Q9HRA1 - HALSA - GREMLIN Contacts

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Q9HRA1 - Htr6 transducer

UniProt:	Q9HRA1	Sequences: MSDGITGALRNAASVVAPDAIRRRFGAKFAVAFIVVLVVIAGAGVFAFQSTETTVEHQTTRQLAESNQLEADAIGAWMEQQRTHARSVSQDEALRDDRRAAPYILLKDQLLPADVVSMHLVNETRGTVVASTELAIEGRSLAELDAPWTTAAVPEGPGNDSAVWATEQSYRSPVLNDEPVMAFASSVPKREGAHLVVVTRIQPQVDRLSDANSTRRTTILNTGDEPVLDSNSRFDAGALTDSIAAVRNDTTAATTTVSNGRVYALSATPHTDWVTVTSVDTGEAFAVRDTVGQTVTVLVVLAVISLAIVGIALGRHTVTPLKRLRNRAQDIESGTFDVDLSTRRIDEVGRLYGSFDDMRVSLQDRIQEAEAAVEEANAAKAEAEELRTDAEDAQAEAERAKATAEAASERLQERAADYSEVMQAVADGDLTERLDEDADEEAMRAVATEFNAMLDGLEATIAQVAGFADEVADETLQVATGAEEIETTSQTVSERIQEIADGAIQQHDDLERAAGEMDELSASIQEVAASSATVAETAADAVERGEAGRDAAESAIDDMAEIESLSADAVDQILALQERMSDIGDIIEFITDIAEQTNMLALNANIEAARADKDGDGFAVVANEVKDLAEETKQAAADIESEIQAVQAETDETVADIRATSEHIDDGVSTVERAAAAIEDTVDAIEDANHGIQEISDATEDQADATQSVVRRVDDVADISQHVTEDAEQVSAAAEEQSASVAEIARSADDLRDRADALATTVNQFETRADADEPDADTTVDASADDTGD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	789 (652)
Sequences:	936 (838)
Seq/√Len:	32.8

BACSU - TLPB TLPA MCPB MCPC MCPA
HALSA - Q9HRA1 HTR2 HTR4 COST Q9HR88 Q9HRN6 Q9HP10 Q9HS86

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
330_D	335_T	6.177	1.00
424_A	429_D	6.083	1.00
344_R	349_G	4.576	1.00
728_E	732_A	4.436	1.00
328_A	351_L	3.623	1.00
28_K	346_D	3.230	1.00
527_V	699_T	3.183	1.00
612_D	615_G	3.029	1.00
552_A	675_A	3.006	1.00
336_F	363_Q	2.970	1.00
372_A	376_A	2.968	1.00
605_N	627_D	2.832	1.00
603_N	621_V	2.822	1.00
351_L	358_M	2.782	1.00
623_N	627_D	2.687	1.00
438_A	447_A	2.663	1.00
535_A	696_S	2.623	1.00
328_A	358_M	2.578	1.00
561_E	663_H	2.524	1.00
598_N	607_E	2.481	1.00
562_I	667_G	2.475	1.00
611_A	615_G	2.463	1.00
602_L	626_K	2.446	0.99
444_R	447_A	2.422	0.99
513_A	712_R	2.369	0.99
586_I	643_I	2.328	0.99
506_Q	727_A	2.325	0.99
599_M	609_A	2.313	0.99
434_L	446_V	2.289	0.99
595_E	606_I	2.251	0.99
594_A	619_A	2.249	0.99
590_I	667_G	2.244	0.99
580_M	586_I	2.232	0.99
615_G	619_A	2.203	0.99
350_R	353_G	2.195	0.99
596_Q	607_E	2.187	0.99
358_M	362_L	2.186	0.99
434_L	447_A	2.173	0.99
559_M	562_I	2.146	0.99
351_L	355_F	2.135	0.99
617_G	624_E	2.088	0.98
503_A	726_D	2.081	0.98
562_I	626_K	2.062	0.98
25_F	317_T	2.057	0.98
77_W	81_Q	2.026	0.98
497_Q	735_E	2.015	0.98
421_V	450_F	2.006	0.98
356_D	359_R	2.006	0.98
44_G	299_V	1.996	0.98
643_I	667_G	1.995	0.98
602_L	619_A	1.995	0.98
640_E	727_A	1.984	0.98
591_T	640_E	1.983	0.98
530_S	691_G	1.978	0.98
586_I	642_E	1.975	0.98
669_S	673_R	1.960	0.97
605_N	631_E	1.952	0.97
521_S	710_V	1.951	0.97
508_D	515_G	1.948	0.97
212_N	215_R	1.946	0.97
725_E	728_E	1.941	0.97
324_L	355_F	1.929	0.97
626_K	737_Q	1.928	0.97
415_A	418_Y	1.925	0.97
351_L	362_L	1.911	0.97
591_T	595_E	1.878	0.97
744_I	751_L	1.850	0.96
528_A	531_S	1.844	0.96
346_D	349_G	1.841	0.96
437_D	447_A	1.840	0.96
705_A	712_R	1.827	0.96
373_V	376_A	1.816	0.96
599_M	605_N	1.797	0.96
418_Y	447_A	1.785	0.96
273_W	276_V	1.783	0.96
609_A	620_V	1.771	0.95
369_A	372_A	1.770	0.95
514_A	713_V	1.767	0.95
562_I	602_L	1.763	0.95
579_R	670_T	1.757	0.95
