GREMLIN Database
Q9HR98 - Cystathionine gamma-synthase
UniProt: Q9HR98 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 405 (379)
Sequences: 10593 (5876)
Seq/√Len: 301.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
197_Q200_A3.4631.00
106_H134_S3.2391.00
145_A179_D3.1021.00
80_G226_V3.0881.00
282_A297_S3.0601.00
79_G200_A2.8991.00
8_E383_A2.8901.00
392_D396_E2.8631.00
275_L279_E2.6911.00
288_T320_D2.6771.00
106_H149_R2.6391.00
6_A383_A2.5131.00
336_F347_S2.5071.00
74_L224_A2.5051.00
171_A306_A2.3741.00
362_K366_E2.3651.00
289_A318_E2.3501.00
171_A175_D2.3301.00
154_F185_G2.3241.00
10_L76_A2.2281.00
280_Y388_I2.2231.00
301_H305_D2.2151.00
195_F271_E2.1401.00
268_R272_A2.1371.00
280_Y392_D2.1231.00
174_A184_F2.0151.00
140_D143_A2.0051.00
168_C173_I1.9841.00
322_D325_D1.9801.00
132_A149_R1.9361.00
249_A252_D1.9331.00
178_D204_D1.9271.00
141_P172_A1.9191.00
351_L354_G1.9081.00
318_E373_S1.9071.00
68_H72_R1.9051.00
8_E264_A1.8961.00
210_T222_G1.8821.00
70_L256_V1.8801.00
277_I388_I1.8761.00
213_Y313_G1.8521.00
105_D153_A1.8421.00
186_V203_A1.8371.00
175_D179_D1.8071.00
269_D272_A1.7891.00
178_D184_F1.7431.00
134_S149_R1.7401.00
7_F194_Y1.7131.00
83_G226_V1.7071.00
102_E128_N1.7071.00
270_H313_G1.7041.00
384_I388_I1.6911.00
142_D145_A1.6881.00
362_K372_D1.6761.00
365_R372_D1.6681.00
273_N384_I1.6681.00
276_A384_I1.6391.00
67_R253_A1.6251.00
279_E296_D1.6191.00
78_E208_H1.6041.00
276_A388_I1.6031.00
106_H132_A1.6001.00
184_F203_A1.5961.00
155_V173_I1.5881.00
333_L349_V1.5801.00
318_E371_T1.5731.00
109_A121_L1.5701.00
197_Q309_S1.5651.00
80_G199_L1.5631.00
276_A279_E1.5621.00
332_A397_A1.5581.00
57_F63_N1.5541.00
136_V147_A1.5531.00
328_R332_A1.5381.00
141_P176_I1.5361.00
145_A180_A1.5201.00
155_V177_T1.5161.00
319_L329_F1.5051.00
106_H152_T1.4831.00
361_P364_D1.4621.00
288_T373_S1.4521.00
334_D393_R1.4451.00
323_L327_K1.4441.00
106_H151_E1.4401.00
190_F342_V1.4321.00
222_G248_L1.4311.00
6_A385_E1.4301.00
277_I379_V1.4211.00
280_Y284_H1.4191.00
276_A385_E1.4181.00
14_H76_A1.4131.00
210_T256_V1.4111.00
75_A83_G1.4081.00
32_L251_F1.3941.00
70_L85_A1.3871.00
171_A307_Q1.3851.00
82_H233_A1.3831.00
323_L372_D1.3821.00
336_F391_L1.3761.00
172_A175_D1.3741.00
83_G224_A1.3731.00
288_T318_E1.3701.00
148_I155_V1.3611.00
210_T224_A1.3591.00
296_D301_H1.3591.00
93_I156_W1.3471.00
148_I182_V1.3461.00
6_A389_A1.3451.00
57_F68_H1.3351.00
