GREMLIN Database
Q9HR93 - Uncharacterized protein
UniProt: Q9HR93 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 297 (242)
Sequences: 148 (89)
Seq/√Len: 5.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_D161_R4.9910.98
65_A161_R3.1750.80
60_V66_V2.9740.75
55_D58_E2.8800.73
60_V233_S2.8290.72
98_A133_A2.5150.62
158_V161_R2.4840.61
246_L278_R2.3820.58
113_N195_T2.3660.57
77_P227_L2.3420.56
52_R167_Y2.3320.56
131_L179_V2.3160.55
198_G281_A2.1370.49
80_R216_P2.0110.45
82_G177_G1.9680.43
208_M232_I1.9350.42
202_V245_V1.9320.42
127_V167_Y1.9260.42
110_V274_E1.8870.41
93_I265_K1.8690.40
95_R130_A1.8660.40
104_L160_D1.8620.40
70_L78_V1.8390.39
179_V185_C1.8320.39
131_L198_G1.8250.38
227_L233_S1.8130.38
232_I251_M1.8120.38
203_A233_S1.7810.37
93_I178_E1.7780.37
72_A140_H1.7770.37
66_V166_F1.7730.37
135_L198_G1.7470.36
151_S266_E1.7460.36
74_N87_G1.7300.35
102_Y203_A1.7190.35
96_N205_G1.7060.35
77_P148_A1.7040.35
201_R213_S1.6760.34
205_G268_L1.6750.34
157_D262_N1.6590.33
199_V231_A1.6550.33
233_S273_I1.6440.33
75_V245_V1.6240.32
143_H193_L1.6180.32
71_T104_L1.6010.31
244_P276_D1.5400.30
195_T200_I1.5280.29
224_I281_A1.5260.29
217_Y220_G1.5160.29
47_A138_I1.5140.29
226_T257_V1.5120.29
160_D173_V1.5100.29
81_K177_G1.5050.29
80_R213_S1.5020.29
210_H233_S1.5000.28
62_N236_A1.4940.28
143_H194_T1.4890.28
56_V130_A1.4700.28
173_V234_R1.4560.27
181_H194_T1.4370.27
59_Y175_V1.4140.26
91_I140_H1.4070.26
269_H277_V1.4040.26
198_G271_S1.3950.26
89_K148_A1.3740.25
213_S268_L1.3650.25
140_H230_Q1.3600.25
135_L249_I1.3570.25
194_T261_D1.3480.24
252_Q277_V1.3380.24
68_A77_P1.3360.24
133_A138_I1.3180.24
103_A126_P1.3170.24
70_L125_E1.3050.23
119_G182_A1.2900.23
203_A277_V1.2820.23
205_G262_N1.2820.23
134_T203_A1.2790.23
231_A274_E1.2780.23
198_G224_I1.2650.22
50_D126_P1.2640.22
110_V243_A1.2460.22
159_L249_I1.2420.22
109_G260_V1.2370.22
55_D110_V1.2320.22
175_V200_I1.2220.21
82_G100_R1.2180.21
59_Y286_G1.2080.21
60_V252_Q1.2030.21
84_N158_V1.1980.21
66_V227_L1.1970.21
178_E181_H1.1910.21
197_A281_A1.1900.21
128_I255_A1.1870.20
159_L232_I1.1740.20
59_Y107_R1.1700.20
135_L235_V1.1610.20
138_I182_A1.1540.20
112_F167_Y1.1500.20
200_I227_L1.1390.19
194_T273_I1.1390.19
135_L197_A1.1360.19
64_E111_P1.1290.19
202_V249_I1.1270.19
75_V80_R1.1260.19
99_L126_P1.1250.19
64_E94_V1.1230.19
60_V286_G1.1080.19
172_A272_G1.1000.19
94_V203_A1.0990.19
76_N181_H1.0970.19
94_V116_T1.0930.18
129_V168_D1.0850.18
134_T249_I1.0790.18
151_S186_H1.0770.18
116_T121_S1.0750.18
142_V174_R1.0750.18
205_G219_R1.0570.18
268_L280_V1.0540.18
205_G215_L1.0530.18
76_N247_V1.0520.18
56_V162_I1.0500.18
215_L268_L1.0480.18
