GREMLIN Database
Q9HR83 - Uncharacterized protein
UniProt: Q9HR83 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 572 (444)
Sequences: 586 (361)
Seq/√Len: 17.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
402_E541_L6.9701.00
120_A125_T4.9761.00
101_T105_V3.8721.00
177_G552_I3.6711.00
381_A438_P3.5771.00
516_P531_D3.4851.00
111_T154_T3.2540.99
265_Q269_E3.2110.99
126_T129_G3.1260.99
129_G137_D3.0600.99
134_H137_D2.9850.99
273_T322_R2.9310.98
132_A136_Y2.9100.98
142_Y146_L2.9070.98
111_T114_V2.7510.98
126_T134_H2.6400.97
136_Y144_I2.5100.96
275_A279_M2.4840.96
272_A318_T2.4840.96
483_D486_N2.4350.95
179_Y183_K2.4160.95
150_T153_G2.3740.94
480_R487_T2.2690.93
402_E406_T2.2570.92
316_L359_V2.2000.91
204_L363_Y2.1970.91
100_G105_V2.1700.91
132_A137_D2.1500.90
159_T164_A2.1450.90
364_M405_L2.0960.89
516_P534_S2.0930.89
379_L510_N2.0530.88
82_S154_T2.0100.87
483_D490_F2.0020.87
384_Y402_E1.9950.87
89_A92_V1.9950.87
140_G164_A1.9840.86
220_D223_V1.9680.86
230_A234_S1.9400.85
148_V152_D1.9200.85
107_A150_T1.9180.85
280_R330_D1.9180.85
109_D112_G1.8990.84
97_V100_G1.8850.83
107_A117_Y1.8840.83
356_A362_I1.8830.83
433_L548_G1.8670.83
150_T154_T1.8580.83
140_G144_I1.8430.82
117_Y146_L1.8310.82
139_A142_Y1.8250.81
437_M539_V1.8210.81
196_P239_R1.8100.81
127_A137_D1.8010.80
352_H425_D1.7890.80
127_A134_H1.7720.79
367_Y436_G1.7480.78
275_A287_I1.7370.78
120_A123_D1.7350.78
431_G548_G1.7340.78
370_T389_D1.7230.77
110_T154_T1.6820.76
142_Y150_T1.6480.74
89_A93_T1.6470.74
439_F564_L1.6370.74
149_T159_T1.6220.73
470_V476_W1.6200.73
83_P111_T1.5980.72
102_A105_V1.5940.71
351_N517_Y1.5890.71
317_E358_V1.5840.71
320_R324_N1.5810.71
540_E544_A1.5770.71
157_T166_T1.5690.70
116_S119_W1.5430.69
378_G381_A1.5330.68
179_Y358_V1.5260.68
493_G496_A1.5220.68
293_H365_M1.5150.67
356_A426_P1.5120.67
262_A315_L1.5030.67
195_V555_L1.5030.67
202_D246_K1.5000.67
507_K531_D1.4930.66
339_A365_M1.4920.66
83_P154_T1.4800.66
140_G146_L1.4670.65
141_E165_T1.4550.64
90_F140_G1.4540.64
208_L247_L1.4520.64
98_E101_T1.4430.64
108_G132_A1.4370.63
518_L526_F1.4320.63
141_E161_Q1.4260.63
279_M287_I1.4190.62
383_I401_L1.4180.62
89_A152_D1.4150.62
202_D244_R1.4100.62
121_F146_L1.3870.60
365_M368_D1.3860.60
146_L150_T1.3850.60
110_T114_V1.3840.60
401_L435_L1.3830.60
277_D281_T1.3820.60
289_V319_V1.3800.60
340_N408_W1.3770.60
120_A148_V1.3760.60
167_S170_D1.3740.60
205_Y336_L1.3710.59
354_E357_A1.3710.59
194_D198_D1.3700.59
119_W146_L1.3690.59
90_F105_V1.3670.59
472_P475_T1.3670.59
309_P313_V1.3640.59
156_D159_T1.3620.59
129_G134_H1.3620.59
449_G522_S1.3600.59
491_D494_D1.3600.59
83_P87_T1.3500.58
379_L513_G1.3400.58
143_T161_Q1.3380.58
441_G529_Y1.3320.57
483_D489_A1.3320.57
107_A120_A1.3270.57
181_S224_D1.3220.57
199_Q565_E1.3180.56
293_H339_A1.3170.56
143_T163_T1.3070.56
