GREMLIN Database
Q9HR84 - Chitinase
UniProt: Q9HR84 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 546 (438)
Sequences: 830 (490)
Seq/√Len: 23.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
407_D515_Y5.7011.00
123_A128_T4.2841.00
406_V425_L3.5241.00
180_G526_F3.5001.00
104_T108_V3.3601.00
114_V117_V3.0201.00
272_Q276_E2.9851.00
233_K236_H2.9751.00
490_P505_S2.9161.00
142_A145_Y2.8820.99
234_S237_D2.8590.99
153_T156_G2.7010.99
323_L366_L2.6270.99
282_A294_L2.6010.99
92_S95_T2.5850.99
388_A428_P2.5370.99
153_T157_T2.3590.98
222_Q225_A2.3400.98
233_K237_D2.2630.97
279_A325_T2.2620.97
231_E236_H2.2400.97
145_Y149_L2.1930.96
231_E235_W2.1670.96
407_D411_S2.1590.96
410_M423_L2.1300.96
420_P520_D2.1290.96
106_V110_A2.1160.95
206_N370_N2.0740.95
324_Q365_A2.0300.94
490_P508_S2.0200.94
514_A518_Q1.9750.93
139_Y149_L1.9640.93
114_V157_T1.9510.93
160_T163_A1.9080.92
149_L153_T1.9060.92
280_D329_K1.8930.92
347_L413_W1.8550.91
129_T137_H1.8380.91
371_V410_M1.8280.90
150_T158_T1.8160.90
100_I108_V1.8160.90
239_T243_D1.8070.90
122_W149_L1.8050.90
100_I103_E1.7880.89
230_L235_W1.7870.89
120_Y123_A1.7800.89
204_H253_L1.7520.88
284_E288_T1.7400.88
84_T88_G1.7290.88
153_T159_D1.7130.87
452_T461_N1.7050.87
102_P105_T1.7050.87
161_T165_L1.6930.87
120_Y149_L1.6890.86
120_Y125_G1.6790.86
372_M375_D1.6740.86
159_D162_S1.6710.86
119_N122_W1.6710.86
120_Y147_I1.6530.85
391_Y407_D1.6410.85
123_A151_V1.6380.85
113_T153_T1.6330.85
106_V109_D1.6330.85
280_D284_E1.6280.84
358_D361_A1.6220.84
129_T132_G1.6220.84
218_V282_A1.6210.84
133_V165_L1.6170.84
361_A364_E1.6090.84
151_V156_G1.6080.84
132_G140_D1.6080.84
85_D97_E1.6010.83
116_D122_W1.6000.83
162_S167_V1.5950.83
92_S120_Y1.5790.82
87_G95_T1.5650.82
139_Y145_Y1.5600.82
103_E108_V1.5540.81
143_G169_D1.5480.81
411_S414_L1.5320.80
112_N115_G1.5200.80
316_K320_T1.5190.80
182_Y186_A1.5130.80
468_D472_N1.5090.79
180_G529_F1.5070.79
319_Y345_T1.5050.79
132_G136_S1.4990.79
296_I326_V1.4960.79
184_Q226_A1.4870.78
142_A173_P1.4860.78
108_V122_W1.4790.78
118_D127_G1.4600.77
87_G97_E1.4570.77
122_W127_G1.4560.77
86_P157_T1.4550.77
134_T138_T1.4520.77
198_P247_D1.4500.77
276_E280_D1.4380.76
110_A120_Y1.4210.75
230_L234_S1.4210.75
116_D120_Y1.4070.74
434_F437_V1.3940.74
269_A322_L1.3830.73
92_S96_S1.3780.73
153_T161_T1.3750.73
481_T505_S1.3750.73
177_R522_G1.3680.72
133_V139_Y1.3580.72
149_L167_V1.3500.71
359_H363_A1.3490.71
231_E234_S1.3460.71
421_A522_G1.3360.70
115_G121_E1.3310.70
100_I107_T1.3290.70
386_H489_V1.3280.70
116_D125_G1.3240.70
363_A369_L1.3240.70
122_W126_D1.3230.70
436_N450_D1.3210.70
287_R341_Y1.3160.69
113_T157_T1.3040.68
230_L233_K1.3030.68
386_H484_D1.2980.68
93_F97_E1.2980.68
259_W301_P1.2970.68
492_L505_S1.2960.68
210_L254_F1.2950.68
119_N123_A1.2890.68
