GREMLIN Database
Q9HR87 - Spermidine/putrescine-binding protein
UniProt: Q9HR87 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 416 (339)
Sequences: 26418 (21387)
Seq/√Len: 1161.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
75_T102_G4.0561.00
77_R102_G3.6881.00
144_R333_S3.5611.00
202_T309_E3.5301.00
75_T100_Q3.1811.00
145_P185_Q3.1481.00
261_V265_E3.0791.00
217_W262_A3.0281.00
94_E100_Q2.7211.00
212_S215_A2.6571.00
99_C334_V2.6511.00
97_F337_N2.6211.00
92_P95_K2.6071.00
92_P341_Y2.6001.00
344_H347_T2.5441.00
258_E262_A2.4771.00
337_N340_A2.4421.00
251_A255_R2.3741.00
77_R104_D2.3041.00
92_P350_N2.2801.00
202_T206_S2.2361.00
92_P96_K2.2181.00
125_D332_P2.2171.00
91_R95_K2.2141.00
158_K364_H2.1871.00
215_A218_A2.1651.00
147_D185_Q2.1431.00
204_V287_D2.1351.00
93_F337_N2.1301.00
88_N91_R2.1271.00
349_K353_W2.1241.00
218_A221_Y2.0941.00
259_A262_A2.0861.00
255_R258_E2.0561.00
74_E334_V2.0391.00
90_Q94_E1.9801.00
200_L309_E1.9791.00
127_A327_L1.9511.00
73_G100_Q1.9481.00
143_I325_T1.9441.00
21_A24_T1.9421.00
161_D165_R1.9361.00
205_V288_I1.9111.00
181_D186_L1.8891.00
203_D207_E1.8881.00
254_E258_E1.8851.00
90_Q338_Y1.8541.00
144_R328_K1.8451.00
350_N354_P1.8281.00
93_F97_F1.8171.00
22_A25_A1.8021.00
111_D114_N1.7631.00
214_D217_W1.7611.00
280_A285_D1.7571.00
347_T350_N1.7271.00
188_G323_T1.7211.00
217_W221_Y1.6981.00
208_S211_R1.6871.00
94_E97_F1.6771.00
88_N92_P1.6761.00
91_R94_E1.6651.00
345_G349_K1.6541.00
96_K344_H1.6471.00
217_W263_L1.6451.00
149_E336_T1.6331.00
258_E261_V1.5981.00
350_N353_W1.5751.00
201_N204_V1.5711.00
259_A263_L1.5661.00
214_D218_A1.5441.00
211_R215_A1.5371.00
252_E255_R1.5311.00
74_E332_P1.5261.00
334_V337_N1.5251.00
273_D276_S1.5181.00
217_W259_A1.5161.00
112_A117_D1.5131.00
326_M339_L1.4871.00
330_S333_S1.4741.00
210_A215_A1.4731.00
333_S336_T1.4611.00
373_R377_T1.4601.00
111_D115_R1.4581.00
107_T111_D1.4561.00
145_P148_Y1.4521.00
80_T103_V1.4501.00
279_T283_A1.4141.00
90_Q103_V1.3991.00
145_P186_L1.3971.00
93_F341_Y1.3941.00
126_H335_S1.3881.00
93_F99_C1.3871.00
156_F164_Q1.3741.00
373_R376_R1.3711.00
112_A115_R1.3671.00
382_D386_D1.3571.00
126_H338_Y1.3561.00
243_D246_A1.3531.00
251_A254_E1.3481.00
330_S335_S1.3431.00
93_F338_Y1.3401.00
165_R181_D1.3341.00
161_D164_Q1.3331.00
200_L311_R1.3131.00
336_T340_A1.3081.00
138_A187_Y1.3041.00
280_A286_I1.3011.00
141_G328_K1.2751.00
198_F311_R1.2661.00
126_H339_L1.2611.00
364_H367_S1.2501.00
99_C337_N1.2421.00
129_F325_T1.2311.00
153_P340_A1.2281.00
345_G364_H1.2261.00
11_Q14_K1.2151.00
197_S310_A1.2151.00
160_T363_P1.2131.00
326_M335_S1.2111.00
205_V219_D1.2111.00
341_Y347_T1.2041.00
266_N269_G1.2001.00
88_N350_N1.1961.00
19_S23_T1.1891.00