444_C447_E1.3010.55
166_T169_G1.3000.55
351_N354_E1.2990.55
296_P341_G1.2960.55
268_R291_W1.2940.55
142_Y162_I1.2940.55
293_H366_A1.2910.55
92_V116_S1.2880.55
207_F248_S1.2810.54
282_Y319_V1.2720.54
117_Y122_G1.2700.54
87_T433_L1.2410.52
117_Y144_I1.2390.52
126_T137_D1.2370.52
102_A163_T1.2200.51
103_V156_D1.2160.50
208_L249_I1.2140.50
119_W134_H1.2140.50
151_G154_T1.2140.50
178_Y288_D1.2120.50
530_D538_K1.2100.50
505_W518_L1.2050.50
142_Y148_V1.2040.50
97_V106_D1.2000.49
95_T161_Q1.1950.49
318_T322_R1.1950.49
289_V316_L1.1940.49
174_K548_G1.1940.49
207_F339_A1.1920.49
252_W294_P1.1890.49
263_A305_S1.1880.49
89_A117_Y1.1870.49
97_V105_V1.1860.48
99_P105_V1.1830.48
509_R534_S1.1820.48
128_A131_T1.1670.47
177_G555_L1.1620.47
405_L409_K1.1620.47
93_T106_D1.1600.47
146_L156_D1.1490.46
379_L515_V1.1480.46
133_S317_E1.1470.46
111_T150_T1.1400.46
289_V359_V1.1380.46
102_A106_D1.1360.45
127_A164_A1.1360.45
269_E322_R1.1330.45
175_V513_G1.1320.45
484_D494_D1.1310.45
427_V546_D1.1240.45
112_G152_D1.1220.45
484_D489_A1.1210.45
89_A140_G1.1190.44
120_A158_A1.1180.44
264_D311_N1.1160.44
301_C304_G1.1150.44
96_T105_V1.1130.44
111_T151_G1.1070.44
485_A490_F1.1070.44
110_T113_S1.1050.44
312_H338_V1.1030.44
130_V137_D1.1030.44
255_S294_P1.1030.44
131_T137_D1.1020.43
126_T136_Y1.1000.43
103_V108_G1.0960.43
252_W371_G1.0950.43
89_A149_T1.0930.43
115_D146_L1.0920.43
165_T168_P1.0900.43
205_Y558_D1.0880.43
253_G442_R1.0860.43
100_G106_D1.0860.43
203_V316_L1.0840.42
99_P131_T1.0820.42
437_M567_I1.0750.42
105_V148_V1.0670.41
110_T139_A1.0670.41
135_T266_A1.0590.41
302_E305_S1.0510.40
559_Y562_T1.0470.40
360_D367_Y1.0460.40
147_T155_T1.0400.40
105_V146_L1.0380.40
221_S224_D1.0380.40
112_G154_T1.0350.40
84_G92_V1.0350.40
98_E103_V1.0260.39
89_A146_L1.0250.39
495_L499_Y1.0240.39
129_G136_Y1.0230.39
138_A144_I1.0220.39
182_W371_G1.0200.39
115_D151_G1.0170.39
219_P223_V1.0150.38
505_W520_N1.0150.38
127_A133_S1.0130.38
339_A366_A1.0100.38
160_Q164_A1.0100.38
178_Y251_G1.0080.38
252_W255_S1.0080.38
98_E105_V1.0040.38
103_V119_W1.0010.38
131_T135_T1.0000.38
216_V275_A1.0000.38
484_D490_F0.9980.37
174_K434_V0.9970.37
86_P99_P0.9960.37
117_Y150_T0.9940.37
205_Y236_K0.9920.37
196_P289_V0.9900.37
531_D551_M0.9890.37
152_D164_A0.9750.36
310_A314_A0.9750.36
142_Y152_D0.9700.36
511_E537_A0.9680.36
511_E514_G0.9640.36
114_V154_T0.9630.36
483_D491_D0.9620.35
196_P240_A0.9620.35
89_A128_A0.9610.35
121_F136_Y0.9610.35
285_D294_P0.9600.35
219_P224_D0.9570.35
128_A135_T0.9550.35
405_L435_L0.9510.35
157_T160_Q0.9500.35
139_A163_T0.9490.35
350_I362_I0.9490.35
305_S308_G0.9490.35
255_S291_W0.9480.35
509_R514_G0.9440.34
195_V400_T0.9420.34
111_T147_T0.9400.34
510_N515_V0.9370.34
252_W293_H0.9340.34
123_D545_E0.9320.34
113_S117_Y0.9310.34
130_V134_H0.9260.34
121_F144_I0.9250.33