91_I176_K1.0470.17
68_A146_D1.0450.17
56_V166_F1.0430.17
166_F285_T1.0430.17
107_R239_E1.0350.17
151_S161_R1.0330.17
142_V199_V1.0270.17
129_V157_D1.0260.17
75_V93_I1.0230.17
181_H255_A1.0170.17
59_Y162_I1.0170.17
202_V273_I1.0110.17
98_A110_V1.0080.17
205_G243_A1.0060.17
107_R116_T0.9990.17
260_V285_T0.9980.17
60_V205_G0.9870.16
243_A278_R0.9860.16
98_A240_G0.9750.16
62_N203_A0.9630.16
249_I255_A0.9610.16
94_V157_D0.9610.16
194_T226_T0.9610.16
257_V261_D0.9520.16
52_R59_Y0.9480.16
104_L146_D0.9290.15
239_E276_D0.9240.15
219_R286_G0.9230.15
109_G199_V0.9150.15
175_V179_V0.9150.15
186_H224_I0.9120.15
73_Q77_P0.9050.15
138_I177_G0.9040.15
75_V102_Y0.9040.15
200_I215_L0.9030.15
70_L226_T0.8960.15
130_A175_V0.8960.15
52_R286_G0.8930.15
58_E233_S0.8880.15
203_A219_R0.8860.14
71_T205_G0.8830.14
51_G66_V0.8820.14
104_L221_G0.8780.14
168_D179_V0.8710.14
143_H235_V0.8700.14
110_V132_A0.8690.14
191_T219_R0.8530.14
158_V270_R0.8520.14
53_L227_L0.8520.14
168_D175_V0.8510.14
143_H181_H0.8490.14
145_D239_E0.8480.14
63_D104_L0.8450.14
124_D163_L0.8420.14
157_D229_S0.8410.14
121_S132_A0.8390.14
55_D111_P0.8380.14
216_P220_G0.8280.14
88_A213_S0.8250.13
186_H203_A0.8240.13
78_V93_I0.8230.13
68_A108_G0.8190.13
227_L273_I0.8190.13
58_E241_D0.8170.13
87_G244_P0.8150.13
51_G205_G0.8110.13
148_A261_D0.8110.13
142_V184_L0.8110.13
134_T200_I0.8090.13
72_A91_I0.8060.13
61_L158_V0.8050.13
102_Y237_L0.7990.13
219_R287_E0.7990.13
103_A249_I0.7980.13
164_P277_V0.7960.13
217_Y221_G0.7960.13
94_V216_P0.7950.13
181_H193_L0.7930.13
96_N209_E0.7910.13
66_V116_T0.7870.13
175_V242_D0.7840.13
81_K141_V0.7840.13
102_Y185_C0.7810.13
109_G121_S0.7810.13
270_R274_E0.7800.13
145_D200_I0.7770.13
70_L194_T0.7740.13
154_L234_R0.7720.13
105_L197_A0.7720.13
240_G262_N0.7700.13
205_G249_I0.7600.12
101_L283_N0.7590.12
62_N234_R0.7590.12
198_G202_V0.7590.12
225_N229_S0.7540.12
125_E206_L0.7500.12
69_Y156_A0.7490.12
101_L268_L0.7450.12
133_A213_S0.7430.12
195_T275_D0.7410.12
82_G218_E0.7380.12
186_H231_A0.7380.12
97_R262_N0.7340.12
75_V170_A0.7340.12
238_Q241_D0.7320.12
96_N270_R0.7310.12
180_L194_T0.7160.12
80_R178_E0.7140.12
52_R141_V0.7120.12
115_A279_I0.7110.12
219_R238_Q0.7090.12
223_G261_D0.7070.12
92_E278_R0.7060.12
106_K209_E0.7060.12
56_V102_Y0.6990.12
155_A274_E0.6960.12
148_A278_R0.6920.11
236_A286_G0.6890.11
164_P242_D0.6890.11
179_V193_L0.6870.11
53_L101_L0.6860.11
201_R226_T0.6840.11
164_P262_N0.6800.11
81_K258_Y0.6800.11
179_V182_A0.6730.11
198_G273_I0.6730.11
132_A199_V0.6720.11
77_P187_H0.6720.11
187_H194_T0.6690.11
165_E282_L0.6680.11
202_V279_I0.6680.11
115_A186_H0.6650.11
107_R288_G0.6640.11
