GREMLIN Database
Q9HR95 - Uncharacterized protein
UniProt: Q9HR95 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 198 (178)
Sequences: 34966 (26139)
Seq/√Len: 1959.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
106_I123_F3.6341.00
102_R126_E3.0481.00
190_D193_T2.8531.00
115_Q118_D2.6141.00
15_R18_P2.4401.00
180_L184_W2.4351.00
135_G168_V2.3781.00
110_R116_P2.2871.00
184_W188_R2.2851.00
127_A179_G2.1311.00
160_L163_W2.0691.00
120_A184_W2.0581.00
36_L142_G2.0151.00
138_G142_G1.9941.00
109_M114_A1.9001.00
25_A29_A1.8561.00
131_G175_G1.8561.00
10_G125_V1.8181.00
29_A137_G1.7781.00
109_M122_L1.7731.00
43_A46_D1.7051.00
161_V165_S1.6651.00
116_P187_A1.6601.00
144_L147_A1.6241.00
118_D121_H1.5851.00
121_H125_V1.5751.00
114_A118_D1.5651.00
102_R105_E1.5561.00
162_E166_G1.5481.00
13_A126_E1.5441.00
144_L148_A1.5421.00
49_L60_A1.5301.00
134_G138_G1.5171.00
33_G141_G1.5171.00
25_A134_G1.4571.00
43_A47_T1.4531.00
147_A151_A1.4411.00
12_R15_R1.4151.00
29_A33_G1.3991.00
131_G135_G1.3851.00
74_V78_M1.3771.00
29_A32_T1.3741.00
117_A121_H1.3711.00
178_A182_P1.3621.00
165_S169_A1.3601.00
14_I21_S1.3441.00
77_A81_V1.3401.00
47_T158_V1.3191.00
140_V144_L1.3181.00
162_E165_S1.3151.00
103_A189_T1.3031.00
29_A141_G1.2971.00
142_G146_T1.2971.00
107_A194_A1.2841.00
33_G145_A1.2681.00
136_V140_V1.2551.00
17_H101_E1.2401.00
70_V74_V1.2381.00
137_G140_V1.2351.00
83_G90_A1.2261.00
158_V161_V1.2261.00
183_A187_A1.2201.00
20_R101_E1.2181.00
44_G47_T1.2161.00
148_A151_A1.2151.00
88_A174_L1.2011.00
185_R189_T1.1901.00
105_E109_M1.1881.00
140_V143_A1.1831.00
106_I119_I1.1801.00
11_L15_R1.1681.00
131_G171_G1.1501.00
183_A186_A1.1441.00
63_P67_V1.1441.00
28_V134_G1.1441.00
110_R119_I1.1431.00
40_G146_T1.1401.00
148_A152_S1.1381.00
192_A196_R1.1341.00
127_A131_G1.1331.00
43_A160_L1.1291.00
103_A194_A1.1271.00
45_F48_T1.1211.00
66_R70_V1.1201.00
158_V162_E1.1181.00
32_T138_G1.1151.00
62_V66_R1.0961.00
19_R22_G1.0801.00
95_M127_A1.0761.00
184_W187_A1.0661.00
46_D73_G1.0621.00
44_G48_T1.0521.00
69_G73_G1.0501.00
189_T193_T1.0371.00
43_A163_W1.0351.00
92_T96_L1.0351.00
23_L27_G1.0321.00
25_A133_L1.0231.00
173_L177_V1.0071.00
100_V103_A1.0061.00
39_V42_A0.9971.00
27_G90_A0.9961.00
107_A111_A0.9861.00
181_Y185_R0.9751.00
88_A178_A0.9741.00
102_R123_F0.9741.00
67_V70_V0.9721.00
36_L167_A0.9681.00
179_G183_A0.9671.00
40_G44_G0.9581.00
147_A150_T0.9561.00
128_A176_A0.9561.00
185_R188_R0.9561.00
33_G138_G0.9561.00
120_A180_L0.9501.00
146_T150_T0.9481.00
125_V129_L0.9461.00
154_G158_V0.9451.00
31_S80_A0.9451.00
189_T194_A0.9261.00
64_L67_V0.9261.00
170_A174_L0.9241.00
22_G26_L0.9191.00
81_V85_G0.9141.00
168_V172_A0.9051.00
42_A73_G0.9021.00
166_G170_A0.8991.00
139_V168_V0.8941.00
170_A173_L0.8931.00
73_G77_A0.8901.00
35_A39_V0.8851.00
116_P188_R0.8751.00
141_G144_L0.8621.00
139_V164_G0.8621.00
18_P22_G0.8591.00
120_A183_A0.8571.00
135_G171_G0.8481.00
25_A137_G0.8411.00
33_G142_G0.8411.00
116_P120_A0.8401.00