137_H147_I1.2890.68
481_T492_L1.2860.67
463_I468_D1.2750.67
151_V155_D1.2740.67
92_S106_V1.2700.66
91_A97_E1.2680.66
160_T169_D1.2620.66
94_T109_D1.2520.65
143_G168_A1.2460.65
258_G295_D1.2460.65
346_A372_M1.2390.64
165_L169_D1.2390.64
120_Y153_T1.2360.64
300_Y372_M1.2350.64
286_M294_L1.2300.64
374_Y426_G1.2290.64
359_H418_F1.2290.64
130_A135_A1.2280.64
118_D124_F1.2280.64
154_G157_T1.2170.63
152_T160_T1.2160.63
84_T91_A1.2140.63
121_E124_F1.2040.62
232_P237_D1.2010.62
101_E106_V1.2010.62
109_D125_G1.2010.62
146_T164_T1.1990.62
232_P236_H1.1970.62
92_S100_I1.1870.61
377_H396_D1.1850.61
423_L522_G1.1740.60
113_T117_V1.1740.60
85_D157_T1.1700.60
95_T108_V1.1690.60
150_T157_T1.1670.60
204_H251_S1.1650.60
115_G122_W1.1640.59
120_Y124_F1.1640.59
230_L237_D1.1590.59
110_A123_A1.1580.59
106_V147_I1.1490.58
199_L250_T1.1470.58
105_T108_V1.1400.58
101_E105_T1.1400.58
377_H381_N1.1390.58
108_V120_Y1.1380.58
296_I366_L1.1360.58
102_P108_V1.1340.57
283_I329_K1.1310.57
484_D489_V1.1310.57
363_A419_D1.1300.57
300_Y346_A1.1280.57
85_D110_A1.1280.57
131_S136_S1.1250.57
488_K511_A1.1250.57
143_G147_I1.1240.57
117_V121_E1.1230.57
159_D163_A1.1180.56
114_V159_D1.1160.56
302_G316_K1.1140.56
139_Y143_G1.1110.56
124_F128_T1.1100.56
90_T100_I1.1100.56
146_T150_T1.1070.56
132_G137_H1.1070.56
95_T98_S1.1030.55
152_T162_S1.1010.55
410_M425_L1.0990.55
85_D113_T1.0980.55
112_N117_V1.0960.55
116_D157_T1.0940.55
118_D149_L1.0930.55
209_F255_S1.0920.55
86_P89_P1.0910.54
516_A524_M1.0860.54
465_E468_D1.0840.54
260_N432_R1.0830.54
358_D491_W1.0820.54
86_P114_V1.0790.54
141_A145_Y1.0780.54
124_F147_I1.0780.54
185_W378_G1.0750.53
145_Y153_T1.0740.53
93_F139_Y1.0730.53
155_D167_V1.0730.53
120_Y139_Y1.0670.53
121_E150_T1.0550.52
374_Y378_G1.0550.52
410_M521_I1.0530.52
352_E404_F1.0510.52
123_A127_G1.0360.51
193_F196_D1.0290.50
453_P456_T1.0280.50
464_K468_D1.0240.50
101_E110_A1.0230.50
505_S508_S1.0230.50
150_T154_G1.0160.49
114_V150_T1.0140.49
162_S166_L1.0110.49
259_W378_G1.0080.49
104_T107_T1.0070.49
82_S96_S1.0060.49
199_L244_L1.0040.48
114_V124_F1.0040.48
130_A134_T1.0030.48
152_T157_T1.0030.48
153_T165_L1.0020.48
117_V126_D1.0010.48
92_S147_I1.0000.48
324_Q327_R0.9990.48
419_D522_G0.9960.48
130_A137_H0.9950.48
222_Q226_A0.9930.48
113_T116_D0.9930.48
101_E104_T0.9910.47
114_V121_E0.9890.47
533_K536_V0.9860.47
115_G158_T0.9850.47
528_T531_G0.9840.47
256_I410_M0.9800.47
83_P173_P0.9790.47
197_I529_F0.9790.47
325_T329_K0.9780.47
435_G499_V0.9760.46
300_Y373_T0.9760.46
150_T162_S0.9750.46
271_S274_S0.9720.46
401_A404_F0.9720.46
160_T164_T0.9720.46
462_G465_E0.9690.46
92_S139_Y0.9670.46
323_L365_A0.9660.46
145_Y155_D0.9660.46
104_T110_A0.9630.46
143_G149_L0.9620.45
282_A286_M0.9620.45
94_T98_S0.9610.45
123_A147_I0.9590.45