207_F558_D0.9220.33
203_V405_L0.9210.33
405_L433_L0.9180.33
359_V385_G0.9150.33
316_L358_V0.9120.33
184_G223_V0.9100.33
105_V121_F0.9010.32
82_S147_T0.9000.32
138_A141_E0.9000.32
130_V136_Y0.8990.32
293_H400_T0.8980.32
82_S114_V0.8960.32
114_V132_A0.8940.32
82_S118_E0.8930.32
153_G164_A0.8910.32
369_F404_T0.8890.32
176_V551_M0.8890.32
117_Y166_T0.8870.31
147_T160_Q0.8840.31
81_G84_G0.8820.31
98_E108_G0.8810.31
542_A550_V0.8780.31
117_Y120_A0.8780.31
219_P254_L0.8780.31
116_S122_G0.8750.31
214_G278_L0.8730.31
86_P111_T0.8710.31
131_T136_Y0.8710.31
89_A119_W0.8670.30
102_A487_T0.8660.30
148_V160_Q0.8660.30
105_V118_E0.8640.30
439_F443_G0.8590.30
117_Y142_Y0.8580.30
89_A144_I0.8580.30
207_F288_D0.8580.30
110_T118_E0.8570.30
474_G480_R0.8550.30
219_P225_H0.8550.30
425_D432_T0.8550.30
182_W192_P0.8540.30
107_A146_L0.8530.30
368_D442_R0.8510.30
146_L164_A0.8450.29
523_E526_F0.8450.29
140_G159_T0.8390.29
438_P551_M0.8390.29
329_E332_R0.8390.29
272_A319_V0.8390.29
89_A116_S0.8390.29
150_T156_D0.8370.29
197_F243_T0.8360.29
222_D226_E0.8350.29
227_S241_A0.8320.29
221_S226_E0.8310.29
343_S346_N0.8280.28
341_G510_N0.8210.28
251_G288_D0.8210.28
113_S120_A0.8190.28
200_V382_P0.8180.28
85_G162_I0.8180.28
99_P141_E0.8140.28
259_E519_W0.8130.28
82_S92_V0.8100.28
345_W348_A0.8070.27
124_G130_V0.8060.27
111_T433_L0.8060.27
117_Y121_F0.8060.27
338_V346_N0.8060.27
536_A540_E0.8040.27
374_H505_W0.8040.27
175_V542_A0.8030.27
134_H144_I0.8030.27
280_R319_V0.8010.27
103_V106_D0.8000.27
514_G537_A0.7950.27
255_S268_R0.7940.27
164_A435_L0.7930.27
480_R484_D0.7910.27
120_A134_H0.7880.27
264_D267_S0.7860.26
311_N315_L0.7850.26
487_T490_F0.7850.26
101_T107_A0.7850.26
448_N451_W0.7830.26
360_D365_M0.7830.26
360_D440_Y0.7830.26
116_S137_D0.7820.26
252_W368_D0.7800.26
293_H374_H0.7800.26
432_T517_Y0.7780.26
406_T541_L0.7750.26
119_W140_G0.7730.26
384_Y517_Y0.7730.26
127_A141_E0.7720.26
255_S488_G0.7720.26
105_V136_Y0.7710.26
565_E568_N0.7700.26
110_T116_S0.7690.26
205_Y284_F0.7690.26
125_T128_A0.7690.26
358_V365_M0.7680.26
84_G98_E0.7680.26
471_I475_T0.7680.26
356_A365_M0.7660.26
158_A162_I0.7630.25
117_Y136_Y0.7630.25
159_T163_T0.7600.25
114_V152_D0.7570.25
95_T98_E0.7560.25
130_V133_S0.7540.25
146_L154_T0.7530.25
188_Y491_D0.7500.25
208_L438_P0.7490.25
147_T161_Q0.7490.25
498_N523_E0.7480.25
291_W294_P0.7430.25
227_S230_A0.7420.24
126_T131_T0.7420.24
249_I287_I0.7360.24
329_E426_P0.7360.24
369_F399_Y0.7340.24
274_T443_G0.7340.24
223_V226_E0.7310.24
89_A98_E0.7300.24
146_L162_I0.7300.24
128_A160_Q0.7300.24
129_G133_S0.7300.24
80_D123_D0.7290.24
263_A307_Q0.7290.24
220_D236_K0.7280.24
490_F494_D0.7280.24
443_G554_E0.7260.24
136_Y142_Y0.7260.24
86_P118_E0.7210.24
100_G138_A0.7200.24
197_F235_L0.7150.23
101_T122_G0.7150.23
236_K558_D0.7140.23
139_A149_T0.7130.23
398_Q407_I0.7110.23
