GREMLIN Database
Q9HR85 - Quinone oxidoreductase
UniProt: Q9HR85 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 380 (304)
Sequences: 49346 (33852)
Seq/√Len: 1941.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
87_R164_L3.1121.00
357_N360_D3.0891.00
82_L154_V2.6361.00
193_T217_R2.6261.00
212_K238_D2.5931.00
163_D166_A2.5621.00
353_S364_G2.5091.00
136_L157_V2.4971.00
55_A70_R2.4761.00
135_D156_P2.4481.00
132_E135_D2.4261.00
252_A255_D2.4011.00
74_V146_Y2.3621.00
165_P352_V2.3181.00
85_R146_Y2.3131.00
217_R239_A2.2361.00
115_L142_T2.2051.00
194_V211_A2.1971.00
338_Q342_A2.1361.00
130_A151_A2.1231.00
79_H126_S2.0941.00
351_V364_G2.0891.00
229_D233_E2.0791.00
78_R81_E2.0651.00
354_G357_N2.0631.00
229_D234_D2.0361.00
208_G237_F2.0331.00
161_V341_A2.0191.00
79_H127_E2.0171.00
189_K192_D2.0051.00
53_V70_R2.0041.00
115_L139_G1.9941.00
80_G127_E1.9881.00
136_L164_L1.9841.00
352_V377_G1.9781.00
116_S164_L1.9441.00
363_L367_S1.9431.00
83_L148_L1.9011.00
100_R366_F1.8961.00
175_G206_V1.8931.00
55_A68_E1.8901.00
183_L214_N1.8431.00
360_D363_L1.8201.00
195_V221_F1.8091.00
213_H344_D1.8031.00
125_E128_S1.7961.00
195_V261_V1.7711.00
353_S361_A1.7631.00
228_V240_G1.7631.00
192_D285_R1.7591.00
219_V261_V1.7561.00
228_V233_E1.7421.00
364_G369_D1.7391.00
262_D281_N1.7301.00
225_E229_D1.7241.00
285_R316_K1.6941.00
157_V164_L1.6851.00
157_V167_Y1.6841.00
222_A228_V1.6771.00
360_D364_G1.6731.00
247_D252_A1.6561.00
225_E242_N1.6541.00
197_S276_V1.6451.00
239_A256_A1.6271.00
230_W234_D1.6261.00
280_L286_V1.5941.00
280_L315_A1.5741.00
77_P148_L1.5701.00
217_R238_D1.5701.00
285_R318_Q1.5671.00
131_Y156_P1.5541.00
83_L146_Y1.5531.00
165_P377_G1.5501.00
225_E245_Q1.5491.00
81_E150_D1.5431.00
143_W362_F1.5371.00
186_G263_V1.5351.00
248_D251_A1.5301.00
223_G243_Y1.5251.00
50_R145_D1.5121.00
242_N245_Q1.5021.00
77_P83_L1.5011.00
86_V115_L1.4951.00
350_T364_G1.4921.00
208_G220_G1.4881.00
131_Y135_D1.4581.00
280_L284_A1.4371.00
136_L160_S1.4151.00
52_W358_A1.4101.00
359_P363_L1.4081.00
88_Y165_P1.4071.00
81_E148_L1.4061.00
80_G150_D1.4031.00
264_Y276_V1.3951.00
124_V133_A1.3841.00
264_Y280_L1.3821.00
99_M362_F1.3451.00
200_A220_G1.3211.00
82_L131_Y1.3081.00
50_R71_E1.3021.00
197_S221_F1.2971.00
338_Q341_A1.2891.00
193_T219_V1.2861.00
213_H339_W1.2811.00
251_A255_D1.2721.00
207_V265_F1.2701.00
228_V242_N1.2541.00
52_W69_L1.2481.00
188_P216_C1.2441.00
74_V83_L1.1991.00
131_Y154_V1.1831.00
184_E332_A1.1701.00
