GREMLIN Database
Q9HR99 - Halocyanin-like
UniProt: Q9HR99 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 157 (131)
Sequences: 416 (359)
Seq/√Len: 31.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_L17_C4.1361.00
78_V131_F3.4361.00
91_A110_T3.1131.00
111_M127_L2.5451.00
73_S156_E2.5391.00
59_P62_G2.5050.99
88_N143_P2.4660.99
131_F153_V2.4470.99
87_H141_C2.3280.99
14_L19_G2.1890.99
91_A111_M2.1650.98
87_H144_H2.1610.98
136_E156_E2.1090.98
71_T156_E1.9750.97
80_W153_V1.9400.97
143_P148_G1.9090.97
34_E41_A1.8710.96
54_T81_E1.8610.96
80_W139_Y1.8540.96
82_F88_N1.7830.95
82_F125_E1.7390.94
17_C20_G1.7280.94
49_Q73_S1.6850.93
78_V139_Y1.6250.92
33_G37_T1.6150.92
38_G42_G1.5840.91
63_F85_S1.5010.88
59_P64_K1.4500.86
55_I58_A1.4380.86
69_E154_V1.3960.84
34_E38_G1.3630.83
72_V131_F1.3560.82
57_V82_F1.3520.82
80_W131_F1.3180.81
23_T27_E1.3020.80
83_E133_T1.2880.79
72_V153_V1.2870.79
47_A50_S1.2510.77
34_E40_E1.2460.77
17_C21_G1.2080.74
19_G24_G1.1810.73
102_P133_T1.1620.71
16_G20_G1.1490.71
90_S142_M1.1260.69
127_L131_F1.1220.69
22_D65_F1.1200.69
77_T128_E1.1190.69
140_V153_V1.1100.68
129_H132_E1.1040.67
90_S112_D1.0960.67
134_A156_E1.0910.67
71_T154_V1.0820.66
20_G28_S1.0760.65
112_D119_A1.0710.65
103_D110_T1.0590.64
40_E44_G1.0520.64
80_W127_L1.0500.64
34_E42_G1.0480.63
102_P111_M1.0470.63
140_V146_A1.0420.63
32_S41_A1.0380.63
14_L20_G1.0380.63
35_E41_A1.0130.61
70_L80_W1.0070.60
61_G104_G1.0060.60
91_A148_G1.0040.60
9_V23_T0.9980.60
44_G47_A0.9960.59
21_G25_D0.9920.59
38_G43_G0.9900.59
80_W129_H0.9860.59
26_D30_S0.9740.58
37_T40_E0.9580.56
118_F121_V0.9570.56
65_F122_D0.9550.56
21_G26_D0.9500.56
59_P154_V0.9480.56
27_E31_E0.9450.55
111_M137_Y0.9370.55
20_G29_D0.9290.54
63_F147_S0.9220.53
28_S31_E0.9170.53
38_G41_A0.8710.49
17_C22_D0.8430.47
13_L16_G0.8430.47
23_T31_E0.8350.46
141_C144_H0.8350.46
88_N148_G0.8340.46
45_E48_S0.8310.46
90_S145_V0.8300.46
55_I80_W0.8270.46
62_G122_D0.8250.46
7_A12_T0.8210.45
23_T30_S0.8090.44
40_E46_E0.8020.44
13_L54_T0.8000.44
36_A47_A0.7970.43
72_V149_M0.7930.43
137_Y140_V0.7880.43
88_N119_A0.7860.42
7_A10_T0.7830.42
26_D47_A0.7790.42
10_T38_G0.7740.42
74_V134_A0.7720.41
122_D125_E0.7670.41
75_G139_Y0.7660.41
25_D30_S0.7640.41
54_T58_A0.7620.41
7_A13_L0.7620.41
86_S122_D0.7600.40
70_L153_V0.7590.40
48_S71_T0.7540.40
21_G31_E0.7540.40
55_I70_L0.7510.40
44_G48_S0.7500.40
35_E40_E0.7500.40
71_T136_E0.7480.39
18_S26_D0.7440.39
121_V125_E0.7440.39
33_G36_A0.7420.39
46_E49_Q0.7410.39
123_A128_E0.7410.39
66_E138_T0.7380.39
53_N58_A0.7360.39
85_S121_V0.7300.38
82_F118_F0.7250.38
33_G38_G0.7250.38
125_E146_A0.7120.37
51_G128_E0.6960.36
91_A129_H0.6960.36
57_V89_V0.6940.35
90_S119_A0.6940.35
104_G124_G0.6930.35
58_A88_N0.6920.35
22_D28_S0.6890.35
92_W111_M0.6870.35
30_S78_V0.6770.34
19_G23_T0.6730.34
59_P63_F0.6710.34
21_G24_G0.6700.34
92_W145_V0.6700.34
71_T134_A0.6660.33
32_S37_T0.6620.33
17_C26_D0.6610.33
34_E37_T0.6600.33
16_G23_T0.6550.33
31_E37_T0.6540.32
65_F79_T0.6510.32
79_T125_E0.6470.32
138_T152_T0.6430.32
85_S123_A0.6420.32
104_G133_T0.6410.32
40_E48_S0.6410.32
80_W91_A0.6340.31
112_D118_F0.6340.31
80_W84_E0.6320.31
72_V89_V0.6300.31
42_G48_S0.6280.31
67_P143_P0.6250.30
74_V156_E0.6220.30
84_E148_G0.6200.30
63_F76_D0.6110.29
10_T17_C0.6100.29
36_A45_E0.6040.29
70_L136_E0.5970.29
112_D122_D0.5860.28
57_V84_E0.5810.28
129_H137_Y0.5800.27
102_P110_T0.5800.27
14_L23_T0.5680.27
61_G147_S0.5660.27
16_G19_G0.5640.26
43_G62_G0.5550.26
145_V150_I0.5540.26
9_V14_L0.5530.26
15_A19_G0.5530.26
63_F143_P0.5460.25
60_D65_F0.5460.25
131_F139_Y0.5390.25
55_I143_P0.5350.25
84_E145_V0.5300.24
31_E44_G0.5290.24
59_P147_S0.5260.24
80_W111_M0.5220.24
43_G128_E0.5190.24
36_A41_A0.5170.24
88_N150_I0.5150.23
7_A30_S0.5080.23
68_S80_W0.5050.23
13_L18_S0.5040.23
53_N57_V0.5030.23
25_D31_E0.5030.23
58_A153_V0.5030.23
55_I151_G0.5010.23
55_I60_D0.5000.23
63_F154_V0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c75A 1 0.6688 99.9 0.499 Contact Map
3ef4A 1 0.5796 99.8 0.531 Contact Map
1iuzA 1 0.6115 99.8 0.537 Contact Map
3erxA 3 0.5796 99.8 0.54 Contact Map
1kdjA 1 0.6051 99.8 0.54 Contact Map
1pazA 1 0.5796 99.8 0.54 Contact Map
1pmyA 1 0.5796 99.8 0.541 Contact Map
1bypA 1 0.6115 99.8 0.541 Contact Map
2ux6A 1 0.5669 99.8 0.542 Contact Map
2pltA 1 0.6115 99.8 0.543 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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