116_V	119_H	1.756	0.95
556_I	703_A	1.729	0.95
511_E	519_E	1.722	0.95
596_Q	602_L	1.720	0.95
586_I	667_G	1.705	0.94
580_M	670_T	1.701	0.94
29_F	317_T	1.700	0.94
503_A	727_A	1.697	0.94
320_P	348_V	1.695	0.94
495_R	726_D	1.695	0.94
433_R	458_E	1.676	0.94
549_R	682_V	1.672	0.94
433_R	455_D	1.666	0.94
579_R	663_H	1.661	0.94
589_F	724_T	1.659	0.93
585_D	605_N	1.656	0.93
554_S	673_R	1.655	0.93
619_A	624_E	1.655	0.93
594_A	611_A	1.653	0.93
627_D	634_Q	1.651	0.93
85_A	88_V	1.650	0.93
595_E	723_V	1.649	0.93
687_D	690_H	1.647	0.93
723_V	726_D	1.632	0.93
149_T	152_A	1.623	0.93
674_A	678_I	1.622	0.93
324_L	328_A	1.621	0.93
639_I	667_G	1.620	0.93
415_A	443_M	1.620	0.93
324_L	351_L	1.618	0.93
496_I	734_A	1.617	0.93
551_A	606_I	1.614	0.92
231_N	235_D	1.612	0.92
601_A	610_R	1.608	0.92
595_E	630_E	1.602	0.92
586_I	635_A	1.597	0.92
580_M	751_L	1.595	0.92
548_G	734_A	1.579	0.92
509_D	587_I	1.578	0.92
591_T	606_I	1.568	0.91
503_A	587_I	1.568	0.91
623_N	633_K	1.562	0.91
558_D	587_I	1.555	0.91
595_E	633_K	1.549	0.91
623_N	640_E	1.545	0.91
545_G	549_R	1.542	0.91
584_G	590_I	1.542	0.91
627_D	630_E	1.540	0.91
429_D	454_L	1.534	0.90
508_D	513_A	1.529	0.90
434_L	443_M	1.525	0.90
415_A	450_F	1.524	0.90
620_V	624_E	1.523	0.90
506_Q	549_R	1.522	0.90
725_E	732_A	1.518	0.90
84_H	115_V	1.516	0.90
595_E	626_K	1.515	0.90
300_V	304_I	1.510	0.90
615_G	667_G	1.507	0.90
328_A	355_F	1.506	0.90
580_M	660_T	1.503	0.90
643_I	660_T	1.489	0.89
419_S	422_M	1.482	0.89
626_K	720_S	1.480	0.89
626_K	642_E	1.472	0.88
447_A	453_M	1.472	0.88
86_R	89_S	1.465	0.88
612_D	617_G	1.464	0.88
372_A	375_E	1.463	0.88
605_N	726_D	1.458	0.88
604_A	621_V	1.457	0.88
552_A	737_Q	1.456	0.88
244_A	248_N	1.448	0.88
506_Q	719_I	1.445	0.88
447_A	450_F	1.441	0.87
602_L	609_A	1.441	0.87
314_G	318_V	1.434	0.87
430_L	443_M	1.431	0.87
511_E	515_G	1.426	0.87
331_I	359_R	1.425	0.87
499_I	670_T	1.421	0.87
243_I	246_V	1.415	0.86
615_G	620_V	1.413	0.86
670_T	674_A	1.408	0.86
437_D	444_R	1.405	0.86
605_N	623_N	1.405	0.86
592_D	623_N	1.402	0.86
364_D	368_E	1.402	0.86
615_G	621_V	1.402	0.86
609_A	619_A	1.401	0.86
468_A	471_V	1.401	0.86
216_R	229_D	1.396	0.86
606_I	623_N	1.395	0.86
506_Q	607_E	1.391	0.85
248_N	252_A	1.383	0.85
150_T	154_P	1.382	0.85
367_Q	371_A	1.381	0.85
314_G	317_T	1.379	0.85
121_V	127_T	1.372	0.85
355_F	362_L	1.372	0.85
419_S	449_E	1.371	0.85
152_A	184_A	1.371	0.85
586_I	589_F	1.368	0.84
520_L	528_A	1.367	0.84
542_V	546_E	1.367	0.84
726_D	737_Q	1.365	0.84
520_L	713_V	1.357	0.84
332_E	541_A	1.356	0.84
508_D	721_Q	1.350	0.84
493_S	735_E	1.347	0.84
499_I	607_E	1.347	0.84
434_L	445_A	1.345	0.83
331_I	362_L	1.344	0.83
548_G	605_N	1.343	0.83
599_M	678_I	1.338	0.83
590_I	624_E	1.338	0.83
624_E	667_G	1.336	0.83
98_R	102_P	1.335	0.83
444_R	448_T	1.333	0.83
422_M	434_L	1.329	0.83
558_D	595_E	1.321	0.82
506_Q	706_T	1.319	0.82
632_T	636_A	1.317	0.82
664_I	667_G	1.317	0.82
562_I	737_Q	1.314	0.82
515_G	717_A	1.310	0.82
301_L	308_I	1.301	0.81
594_A	602_L	1.296	0.81
626_K	631_E	1.293	0.81
527_V	605_N	1.290	0.81
582_D	645_A	1.286	0.81
