GREMLIN Database
Q9HR81 - Uncharacterized protein
UniProt: Q9HR81 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 217 (183)
Sequences: 1346 (1034)
Seq/√Len: 76.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
134_E137_R6.4061.00
139_L145_A5.3231.00
79_L97_A4.0901.00
134_E138_V4.0481.00
107_S137_R3.2831.00
136_A198_L3.2461.00
135_L145_A3.0481.00
105_V110_V2.9251.00
72_V98_G2.9071.00
103_V138_V2.5621.00
79_L95_L2.3341.00
51_L135_L2.3021.00
48_A112_I2.2801.00
59_A69_V2.2081.00
113_A139_L2.2071.00
47_V68_D2.2011.00
49_L138_V2.1721.00
53_C71_C2.1351.00
52_G115_Y2.0911.00
117_A120_H1.9471.00
135_L139_L1.9131.00
82_A95_L1.9061.00
190_D203_S1.9001.00
52_G118_T1.8581.00
113_A138_V1.8491.00
42_C112_I1.8471.00
49_L110_V1.8451.00
50_D53_C1.8081.00
104_P134_E1.7891.00
76_T97_A1.7881.00
51_L100_A1.7801.00
81_E85_R1.6811.00
56_G82_A1.6641.00
17_N75_S1.6631.00
55_N78_L1.6481.00
184_Y192_D1.6461.00
24_A55_N1.6281.00
17_N76_T1.6251.00
117_A121_H1.6011.00
53_C73_D1.5350.99
20_A23_F1.4930.99
16_Y121_H1.4610.99
77_G80_S1.4290.99
120_H149_A1.4250.99
98_G104_P1.4070.99
86_A95_L1.3790.99
119_L122_L1.3690.98
23_F78_L1.3360.98
24_A85_R1.3320.98
60_E85_R1.3320.98
103_V134_E1.3110.98
116_V149_A1.3080.98
190_D194_A1.2980.98
86_A91_F1.2730.98
107_S134_E1.2650.97
16_Y19_I1.2550.97
125_R192_D1.2420.97
100_A118_T1.2020.96
120_H150_W1.2010.96
105_V137_R1.1790.96
61_L64_A1.1650.96
75_S78_L1.1650.96
151_S154_H1.1440.95
73_D79_L1.1380.95
104_P137_R1.1240.95
191_A194_A1.1160.95
55_N117_A1.0910.94
34_V38_L1.0910.94
105_V138_V1.0830.94
15_T19_I1.0770.94
182_H188_E1.0680.93
23_F27_R1.0640.93
14_R18_R1.0620.93
63_A91_F1.0610.93
121_H150_W1.0520.93
118_T122_L1.0520.93
120_H151_S1.0510.93
132_L147_V1.0490.93
164_D167_V1.0190.92
55_N85_R1.0190.92
131_S181_Y1.0160.91
34_V58_H0.9930.90
106_A109_T0.9830.90
72_V105_V0.9820.90
52_G114_V0.9740.90
70_V110_V0.9570.89
59_A63_A0.9470.88
14_R141_P0.9460.88
131_S135_L0.9420.88
118_T121_H0.9300.87
136_A139_L0.9260.87
18_R21_S0.9030.86
80_S83_R0.8990.86
103_V110_V0.8940.85
59_A95_L0.8890.85
57_R117_A0.8840.85
43_A46_A0.8820.84
86_A93_A0.8820.84
116_V150_W0.8820.84
152_T185_D0.8760.84
117_A150_W0.8750.84
19_I27_R0.8730.84
57_R116_V0.8690.84
150_W169_W0.8650.83
58_H116_V0.8550.83
47_V110_V0.8530.82
78_L117_A0.8530.82
48_A66_A0.8420.82
55_N81_E0.8390.81
71_C95_L0.8330.81
126_D130_A0.8330.81
45_P67_A0.8280.80
197_D201_V0.8270.80
16_Y22_H0.8270.80
23_F26_T0.8240.80
185_D188_E0.8220.80
36_S40_E0.8210.80
48_A62_L0.8170.80
60_E86_A0.8170.80
47_V109_T0.8170.80
51_L139_L0.8150.79
76_T80_S0.8110.79
22_H26_T0.8080.79
52_G122_L0.8030.78
100_A134_E0.8000.78
55_N116_V0.7990.78
198_L202_S0.7900.77
99_D102_C0.7840.77
150_W179_R0.7760.76
36_S108_G0.7760.76
116_V120_H0.7740.76
121_H149_A0.7740.76
78_L150_W0.7560.74
82_A119_L0.7540.74
107_S138_V0.7540.74
69_V112_I0.7530.74
150_W180_F0.7520.74
71_C82_A0.7510.74
31_W150_W0.7500.74
72_V96_V0.7500.74
96_V105_V0.7450.73
122_L181_Y0.7390.72
117_A149_A0.7380.72
79_L83_R0.7370.72
124_D130_A0.7350.72