86_V147_S1.1661.00
63_D66_S1.1651.00
50_R356_E1.1571.00
225_E228_V1.1411.00
87_R136_L1.1401.00
77_P81_E1.1301.00
80_G151_A1.1301.00
149_L154_V1.1291.00
252_A256_A1.1191.00
184_E335_Q1.1121.00
200_A222_A1.1081.00
88_Y377_G1.1081.00
209_Q346_E1.1071.00
193_T262_D1.1041.00
220_G237_F1.1001.00
91_V361_A1.1001.00
223_G244_K1.0971.00
51_E72_R1.0961.00
224_S242_N1.0901.00
335_Q338_Q1.0881.00
278_T309_Q1.0871.00
99_M366_F1.0721.00
166_A346_E1.0711.00
179_Y183_L1.0681.00
230_W371_I1.0671.00
192_D262_D1.0621.00
339_W344_D1.0591.00
248_D252_A1.0581.00
178_A210_I1.0561.00
186_G287_A1.0561.00
358_A376_V1.0551.00
52_W355_L1.0521.00
76_E121_G1.0371.00
180_F332_A1.0361.00
354_G377_G1.0281.00
69_L356_E1.0231.00
185_V316_K1.0161.00
245_Q252_A1.0151.00
84_V137_V1.0091.00
257_A260_G1.0091.00
250_S278_T1.0071.00
88_Y164_L1.0071.00
334_E338_Q1.0011.00
143_W358_A0.9921.00
88_Y375_V0.9861.00
87_R116_S0.9861.00
162_A167_Y0.9841.00
92_D113_E0.9751.00
92_D114_P0.9741.00
175_G336_L0.9741.00
268_V272_I0.9721.00
211_A216_C0.9711.00
89_L143_W0.9691.00
219_V239_A0.9661.00
364_G374_Q0.9601.00
96_R365_L0.9501.00
183_L335_Q0.9501.00
208_G218_V0.9481.00
363_L366_F0.9481.00
171_L340_V0.9431.00
178_A207_V0.9391.00
85_R145_D0.9371.00
266_D269_G0.9311.00
62_P66_S0.9301.00
250_S275_A0.9291.00
62_P65_D0.9291.00
274_D278_T0.9221.00
196_V207_V0.9201.00
87_R120_V0.9201.00
124_V128_S0.9121.00
90_S114_P0.9121.00
221_F243_Y0.9121.00
179_Y335_Q0.9101.00
253_L261_V0.9091.00
181_G289_C0.9071.00
89_L142_T0.9071.00
128_S151_A0.9001.00
250_S254_D0.8961.00
181_G265_F0.8921.00
275_A278_T0.8921.00
330_G334_E0.8871.00
197_S264_Y0.8871.00
143_W376_V0.8831.00
205_S230_W0.8801.00
188_P192_D0.8761.00
310_L317_V0.8751.00
196_V211_A0.8741.00
119_V131_Y0.8711.00
223_G228_V0.8711.00
53_V72_R0.8671.00
192_D263_V0.8661.00
195_V279_K0.8651.00
227_K371_I0.8631.00
83_L121_G0.8611.00
76_E83_L0.8611.00
210_I336_L0.8601.00
83_L120_V0.8601.00
220_G231_L0.8591.00
219_V241_I0.8561.00
222_A240_G0.8541.00
234_D346_E0.8531.00
80_G125_E0.8521.00
132_E156_P0.8521.00
283_D314_R0.8461.00
183_L210_I0.8441.00
176_R332_A0.8401.00
335_Q339_W0.8341.00
115_L147_S0.8321.00
309_Q313_P0.8321.00
138_S337_G0.8311.00
331_E335_Q0.8241.00
160_S341_A0.8231.00
224_S227_K0.8211.00
129_D151_A0.8201.00
53_V110_T0.8171.00
219_V253_L0.8161.00
210_I339_W0.8151.00
193_T261_V0.8151.00
234_D348_R0.8101.00
351_V360_D0.8101.00
251_A254_D0.8041.00
121_G133_A0.7991.00
181_G207_V0.7981.00