139_Y151_V0.9570.45
137_H140_D0.9560.45
98_S105_T0.9550.45
123_A150_T0.9530.45
93_F108_V0.9510.45
85_D159_D0.9500.45
495_P498_N0.9480.44
253_L342_Q0.9470.44
464_K467_W0.9450.44
93_F147_I0.9450.44
113_T121_E0.9440.44
139_Y147_I0.9430.44
92_S108_V0.9400.44
385_N388_A0.9400.44
113_T124_F0.9370.44
88_G117_V0.9360.44
150_T156_G0.9340.44
129_T134_T0.9290.43
93_F103_E0.9280.43
102_P109_D0.9250.43
448_P452_T0.9190.42
390_L406_V0.9180.42
210_L256_I0.9170.42
100_I105_T0.9120.42
205_V410_M0.9110.42
504_D512_K0.9100.42
106_V120_Y0.9090.42
163_A167_V0.9080.42
483_W508_S0.9070.42
163_A166_L0.9050.42
365_A372_M0.9030.41
143_G153_T0.9030.41
249_E339_K0.9000.41
103_E143_G0.9000.41
431_G434_F0.9000.41
106_V124_F0.8980.41
204_H342_Q0.8960.41
259_W300_Y0.8930.41
479_Y494_S0.8930.41
100_I106_V0.8900.41
479_Y499_V0.8850.40
119_N157_T0.8810.40
456_T468_D0.8810.40
376_Y409_S0.8790.40
232_P235_W0.8790.40
376_Y404_F0.8780.40
121_E128_T0.8760.40
122_W147_I0.8750.39
108_V139_Y0.8720.39
216_G277_R0.8720.39
117_V120_Y0.8700.39
90_T95_T0.8690.39
121_E165_L0.8670.39
301_P375_D0.8640.39
411_S519_H0.8630.39
122_W145_Y0.8600.38
97_E108_V0.8600.38
148_E160_T0.8590.38
100_I110_A0.8580.38
134_T139_Y0.8570.38
279_A326_V0.8550.38
118_D154_G0.8550.38
363_A372_M0.8520.38
482_F492_L0.8520.38
406_V410_M0.8490.38
375_D378_G0.8490.38
108_V149_L0.8480.38
185_W532_D0.8480.38
92_S107_T0.8440.37
273_A328_E0.8440.37
210_L285_I0.8420.37
113_T158_T0.8390.37
110_A151_V0.8380.37
276_E325_T0.8370.37
96_S113_T0.8350.37
209_F346_A0.8330.37
168_A284_E0.8320.37
86_P119_N0.8320.37
119_N149_L0.8300.37
194_P244_L0.8300.37
142_A149_L0.8300.37
302_G305_G0.8290.36
444_G447_Q0.8280.36
230_L236_H0.8280.36
251_S292_D0.8270.36
98_S120_Y0.8260.36
305_G311_V0.8250.36
101_E107_T0.8250.36
99_V102_P0.8220.36
86_P92_S0.8220.36
177_R424_S0.8210.36
357_L369_L0.8150.36
124_F127_G0.8140.35
106_V119_N0.8140.35
120_Y169_D0.8100.35
108_V143_G0.8100.35
108_V112_N0.8090.35
115_G119_N0.8090.35
271_S318_R0.8070.35
276_E329_K0.8050.35
97_E102_P0.8030.35
133_V136_S0.8000.35
152_T159_D0.7990.35
158_T161_T0.7990.35
91_A120_Y0.7970.34
92_S169_D0.7950.34
103_E106_V0.7940.34
369_L418_F0.7910.34
145_Y167_V0.7910.34
116_D119_N0.7850.34
115_G150_T0.7820.33
105_T110_A0.7810.33
120_Y143_G0.7810.33
209_F258_G0.7800.33
93_F143_G0.7800.33
457_W460_D0.7790.33
149_L156_G0.7760.33
148_E159_D0.7740.33
143_G167_V0.7740.33
153_T167_V0.7730.33
313_D317_Q0.7720.33
218_V294_L0.7720.33
120_Y128_T0.7720.33
270_Q314_G0.7700.33
176_G517_A0.7690.33
137_H153_T0.7690.33
485_D488_K0.7680.33
84_T87_G0.7660.32
147_I151_V0.7660.32
122_W139_Y0.7650.32
99_V105_T0.7640.32
147_I153_T0.7640.32
317_Q321_E0.7630.32
117_V125_G0.7620.32
259_W375_D0.7580.32
182_Y365_A0.7550.32
253_L370_N0.7510.32
153_T158_T0.7500.31