167_Y235_V0.6630.11
55_D62_N0.6610.11
184_L199_V0.6600.11
69_Y138_I0.6600.11
167_Y186_H0.6570.11
181_H206_L0.6550.11
202_V242_D0.6510.11
125_E185_C0.6510.11
69_Y141_V0.6510.11
66_V241_D0.6480.11
171_D239_E0.6470.11
203_A253_N0.6460.11
110_V241_D0.6460.11
115_A185_C0.6450.11
52_R239_E0.6440.11
143_H180_L0.6430.11
55_D242_D0.6410.11
229_S258_Y0.6400.11
60_V172_A0.6390.11
83_Y205_G0.6350.11
63_D83_Y0.6340.11
120_L206_L0.6330.11
149_Y268_L0.6300.11
162_I223_G0.6280.11
71_T242_D0.6280.11
89_K225_N0.6230.11
185_C271_S0.6220.11
148_A200_I0.6220.11
115_A181_H0.6210.11
198_G215_L0.6170.10
142_V159_L0.6130.10
71_T179_V0.6090.10
84_N87_G0.6070.10
106_K166_F0.6070.10
92_E179_V0.6070.10
79_T262_N0.6040.10
164_P234_R0.6020.10
108_G279_I0.6000.10
58_E149_Y0.5970.10
193_L220_G0.5960.10
79_T171_D0.5960.10
57_L198_G0.5940.10
225_N258_Y0.5930.10
130_A154_L0.5920.10
132_A145_D0.5910.10
177_G186_H0.5880.10
59_Y239_E0.5880.10
56_V151_S0.5870.10
93_I150_Y0.5870.10
124_D186_H0.5850.10
100_R221_G0.5840.10
75_V178_E0.5830.10
162_I235_V0.5830.10
128_I279_I0.5820.10
91_I230_Q0.5800.10
67_T103_A0.5780.10
124_D167_Y0.5770.10
213_S216_P0.5770.10
134_T184_L0.5750.10
140_H184_L0.5630.10
234_R245_V0.5630.10
65_A74_N0.5610.10
186_H240_G0.5600.10
79_T117_D0.5590.10
55_D59_Y0.5570.10
69_Y179_V0.5530.10
178_E206_L0.5520.10
97_R198_G0.5490.10
185_C255_A0.5490.10
130_A249_I0.5490.10
53_L241_D0.5470.10
70_L93_I0.5460.10
53_L99_L0.5450.10
277_V287_E0.5440.10
88_A227_L0.5420.10
164_P199_V0.5410.10
265_K279_I0.5380.09
178_E220_G0.5380.09
66_V80_R0.5380.09
56_V66_V0.5370.09
76_N206_L0.5360.09
186_H210_H0.5330.09
151_S231_A0.5330.09
100_R252_Q0.5310.09
191_T252_Q0.5310.09
194_T255_A0.5310.09
92_E223_G0.5270.09
68_A195_T0.5270.09
209_E229_S0.5230.09
146_D275_D0.5230.09
95_R249_I0.5190.09
163_L181_H0.5180.09
110_V252_Q0.5160.09
88_A215_L0.5160.09
210_H241_D0.5130.09
57_L164_P0.5130.09
138_I273_I0.5130.09
156_A159_L0.5100.09
174_R185_C0.5100.09
199_V202_V0.5080.09
140_H143_H0.5080.09
103_A112_F0.5070.09
128_I272_G0.5060.09
129_V132_A0.5060.09
148_A219_R0.5030.09
116_T215_L0.5020.09
53_L61_L0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gw7A 2 0.6195 98.1 0.927 Contact Map
2pq7A 2 0.5556 98 0.929 Contact Map
2dqbA 4 0.7879 98 0.93 Contact Map
2qgsA 2 0.6532 97.9 0.931 Contact Map
3djbA 2 0.5993 97.9 0.931 Contact Map
4r8zA 2 0.6296 97.8 0.932 Contact Map
3b57A 2 0.5724 97.8 0.933 Contact Map
3dtoA 2 0.6027 97.8 0.933 Contact Map
2hekA 4 0.7374 97.7 0.934 Contact Map
2pjqA 2 0.6633 97.7 0.934 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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