371_A	375_E	1.279	0.80
620_V	667_G	1.269	0.80
607_E	667_G	1.268	0.80
685_I	733_A	1.262	0.79
122_N	126_G	1.258	0.79
371_A	374_E	1.255	0.79
117_S	200_R	1.255	0.79
531_S	556_I	1.254	0.79
426_A	429_D	1.252	0.79
414_R	438_A	1.252	0.79
216_R	230_S	1.247	0.78
81_Q	87_S	1.244	0.78
499_I	579_R	1.239	0.78
595_E	602_L	1.239	0.78
615_G	639_I	1.236	0.78
33_F	39_V	1.233	0.78
737_Q	744_I	1.232	0.78
519_E	705_A	1.228	0.77
319_T	338_V	1.227	0.77
52_E	56_E	1.224	0.77
453_M	712_R	1.220	0.77
461_I	520_L	1.215	0.77
607_E	635_A	1.210	0.76
605_N	664_I	1.208	0.76
545_G	593_I	1.199	0.76
725_E	729_Q	1.194	0.75
89_S	187_V	1.191	0.75
552_A	562_I	1.187	0.75
488_T	538_A	1.180	0.74
527_V	723_V	1.180	0.74
185_S	198_V	1.178	0.74
632_T	639_I	1.178	0.74
606_I	640_E	1.173	0.74
678_I	681_T	1.172	0.74
675_A	737_Q	1.167	0.74
453_M	500_A	1.165	0.73
562_I	595_E	1.161	0.73
331_I	351_L	1.158	0.73
664_I	668_V	1.153	0.73
607_E	610_R	1.149	0.72
505_Q	716_V	1.146	0.72
538_A	688_A	1.145	0.72
502_G	719_I	1.142	0.72
502_G	726_D	1.142	0.72
127_T	130_A	1.140	0.72
737_Q	751_L	1.140	0.72
339_D	356_D	1.140	0.72
116_V	202_Q	1.139	0.72
621_V	624_E	1.135	0.72
630_E	727_A	1.134	0.71
465_A	748_A	1.133	0.71
509_D	623_N	1.131	0.71
555_A	632_T	1.130	0.71
521_S	640_E	1.129	0.71
611_A	622_A	1.128	0.71
129_V	133_E	1.127	0.71
717_A	720_S	1.126	0.71
510_L	717_A	1.123	0.71
449_E	596_Q	1.118	0.70
598_N	626_K	1.115	0.70
562_I	642_E	1.114	0.70
558_D	723_V	1.113	0.70
38_V	199_T	1.112	0.70
167_E	170_Y	1.111	0.70
530_S	627_D	1.110	0.70
523_S	633_K	1.106	0.70
660_T	664_I	1.105	0.69
199_T	204_Q	1.102	0.69
513_A	717_A	1.100	0.69
208_L	227_V	1.100	0.69
678_I	702_Q	1.095	0.69
101_A	105_L	1.094	0.69
457_L	688_A	1.088	0.68
587_I	691_G	1.086	0.68
106_L	110_L	1.084	0.68
588_E	640_E	1.084	0.68
253_A	256_T	1.083	0.68
231_N	234_F	1.077	0.67
37_L	518_D	1.076	0.67
535_A	693_Q	1.075	0.67
221_N	273_W	1.075	0.67
618_F	622_A	1.074	0.67
611_A	619_A	1.074	0.67
421_V	447_A	1.073	0.67
105_L	435_D	1.073	0.67
445_A	449_E	1.070	0.67
729_Q	732_A	1.070	0.67
609_A	624_E	1.068	0.67
491_T	717_A	1.068	0.67
582_D	638_D	1.068	0.67
532_A	700_E	1.067	0.67
606_I	726_D	1.067	0.67
449_E	737_Q	1.065	0.67
708_S	724_T	1.065	0.67
356_D	360_V	1.063	0.66
626_K	751_L	1.056	0.66
35_V	313_L	1.056	0.66
415_A	444_R	1.056	0.66
74_I	148_W	1.054	0.66
488_T	727_A	1.054	0.66
587_I	723_V	1.053	0.66
510_L	514_A	1.052	0.66
214_T	283_E	1.050	0.65
48_F	291_V	1.049	0.65
547_A	550_D	1.046	0.65
589_F	631_E	1.041	0.65
606_I	723_V	1.040	0.65
607_E	626_K	1.040	0.65
418_Y	712_R	1.038	0.65
195_L	300_V	1.038	0.65
610_R	671_V	1.038	0.65
414_R	444_R	1.038	0.65
510_L	636_A	1.036	0.64
598_N	621_V	1.034	0.64
199_T	203_P	1.033	0.64
262_V	265_L	1.032	0.64
590_I	635_A	1.031	0.64
555_A	678_I	1.030	0.64
702_Q	709_V	1.028	0.64
121_V	125_R	1.026	0.64
535_A	688_A	1.026	0.64
499_I	667_G	1.024	0.63
450_F	471_V	1.024	0.63
451_N	457_L	1.022	0.63
530_S	632_T	1.021	0.63
502_G	595_E	1.020	0.63
270_H	273_W	1.019	0.63
678_I	695_I	1.018	0.63
596_Q	619_A	1.017	0.63
617_G	620_V	1.014	0.63
468_A	734_A	1.013	0.63
579_R	751_L	1.013	0.63
