GREMLIN Database
Q9HRA0 - ABC transporter (Lipoprotein)
UniProt: Q9HRA0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 322 (285)
Sequences: 3613 (2567)
Seq/√Len: 152.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
301_A306_D4.5811.00
108_F160_H3.7401.00
63_C72_L3.3551.00
300_E304_A3.3451.00
289_D293_D3.2761.00
158_V165_I3.1561.00
253_E257_D3.1131.00
134_R162_A2.9181.00
297_E301_A2.8421.00
112_R298_T2.6131.00
189_Y216_R2.5811.00
172_I203_A2.5251.00
136_V158_V2.5221.00
116_L294_A2.5061.00
47_Q74_S2.5031.00
156_A310_P2.4681.00
15_D19_R2.4671.00
118_T134_R2.4601.00
299_R303_V2.4521.00
135_T166_D2.4241.00
135_T168_L2.4101.00
51_A78_A2.4091.00
27_D249_Y2.3911.00
9_D15_D2.3331.00
23_R249_Y2.1801.00
118_T194_D2.1141.00
143_D148_H2.0771.00
269_G272_T2.0771.00
294_A297_E2.0751.00
288_P291_V2.0711.00
54_S84_F1.9541.00
117_L288_P1.9161.00
54_S79_A1.9061.00
106_G240_M1.9031.00
296_G299_R1.8931.00
22_Q25_R1.8641.00
112_R161_T1.8541.00
296_G300_E1.8521.00
292_T296_G1.8401.00
110_A277_V1.8301.00
139_V207_V1.8291.00
135_T193_A1.7921.00
51_A79_A1.7451.00
23_R27_D1.7221.00
18_N22_Q1.7021.00
293_D297_E1.6971.00
112_R160_H1.6951.00
250_D254_A1.6841.00
101_F247_A1.6821.00
160_H298_T1.6761.00
61_V82_Q1.6751.00
276_S299_R1.6561.00
113_L295_L1.6521.00
103_E149_G1.6231.00
300_E303_V1.6231.00
190_D214_N1.6081.00
174_D177_D1.5891.00
181_A203_A1.5681.00
102_E269_G1.5641.00
155_Q159_T1.5621.00
301_A307_I1.5601.00
289_D292_T1.5591.00
151_H155_Q1.5521.00
110_A219_I1.5361.00
270_L303_V1.5171.00
24_A252_I1.5141.00
117_L291_V1.5051.00
22_Q26_L1.4861.00
115_A165_I1.4621.00
182_R213_A1.4451.00
115_A118_T1.4381.00
182_R186_A1.4271.00
168_L193_A1.4261.00
178_V203_A1.4201.00
24_A28_H1.3901.00
185_A196_V1.3881.00
220_G225_Q1.3661.00
28_H249_Y1.3621.00
294_A298_T1.3381.00
254_A259_D1.3201.00
189_Y211_A1.3191.00
301_A304_A1.2911.00
273_N276_S1.2761.00
91_V98_S1.2761.00
102_E105_T1.2621.00
35_H53_S1.2421.00
293_D296_G1.2381.00
182_R209_Q1.2331.00
186_A190_D1.2161.00
28_H253_E1.2021.00
140_G147_T1.1891.00
243_R246_T1.1861.00
50_L63_C1.1861.00
109_Q299_R1.1811.00
17_A248_V1.1791.00
8_L34_N1.1791.00
69_A89_T1.1721.00
110_A240_M1.1711.00
105_T271_A1.1681.00
77_A93_A1.1681.00
108_F298_T1.1671.00
23_R245_D1.1431.00
118_T195_I1.1431.00
51_A75_A1.1311.00
208_L236_V1.1301.00
172_I184_A1.1251.00
47_Q51_A1.1200.99
115_A161_T1.1190.99
73_E77_A1.1170.99
60_L252_I1.1130.99
106_G275_V1.1080.99
118_T158_V1.0940.99
19_R22_Q1.0900.99
113_L238_A1.0890.99
118_T133_A1.0850.99
97_A260_L1.0840.99
135_T192_G1.0830.99
109_Q295_L1.0800.99
170_A188_M1.0780.99
51_A55_N1.0760.99
133_A194_D1.0650.99
116_L291_V1.0570.99
25_R31_A1.0540.99
183_T186_A1.0500.99
298_T301_A1.0490.99
249_Y253_E1.0460.99
76_A93_A1.0450.99
57_A82_Q1.0370.99
207_V218_A1.0300.99
215_G235_V1.0300.99
53_S58_Y1.0290.99
33_T58_Y1.0260.99
113_L287_I1.0210.99
250_D253_E1.0130.99
137_G193_A1.0090.99
27_D253_E1.0050.99
137_G188_M1.0020.99
186_A210_A1.0010.99
50_L75_A1.0000.99
37_P49_T0.9980.99
8_L18_N0.9930.99
217_Y237_L0.9850.99
97_A266_V0.9850.99