246_K363_Y0.7090.23
101_T106_D0.7080.23
79_V91_T0.7070.23
214_G217_V0.7070.23
446_V475_T0.7040.23
242_D332_R0.7040.23
139_A145_E0.7030.23
106_D129_G0.7020.23
121_F124_G0.7010.23
386_T510_N0.7000.23
113_S116_S0.7000.23
104_T159_T0.6990.23
84_G93_T0.6990.23
116_S125_T0.6960.22
272_A322_R0.6950.22
259_E302_E0.6950.22
144_I148_V0.6930.22
103_V107_A0.6920.22
251_G371_G0.6890.22
380_N516_P0.6890.22
116_S120_A0.6870.22
108_G163_T0.6870.22
342_G364_M0.6870.22
92_V160_Q0.6870.22
249_I272_A0.6870.22
246_K335_D0.6860.22
405_L534_S0.6860.22
149_T153_G0.6860.22
90_F100_G0.6850.22
298_R304_G0.6850.22
100_G146_L0.6840.22
500_E503_D0.6830.22
125_T138_A0.6830.22
250_G371_G0.6810.22
81_G93_T0.6800.22
220_D224_D0.6760.22
470_V474_G0.6760.22
104_T522_S0.6750.22
108_G156_D0.6750.22
80_D115_D0.6750.22
180_P554_E0.6750.22
188_Y483_D0.6750.22
127_A131_T0.6740.22
208_L278_L0.6730.22
120_A147_T0.6730.22
384_Y554_E0.6720.22
111_T120_A0.6720.22
188_Y298_R0.6710.21
112_G151_G0.6700.21
492_Y517_Y0.6680.21
83_P90_F0.6670.21
114_V118_E0.6670.21
142_Y153_G0.6670.21
109_D119_W0.6660.21
229_L232_F0.6660.21
241_A284_F0.6650.21
302_E438_P0.6650.21
88_A382_P0.6650.21
145_E156_D0.6640.21
91_T116_S0.6640.21
182_W205_Y0.6630.21
476_W479_L0.6620.21
279_M319_V0.6610.21
119_W142_Y0.6600.21
157_T161_Q0.6600.21
255_S368_D0.6590.21
154_T158_A0.6590.21
111_T310_A0.6570.21
99_P146_L0.6570.21
99_P159_T0.6570.21
135_T433_L0.6560.21
98_E137_D0.6560.21
132_A317_E0.6550.21
127_A162_I0.6540.21
113_S154_T0.6540.21
387_P568_N0.6540.21
192_P203_V0.6530.21
310_A544_A0.6520.21
96_T101_T0.6520.21
124_G131_T0.6520.21
96_T128_A0.6510.21
376_T395_D0.6490.21
187_D316_L0.6480.21
122_G141_E0.6470.21
119_W123_D0.6470.21
507_K518_L0.6460.20
207_F294_P0.6460.20
189_D406_T0.6450.20
100_G112_G0.6450.20
92_V101_T0.6440.20
273_T522_S0.6440.20
103_V134_H0.6440.20
494_D498_N0.6430.20
182_W190_F0.6430.20
105_V108_G0.6400.20
528_S538_K0.6390.20
230_A450_I0.6390.20
201_T553_W0.6390.20
507_K516_P0.6390.20
92_V102_A0.6360.20
82_S86_P0.6360.20
119_W144_I0.6340.20
363_Y514_G0.6330.20
438_P555_L0.6320.20
114_V150_T0.6320.20
182_W252_W0.6310.20
90_F93_T0.6300.20
139_A155_T0.6280.20
381_A516_P0.6240.20
504_A508_Q0.6240.20
310_A351_N0.6240.20
357_A544_A0.6230.20
93_T100_G0.6220.20
486_N490_F0.6220.20
202_D335_D0.6220.20
82_S141_E0.6220.20
249_I275_A0.6210.20
95_T164_A0.6200.19
273_T277_D0.6190.19
242_D337_S0.6190.19
91_T137_D0.6180.19
85_G98_E0.6150.19
345_W399_Y0.6140.19
237_Q473_P0.6140.19
285_D441_G0.6140.19
88_A107_A0.6130.19
134_H146_L0.6120.19
257_G380_N0.6120.19
161_Q166_T0.6110.19
245_L530_D0.6100.19
372_V554_E0.6090.19
174_K361_D0.6090.19
209_D254_L0.6080.19
367_Y371_G0.6060.19
269_E273_T0.6060.19
261_A271_F0.6040.19
385_G519_W0.6040.19
108_G112_G0.6030.19
92_V95_T0.6020.19
111_T122_G0.6010.19
434_V520_N0.5960.19