70_L224_A1.3341.00
265_P381_I1.3331.00
28_S69_A1.3231.00
174_A178_D1.3191.00
248_L253_A1.3181.00
199_L228_N1.3181.00
267_M270_H1.3121.00
284_H392_D1.3091.00
227_T233_A1.3081.00
84_F233_A1.3071.00
277_I391_L1.3071.00
97_A154_F1.3061.00
157_M170_I1.2851.00
169_D172_A1.2841.00
109_A113_L1.2771.00
132_A151_E1.2751.00
102_E105_D1.2711.00
142_D146_D1.2701.00
157_M184_F1.2651.00
86_F225_L1.2551.00
336_F387_L1.2441.00
148_I176_I1.2421.00
349_V375_I1.2401.00
196_Q201_L1.2371.00
174_A203_A1.2341.00
273_N381_I1.2291.00
377_V391_L1.2251.00
183_L232_L1.2161.00
225_L236_V1.2151.00
101_V107_V1.2141.00
40_E331_D1.2131.00
74_L226_V1.2131.00
305_D311_Y1.2121.00
185_G207_A1.2091.00
230_D234_D1.2061.00
335_E387_L1.2031.00
220_A256_V1.1911.00
277_I387_L1.1901.00
278_A295_L1.1801.00
171_A201_L1.1771.00
274_A278_A1.1761.00
316_S374_L1.1751.00
301_H311_Y1.1741.00
91_A246_N1.1721.00
37_A337_N1.1701.00
271_E310_G1.1651.00
294_G311_Y1.1581.00
214_L260_I1.1581.00
165_I293_P1.1551.00
7_F197_Q1.1491.00
282_A295_L1.1461.00
210_T214_L1.1421.00
122_E135_F1.1381.00
269_D273_N1.1371.00
111_D166_K1.1361.00
96_A185_G1.1351.00
215_N220_A1.1321.00
302_D305_D1.1281.00
42_D331_D1.1261.00
84_F237_E1.1251.00
264_A268_R1.1241.00
345_V381_I1.1191.00
11_A264_A1.1181.00
175_D178_D1.1121.00
144_V173_I1.1051.00
108_V147_A1.1041.00
121_L133_V1.1041.00
300_Q303_L1.0991.00
177_T184_F1.0921.00
304_A311_Y1.0881.00
220_A252_D1.0881.00
165_I315_L1.0811.00
279_E282_A1.0751.00
219_D258_R1.0731.00
86_F95_T1.0661.00
74_L214_L1.0631.00
222_G256_V1.0601.00
42_D327_K1.0601.00
148_I180_A1.0581.00
272_A276_A1.0561.00
81_D230_D1.0551.00
155_V182_V1.0551.00
68_H71_E1.0511.00
82_H237_E1.0471.00
145_A176_I1.0421.00
277_I384_I1.0361.00
95_T246_N1.0351.00
278_A290_V1.0341.00
26_V337_N1.0301.00
207_A225_L1.0291.00
143_A146_D1.0281.00
73_R257_L1.0221.00
388_I392_D1.0201.00
41_L331_D1.0141.00
97_A101_V1.0121.00
94_A98_F1.0091.00
195_F310_G1.0051.00
302_D306_A0.9991.00
170_I203_A0.9941.00
364_D367_A0.9931.00
101_V105_D0.9931.00
84_F236_V0.9911.00
73_R260_I0.9891.00
389_A392_D0.9891.00
265_P269_D0.9841.00
81_D229_N0.9831.00
139_T300_Q0.9821.00
298_H301_H0.9801.00
94_A120_M0.9791.00
157_M186_V0.9771.00
329_F375_I0.9691.00
88_S221_V0.9661.00
301_H304_A0.9661.00
93_I207_A0.9631.00
329_F349_V0.9631.00
329_F391_L0.9581.00
218_S344_G0.9571.00
324_A328_R0.9551.00
251_F255_L0.9531.00
62_L241_Q0.9531.00
12_V381_I0.9531.00