338_Y342_M1.1861.00
150_A154_Y1.1801.00
220_E288_I1.1661.00
223_V226_Y1.1591.00
151_W154_Y1.1531.00
90_Q101_T1.1461.00
152_K157_D1.1461.00
309_E312_V1.1411.00
199_A291_V1.1331.00
204_V207_E1.1331.00
22_A26_L1.1291.00
127_A325_T1.1251.00
138_A182_A1.1241.00
267_A270_V1.1241.00
125_D330_S1.1201.00
255_R259_A1.1161.00
262_A265_E1.1121.00
327_L330_S1.1061.00
386_D389_D1.1041.00
198_F288_I1.1031.00
237_M242_I1.1031.00
362_V365_Q1.0931.00
276_S279_T1.0931.00
216_A288_I1.0911.00
158_K362_V1.0831.00
113_F116_L1.0811.00
137_L143_I1.0811.00
76_I338_Y1.0711.00
96_K341_Y1.0681.00
150_A153_P1.0661.00
346_I349_K1.0631.00
93_F334_V1.0621.00
247_T250_D1.0611.00
216_A220_E1.0611.00
101_T338_Y1.0581.00
385_Q389_D1.0541.00
219_D288_I1.0541.00
78_H324_T1.0531.00
328_K333_S1.0461.00
112_A116_L1.0441.00
188_G325_T1.0411.00
180_F323_T1.0401.00
114_N117_D1.0361.00
346_I350_N1.0291.00
88_N354_P1.0271.00
21_A25_A1.0231.00
89_V92_P1.0191.00
150_A336_T1.0161.00
113_F133_W1.0121.00
94_E98_D1.0111.00
76_I334_V1.0111.00
92_P347_T1.0091.00
298_G302_R1.0031.00
23_T26_L1.0031.00
248_H253_V0.9961.00
225_V228_L0.9931.00
326_M336_T0.9911.00
79_L124_F0.9881.00
303_G306_F0.9861.00
279_T282_A0.9851.00
203_D307_E0.9741.00
69_T72_S0.9701.00
235_I238_L0.9611.00
89_V347_T0.9601.00
92_P346_I0.9521.00
326_M330_S0.9451.00
123_E327_L0.9371.00
250_D253_V0.9341.00
223_V227_D0.9341.00
144_R330_S0.9331.00
191_Q324_T0.9311.00
25_A28_G0.9291.00
159_Y164_Q0.9261.00
228_L231_W0.9241.00
388_I391_S0.9241.00
113_F117_D0.9211.00
281_L308_Y0.9161.00
250_D254_E0.9161.00
386_D390_K0.9141.00
115_R118_D0.9111.00
136_D140_A0.9081.00
180_F186_L0.9031.00
76_I332_P0.9021.00
17_A21_A0.8971.00
144_R336_T0.8951.00
96_K346_I0.8951.00
275_G278_N0.8941.00
338_Y341_Y0.8911.00
143_I187_Y0.8901.00
349_K365_Q0.8901.00
157_D164_Q0.8891.00
324_T339_L0.8881.00
209_D219_D0.8831.00
217_W220_E0.8811.00
236_V241_G0.8811.00
194_G320_W0.8711.00
79_L106_F0.8701.00
181_D184_G0.8671.00
384_L387_I0.8521.00
208_S215_A0.8511.00
291_V296_I0.8501.00
203_D206_S0.8491.00
160_T163_F0.8491.00
135_P139_E0.8451.00
73_G98_D0.8301.00
12_Y15_T0.8281.00
13_V16_A0.8271.00
128_T324_T0.8261.00
394_Y397_V0.8221.00
18_L22_A0.8211.00
200_L209_D0.8211.00
231_W234_Q0.8181.00
335_S339_L0.8151.00
117_D140_A0.8141.00
145_P187_Y0.8141.00
299_S302_R0.8131.00
374_R377_T0.8131.00
17_A20_A0.8131.00
71_S74_E0.8121.00
68_N71_S0.8071.00
106_F115_R0.8061.00
209_D215_A0.8061.00
159_Y343_Q0.8051.00
146_L339_L0.8001.00
153_P157_D0.7951.00
249_T252_E0.7921.00
161_D363_P0.7881.00
324_T342_M0.7861.00
144_R326_M0.7841.00
144_R327_L0.7841.00
213_Y217_W0.7801.00
23_T27_A0.7791.00
138_A143_I0.7791.00
267_A271_Y0.7771.00
261_V264_F0.7771.00
309_E313_P0.7761.00