381_A407_I0.5940.19
114_V147_T0.5910.18
88_A117_Y0.5890.18
85_G128_A0.5870.18
89_A157_T0.5870.18
205_Y551_M0.5870.18
85_G114_V0.5870.18
241_A447_E0.5850.18
249_I278_L0.5850.18
107_A148_V0.5840.18
86_P109_D0.5790.18
160_Q545_E0.5780.18
193_A231_S0.5770.18
481_G491_D0.5770.18
484_D488_G0.5770.18
240_A243_T0.5760.18
83_P89_A0.5740.18
518_L531_D0.5740.18
341_G350_I0.5730.18
96_T163_T0.5720.18
142_Y164_A0.5690.18
178_Y250_G0.5670.18
127_A544_A0.5670.18
311_N432_T0.5650.17
506_T522_S0.5630.17
99_P124_G0.5620.17
104_T156_D0.5620.17
95_T125_T0.5610.17
384_Y541_L0.5610.17
316_L355_V0.5610.17
440_Y553_W0.5600.17
379_L535_I0.5600.17
119_W159_T0.5590.17
112_G123_D0.5590.17
372_V557_Q0.5590.17
374_H519_W0.5590.17
195_V264_D0.5580.17
81_G115_D0.5570.17
258_F342_G0.5560.17
120_A124_G0.5540.17
440_Y549_G0.5530.17
105_V142_Y0.5530.17
106_D162_I0.5530.17
269_E318_T0.5520.17
178_Y339_A0.5520.17
492_Y496_A0.5510.17
85_G101_T0.5500.17
147_T154_T0.5500.17
365_M373_W0.5470.17
89_A130_V0.5460.17
267_S338_V0.5460.17
176_V567_I0.5460.17
96_T104_T0.5460.17
173_F543_V0.5450.17
275_A319_V0.5440.17
516_P527_I0.5430.17
378_G448_N0.5430.17
532_P546_D0.5400.17
82_S85_G0.5400.17
374_H387_P0.5390.17
125_T147_T0.5390.17
344_D348_A0.5380.17
247_L355_V0.5370.17
116_S144_I0.5370.17
363_Y434_V0.5330.16
470_V475_T0.5330.16
362_I409_K0.5320.16
119_W133_S0.5310.16
207_F252_W0.5310.16
406_T545_E0.5310.16
86_P150_T0.5300.16
264_D268_R0.5300.16
82_S91_T0.5290.16
188_Y425_D0.5290.16
181_S343_S0.5270.16
117_Y133_S0.5270.16
116_S138_A0.5260.16
95_T124_G0.5250.16
145_E161_Q0.5250.16
95_T160_Q0.5250.16
231_S478_D0.5240.16
315_L319_V0.5230.16
86_P114_V0.5220.16
294_P371_G0.5220.16
276_V322_R0.5210.16
128_A153_G0.5210.16
83_P155_T0.5190.16
83_P151_G0.5190.16
225_H451_W0.5180.16
82_S87_T0.5160.16
395_D526_F0.5160.16
399_Y402_E0.5140.16
153_G156_D0.5120.16
359_V362_I0.5120.16
252_W488_G0.5100.16
139_A159_T0.5090.16
404_T531_D0.5080.16
197_F231_S0.5080.16
294_P368_D0.5070.16
360_D424_G0.5070.16
241_A444_C0.5060.16
112_G119_W0.5060.16
485_A491_D0.5050.16
105_V109_D0.5050.16
211_Q278_L0.5050.16
111_T115_D0.5040.15
110_T150_T0.5040.15
98_E106_D0.5040.15
441_G495_L0.5030.15
260_D263_A0.5030.15
208_L279_M0.5030.15
115_D161_Q0.5020.15
337_S363_Y0.5010.15
207_F368_D0.5000.15
374_H426_P0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3arxA 1 0.8339 100 0.361 Contact Map
1edqA 1 0.8147 100 0.368 Contact Map
1itxA 1 0.6556 100 0.416 Contact Map
4dwsA 1 0.7115 100 0.446 Contact Map
3oa5A 1 0.7238 100 0.449 Contact Map
1kfwA 1 0.6294 100 0.452 Contact Map
3w4rA 1 0.6294 100 0.453 Contact Map
1wb0A 2 0.6119 100 0.466 Contact Map
1w9pA 1 0.6049 100 0.467 Contact Map
3fy1A 1 0.6171 100 0.468 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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