99_A106_I0.8341.00
9_M109_M0.8331.00
181_Y184_W0.8331.00
108_V111_A0.8311.00
29_A134_G0.8261.00
28_V32_T0.8251.00
135_G139_V0.8231.00
21_S130_C0.8201.00
93_A97_V0.8191.00
191_P194_A0.8111.00
114_A119_I0.8081.00
169_A173_L0.8071.00
9_M122_L0.8061.00
120_A187_A0.8021.00
164_G168_V0.8001.00
42_A46_D0.7971.00
166_G169_A0.7971.00
124_V180_L0.7931.00
125_V128_A0.7921.00
103_A107_A0.7841.00
132_G172_A0.7831.00
98_A126_E0.7771.00
31_S34_T0.7731.00
133_L136_V0.7661.00
124_V176_A0.7551.00
67_V71_P0.7551.00
32_T171_G0.7551.00
163_W167_A0.7501.00
167_A171_G0.7461.00
72_G76_A0.7421.00
171_G175_G0.7401.00
17_H20_R0.7351.00
39_V43_A0.7271.00
108_V112_A0.7231.00
161_V164_G0.7221.00
146_T157_T0.7201.00
61_D64_L0.7141.00
135_G175_G0.7111.00
90_A109_M0.7091.00
43_A162_E0.7091.00
159_V164_G0.7051.00
104_P108_V0.7051.00
163_W166_G0.7041.00
127_A175_G0.7031.00
143_A164_G0.7011.00
192_A195_F0.7011.00
141_G145_A0.7011.00
24_A28_V0.6931.00
95_M98_A0.6911.00
9_M13_A0.6901.00
94_V98_A0.6871.00
13_A105_E0.6811.00
143_A159_V0.6781.00
68_W71_P0.6751.00
86_L90_A0.6721.00
66_R69_G0.6711.00
110_R191_P0.6701.00
92_T178_A0.6621.00
70_V73_G0.6591.00
24_A27_G0.6571.00
131_G179_G0.6431.00
80_A84_A0.6421.00
83_G87_G0.6411.00
143_A147_A0.6401.00
90_A93_A0.6371.00
71_P75_L0.6351.00
145_A148_A0.6301.00
126_E129_L0.6251.00
13_A102_R0.6241.00
37_T142_G0.6181.00
122_L125_V0.6171.00
124_V128_A0.6161.00
19_R23_L0.6161.00
11_L129_L0.6131.00
24_A94_V0.6131.00
98_A102_R0.6121.00
171_G178_A0.6111.00
149_V153_A0.6021.00
18_P21_S0.6011.00
63_P66_R0.6001.00
46_D49_L0.5991.00
27_G31_S0.5971.00
169_A172_A0.5901.00
105_E108_V0.5901.00
182_P186_A0.5881.00
107_A191_P0.5871.00
43_A48_T0.5861.00
136_V139_V0.5851.00
159_V163_W0.5831.00
71_P74_V0.5801.00
103_A185_R0.5801.00
41_V45_F0.5791.00
100_V185_R0.5781.00
120_A124_V0.5781.00
132_G135_G0.5751.00
127_A182_P0.5741.00
21_S25_A0.5701.00
91_I131_G0.5681.00
123_F126_E0.5681.00
13_A20_R0.5671.00
165_S168_V0.5651.00
127_A183_A0.5651.00
154_G157_T0.5601.00
128_A175_G0.5601.00
132_G136_V0.5541.00
159_V162_E0.5511.00
187_A191_P0.5461.00
72_G75_L0.5421.00
94_V109_M0.5411.00
76_A80_A0.5391.00
27_G44_G0.5391.00
41_V44_G0.5381.00
147_A157_T0.5361.00
74_V77_A0.5361.00
37_T40_G0.5321.00
139_V143_A0.5301.00
28_V91_I0.5291.00
129_L133_L0.5251.00
35_A167_A0.5251.00
99_A123_F0.5211.00
25_A130_C0.5191.00
36_L40_G0.5141.00
90_A111_A0.5131.00
29_A138_G0.5131.00
20_R27_G0.5111.00
172_A176_A0.5051.00
42_A76_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zdqA 2 0.899 6.8 0.917 Contact Map
4av3A 2 0.5455 6.4 0.918 Contact Map
2nwlA 3 0.8838 6.4 0.918 Contact Map
3b5xA 2 0.8788 5.7 0.92 Contact Map
3b60A 2 0.8687 4.6 0.923 Contact Map
2ih3C 4 0.4141 3.9 0.926 Contact Map
4pl0A 2 0.4747 3.8 0.926 Contact Map
2z73A 2 0.9444 3.8 0.926 Contact Map
4zwjA 1 0.9444 3.6 0.927 Contact Map
2kogA 1 0.2071 3.2 0.929 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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