78_R148_L0.7961.00
226_E229_D0.7961.00
91_V365_L0.7951.00
185_V318_Q0.7931.00
353_S357_N0.7921.00
250_S279_K0.7871.00
193_T259_D0.7861.00
219_V256_A0.7841.00
120_V146_Y0.7821.00
365_L374_Q0.7811.00
200_A231_L0.7791.00
249_Y275_A0.7791.00
182_L211_A0.7791.00
231_L237_F0.7751.00
92_D95_M0.7681.00
178_A203_V0.7681.00
94_Y113_E0.7671.00
69_L355_L0.7661.00
85_R120_V0.7641.00
211_A218_V0.7631.00
91_V143_W0.7621.00
267_N289_C0.7601.00
162_A340_V0.7571.00
339_W342_A0.7551.00
306_K309_Q0.7521.00
178_A206_V0.7511.00
248_D275_A0.7481.00
233_E239_A0.7461.00
124_V132_E0.7441.00
80_G126_S0.7411.00
50_R69_L0.7381.00
72_R110_T0.7331.00
331_E334_E0.7311.00
188_P263_V0.7281.00
194_V216_C0.7261.00
264_Y286_V0.7251.00
288_V317_V0.7231.00
139_G149_L0.7221.00
137_V154_V0.7211.00
196_V220_G0.7171.00
276_V286_V0.7171.00
142_T147_S0.7151.00
82_L151_A0.7151.00
218_V238_D0.7141.00
92_D173_M0.7141.00
370_N374_Q0.7121.00
180_F314_R0.7111.00
121_G131_Y0.7081.00
364_G367_S0.7081.00
138_S157_V0.7081.00
339_W343_G0.7051.00
214_N335_Q0.7031.00
233_E240_G0.7021.00
54_F66_S0.7021.00
245_Q248_D0.7011.00
310_L315_A0.6971.00
351_V374_Q0.6951.00
187_A316_K0.6951.00
77_P125_E0.6941.00
259_D281_N0.6931.00
349_E352_V0.6891.00
92_D174_P0.6871.00
62_P68_E0.6861.00
51_E110_T0.6851.00
113_E173_M0.6841.00
282_V313_P0.6811.00
114_P173_M0.6791.00
222_A231_L0.6781.00
174_P202_A0.6771.00
353_S374_Q0.6771.00
187_A318_Q0.6761.00
263_V287_A0.6761.00
187_A285_R0.6751.00
261_V264_Y0.6741.00
353_S376_V0.6741.00
178_A182_L0.6711.00
75_P148_L0.6711.00
230_W348_R0.6701.00
273_S286_V0.6681.00
155_A333_S0.6651.00
155_A334_E0.6641.00
205_S348_R0.6631.00
65_D363_L0.6601.00
216_C263_V0.6571.00
52_W359_P0.6571.00
249_Y253_L0.6561.00
228_V231_L0.6551.00
337_G341_A0.6511.00
253_L279_K0.6491.00
179_Y339_W0.6491.00
239_A252_A0.6461.00
93_P97_G0.6451.00
179_Y336_L0.6441.00
208_G235_L0.6421.00
84_V139_G0.6401.00
230_W235_L0.6381.00
87_R377_G0.6381.00
197_S272_I0.6381.00
159_P341_A0.6351.00
295_Y306_K0.6331.00
130_A330_G0.6321.00
310_L319_G0.6321.00
173_M177_T0.6311.00
130_A133_A0.6301.00
177_T203_V0.6301.00
254_D257_A0.6291.00
138_S172_G0.6291.00
75_P146_Y0.6281.00
52_W67_F0.6281.00
105_Y109_W0.6271.00
212_K218_V0.6261.00
136_L161_V0.6251.00
186_G285_R0.6251.00
222_A243_Y0.6231.00
130_A156_P0.6221.00
94_Y98_R0.6211.00
221_F241_I0.6211.00
228_V243_Y0.6171.00
254_D260_G0.6161.00
231_L240_G0.6161.00
64_M363_L0.6151.00
135_D160_S0.6141.00
261_V279_K0.6131.00