382_D385_Q0.7731.00
375_Q379_L0.7711.00
133_W136_D0.7711.00
231_W235_I0.7711.00
260_T264_F0.7681.00
164_Q186_L0.7661.00
108_S111_D0.7651.00
383_D386_D0.7611.00
225_V231_W0.7581.00
201_N284_G0.7581.00
277_L289_A0.7581.00
87_A91_R0.7561.00
76_I335_S0.7551.00
84_Y87_A0.7531.00
29_C32_G0.7441.00
215_A219_D0.7431.00
151_W340_A0.7431.00
236_V240_E0.7411.00
20_A23_T0.7411.00
223_V231_W0.7411.00
94_E101_T0.7381.00
78_H126_H0.7371.00
239_R242_I0.7351.00
134_L138_A0.7341.00
77_R125_D0.7331.00
29_C33_L0.7321.00
89_V341_Y0.7301.00
224_G227_D0.7291.00
74_E99_C0.7291.00
238_L241_G0.7281.00
89_V350_N0.7251.00
198_F290_F0.7221.00
158_K345_G0.7211.00
144_R148_Y0.7191.00
242_I252_E0.7181.00
249_T253_V0.7181.00
28_G31_G0.7141.00
227_D231_W0.7141.00
278_N282_A0.7131.00
162_L165_R0.7121.00
163_F193_F0.7101.00
363_P366_S0.7091.00
78_H103_V0.7061.00
374_R378_V0.7051.00
372_N376_R0.7041.00
340_A344_H0.7031.00
18_L24_T0.7021.00
371_L375_Q0.7021.00
125_D331_H0.7011.00
345_G362_V0.7001.00
237_M241_G0.6991.00
67_D70_Q0.6991.00
159_Y163_F0.6971.00
238_L392_R0.6901.00
160_T164_Q0.6881.00
212_S315_E0.6851.00
392_R395_T0.6851.00
19_S25_A0.6841.00
14_K17_A0.6841.00
18_L21_A0.6831.00
370_R373_R0.6821.00
224_G231_W0.6811.00
302_R305_R0.6801.00
79_L104_D0.6801.00
200_L205_V0.6791.00
127_A143_I0.6781.00
240_E255_R0.6761.00
372_N375_Q0.6761.00
20_A24_T0.6721.00
375_Q378_V0.6721.00
33_L36_G0.6701.00
104_D124_F0.6671.00
82_S86_A0.6651.00
160_T366_S0.6641.00
232_G235_I0.6611.00
280_A283_A0.6601.00
147_D336_T0.6601.00
268_A271_Y0.6581.00
147_D186_L0.6541.00
203_D284_G0.6531.00
223_V228_L0.6531.00
14_K18_L0.6531.00
144_R329_G0.6521.00
97_F334_V0.6521.00
100_Q103_V0.6501.00
157_D160_T0.6491.00
134_L188_G0.6491.00
83_G86_A0.6481.00
70_Q73_G0.6481.00
276_S280_A0.6471.00
233_V237_M0.6471.00
236_V239_R0.6471.00
147_D150_A0.6441.00
232_G236_V0.6441.00
345_G348_A0.6421.00
393_F396_G0.6411.00
387_I390_K0.6361.00
234_Q241_G0.6341.00
199_A308_Y0.6341.00
16_A20_A0.6341.00
229_P234_Q0.6341.00
237_M240_E0.6331.00
158_K363_P0.6311.00
235_I241_G0.6301.00
383_D387_I0.6291.00
226_Y229_P0.6291.00
144_R149_E0.6281.00
275_G279_T0.6261.00
235_I239_R0.6241.00
226_Y231_W0.6241.00
157_D161_D0.6241.00
224_G229_P0.6241.00
12_Y16_A0.6231.00
227_D234_Q0.6221.00
17_A24_T0.6211.00
240_E259_A0.6201.00
189_V339_L0.6181.00
89_V342_M0.6171.00
274_V277_L0.6171.00
151_W336_T0.6101.00
234_Q239_R0.6101.00
229_P233_V0.6071.00
358_G361_V0.6071.00
27_A31_G0.6061.00
246_A249_T0.6061.00
205_V287_D0.6061.00
363_P367_S0.6051.00
16_A19_S0.6051.00
138_A141_G0.6051.00
257_R261_V0.6051.00
179_N182_A0.6041.00
24_T27_A0.6031.00
371_L374_R0.6031.00
378_V381_I0.6011.00
392_R396_G0.6011.00
78_H128_T0.5991.00
74_E77_R0.5981.00