261_R	335_T	1.012	0.63
548_G	747_S	1.011	0.62
623_N	731_S	1.010	0.62
408_S	418_Y	1.008	0.62
464_V	663_H	1.008	0.62
464_V	582_D	1.006	0.62
642_E	675_A	1.004	0.62
593_I	603_N	1.002	0.62
660_T	688_A	0.999	0.61
170_Y	182_A	0.999	0.61
507_H	721_Q	0.998	0.61
298_L	328_A	0.997	0.61
674_A	716_V	0.997	0.61
358_M	527_V	0.997	0.61
415_A	472_A	0.993	0.61
492_V	685_I	0.993	0.61
660_T	675_A	0.990	0.61
595_E	614_D	0.986	0.60
514_A	518_D	0.984	0.60
677_A	719_I	0.981	0.60
619_A	667_G	0.980	0.60
545_G	631_E	0.979	0.60
59_T	67_N	0.979	0.60
440_E	444_R	0.978	0.60
555_A	643_I	0.977	0.60
434_L	450_F	0.976	0.60
593_I	621_V	0.975	0.60
461_I	464_V	0.975	0.60
516_E	605_N	0.972	0.59
538_A	675_A	0.972	0.59
464_V	488_T	0.970	0.59
344_R	635_A	0.968	0.59
583_I	590_I	0.965	0.59
421_V	434_L	0.962	0.59
491_T	722_H	0.962	0.59
601_A	678_I	0.960	0.58
531_S	664_I	0.959	0.58
558_D	720_S	0.959	0.58
727_A	731_S	0.958	0.58
125_R	129_V	0.957	0.58
591_T	726_D	0.957	0.58
617_G	638_D	0.955	0.58
340_L	352_Y	0.952	0.58
721_Q	725_E	0.949	0.57
579_R	671_V	0.948	0.57
590_I	598_N	0.945	0.57
607_E	661_S	0.943	0.57
128_V	152_A	0.943	0.57
336_F	362_L	0.939	0.57
447_A	451_N	0.938	0.57
495_R	716_V	0.937	0.57
598_N	603_N	0.936	0.56
548_G	678_I	0.934	0.56
545_G	734_A	0.933	0.56
626_K	712_R	0.933	0.56
506_Q	667_G	0.933	0.56
642_E	660_T	0.932	0.56
609_A	667_G	0.930	0.56
589_F	667_G	0.930	0.56
589_F	639_I	0.929	0.56
170_Y	202_Q	0.928	0.56
460_T	684_A	0.927	0.56
293_Q	749_D	0.926	0.56
593_I	631_E	0.925	0.56
186_S	280_D	0.923	0.55
428_G	678_I	0.923	0.55
83_T	275_T	0.922	0.55
721_Q	726_D	0.922	0.55
450_F	458_E	0.921	0.55
590_I	615_G	0.920	0.55
499_I	506_Q	0.920	0.55
513_A	516_E	0.919	0.55
533_T	694_E	0.919	0.55
595_E	717_A	0.918	0.55
534_V	552_A	0.918	0.55
436_E	444_R	0.917	0.55
328_A	332_E	0.916	0.55
289_D	305_S	0.915	0.55
517_M	668_V	0.914	0.55
520_L	645_A	0.912	0.54
172_S	175_L	0.911	0.54
179_P	186_S	0.911	0.54
640_E	723_V	0.910	0.54
731_S	735_E	0.909	0.54
118_M	121_V	0.909	0.54
438_A	527_V	0.908	0.54
47_A	320_P	0.907	0.54
491_T	728_E	0.907	0.54
527_V	623_N	0.907	0.54
344_R	359_R	0.905	0.54
327_R	340_L	0.904	0.54
606_I	717_A	0.903	0.54
170_Y	273_W	0.900	0.53
506_Q	731_S	0.898	0.53
509_D	716_V	0.894	0.53
213_S	219_I	0.894	0.53
710_V	723_V	0.893	0.53
349_G	352_Y	0.889	0.53
328_A	331_I	0.888	0.52
471_V	731_S	0.888	0.52
149_T	153_V	0.888	0.52
592_D	599_M	0.883	0.52
605_N	688_A	0.883	0.52
599_M	626_K	0.882	0.52
506_Q	635_A	0.881	0.52
186_S	198_V	0.880	0.52
511_E	595_E	0.878	0.52
586_I	660_T	0.877	0.52
325_R	331_I	0.877	0.52
636_A	724_T	0.876	0.51
548_G	585_D	0.875	0.51
524_I	696_S	0.875	0.51
181_M	186_S	0.875	0.51
549_R	588_E	0.875	0.51
70_E	78_M	0.873	0.51
626_K	633_K	0.871	0.51
500_A	507_H	0.871	0.51
505_Q	732_A	0.869	0.51
584_G	692_I	0.868	0.51
581_S	665_D	0.866	0.51
378_A	459_A	0.861	0.50
511_E	721_Q	0.860	0.50
602_L	612_D	0.858	0.50
525_Q	707_Q	0.858	0.50
264_A	269_P	0.857	0.50
500_A	510_L	0.857	0.50
218_T	276_V	0.857	0.50
702_Q	721_Q	0.857	0.50
512_R	515_G	0.855	0.50
590_I	617_G	0.854	0.50
334_G	695_I	0.854	0.50