93_A96_V0.9840.99
238_A278_Q0.9820.99
238_A279_Y0.9800.99
177_D180_A0.9780.99
64_V87_V0.9640.98
54_S82_Q0.9600.98
18_N34_N0.9570.98
243_R276_S0.9570.98
246_T250_D0.9540.98
51_A54_S0.9500.98
212_Q234_D0.9470.98
189_Y196_V0.9440.98
210_A213_A0.9420.98
39_S42_E0.9390.98
112_R294_A0.9380.98
218_A235_V0.9350.98
208_L218_A0.9340.98
47_Q75_A0.9330.98
102_E267_S0.9320.98
86_I89_T0.9320.98
284_G292_T0.9280.98
217_Y286_A0.9280.98
170_A184_A0.9270.98
241_V276_S0.9270.98
195_I219_I0.9220.98
172_I181_A0.9140.98
186_A214_N0.9100.98
162_A165_I0.9070.98
83_Q260_L0.9060.98
155_Q167_V0.9060.98
37_P40_I0.9050.98
92_D98_S0.8990.98
20_G245_D0.8950.98
107_S150_F0.8940.98
69_A73_E0.8930.97
60_L255_T0.8860.97
168_L191_A0.8850.97
60_L85_M0.8850.97
197_Y240_M0.8780.97
180_A183_T0.8750.97
117_L237_L0.8740.97
112_R116_L0.8730.97
59_D82_Q0.8730.97
158_V167_V0.8720.97
62_C85_M0.8660.97
298_T307_I0.8580.97
50_L72_L0.8510.97
133_A192_G0.8480.97
208_L235_V0.8470.97
297_E300_E0.8460.97
300_E306_D0.8440.96
70_D73_E0.8380.96
220_G239_S0.8370.96
55_N79_A0.8370.96
25_R32_Y0.8310.96
73_E96_V0.8310.96
102_E272_T0.8280.96
188_M193_A0.8200.96
211_A218_A0.8180.96
85_M99_Y0.8170.96
226_S278_Q0.8150.96
73_E93_A0.8150.96
210_A214_N0.8140.96
83_Q255_T0.8120.96
37_P42_E0.8000.95
107_S240_M0.8000.95
268_L272_T0.7970.95
117_L195_I0.7950.95
254_A257_D0.7940.95
114_A219_I0.7900.95
218_A236_V0.7900.95
155_Q169_A0.7860.95
273_N303_V0.7810.95
54_S75_A0.7750.94
283_L286_A0.7740.94
115_A162_A0.7730.94
134_R194_D0.7730.94
290_A293_D0.7730.94
253_E256_I0.7710.94
72_L96_V0.7710.94
151_H169_A0.7630.94
21_A25_R0.7600.94
21_A32_Y0.7600.94
6_G14_N0.7590.94
138_F151_H0.7590.94
297_E306_D0.7580.94
113_L219_I0.7580.94
112_R158_V0.7570.94
302_L307_I0.7450.93
23_R246_T0.7390.93
8_L15_D0.7380.93
222_D242_K0.7370.93
101_F242_K0.7370.93
138_F199_A0.7360.93
11_R228_S0.7360.93
150_F199_A0.7350.93
290_A294_A0.7320.92
87_V244_I0.7270.92
17_A244_I0.7260.92
183_T187_A0.7190.92
50_L54_S0.7180.92
50_L68_Q0.7180.92
81_D94_S0.7170.92
88_D242_K0.7160.92
179_E182_R0.7120.91
115_A134_R0.7100.91
116_L161_T0.7080.91
195_I237_L0.7080.91
5_L176_E0.7080.91
24_A249_Y0.7030.91
20_G24_A0.7020.91
19_R223_S0.7020.91
118_T165_I0.7010.91
180_A184_A0.7000.91
134_R164_D0.7000.91
24_A32_Y0.6980.91
150_F221_V0.6980.91
119_T133_A0.6970.91
224_D279_Y0.6970.91
97_A251_A0.6950.90
141_G201_G0.6910.90
28_H256_I0.6900.90
209_Q212_Q0.6870.90
185_A189_Y0.6860.90
241_V278_Q0.6850.90
105_T269_G0.6820.90
219_I238_A0.6820.90
150_F222_D0.6820.90
16_A245_D0.6800.89
199_A221_V0.6790.89
99_Y251_A0.6780.89
55_N78_A0.6730.89
103_E240_M0.6680.89
160_H163_S0.6670.89
221_V242_K0.6650.88
34_N38_D0.6650.88
139_V185_A0.6650.88
251_A254_A0.6640.88
108_F157_G0.6630.88
113_L117_L0.6600.88
186_A213_A0.6590.88
151_H171_Y0.6580.88
40_I67_R0.6560.88
143_D173_G0.6520.87
270_L302_L0.6520.87
62_C252_I0.6510.87
107_S197_Y0.6490.87
287_I291_V0.6490.87
261_P264_D0.6490.87
18_N32_Y0.6490.87
146_L149_G0.6480.87
107_S199_A0.6470.87
69_A91_V0.6470.87
24_A30_I0.6460.87
103_E242_K0.6460.87
159_T163_S0.6460.87