66_A69_T0.5961.00
235_I240_E0.5951.00
29_C35_D0.5941.00
104_D115_R0.5921.00
32_G35_D0.5921.00
390_K393_F0.5921.00
234_Q238_L0.5901.00
74_E98_D0.5891.00
17_A23_T0.5891.00
192_R322_E0.5871.00
29_C34_D0.5851.00
34_D37_G0.5851.00
15_T19_S0.5841.00
202_T307_E0.5841.00
380_R383_D0.5841.00
391_S394_Y0.5821.00
126_H324_T0.5811.00
182_A185_Q0.5801.00
94_E99_C0.5781.00
72_S75_T0.5771.00
337_N341_Y0.5751.00
211_R314_D0.5741.00
66_A70_Q0.5741.00
14_K25_A0.5741.00
209_D311_R0.5731.00
266_N270_V0.5721.00
296_I299_S0.5721.00
376_R379_L0.5711.00
19_S22_A0.5701.00
225_V232_G0.5691.00
194_G322_E0.5681.00
26_L29_C0.5671.00
247_T253_V0.5671.00
225_V229_P0.5651.00
125_D335_S0.5651.00
390_K395_T0.5641.00
295_W299_S0.5641.00
229_P232_G0.5621.00
210_A219_D0.5621.00
352_M360_N0.5621.00
256_I260_T0.5601.00
97_F338_Y0.5591.00
152_K156_F0.5581.00
74_E78_H0.5581.00
213_Y259_A0.5561.00
294_N297_N0.5551.00
76_I126_H0.5551.00
357_G361_V0.5551.00
272_A276_S0.5551.00
277_L286_I0.5551.00
390_K394_Y0.5531.00
113_F136_D0.5531.00
77_R80_T0.5511.00
381_I384_L0.5501.00
123_E329_G0.5491.00
135_P138_A0.5481.00
223_V229_P0.5481.00
278_N291_V0.5471.00
249_T254_E0.5471.00
233_V241_G0.5441.00
254_E257_R0.5421.00
349_K370_R0.5421.00
13_V24_T0.5421.00
76_I101_T0.5411.00
253_V256_I0.5411.00
129_F137_L0.5401.00
379_L382_D0.5381.00
130_D133_W0.5341.00
227_D230_F0.5331.00
94_E338_Y0.5321.00
317_G320_W0.5321.00
326_M333_S0.5311.00
254_E261_V0.5291.00
146_L336_T0.5291.00
246_A250_D0.5271.00
149_E333_S0.5271.00
252_E256_I0.5251.00
77_R124_F0.5241.00
137_L142_L0.5241.00
181_D185_Q0.5231.00
156_F160_T0.5231.00
154_Y157_D0.5231.00
13_V20_A0.5231.00
217_W266_N0.5231.00
224_G286_I0.5221.00
224_G230_F0.5221.00
336_T339_L0.5211.00
332_P335_S0.5211.00
274_V278_N0.5211.00
110_L113_F0.5191.00
296_I300_L0.5191.00
68_N72_S0.5161.00
199_A310_A0.5161.00
18_L25_A0.5151.00
227_D232_G0.5131.00
393_F397_V0.5121.00
78_H338_Y0.5121.00
341_Y344_H0.5111.00
344_H348_A0.5101.00
206_S209_D0.5091.00
389_D393_F0.5081.00
268_A272_A0.5071.00
232_G241_G0.5061.00
385_Q388_I0.5051.00
113_F137_L0.5041.00
186_L189_V0.5041.00
253_V257_R0.5031.00
223_V233_V0.5031.00
384_L388_I0.5021.00
348_A362_V0.5001.00
201_N206_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mfiA 1 0.7933 100 0.334 Contact Map
3uorA 1 0.7764 100 0.336 Contact Map
4r2fA 1 0.774 100 0.345 Contact Map
4r9fA 1 0.774 100 0.345 Contact Map
3woaA 1 0.8534 100 0.369 Contact Map
3vxbA 1 0.7644 100 0.38 Contact Map
2xd3A 1 0.7548 100 0.381 Contact Map
4g68A 1 0.762 100 0.39 Contact Map
4gl0A 1 0.762 100 0.392 Contact Map
2w7yA 1 0.7764 100 0.397 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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