717_A	724_T	0.853	0.50
246_V	251_T	0.850	0.49
303_V	324_L	0.850	0.49
456_G	750_D	0.849	0.49
351_L	361_S	0.843	0.49
414_R	417_D	0.843	0.49
310_G	692_I	0.841	0.49
642_E	667_G	0.841	0.49
104_I	109_Q	0.840	0.48
446_V	518_D	0.839	0.48
507_H	595_E	0.838	0.48
32_A	315_R	0.837	0.48
453_M	457_L	0.837	0.48
504_I	728_E	0.833	0.48
524_I	715_D	0.831	0.48
494_E	550_D	0.830	0.48
631_E	717_A	0.830	0.48
327_R	338_V	0.828	0.48
558_D	591_T	0.826	0.47
408_S	411_L	0.825	0.47
438_A	443_M	0.824	0.47
673_R	709_V	0.822	0.47
283_E	301_L	0.821	0.47
461_I	748_A	0.819	0.47
443_M	450_F	0.817	0.47
491_T	732_A	0.816	0.47
552_A	664_I	0.816	0.47
635_A	702_Q	0.816	0.47
457_L	579_R	0.814	0.46
601_A	664_I	0.813	0.46
187_V	205_V	0.811	0.46
556_I	678_I	0.809	0.46
328_A	362_L	0.808	0.46
591_T	636_A	0.807	0.46
488_T	585_D	0.807	0.46
612_D	632_T	0.805	0.46
630_E	726_D	0.804	0.46
414_R	439_D	0.804	0.46
132_T	140_S	0.801	0.45
376_A	499_I	0.800	0.45
630_E	643_I	0.800	0.45
551_A	670_T	0.800	0.45
638_D	733_A	0.799	0.45
196_V	273_W	0.797	0.45
636_A	660_T	0.797	0.45
660_T	678_I	0.795	0.45
183_F	196_V	0.794	0.45
616_D	635_A	0.792	0.45
40_I	321_L	0.792	0.45
493_S	497_Q	0.791	0.44
268_T	500_A	0.791	0.44
443_M	467_F	0.788	0.44
130_A	133_E	0.788	0.44
595_E	605_N	0.786	0.44
177_D	613_K	0.781	0.44
417_D	438_A	0.781	0.44
247_R	300_V	0.780	0.44
518_D	522_A	0.778	0.43
217_T	268_T	0.777	0.43
492_V	731_S	0.776	0.43
627_D	667_G	0.775	0.43
471_V	685_I	0.773	0.43
509_D	637_A	0.773	0.43
414_R	447_A	0.772	0.43
614_D	713_V	0.771	0.43
637_A	716_V	0.770	0.43
517_M	520_L	0.768	0.43
696_S	737_Q	0.765	0.42
610_R	717_A	0.765	0.42
696_S	744_I	0.764	0.42
663_H	678_I	0.764	0.42
612_D	624_E	0.763	0.42
25_F	321_L	0.762	0.42
464_V	691_G	0.761	0.42
317_T	340_L	0.761	0.42
230_S	409_E	0.761	0.42
700_E	708_S	0.760	0.42
101_A	108_D	0.758	0.42
97_D	100_A	0.758	0.42
495_R	605_N	0.756	0.42
516_E	737_Q	0.756	0.42
148_W	172_S	0.753	0.41
329_Q	350_R	0.752	0.41
592_D	630_E	0.752	0.41
221_N	227_V	0.751	0.41
321_L	350_R	0.750	0.41
120_L	320_P	0.748	0.41
541_A	684_A	0.748	0.41
502_G	723_V	0.748	0.41
127_T	131_S	0.747	0.41
154_P	163_V	0.746	0.41
508_D	723_V	0.744	0.41
324_L	338_V	0.744	0.41
538_A	672_E	0.744	0.41
635_A	667_G	0.744	0.41
331_I	358_M	0.743	0.41
586_I	602_L	0.743	0.41
152_A	252_A	0.742	0.40
248_N	275_T	0.742	0.40
594_A	625_V	0.742	0.40
299_V	303_V	0.740	0.40
212_N	220_L	0.738	0.40
595_E	631_E	0.738	0.40
213_S	217_T	0.738	0.40
434_L	685_I	0.737	0.40
541_A	619_A	0.737	0.40
497_Q	707_Q	0.737	0.40
644_Q	737_Q	0.737	0.40
517_M	705_A	0.736	0.40
508_D	511_E	0.734	0.40
340_L	356_D	0.732	0.40
602_L	624_E	0.731	0.40
99_R	120_L	0.731	0.40
321_L	500_A	0.731	0.40
189_K	192_G	0.729	0.39
674_A	688_A	0.727	0.39
673_R	680_D	0.727	0.39
55_V	59_T	0.725	0.39
321_L	351_L	0.725	0.39
336_F	366_I	0.721	0.39
215_R	230_S	0.720	0.39
505_Q	509_D	0.717	0.38
545_G	682_V	0.717	0.38
594_A	622_A	0.717	0.38
631_E	639_I	0.716	0.38
527_V	606_I	0.714	0.38
416_A	419_S	0.713	0.38
368_E	372_A	0.713	0.38
128_V	131_S	0.712	0.38
246_V	249_D	0.712	0.38
411_L	443_M	0.712	0.38