44_A66_A0.7340.72
49_L105_V0.7310.72
28_E57_R0.7310.72
135_L147_V0.7290.71
55_N121_H0.7290.71
132_L189_F0.7270.71
51_L145_A0.7260.71
139_L143_G0.7170.70
121_H181_Y0.7130.70
109_T137_R0.7110.70
191_A195_A0.7030.69
50_D115_Y0.7000.68
190_D197_D0.7000.68
16_Y150_W0.6990.68
130_A133_T0.6970.68
16_Y27_R0.6940.68
59_A93_A0.6920.67
55_N150_W0.6880.67
49_L203_S0.6850.67
58_H114_V0.6820.66
58_H151_S0.6820.66
59_A71_C0.6790.66
118_T131_S0.6780.66
59_A124_D0.6750.66
70_V96_V0.6730.65
117_A148_S0.6710.65
31_W37_F0.6700.65
53_C79_L0.6670.65
49_L135_L0.6630.64
149_A181_Y0.6590.64
75_S117_A0.6540.63
80_S140_A0.6520.63
47_V70_V0.6500.63
158_D172_P0.6450.62
104_P138_V0.6440.62
57_R151_S0.6390.61
66_A69_V0.6300.60
80_S84_D0.6290.60
117_A181_Y0.6290.60
195_A201_V0.6290.60
111_D140_A0.6280.60
83_R94_T0.6210.59
19_I23_F0.6180.59
79_L93_A0.6170.59
103_V107_S0.6110.58
80_S202_S0.6050.57
132_L136_A0.6050.57
13_Q24_A0.6050.57
174_G199_R0.6040.57
23_F55_N0.6010.57
82_A93_A0.6000.56
104_P184_Y0.5990.56
57_R119_L0.5950.56
16_Y117_A0.5950.56
47_V91_F0.5940.56
34_V37_F0.5940.56
57_R78_L0.5920.55
37_F146_L0.5910.55
26_T121_H0.5910.55
191_A199_R0.5900.55
158_D161_T0.5890.55
167_V171_L0.5860.55
109_T114_V0.5860.55
193_L199_R0.5840.54
175_E178_P0.5830.54
16_Y26_T0.5800.54
58_H148_S0.5770.54
154_H167_V0.5760.53
48_A69_V0.5690.53
58_H154_H0.5680.52
119_L147_V0.5680.52
26_T55_N0.5670.52
118_T148_S0.5660.52
149_A184_Y0.5650.52
77_G81_E0.5650.52
60_E93_A0.5640.52
36_S199_R0.5630.52
144_T147_V0.5630.52
115_Y121_H0.5630.52
109_T140_A0.5620.52
108_G140_A0.5620.52
113_A135_L0.5610.52
19_I22_H0.5590.51
72_V103_V0.5590.51
107_S140_A0.5580.51
46_A84_D0.5580.51
80_S195_A0.5470.50
42_C144_T0.5430.49
73_D78_L0.5400.49
120_H148_S0.5380.49
123_R190_D0.5380.49
148_S178_P0.5380.49
64_A140_A0.5370.49
195_A202_S0.5350.48
74_A99_D0.5340.48
84_D173_G0.5330.48
57_R121_H0.5320.48
57_R120_H0.5310.48
164_D169_W0.5310.48
78_L120_H0.5310.48
35_E39_D0.5300.48
116_V181_Y0.5270.47
75_S150_W0.5260.47
26_T117_A0.5240.47
42_C133_T0.5240.47
133_T191_A0.5220.47
157_F166_T0.5200.46
49_L103_V0.5190.46
55_N120_H0.5180.46
167_V170_T0.5170.46
71_C79_L0.5170.46
52_G56_G0.5130.46
108_G141_P0.5130.46
52_G121_H0.5120.45
14_R80_S0.5100.45
80_S109_T0.5090.45
148_S193_L0.5090.45
133_T202_S0.5080.45
81_E84_D0.5080.45
194_A200_V0.5060.45
199_R203_S0.5060.45
141_P197_D0.5060.45
26_T120_H0.5040.44
33_E146_L0.5030.44
121_H148_S0.5020.44
107_S195_A0.5010.44
121_H179_R0.5000.44
117_A131_S0.5000.44
84_D133_T0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4obxA 2 0.9078 100 0.455 Contact Map
1y8cA 1 0.9355 100 0.466 Contact Map
1wznA 4 0.9032 100 0.475 Contact Map
3dtnA 2 0.9447 100 0.475 Contact Map
3bxoA 2 0.9078 100 0.475 Contact Map
2yqzA 1 0.9124 100 0.475 Contact Map
4hgzA 4 0.8894 100 0.477 Contact Map
4pneA 2 0.9124 100 0.477 Contact Map
3ou2A 1 0.8986 100 0.478 Contact Map
4kdcA 1 0.8848 100 0.479 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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