157_G160_H0.6450.87
18_N21_A0.6450.87
69_A86_I0.6410.87
75_A78_A0.6410.87
104_Q309_V0.6410.87
140_G171_Y0.6410.87
198_H207_V0.6390.86
99_Y268_L0.6390.86
277_V295_L0.6390.86
236_V239_S0.6370.86
208_L229_N0.6370.86
156_A159_T0.6340.86
140_G151_H0.6320.86
23_R26_L0.6310.86
119_T164_D0.6300.86
109_Q270_L0.6290.86
46_T68_Q0.6280.85
74_S78_A0.6280.85
229_N235_V0.6280.85
42_E48_A0.6230.85
184_A188_M0.6230.85
287_I292_T0.6230.85
212_Q235_V0.6220.85
85_M251_A0.6210.85
58_Y82_Q0.6210.85
90_A100_V0.6210.85
17_A64_V0.6190.85
246_T249_Y0.6190.85
26_L81_D0.6190.85
108_F112_R0.6180.84
255_T260_L0.6160.84
273_N299_R0.6160.84
206_G210_A0.6150.84
25_R28_H0.6140.84
112_R295_L0.6130.84
92_D264_D0.6120.84
291_V295_L0.6100.84
38_D42_E0.6090.84
226_S234_D0.6070.83
110_A238_A0.6060.83
270_L299_R0.6040.83
104_Q149_G0.6030.83
47_Q71_G0.6030.83
250_D272_T0.6030.83
117_L217_Y0.6020.83
284_G287_I0.6010.83
52_A56_P0.6010.83
64_V99_Y0.5970.82
90_A98_S0.5930.82
25_R30_I0.5920.82
224_D278_Q0.5920.82
269_G274_G0.5910.82
200_A206_G0.5900.82
181_A206_G0.5880.81
36_E42_E0.5880.81
189_Y210_A0.5840.81
234_D285_P0.5810.81
254_A266_V0.5800.81
98_S264_D0.5800.81
250_D268_L0.5800.81
283_L287_I0.5760.80
181_A204_G0.5740.80
6_G10_D0.5740.80
160_H301_A0.5730.80
30_I252_I0.5730.80
97_A261_P0.5710.80
211_A216_R0.5710.80
254_A261_P0.5690.79
19_R245_D0.5670.79
86_I91_V0.5670.79
37_P41_A0.5660.79
117_L287_I0.5660.79
204_G221_V0.5630.79
200_A204_G0.5620.79
152_A312_E0.5620.79
113_L116_L0.5600.78
283_L292_T0.5600.78
148_H171_Y0.5580.78
227_R234_D0.5570.78
5_L67_R0.5550.78
119_T217_Y0.5540.78
154_F197_Y0.5520.77
107_S146_L0.5510.77
139_V198_H0.5510.77
100_V267_S0.5480.77
84_F95_N0.5470.77
113_L291_V0.5470.77
138_F147_T0.5460.77
83_Q97_A0.5450.76
154_F157_G0.5450.76
34_N37_P0.5450.76
24_A256_I0.5440.76
136_V165_I0.5440.76
135_T191_A0.5430.76
146_L197_Y0.5420.76
142_V175_F0.5390.76
97_A254_A0.5390.76
136_V154_F0.5380.75
16_A19_R0.5380.75
137_G185_A0.5360.75
66_F175_F0.5350.75
156_A160_H0.5350.75
225_Q228_S0.5350.75
189_Y214_N0.5340.75
161_T165_I0.5320.75
168_L188_M0.5260.74
152_A156_A0.5250.74
150_F242_K0.5230.73
291_V294_A0.5230.73
87_V248_V0.5220.73
74_S77_A0.5210.73
285_P289_D0.5200.73
246_T274_G0.5200.73
247_A274_G0.5180.73
202_G205_V0.5170.73
19_R23_R0.5150.72
200_A203_A0.5130.72
61_V84_F0.5130.72
33_T56_P0.5110.72
63_C68_Q0.5100.72
60_L83_Q0.5080.71
59_D81_D0.5070.71
75_A84_F0.5060.71
32_Y39_S0.5060.71
234_D286_A0.5020.70
53_S61_V0.5020.70
226_S283_L0.5020.70
224_D239_S0.5010.70
182_R210_A0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3s99A 1 0.9193 100 0.37 Contact Map
4pevA 1 0.9627 100 0.39 Contact Map
4iilA 1 0.9286 100 0.432 Contact Map
2fqxA 1 0.9286 100 0.433 Contact Map
4p98A 1 0.9006 100 0.436 Contact Map
2hqbA 1 0.8634 100 0.468 Contact Map
4ycsA 1 0.3571 100 0.616 Contact Map
4wzzA 1 0.8571 99.6 0.773 Contact Map
4pe6A 1 0.8789 99.5 0.788 Contact Map
5braA 1 0.8354 99.4 0.804 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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