663_H	691_G	0.711	0.38
523_S	527_V	0.711	0.38
623_N	630_E	0.710	0.38
705_A	727_A	0.710	0.38
422_M	447_A	0.710	0.38
556_I	692_I	0.709	0.38
415_A	446_V	0.709	0.38
450_F	706_T	0.708	0.38
177_D	221_N	0.707	0.38
457_L	587_I	0.707	0.38
499_I	723_V	0.707	0.38
436_E	448_T	0.706	0.38
137_E	140_S	0.706	0.38
678_I	724_T	0.702	0.37
115_V	119_H	0.702	0.37
130_A	134_L	0.701	0.37
449_E	630_E	0.699	0.37
588_E	638_D	0.698	0.37
122_N	202_Q	0.698	0.37
579_R	668_V	0.698	0.37
332_E	357_D	0.698	0.37
583_I	623_N	0.696	0.37
308_I	378_A	0.696	0.37
304_I	713_V	0.696	0.37
636_A	642_E	0.696	0.37
562_I	720_S	0.695	0.37
617_G	621_V	0.694	0.37
201_I	248_N	0.693	0.37
512_R	721_Q	0.693	0.37
357_D	362_L	0.692	0.37
504_I	725_E	0.692	0.37
418_Y	436_E	0.691	0.36
82_R	85_A	0.690	0.36
28_K	362_L	0.689	0.36
58_Q	63_L	0.689	0.36
429_D	453_M	0.688	0.36
660_T	667_G	0.687	0.36
585_D	727_A	0.686	0.36
591_T	720_S	0.685	0.36
544_R	680_D	0.684	0.36
612_D	619_A	0.683	0.36
109_Q	151_A	0.682	0.36
527_V	698_A	0.682	0.36
679_E	703_A	0.682	0.36
328_A	361_S	0.682	0.36
306_L	321_L	0.681	0.36
268_T	276_V	0.680	0.36
252_A	255_T	0.680	0.36
515_G	519_E	0.680	0.36
516_E	548_G	0.678	0.35
454_L	699_T	0.678	0.35
120_L	199_T	0.678	0.35
45_V	49_Q	0.677	0.35
351_L	357_D	0.676	0.35
148_W	187_V	0.676	0.35
727_A	738_S	0.676	0.35
252_A	258_S	0.676	0.35
87_S	91_D	0.676	0.35
471_V	587_I	0.675	0.35
534_V	559_M	0.675	0.35
434_L	514_A	0.674	0.35
459_A	497_Q	0.674	0.35
55_V	305_S	0.674	0.35
507_H	591_T	0.673	0.35
299_V	354_S	0.672	0.35
246_V	275_T	0.671	0.35
105_L	198_V	0.671	0.35
78_M	297_V	0.668	0.35
498_E	502_G	0.668	0.35
595_E	721_Q	0.668	0.35
418_Y	443_M	0.666	0.35
169_S	273_W	0.665	0.34
518_D	705_A	0.664	0.34
44_G	298_L	0.663	0.34
509_D	717_A	0.663	0.34
414_R	419_S	0.663	0.34
580_M	675_A	0.663	0.34
513_A	671_V	0.662	0.34
467_F	682_V	0.662	0.34
632_T	642_E	0.662	0.34
506_Q	610_R	0.661	0.34
218_T	275_T	0.660	0.34
224_D	273_W	0.660	0.34
81_Q	92_E	0.659	0.34
661_S	665_D	0.659	0.34
610_R	728_E	0.659	0.34
434_L	449_E	0.657	0.34
511_E	591_T	0.656	0.34
436_E	443_M	0.656	0.34
591_T	637_A	0.656	0.34
489_S	626_K	0.655	0.34
678_I	737_Q	0.654	0.34
453_M	626_K	0.654	0.34
531_S	748_A	0.654	0.34
39_V	349_G	0.651	0.33
153_V	195_L	0.649	0.33
541_A	703_A	0.648	0.33
579_R	667_G	0.648	0.33
559_M	667_G	0.646	0.33
502_G	606_I	0.646	0.33
596_Q	605_N	0.646	0.33
152_A	155_E	0.645	0.33
712_R	737_Q	0.645	0.33
153_V	243_I	0.641	0.33
517_M	713_V	0.641	0.33
668_V	677_A	0.641	0.33
556_I	663_H	0.640	0.33
588_E	715_D	0.638	0.32
635_A	675_A	0.635	0.32
468_A	506_Q	0.634	0.32
524_I	643_I	0.634	0.32
29_F	44_G	0.634	0.32
597_T	602_L	0.634	0.32
608_A	622_A	0.633	0.32
411_L	441_E	0.632	0.32
717_A	723_V	0.632	0.32
712_R	723_V	0.632	0.32
582_D	586_I	0.632	0.32
32_A	35_V	0.631	0.32
421_V	548_G	0.630	0.32
506_Q	640_E	0.628	0.32
607_E	612_D	0.627	0.32
148_W	151_A	0.626	0.32
138_G	141_L	0.624	0.31
529_A	533_T	0.623	0.31
220_L	273_W	0.623	0.31
468_A	528_A	0.622	0.31
517_M	735_E	0.622	0.31
368_E	689_N	0.622	0.31
531_S	611_A	0.621	0.31
492_V	635_A	0.621	0.31
536_E	697_D	0.621	0.31