280_Y395_F0.9521.00
291_H318_E0.9451.00
134_S147_A0.9411.00
215_N256_V0.9411.00
271_E275_L0.9371.00
122_E126_E0.9361.00
193_P208_H0.9351.00
118_R122_E0.9331.00
199_L206_V0.9331.00
156_W185_G0.9331.00
390_D393_R0.9321.00
325_D373_S0.9271.00
67_R248_L0.9271.00
317_F377_V0.9241.00
205_V227_T0.9231.00
137_D143_A0.9221.00
79_G197_Q0.9201.00
90_T93_I0.9191.00
191_L308_Q0.9171.00
264_A269_D0.9141.00
109_A135_F0.9101.00
190_F314_I0.9071.00
170_I174_A0.9051.00
112_D166_K0.9051.00
194_Y268_R0.9041.00
30_I251_F0.9041.00
157_M168_C0.9031.00
82_H230_D0.9001.00
138_A144_V0.8961.00
281_L317_F0.8941.00
109_A133_V0.8931.00
85_A224_A0.8921.00
17_S72_R0.8911.00
24_G39_Q0.8901.00
277_I377_V0.8891.00
286_R320_D0.8801.00
330_L349_V0.8801.00
261_K346_E0.8791.00
353_A365_R0.8761.00
336_F377_V0.8751.00
81_D227_T0.8721.00
211_T221_V0.8701.00
279_E295_L0.8691.00
284_H395_F0.8671.00
177_T182_V0.8651.00
274_A292_Y0.8641.00
97_A121_L0.8641.00
160_P196_Q0.8561.00
322_D373_S0.8561.00
60_S67_R0.8561.00
167_L300_Q0.8521.00
286_R395_F0.8521.00
385_E389_A0.8521.00
157_M173_I0.8481.00
67_R85_A0.8461.00
289_A373_S0.8461.00
154_F183_L0.8451.00
100_A232_L0.8451.00
393_R397_A0.8421.00
173_I184_F0.8411.00
170_I196_Q0.8401.00
96_A205_V0.8401.00
19_R23_H0.8391.00
196_Q307_Q0.8371.00
170_I201_L0.8311.00
210_T248_L0.8281.00
275_L310_G0.8221.00
101_V154_F0.8201.00
8_E269_D0.8191.00
156_W207_A0.8191.00
108_V136_V0.8161.00
28_S257_L0.8161.00
336_F349_V0.8151.00
327_K331_D0.8151.00
205_V232_L0.8121.00
321_G325_D0.8111.00
86_F91_A0.8091.00
332_A394_G0.8061.00
10_L14_H0.8061.00
273_N277_I0.8041.00
101_V131_V0.8041.00
194_Y267_M0.8041.00
30_I254_Y0.8031.00
94_A244_L0.8021.00
141_P145_A0.8001.00
176_I180_A0.7991.00
167_L303_L0.7951.00
96_A225_L0.7931.00
81_D228_N0.7870.99
275_L292_Y0.7870.99
205_V225_L0.7850.99
86_F240_Q0.7850.99
284_H396_E0.7840.99
315_L377_V0.7800.99
264_A383_A0.7780.99
275_L282_A0.7780.99
322_D326_A0.7700.99
214_L256_V0.7690.99
280_Y391_L0.7680.99
107_V154_F0.7680.99
138_A168_C0.7660.99
128_N235_S0.7640.99
82_H229_N0.7590.99
160_P307_Q0.7590.99
82_H227_T0.7580.99
102_E153_A0.7580.99
336_F379_V0.7560.99
204_D228_N0.7560.99
208_H226_V0.7540.99
99_A236_V0.7530.99
324_A327_K0.7510.99
276_A280_Y0.7500.99
329_F333_L0.7490.99
107_V121_L0.7470.99
385_E388_I0.7420.99
272_A384_I0.7370.99
9_T335_E0.7360.99
273_N379_V0.7360.99
279_E283_D0.7360.99
362_K365_R0.7350.99
7_F10_L0.7290.99
