GREMLIN Database
Q9HR86 - Uncharacterized protein
UniProt: Q9HR86 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 210 (204)
Sequences: 55686 (38732)
Seq/√Len: 2711.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_A29_G3.1741.00
2_D26_H2.6801.00
19_R176_Q2.6251.00
177_T194_V2.5341.00
79_A83_D2.5211.00
65_G182_L2.3691.00
30_M50_A2.3071.00
57_A94_D2.2491.00
99_R138_A2.1651.00
28_R63_C2.1411.00
19_R179_A2.0781.00
19_R23_D2.0671.00
4_L63_C1.9981.00
103_L178_L1.9511.00
144_P178_L1.9221.00
68_F102_M1.9061.00
28_R46_T1.8881.00
202_A206_A1.8661.00
2_D28_R1.8431.00
50_A55_D1.8411.00
5_V17_T1.8301.00
23_D183_T1.8271.00
67_V182_L1.8181.00
28_R48_V1.7541.00
132_L139_H1.7341.00
6_A68_F1.7091.00
26_H46_T1.6911.00
16_L175_A1.6761.00
142_V181_A1.6711.00
176_Q180_A1.6421.00
86_I131_R1.6101.00
86_I90_S1.5991.00
200_P203_E1.5861.00
179_A183_T1.5791.00
23_D179_A1.5721.00
57_A91_A1.5691.00
64_D98_D1.5571.00
85_A128_A1.4961.00
19_R22_D1.4931.00
104_S108_A1.4871.00
53_T79_A1.4861.00
83_D86_I1.4861.00
69_A103_L1.4851.00
126_A130_A1.4681.00
16_L67_V1.4621.00
3_V25_H1.4511.00
25_H183_T1.4361.00
78_D127_D1.4131.00
16_L69_A1.4081.00
57_A95_A1.4031.00
9_H31_I1.3951.00
12_V147_L1.3911.00
203_E206_A1.3881.00
17_T29_G1.3841.00
99_R140_T1.3831.00
93_E135_S1.3741.00
19_R175_A1.3501.00
180_A184_A1.3491.00
109_D193_E1.3451.00
55_D58_D1.3421.00
75_E79_A1.3421.00
52_L84_G1.2841.00
66_V92_A1.2661.00
33_D36_Q1.2571.00
167_G197_G1.2491.00
88_L100_F1.2461.00
81_D124_A1.2441.00
103_L144_P1.2391.00
67_V178_L1.2351.00
33_D47_P1.2331.00
102_M132_L1.2301.00
8_A17_T1.2201.00
142_V178_L1.2201.00
29_G45_A1.2181.00
92_A100_F1.2141.00
4_L30_M1.2131.00
130_A133_R1.2061.00
143_R191_T1.2031.00
165_A199_T1.1991.00
3_V65_G1.1951.00
90_S93_E1.1951.00
19_R172_A1.1871.00
21_A45_A1.1851.00
144_P174_V1.1831.00
58_D61_A1.1791.00
114_G117_D1.1791.00
3_V20_L1.1711.00
123_A127_D1.1511.00
56_V91_A1.1471.00
121_Y125_K1.1461.00
52_L70_A1.1431.00
92_A97_V1.1391.00
169_I174_V1.1351.00
102_M128_A1.1291.00
171_C175_A1.1291.00
61_A95_A1.1271.00
15_H172_A1.1241.00
11_R149_T1.1191.00
80_V84_G1.1171.00
129_D143_R1.1021.00
18_E22_D1.1011.00
138_A188_R1.0811.00
6_A88_L1.0791.00
133_R141_I1.0781.00
89_L100_F1.0751.00
101_V142_V1.0731.00
66_V88_L1.0711.00
148_T170_P1.0711.00
133_R191_T1.0581.00
69_A178_L1.0571.00
102_M141_I1.0481.00
72_S80_V1.0431.00
68_F85_A1.0371.00
20_L179_A1.0311.00
143_R193_E1.0191.00
83_D87_R1.0151.00
163_D202_A1.0131.00
151_A154_G1.0121.00
21_A44_G1.0121.00
34_P49_V1.0111.00
60_V66_V1.0101.00
57_A61_A1.0081.00
157_T160_D1.0041.00
147_L174_V1.0031.00
60_V63_C0.9931.00
90_S94_D0.9821.00
104_S129_D0.9781.00
173_D196_A0.9701.00
82_R127_D0.9571.00
2_D63_C0.9521.00
163_D200_P0.9461.00
28_R62_G0.9441.00
48_V59_A0.9341.00
30_M56_V0.9331.00
36_Q40_I0.9281.00
87_R90_S0.9281.00
60_V95_A0.9281.00
78_D82_R0.9271.00
31_I47_P0.9221.00
39_T42_G0.9181.00
11_R171_C0.9131.00
16_L20_L0.9121.00
30_M59_A0.9111.00
140_T181_A0.9061.00
60_V91_A0.9051.00
176_Q179_A0.8981.00
93_E137_V0.8921.00
91_A95_A0.8911.00
15_H18_E0.8911.00
170_P173_D0.8891.00
100_F132_L0.8871.00
156_V160_D0.8741.00
98_D138_A0.8741.00
38_D41_D0.8651.00
77_L124_A0.8601.00
66_V100_F0.8521.00
106_M145_G0.8501.00
15_H171_C0.8461.00
78_D83_D0.8401.00
2_D64_D0.8401.00
55_D59_A0.8361.00