92_S102_P0.7470.31
427_L513_T0.7450.31
331_D338_G0.7450.31
449_F466_Y0.7440.31
183_M528_T0.7430.31
428_P525_M0.7400.31
131_S134_T0.7380.31
124_F149_L0.7370.31
275_R298_W0.7370.31
209_F375_D0.7360.31
122_W125_G0.7350.31
97_E100_I0.7330.30
483_W488_K0.7320.30
376_Y406_V0.7310.30
88_G95_T0.7300.30
209_F295_D0.7280.30
157_T169_D0.7270.30
479_Y492_L0.7250.30
85_D155_D0.7240.30
151_V205_V0.7230.30
123_A158_T0.7190.30
123_A126_D0.7180.30
99_V104_T0.7180.30
439_S442_N0.7180.30
510_E514_A0.7140.29
91_A95_T0.7130.29
198_P250_T0.7120.29
119_N137_H0.7100.29
346_A373_T0.7090.29
179_V378_G0.7080.29
296_I323_L0.7070.29
108_V147_I0.7070.29
221_I261_D0.7050.29
90_T107_T0.7040.29
149_L159_D0.7040.29
85_D95_T0.7030.29
298_W301_P0.7010.29
123_A149_L0.7000.29
213_R238_H0.7000.29
114_V125_G0.6970.28
122_W160_T0.6970.28
129_T135_A0.6960.28
292_D431_G0.6960.28
93_F100_I0.6940.28
116_D121_E0.6910.28
223_E226_A0.6910.28
313_D444_G0.6910.28
84_T96_S0.6900.28
137_H149_L0.6900.28
481_T490_P0.6900.28
120_Y151_V0.6890.28
114_V126_D0.6890.28
364_E518_Q0.6890.28
116_D123_A0.6870.28
242_D289_H0.6870.28
105_T121_E0.6810.27
226_A229_V0.6810.27
142_A162_S0.6800.27
118_D121_E0.6790.27
360_A363_A0.6770.27
130_A167_V0.6770.27
431_G503_Y0.6770.27
133_V137_H0.6730.27
119_N128_T0.6690.27
85_D115_G0.6680.27
456_T464_K0.6680.27
92_S98_S0.6670.27
247_D250_T0.6670.27
90_T94_T0.6670.27
101_E108_V0.6660.27
218_V289_H0.6660.27
188_W260_N0.6640.27
117_V124_F0.6640.27
94_T97_E0.6620.26
187_Q225_A0.6610.26
126_D129_T0.6580.26
173_P469_I0.6560.26
257_G295_D0.6560.26
89_P151_V0.6560.26
92_S143_G0.6550.26
300_Y304_G0.6530.26
167_V171_G0.6530.26
151_V163_A0.6520.26
117_V147_I0.6510.26
168_A171_G0.6510.26
86_P98_S0.6500.26
386_H389_P0.6500.26
142_A208_A0.6490.26
142_A154_G0.6490.26
231_E237_D0.6480.26
86_P90_T0.6470.26
146_T166_L0.6460.26
207_Y343_L0.6460.26
85_D117_V0.6450.26
463_I467_W0.6440.25
194_P205_V0.6440.25
85_D121_E0.6430.25
130_A139_Y0.6420.25
357_L362_N0.6410.25
207_Y532_D0.6400.25
114_V122_W0.6400.25
85_D114_V0.6390.25
125_G128_T0.6380.25
209_F301_P0.6370.25
134_T158_T0.6350.25
149_L155_D0.6340.25
95_T165_L0.6310.25
92_S119_N0.6290.25
249_E479_Y0.6290.25
145_Y161_T0.6280.25
152_T156_G0.6270.25
116_D165_L0.6270.25
241_F252_F0.6250.24
431_G469_I0.6240.24
300_Y319_Y0.6220.24
259_W262_S0.6190.24
97_E130_A0.6190.24
131_S138_T0.6170.24
338_G341_Y0.6170.24
102_P106_V0.6150.24
135_A139_Y0.6140.24
327_R341_Y0.6110.24
144_E156_G0.6100.24
418_F422_Q0.6080.24
104_T143_G0.6070.24
87_G98_S0.6070.24
141_A147_I0.6070.24
124_F145_Y0.6060.23
367_D378_G0.6030.23
348_S531_G0.6010.23
323_L416_T0.5990.23
317_Q358_D0.5990.23
301_P378_G0.5980.23
405_Y408_A0.5970.23
86_P95_T0.5970.23
149_L160_T0.5960.23
508_S511_A0.5960.23
106_V123_A0.5950.23
92_S99_V0.5930.23