248_L256_V0.7290.99
330_L375_I0.7280.99
347_S377_V0.7270.99
126_E132_A0.7260.99
70_L210_T0.7260.99
70_L214_L0.7210.99
71_E237_E0.7210.99
178_D182_V0.7190.99
291_H298_H0.7180.99
105_D151_E0.7180.99
325_D328_R0.7150.99
25_D31_H0.7130.99
271_E313_G0.7110.99
101_V153_A0.7090.99
136_V143_A0.7090.99
235_S239_L0.7090.99
87_G246_N0.7070.99
141_P144_V0.7060.99
292_Y315_L0.7030.99
74_L85_A0.7020.99
108_V152_T0.6990.99
195_F267_M0.6960.99
201_L307_Q0.6960.99
32_L220_A0.6910.99
146_D150_P0.6900.99
117_T156_W0.6890.99
86_F246_N0.6880.99
231_A235_S0.6870.99
255_L258_R0.6850.99
58_L62_L0.6840.99
123_T238_F0.6820.99
78_E206_V0.6820.99
286_R325_D0.6810.99
214_L263_L0.6800.98
106_H150_P0.6800.98
169_D306_A0.6790.98
134_S151_E0.6790.98
161_T166_K0.6770.98
32_L254_Y0.6760.98
251_F254_Y0.6750.98
74_L210_T0.6750.98
143_A147_A0.6740.98
188_N208_H0.6720.98
195_F309_S0.6720.98
277_I280_Y0.6710.98
161_T164_R0.6680.98
317_F375_I0.6670.98
7_F11_A0.6660.98
100_A185_G0.6640.98
27_V254_Y0.6640.98
394_G397_A0.6630.98
308_Q311_Y0.6630.98
287_V317_F0.6610.98
166_K300_Q0.6610.98
98_F129_L0.6590.98
155_V178_D0.6590.98
167_L304_A0.6570.98
85_A248_L0.6560.98
170_I184_F0.6560.98
389_A393_R0.6550.98
188_N198_P0.6550.98
185_G205_V0.6540.98
84_F225_L0.6540.98
286_R396_E0.6530.98
121_L156_W0.6510.98
35_T341_S0.6510.98
287_V395_F0.6470.98
275_L294_G0.6440.98
167_L298_H0.6430.98
272_A310_G0.6410.98
391_L395_F0.6400.98
363_P367_A0.6370.98
140_D146_D0.6350.98
88_S247_M0.6340.98
271_E311_Y0.6330.98
291_H316_S0.6320.98
145_A172_A0.6310.98
286_R319_L0.6300.98
172_A176_I0.6300.98
329_F395_F0.6290.98
81_D233_A0.6260.97
159_T188_N0.6230.97
19_R31_H0.6230.97
63_N68_H0.6220.97
144_V155_V0.6220.97
53_D56_Q0.6220.97
71_E85_A0.6210.97
103_P130_G0.6190.97
188_N191_L0.6170.97
87_G247_M0.6140.97
221_V247_M0.6140.97
107_V133_V0.6110.97
278_A315_L0.6100.97
328_R331_D0.6090.97
353_A372_D0.6090.97
349_V377_V0.6080.97
112_D161_T0.6080.97
96_A100_A0.6070.97
155_V176_I0.6050.97
148_I152_T0.6040.97
191_L304_A0.6040.97
72_R76_A0.6000.97
193_P214_L0.6000.97
270_H273_N0.5990.97
366_E371_T0.5980.97
10_L79_G0.5960.97
332_A393_R0.5950.97
220_A259_G0.5940.97
136_V144_V0.5930.96
213_Y314_I0.5920.96
248_L252_D0.5910.96
329_F394_G0.5910.96
110_F138_A0.5900.96
318_E374_L0.5900.96
93_I117_T0.5890.96
283_D392_D0.5860.96
303_L306_A0.5860.96
294_G301_H0.5850.96
347_S387_L0.5830.96
333_L336_F0.5820.96
69_A257_L0.5820.96
