38_A87_A0.8030.87
109_F164_A0.8000.86
19_N71_A0.8000.86
13_D20_A0.7920.86
109_F163_L0.7810.85
9_L17_T0.7720.84
51_D55_A0.7710.84
13_D17_T0.7700.84
103_L106_G0.7690.84
71_A75_S0.7690.84
63_A115_V0.7660.84
112_S135_T0.7630.84
137_L210_A0.7620.84
53_V57_R0.7580.83
15_V47_A0.7540.83
186_V189_A0.7480.83
19_N49_G0.7480.83
54_V58_L0.7440.82
10_G13_D0.7410.82
9_L58_L0.7320.81
79_A106_G0.7310.81
27_V30_A0.7270.81
23_G79_A0.7270.81
23_G137_L0.7250.81
164_A218_P0.7240.80
105_V164_A0.7240.80
13_D67_L0.7140.80
61_T118_G0.7100.79
25_L40_I0.7050.79
85_V102_A0.7040.79
105_V157_V0.7020.78
204_K215_V0.6990.78
50_L178_V0.6980.78
91_T208_G0.6930.78
16_T118_G0.6880.77
216_F220_F0.6840.77
10_G17_T0.6840.77
87_A146_V0.6770.76
152_Q156_I0.6760.76
15_V53_V0.6750.76
26_A40_I0.6750.76
149_G152_Q0.6740.76
55_A68_D0.6740.76
111_A122_A0.6710.75
76_F136_T0.6700.75
55_A72_D0.6700.75
15_V40_I0.6650.75
112_S165_V0.6640.74
27_V82_C0.6600.74
206_L214_L0.6520.73
19_N65_K0.6470.73
86_A134_Q0.6450.72
211_G215_V0.6430.72
66_H125_T0.6430.72
45_A76_F0.6380.72
189_A194_A0.6380.72
22_L65_K0.6370.71
118_G121_T0.6370.71
114_V118_G0.6360.71
205_A208_G0.6360.71
135_T163_L0.6330.71
166_L218_P0.6330.71
157_V160_A0.6310.71
89_G106_G0.6300.71
113_A205_A0.6290.70
174_P220_F0.6270.70
71_A84_V0.6230.70
216_F219_R0.6230.70
167_M173_Y0.6220.70
16_T69_S0.6220.70
17_T63_A0.6220.70
76_F168_V0.6210.69
181_A184_M0.6200.69
36_L165_V0.6180.69
9_L67_L0.6150.69
43_V46_I0.6110.68
82_C86_A0.6110.68
168_V196_A0.6090.68
22_L43_V0.6090.68
93_Q128_E0.6080.68
118_G136_T0.6050.67
123_Y138_A0.6040.67
198_L202_F0.6020.67
162_V165_V0.6000.67
27_V54_V0.5990.67
160_A164_A0.5970.66
127_H178_V0.5960.66
107_A111_A0.5930.66
66_H129_H0.5930.66
10_G212_A0.5910.66
14_A17_T0.5900.66
183_A192_V0.5880.65
90_N151_E0.5840.65
20_A73_V0.5830.65
76_F139_A0.5830.65
162_V215_V0.5800.64
17_T115_V0.5800.64
53_V181_A0.5790.64
18_A45_A0.5770.64
28_V104_V0.5760.64
101_G142_L0.5750.64
212_A220_F0.5750.64
11_V57_R0.5730.63
156_I160_A0.5700.63
123_Y126_G0.5700.63
130_T137_L0.5660.62
186_V191_A0.5640.62
13_D61_T0.5630.62
71_A207_F0.5630.62
32_S85_V0.5620.62
108_G152_Q0.5610.62
112_S122_A0.5610.62
204_K208_G0.5600.62
119_L135_T0.5600.62
21_A25_L0.5580.61
149_G153_P0.5550.61
29_T33_N0.5550.61
66_H70_L0.5490.60
129_H215_V0.5480.60
16_T26_A0.5480.60
155_V158_G0.5480.60
15_V21_A0.5420.59
195_P199_A0.5410.59
76_F83_I0.5410.59
191_A194_A0.5380.59
74_A80_P0.5380.59
30_A49_G0.5370.58
10_G14_A0.5360.58
93_Q161_G0.5360.58
69_S76_F0.5350.58
66_H69_S0.5340.58
183_A188_Q0.5330.58
25_L28_V0.5320.58
86_A90_N0.5310.58
23_G75_S0.5290.57
75_S181_A0.5290.57
76_F106_G0.5260.57
100_I215_V0.5250.57
32_S35_R0.5250.57
193_V196_A0.5190.56
190_G193_V0.5180.56
34_P83_I0.5180.56
124_D170_T0.5170.56
43_V47_A0.5160.55
130_T133_V0.5150.55
9_L13_D0.5140.55
164_A168_V0.5140.55
166_L180_D0.5130.55
42_L216_F0.5130.55
59_G181_A0.5130.55
109_F135_T0.5130.55
41_V83_I0.5120.55
25_L159_A0.5120.55
196_A199_A0.5120.55
77_G118_G0.5110.55
62_P125_T0.5100.55
23_G61_T0.5100.55
52_G72_D0.5100.55
52_G68_D0.5090.54
12_A80_P0.5070.54
49_G173_Y0.5060.54
70_L114_V0.5050.54
71_A126_G0.5040.54
175_D198_L0.5040.54
74_A114_V0.5030.54
197_A203_P0.5000.53
166_L169_S0.5000.53
204_K207_F0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mndA 2 0.7289 99.6 0.717 Contact Map
4o6mA 2 0.76 99.6 0.733 Contact Map
4q2eA 2 0.4 2.8 0.966 Contact Map
4kt0K 1 0.2267 2.6 0.967 Contact Map
3tx3A 2 0.7022 2 0.969 Contact Map
3l1lA 2 0.7289 1.7 0.97 Contact Map
4z7fA 2 0.2889 1.6 0.971 Contact Map
4ftgE 1 0.0711 1.1 0.973 Contact Map
2a65A 2 0.5111 1 0.974 Contact Map
2gsmB 1 0.3911 0.9 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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