208_G231_L0.6111.00
155_A337_G0.6101.00
210_I214_N0.6091.00
362_F366_F0.6061.00
80_G152_A0.6051.00
120_V124_V0.6031.00
116_S157_V0.6021.00
241_I256_A0.6001.00
271_P275_A0.5991.00
139_G154_V0.5971.00
116_S168_L0.5951.00
86_V89_L0.5951.00
314_R324_D0.5951.00
181_G320_L0.5921.00
274_D309_Q0.5911.00
97_G102_S0.5901.00
266_D286_V0.5871.00
179_Y332_A0.5871.00
96_R366_F0.5861.00
263_V285_R0.5851.00
222_A242_N0.5841.00
209_Q235_L0.5821.00
92_D373_K0.5811.00
116_S136_L0.5811.00
61_E107_D0.5811.00
88_Y352_V0.5781.00
340_V347_H0.5771.00
364_G370_N0.5761.00
159_P167_Y0.5751.00
287_A320_L0.5751.00
207_V289_C0.5721.00
272_I276_V0.5711.00
194_V263_V0.5671.00
84_V154_V0.5671.00
93_P201_G0.5671.00
271_P274_D0.5661.00
190_P214_N0.5651.00
88_Y116_S0.5641.00
219_V257_A0.5631.00
264_Y279_K0.5631.00
308_P311_I0.5621.00
193_T257_A0.5621.00
206_V210_I0.5611.00
75_P83_L0.5611.00
140_N155_A0.5591.00
200_A208_G0.5561.00
177_T289_C0.5551.00
67_F362_F0.5551.00
174_P206_V0.5521.00
151_A154_V0.5501.00
129_D132_E0.5481.00
96_R100_R0.5471.00
241_I252_A0.5461.00
190_P215_G0.5451.00
184_E214_N0.5451.00
241_I247_D0.5451.00
112_G143_W0.5431.00
124_V135_D0.5381.00
86_V139_G0.5381.00
89_L376_V0.5381.00
125_E133_A0.5371.00
340_V345_I0.5371.00
69_L358_A0.5371.00
74_V148_L0.5331.00
206_V345_I0.5321.00
182_L210_I0.5321.00
195_V264_Y0.5321.00
73_D76_E0.5311.00
200_A227_K0.5311.00
116_S167_Y0.5301.00
222_A227_K0.5301.00
259_D262_D0.5221.00
163_D352_V0.5211.00
266_D290_G0.5201.00
206_V209_Q0.5201.00
241_I249_Y0.5201.00
74_V77_P0.5171.00
309_Q312_A0.5171.00
98_R105_Y0.5171.00
77_P127_E0.5171.00
131_Y151_A0.5151.00
138_S155_A0.5151.00
205_S235_L0.5121.00
197_S249_Y0.5121.00
184_E331_E0.5091.00
136_L167_Y0.5081.00
164_L167_Y0.5081.00
157_V160_S0.5081.00
309_Q315_A0.5071.00
181_G287_A0.5061.00
66_S359_P0.5051.00
212_K237_F0.5051.00
104_S107_D0.5051.00
97_G291_Q0.5031.00
139_G147_S0.5031.00
179_Y214_N0.5031.00
84_V115_L0.5011.00
86_V142_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gi2A 2 0.9 100 0.274 Contact Map
3uogA 4 0.8184 100 0.283 Contact Map
4hfmA 2 0.85 100 0.285 Contact Map
4j6fA 2 0.8421 100 0.287 Contact Map
3ukoA 4 0.8395 100 0.29 Contact Map
4a27A 2 0.7895 100 0.291 Contact Map
4ej6A 1 0.8026 100 0.293 Contact Map
1f8fA 4 0.8211 100 0.294 Contact Map
4nh4A 2 0.8605 100 0.295 Contact Map
3qwbA 2 0.8421 100 0.298 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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