673_R	676_A	0.620	0.31
720_S	723_V	0.620	0.31
344_R	356_D	0.620	0.31
38_V	186_S	0.618	0.31
635_A	741_V	0.618	0.31
213_S	216_R	0.618	0.31
581_S	663_H	0.617	0.31
602_L	620_V	0.617	0.31
580_M	667_G	0.617	0.31
591_T	642_E	0.616	0.31
724_T	731_S	0.615	0.31
516_E	585_D	0.615	0.31
609_A	615_G	0.615	0.31
489_S	737_Q	0.615	0.31
605_N	610_R	0.614	0.31
197_V	201_I	0.614	0.31
562_I	614_D	0.613	0.31
354_S	361_S	0.612	0.31
596_Q	728_E	0.612	0.31
669_S	709_V	0.612	0.31
358_M	605_N	0.611	0.31
450_F	593_I	0.610	0.30
615_G	626_K	0.609	0.30
589_F	660_T	0.609	0.30
558_D	730_V	0.609	0.30
630_E	732_A	0.609	0.30
450_F	582_D	0.609	0.30
182_A	202_Q	0.608	0.30
737_Q	750_D	0.607	0.30
734_A	738_S	0.606	0.30
113_A	117_S	0.606	0.30
202_Q	221_N	0.606	0.30
510_L	716_V	0.606	0.30
288_R	292_G	0.606	0.30
99_R	337_D	0.605	0.30
411_L	454_L	0.605	0.30
229_D	301_L	0.605	0.30
25_F	39_V	0.603	0.30
611_A	620_V	0.603	0.30
698_A	703_A	0.603	0.30
117_S	133_E	0.602	0.30
552_A	734_A	0.600	0.30
598_N	605_N	0.598	0.30
602_L	737_Q	0.596	0.30
284_A	321_L	0.596	0.30
167_E	171_R	0.596	0.30
555_A	589_F	0.594	0.29
242_S	249_D	0.593	0.29
587_I	636_A	0.593	0.29
591_T	635_A	0.592	0.29
630_E	667_G	0.592	0.29
440_E	453_M	0.592	0.29
636_A	640_E	0.592	0.29
119_H	200_R	0.592	0.29
251_T	300_V	0.591	0.29
513_A	637_A	0.591	0.29
518_D	585_D	0.590	0.29
471_V	498_E	0.590	0.29
595_E	625_V	0.590	0.29
415_A	447_A	0.589	0.29
514_A	705_A	0.589	0.29
617_G	639_I	0.589	0.29
588_E	737_Q	0.589	0.29
224_D	229_D	0.586	0.29
242_S	246_V	0.586	0.29
735_E	746_R	0.586	0.29
186_S	267_A	0.586	0.29
265_L	269_P	0.585	0.29
544_R	684_A	0.585	0.29
585_D	741_V	0.585	0.29
56_E	262_V	0.585	0.29
593_I	734_A	0.584	0.29
502_G	728_E	0.584	0.29
506_Q	606_I	0.581	0.28
623_N	716_V	0.581	0.28
510_L	552_A	0.581	0.28
520_L	535_A	0.580	0.28
539_A	542_V	0.580	0.28
273_W	280_D	0.579	0.28
621_V	625_V	0.579	0.28
114_D	268_T	0.579	0.28
555_A	599_M	0.579	0.28
493_S	636_A	0.577	0.28
493_S	523_S	0.576	0.28
102_P	181_M	0.576	0.28
503_A	723_V	0.576	0.28
616_D	623_N	0.576	0.28
590_I	607_E	0.575	0.28
148_W	169_S	0.574	0.28
534_V	610_R	0.574	0.28
603_N	617_G	0.574	0.28
447_A	514_A	0.574	0.28
41_A	45_V	0.573	0.28
461_I	753_D	0.573	0.28
450_F	605_N	0.573	0.28
489_S	686_E	0.573	0.28
514_A	716_V	0.573	0.28
706_T	723_V	0.572	0.28
138_G	143_E	0.571	0.28
545_G	643_I	0.571	0.28
599_M	688_A	0.570	0.28
418_Y	422_M	0.568	0.28
558_D	596_Q	0.568	0.28
88_V	378_A	0.568	0.28
524_I	710_V	0.568	0.28
635_A	661_S	0.568	0.28
155_E	305_S	0.567	0.28
133_E	136_I	0.567	0.28
440_E	545_G	0.567	0.28
215_R	224_D	0.567	0.28
324_L	340_L	0.566	0.27
30_A	70_E	0.565	0.27
43_A	298_L	0.564	0.27
167_E	172_S	0.564	0.27
591_T	732_A	0.563	0.27
582_D	606_I	0.562	0.27
364_D	367_Q	0.560	0.27
443_M	598_N	0.559	0.27
541_A	607_E	0.557	0.27
169_S	267_A	0.557	0.27
464_V	556_I	0.557	0.27
355_F	358_M	0.557	0.27
270_H	276_V	0.556	0.27
548_G	591_T	0.556	0.27
307_A	352_Y	0.556	0.27
548_G	674_A	0.555	0.27
502_G	727_A	0.555	0.27
57_H	326_N	0.554	0.27
125_R	131_S	0.553	0.27
523_S	691_G	0.553	0.27
595_E	720_S	0.553	0.27
606_I	716_V	0.552	0.27