340_V350_E0.5810.96
68_H82_H0.5790.96
70_L257_L0.5790.96
20_E23_H0.5790.96
261_K345_V0.5790.96
275_L295_L0.5770.96
7_F264_A0.5760.96
95_T225_L0.5760.96
171_A200_A0.5740.96
139_T166_K0.5740.96
35_T339_A0.5740.96
122_E364_D0.5720.96
128_N239_L0.5710.96
32_L249_A0.5710.96
303_L307_Q0.5710.96
278_A294_G0.5710.96
347_S391_L0.5700.96
208_H224_A0.5700.96
349_V391_L0.5680.95
71_E83_G0.5680.95
6_A10_L0.5680.95
149_R152_T0.5680.95
328_R397_A0.5670.95
229_N234_D0.5660.95
111_D137_D0.5660.95
282_A298_H0.5650.95
334_D397_A0.5650.95
33_A36_Y0.5650.95
233_A237_E0.5620.95
23_H31_H0.5610.95
314_I342_V0.5600.95
160_P191_L0.5600.95
227_T232_L0.5580.95
234_D238_F0.5570.95
319_L395_F0.5560.95
170_I186_V0.5550.95
360_I364_D0.5540.95
350_E355_M0.5540.95
108_V138_A0.5530.95
118_R135_F0.5530.95
100_A235_S0.5510.95
217_H258_R0.5500.95
96_A207_A0.5500.95
295_L301_H0.5500.95
39_Q55_G0.5480.95
96_A232_L0.5480.95
95_T240_Q0.5470.94
326_A373_S0.5450.94
13_S337_N0.5450.94
320_D325_D0.5440.94
66_T257_L0.5440.94
159_T196_Q0.5440.94
26_V37_A0.5430.94
124_L243_G0.5430.94
228_N231_A0.5420.94
23_H57_F0.5400.94
108_V134_S0.5400.94
124_L239_L0.5390.94
360_I368_M0.5380.94
366_E372_D0.5360.94
177_T180_A0.5360.94
327_K354_G0.5290.93
42_D53_D0.5280.93
108_V155_V0.5270.93
119_R123_T0.5270.93
115_A357_H0.5270.93
19_R25_D0.5270.93
268_R271_E0.5240.93
288_T319_L0.5230.93
339_A348_L0.5230.93
363_P366_E0.5230.93
124_L244_L0.5220.93
191_L196_Q0.5200.93
273_N276_A0.5170.93
304_A308_Q0.5160.93
111_D367_A0.5150.93
361_P365_R0.5140.92
165_I316_S0.5130.92
176_I179_D0.5120.92
64_N67_R0.5120.92
70_L260_I0.5110.92
75_A82_H0.5100.92
72_R75_A0.5100.92
41_L327_K0.5100.92
282_A296_D0.5090.92
19_R24_G0.5070.92
137_D140_D0.5060.92
213_Y270_H0.5060.92
271_E274_A0.5050.92
96_A239_L0.5030.92
292_Y311_Y0.5020.92
275_L278_A0.5020.92
34_S221_V0.5010.92
125_F131_V0.5010.92
168_C303_L0.5010.92
331_D338_L0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ibjA 4 0.9383 100 0.391 Contact Map
1qgnA 4 0.9679 100 0.4 Contact Map
3ri6A 4 0.8222 100 0.422 Contact Map
3cogA 4 0.9605 100 0.426 Contact Map
4iy7A 4 0.9407 100 0.437 Contact Map
4kamA 4 0.8864 100 0.439 Contact Map
4itxA 4 0.9556 100 0.455 Contact Map
1e5eA 4 0.9654 100 0.459 Contact Map
3ndnA 4 0.958 100 0.48 Contact Map
4oc9A 5 0.9556 100 0.488 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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