118_D159_D0.5930.23
323_L362_N0.5920.23
221_I227_M0.5890.23
321_E325_T0.5890.23
121_E158_T0.5890.23
85_D92_S0.5870.23
113_T118_D0.5860.22
433_S437_V0.5830.22
120_Y145_Y0.5800.22
106_V122_W0.5800.22
245_V281_T0.5800.22
93_F106_V0.5790.22
207_Y291_F0.5790.22
350_D353_K0.5770.22
108_V113_T0.5770.22
137_H145_Y0.5770.22
176_G522_G0.5760.22
422_Q491_W0.5750.22
262_S301_P0.5750.22
179_V525_M0.5740.22
117_V122_W0.5740.22
85_D90_T0.5740.22
120_Y137_H0.5670.22
384_T390_L0.5670.22
292_D344_T0.5660.22
134_T146_T0.5660.22
89_P93_F0.5620.21
120_Y126_D0.5620.21
375_D432_R0.5620.21
209_F532_D0.5610.21
221_I226_A0.5580.21
487_A491_W0.5570.21
195_G240_G0.5550.21
102_P141_A0.5550.21
348_S357_L0.5540.21
129_T147_I0.5530.21
427_L502_S0.5530.21
440_S443_N0.5530.21
92_S149_L0.5520.21
501_V531_G0.5520.21
142_A153_T0.5520.21
198_P201_K0.5510.21
217_A420_P0.5510.21
96_S107_T0.5500.21
95_T101_E0.5490.21
118_D122_W0.5490.21
273_A280_D0.5480.21
195_G282_A0.5480.21
109_D133_V0.5480.21
86_P153_T0.5470.21
523_G527_W0.5460.21
91_A96_S0.5450.21
88_G157_T0.5440.21
273_A480_E0.5430.20
109_D146_T0.5430.20
456_T471_Q0.5420.20
92_S101_E0.5420.20
366_L369_L0.5420.20
97_E122_W0.5410.20
85_D101_E0.5380.20
410_M414_L0.5370.20
147_I159_D0.5370.20
119_N139_Y0.5350.20
117_V156_G0.5350.20
275_R279_A0.5350.20
451_G455_G0.5350.20
93_F98_S0.5350.20
102_P107_T0.5340.20
116_D134_T0.5330.20
507_R511_A0.5330.20
114_V120_Y0.5310.20
492_L500_L0.5300.20
144_E166_L0.5270.20
286_M326_V0.5260.20
185_W192_Y0.5260.20
95_T104_T0.5260.20
212_V268_A0.5260.20
130_A136_S0.5260.20
150_T153_T0.5250.20
87_G90_T0.5250.20
134_T137_H0.5250.20
280_D498_N0.5240.20
93_F149_L0.5240.20
238_H433_S0.5230.20
303_G348_S0.5230.20
98_S107_T0.5210.19
162_S169_D0.5210.19
387_Q481_T0.5190.19
91_A102_P0.5180.19
268_A278_F0.5180.19
82_S93_F0.5180.19
266_S315_D0.5160.19
87_G115_G0.5160.19
356_G385_N0.5160.19
433_S449_F0.5150.19
245_V433_S0.5110.19
345_T353_K0.5110.19
282_A326_V0.5100.19
188_W224_N0.5100.19
410_M508_S0.5100.19
110_A153_T0.5090.19
185_W207_Y0.5080.19
94_T99_V0.5060.19
145_Y151_V0.5060.19
84_T98_S0.5060.19
367_D374_Y0.5050.19
386_H487_A0.5050.19
115_G155_D0.5040.19
106_V125_G0.5030.19
114_V173_P0.5020.19
118_D126_D0.5010.19
468_D471_Q0.5000.19
245_V248_P0.5000.19
82_S92_S0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3arxA 1 0.8755 100 0.312 Contact Map
1edqA 1 0.859 100 0.328 Contact Map
1itxA 1 0.6923 100 0.37 Contact Map
1kfwA 1 0.6703 100 0.405 Contact Map
4dwsA 1 0.7509 100 0.409 Contact Map
3w4rA 1 0.6502 100 0.416 Contact Map
3oa5A 1 0.7399 100 0.417 Contact Map
1w9pA 1 0.6447 100 0.42 Contact Map
1ll7A 1 0.641 100 0.422 Contact Map
3fy1A 1 0.641 100 0.425 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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