17_T27_V0.8361.00
91_A94_D0.8321.00
133_R139_H0.8311.00
32_R51_D0.8281.00
36_Q39_T0.8271.00
56_V87_R0.8261.00
2_D25_H0.8211.00
180_A183_T0.8201.00
152_G156_V0.8191.00
37_T41_D0.8171.00
93_E136_P0.8111.00
155_R159_A0.8051.00
72_S76_A0.8041.00
15_H19_R0.8011.00
89_L132_L0.7901.00
21_A27_V0.7851.00
145_G195_L0.7821.00
30_M55_D0.7811.00
128_A132_L0.7801.00
150_D170_P0.7781.00
175_A179_A0.7701.00
152_G160_D0.7691.00
26_H44_G0.7671.00
25_H64_D0.7661.00
65_G99_R0.7641.00
6_A70_A0.7591.00
16_L178_L0.7561.00
85_A132_L0.7531.00
152_G155_R0.7521.00
89_L131_R0.7511.00
3_V67_V0.7511.00
147_L169_I0.7481.00
141_I191_T0.7451.00
152_G157_T0.7441.00
38_D42_G0.7431.00
139_H189_D0.7421.00
33_D49_V0.7361.00
78_D123_A0.7281.00
151_A160_D0.7251.00
39_T43_L0.7231.00
112_S116_E0.7221.00
60_V92_A0.7181.00
72_S77_L0.7151.00
165_A200_P0.7141.00
151_A156_V0.7121.00
20_L182_L0.7091.00
87_R91_A0.7061.00
53_T80_V0.7031.00
3_V182_L0.7011.00
155_R160_D0.7011.00
99_R185_P0.7001.00
152_G159_A0.6931.00
154_G158_V0.6881.00
127_D130_A0.6871.00
142_V194_V0.6871.00
185_P188_R0.6861.00
4_L50_A0.6861.00
127_D131_R0.6801.00
90_S131_R0.6791.00
123_A130_A0.6781.00
107_G122_L0.6781.00
151_A157_T0.6751.00
4_L60_V0.6731.00
141_I189_D0.6651.00
85_A89_L0.6621.00
162_L202_A0.6601.00
76_A80_V0.6591.00
12_V174_V0.6551.00
154_G159_A0.6551.00
153_T157_T0.6531.00
108_A143_R0.6491.00
33_D38_D0.6411.00
15_H175_A0.6411.00
151_A155_R0.6391.00
60_V88_L0.6381.00
167_G196_A0.6351.00
76_A79_A0.6341.00
144_P147_L0.6321.00
68_F88_L0.6321.00
36_Q41_D0.6311.00
156_V159_A0.6291.00
142_V177_T0.6221.00
51_D54_D0.6151.00
23_D176_Q0.6131.00
14_Q18_E0.6131.00
105_S108_A0.6121.00
101_V181_A0.6121.00
23_D180_A0.6121.00
29_G47_P0.6051.00
153_T156_V0.6041.00
84_G87_R0.6041.00
18_E172_A0.6031.00
5_V20_L0.5991.00
154_G157_T0.5981.00
119_R122_L0.5901.00
101_V182_L0.5881.00
59_A63_C0.5871.00
2_D62_G0.5831.00
132_L141_I0.5781.00
65_G98_D0.5751.00
56_V60_V0.5741.00
108_A129_D0.5741.00
35_A38_D0.5731.00
60_V97_V0.5721.00
48_V55_D0.5701.00
151_A158_V0.5651.00
123_A126_A0.5651.00
154_G160_D0.5651.00
81_D125_K0.5621.00
153_T159_A0.5591.00
111_P118_L0.5531.00
20_L25_H0.5531.00
78_D124_A0.5521.00
125_K128_A0.5521.00
72_S81_D0.5501.00
65_G101_V0.5501.00
28_R59_A0.5481.00
30_M48_V0.5481.00
146_S168_S0.5451.00
50_A59_A0.5441.00
34_P38_D0.5431.00
124_A128_A0.5421.00
155_R158_V0.5411.00
150_D172_A0.5381.00
69_A144_P0.5381.00
37_T40_I0.5381.00
145_G167_G0.5341.00
18_E43_L0.5311.00
71_G81_D0.5301.00
25_H65_G0.5291.00
120_S124_A0.5281.00
120_S123_A0.5281.00
138_A186_A0.5281.00
4_L59_A0.5281.00
164_P201_V0.5271.00
153_T160_D0.5231.00
153_T158_V0.5221.00
121_Y124_A0.5201.00
93_E134_E0.5171.00
179_A182_L0.5151.00
2_D46_T0.5151.00
75_E86_I0.5121.00
85_A102_M0.5071.00
4_L66_V0.5061.00
6_A30_M0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1i24A 4 1 100 0.235 Contact Map
4wkgA 5 0.9952 100 0.24 Contact Map
3slgA 4 0.9952 100 0.244 Contact Map
2bllA 2 0.9952 100 0.245 Contact Map
2x4gA 2 0.9667 100 0.248 Contact Map
1sb8A 2 1 100 0.249 Contact Map
2yy7A 2 0.9905 100 0.25 Contact Map
4pvcA 2 1 100 0.252 Contact Map
2c5aA 2 0.9905 100 0.252 Contact Map
3m2pA 2 0.9619 100 0.253 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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