46_F	313_L	0.552	0.27
445_A	460_T	0.551	0.26
625_V	636_A	0.551	0.26
716_V	727_A	0.551	0.26
436_E	558_D	0.550	0.26
358_M	730_V	0.550	0.26
412_Q	443_M	0.549	0.26
111_L	114_D	0.549	0.26
516_E	631_E	0.549	0.26
534_V	579_R	0.548	0.26
305_S	308_I	0.548	0.26
504_I	681_T	0.548	0.26
616_D	619_A	0.547	0.26
553_E	747_S	0.546	0.26
589_F	616_D	0.545	0.26
732_A	735_E	0.545	0.26
701_D	716_V	0.544	0.26
44_G	48_F	0.541	0.26
602_L	701_D	0.540	0.26
532_A	535_A	0.540	0.26
439_D	641_S	0.538	0.26
595_E	726_D	0.538	0.26
197_V	202_Q	0.538	0.26
586_I	721_Q	0.537	0.26
131_S	136_I	0.537	0.26
589_F	681_T	0.536	0.26
611_A	621_V	0.535	0.25
23_R	28_K	0.535	0.25
509_D	723_V	0.535	0.25
527_V	726_D	0.535	0.25
586_I	620_V	0.535	0.25
77_W	284_A	0.534	0.25
496_I	707_Q	0.533	0.25
298_L	330_D	0.532	0.25
507_H	512_R	0.532	0.25
507_H	717_A	0.532	0.25
225_E	235_D	0.531	0.25
372_A	498_E	0.531	0.25
499_I	516_E	0.531	0.25
355_F	369_A	0.531	0.25
168_Q	220_L	0.530	0.25
172_S	176_N	0.528	0.25
601_A	674_A	0.528	0.25
503_A	660_T	0.527	0.25
579_R	630_E	0.526	0.25
640_E	705_A	0.526	0.25
741_V	751_L	0.525	0.25
30_A	33_F	0.525	0.25
463_Q	491_T	0.525	0.25
695_I	709_V	0.524	0.25
527_V	706_T	0.524	0.25
373_V	677_A	0.524	0.25
596_Q	692_I	0.524	0.25
334_G	428_G	0.524	0.25
527_V	671_V	0.523	0.25
514_A	619_A	0.522	0.25
121_V	129_V	0.521	0.25
122_N	182_A	0.521	0.25
218_T	260_G	0.521	0.25
352_Y	358_M	0.521	0.25
636_A	717_A	0.521	0.25
419_S	563_E	0.520	0.25
410_R	414_R	0.520	0.25
497_Q	713_V	0.519	0.24
592_D	634_Q	0.519	0.24
606_I	633_K	0.518	0.24
588_E	722_H	0.518	0.24
28_K	33_F	0.518	0.24
492_V	705_A	0.518	0.24
198_V	203_P	0.517	0.24
595_E	599_M	0.517	0.24
85_A	121_V	0.517	0.24
359_R	363_Q	0.516	0.24
453_M	548_G	0.516	0.24
48_F	51_T	0.515	0.24
440_E	443_M	0.514	0.24
453_M	496_I	0.514	0.24
559_M	642_E	0.514	0.24
705_A	708_S	0.513	0.24
453_M	727_A	0.511	0.24
587_I	593_I	0.511	0.24
187_V	196_V	0.511	0.24
226_P	231_N	0.511	0.24
31_V	699_T	0.510	0.24
33_F	280_D	0.510	0.24
555_A	639_I	0.510	0.24
347_E	629_A	0.510	0.24
25_F	294_T	0.509	0.24
120_L	187_V	0.509	0.24
471_V	640_E	0.509	0.24
586_I	737_Q	0.509	0.24
726_D	730_V	0.508	0.24
370_E	374_E	0.508	0.24
131_S	135_A	0.507	0.24
671_V	688_A	0.506	0.24
489_S	712_R	0.506	0.24
488_T	636_A	0.506	0.24
454_L	645_A	0.505	0.24
31_V	302_A	0.504	0.24
535_A	734_A	0.504	0.24
496_I	696_S	0.503	0.24
491_T	736_E	0.503	0.24
284_A	295_V	0.503	0.24
91_D	95_R	0.502	0.23
579_R	661_S	0.502	0.23
457_L	630_E	0.502	0.23
430_L	528_A	0.501	0.23
555_A	706_T	0.500	0.23
358_M	361_S	0.500	0.23

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3zx6A	2	0.384	100	0.627	Contact Map
1qu7A	2	0.2877	100	0.688	Contact Map
2ch7A	2	0.3916	100	0.699	Contact Map
3g67A	2	0.2649	100	0.758	Contact Map
4i3mA	2	0.1888	99.9	0.861	Contact Map
3c8cA	2	0.2928	99.8	0.884	Contact Map
3lifA	1	0.2915	99.8	0.886	Contact Map
3licA	2	0.2852	99.7	0.89	Contact Map
3lidA	2	0.3029	99.7	0.891	Contact Map
3e4oA	2	0.27	99.7	0.892	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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