Q9HR81 - HALSA - GREMLIN Contacts

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Q9HR81 - Uncharacterized protein

UniProt:	Q9HR81	Sequences: MTDTPHAADRDVQRTYNRIASHFAKTREYPWPEVESFLDEECAAPAVALDLGCGNGRHAELLAAQAADVVCVDASTGLLSEARDRAAANDFDATLVAGDAACVPVASGTVDIAVYVATLHHLRDRDARVASLTELARVLAPEGTALVSAWSTAHDRFDATTGFDTTVDWTLPGGETVPRFYHVYDPDEFDADLAASDLRVVSSTVSSGNCYAVVAPA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	217 (183)
Sequences:	1346 (1034)
Seq/√Len:	76.4

ECOLI - UBIE UBIG CMOA SMTA BIOC YJHP TEHB TAM YAFE CMOB
BACSU - YRRT MENG YBAJ YCGJ YXBB YQEM YRHH YODH YDAC YXJB
HALSA - Q9HR81 Q9HND6 Q9HMT2 Q9HQ85 Q9HR63 Q9HRX3 Q9HSK6 ARSM
SULSO - Q97ZU8 Q7LXN7 Q97X57 Q97WT7 Q97WN4 Q97XD7 Q97YX4 Q97WH3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
134_E	137_R	6.406	1.00
139_L	145_A	5.323	1.00
79_L	97_A	4.090	1.00
134_E	138_V	4.048	1.00
107_S	137_R	3.283	1.00
136_A	198_L	3.246	1.00
135_L	145_A	3.048	1.00
105_V	110_V	2.925	1.00
72_V	98_G	2.907	1.00
103_V	138_V	2.562	1.00
79_L	95_L	2.334	1.00
51_L	135_L	2.302	1.00
48_A	112_I	2.280	1.00
59_A	69_V	2.208	1.00
113_A	139_L	2.207	1.00
47_V	68_D	2.201	1.00
49_L	138_V	2.172	1.00
53_C	71_C	2.135	1.00
52_G	115_Y	2.091	1.00
117_A	120_H	1.947	1.00
135_L	139_L	1.913	1.00
82_A	95_L	1.906	1.00
190_D	203_S	1.900	1.00
52_G	118_T	1.858	1.00
113_A	138_V	1.849	1.00
42_C	112_I	1.847	1.00
49_L	110_V	1.845	1.00
50_D	53_C	1.808	1.00
104_P	134_E	1.789	1.00
76_T	97_A	1.788	1.00
51_L	100_A	1.780	1.00
81_E	85_R	1.681	1.00
56_G	82_A	1.664	1.00
17_N	75_S	1.663	1.00
55_N	78_L	1.648	1.00
184_Y	192_D	1.646	1.00
24_A	55_N	1.628	1.00
17_N	76_T	1.625	1.00
117_A	121_H	1.601	1.00
53_C	73_D	1.535	0.99
20_A	23_F	1.493	0.99
16_Y	121_H	1.461	0.99
77_G	80_S	1.429	0.99
120_H	149_A	1.425	0.99
98_G	104_P	1.407	0.99
86_A	95_L	1.379	0.99
119_L	122_L	1.369	0.98
23_F	78_L	1.336	0.98
24_A	85_R	1.332	0.98
60_E	85_R	1.332	0.98
103_V	134_E	1.311	0.98
116_V	149_A	1.308	0.98
190_D	194_A	1.298	0.98
86_A	91_F	1.273	0.98
107_S	134_E	1.265	0.97
16_Y	19_I	1.255	0.97
125_R	192_D	1.242	0.97
100_A	118_T	1.202	0.96
120_H	150_W	1.201	0.96
105_V	137_R	1.179	0.96
61_L	64_A	1.165	0.96
75_S	78_L	1.165	0.96
151_S	154_H	1.144	0.95
73_D	79_L	1.138	0.95
104_P	137_R	1.124	0.95
191_A	194_A	1.116	0.95
55_N	117_A	1.091	0.94
34_V	38_L	1.091	0.94
105_V	138_V	1.083	0.94
15_T	19_I	1.077	0.94
182_H	188_E	1.068	0.93
23_F	27_R	1.064	0.93
14_R	18_R	1.062	0.93
63_A	91_F	1.061	0.93
121_H	150_W	1.052	0.93
118_T	122_L	1.052	0.93
120_H	151_S	1.051	0.93
132_L	147_V	1.049	0.93
164_D	167_V	1.019	0.92
55_N	85_R	1.019	0.92
131_S	181_Y	1.016	0.91
34_V	58_H	0.993	0.90
106_A	109_T	0.983	0.90
72_V	105_V	0.982	0.90
52_G	114_V	0.974	0.90
70_V	110_V	0.957	0.89
59_A	63_A	0.947	0.88
14_R	141_P	0.946	0.88
131_S	135_L	0.942	0.88
118_T	121_H	0.930	0.87
136_A	139_L	0.926	0.87
18_R	21_S	0.903	0.86
80_S	83_R	0.899	0.86
103_V	110_V	0.894	0.85
59_A	95_L	0.889	0.85
57_R	117_A	0.884	0.85
43_A	46_A	0.882	0.84
86_A	93_A	0.882	0.84
116_V	150_W	0.882	0.84
152_T	185_D	0.876	0.84
117_A	150_W	0.875	0.84
19_I	27_R	0.873	0.84
57_R	116_V	0.869	0.84
150_W	169_W	0.865	0.83
58_H	116_V	0.855	0.83
47_V	110_V	0.853	0.82
78_L	117_A	0.853	0.82
48_A	66_A	0.842	0.82
55_N	81_E	0.839	0.81
71_C	95_L	0.833	0.81
126_D	130_A	0.833	0.81
45_P	67_A	0.828	0.80
197_D	201_V	0.827	0.80
16_Y	22_H	0.827	0.80
23_F	26_T	0.824	0.80
185_D	188_E	0.822	0.80
36_S	40_E	0.821	0.80
48_A	62_L	0.817	0.80
60_E	86_A	0.817	0.80
47_V	109_T	0.817	0.80
51_L	139_L	0.815	0.79
76_T	80_S	0.811	0.79
22_H	26_T	0.808	0.79
52_G	122_L	0.803	0.78
100_A	134_E	0.800	0.78
55_N	116_V	0.799	0.78
198_L	202_S	0.790	0.77
99_D	102_C	0.784	0.77
150_W	179_R	0.776	0.76
36_S	108_G	0.776	0.76
116_V	120_H	0.774	0.76
121_H	149_A	0.774	0.76
78_L	150_W	0.756	0.74
82_A	119_L	0.754	0.74
107_S	138_V	0.754	0.74
69_V	112_I	0.753	0.74
150_W	180_F	0.752	0.74
71_C	82_A	0.751	0.74
31_W	150_W	0.750	0.74
72_V	96_V	0.750	0.74
96_V	105_V	0.745	0.73
122_L	181_Y	0.739	0.72
117_A	149_A	0.738	0.72
79_L	83_R	0.737	0.72
124_D	130_A	0.735	0.72
44_A	66_A	0.734	0.72
49_L	105_V	0.731	0.72
28_E	57_R	0.731	0.72
135_L	147_V	0.729	0.71
55_N	121_H	0.729	0.71
132_L	189_F	0.727	0.71
51_L	145_A	0.726	0.71
139_L	143_G	0.717	0.70
121_H	181_Y	0.713	0.70
109_T	137_R	0.711	0.70
191_A	195_A	0.703	0.69
50_D	115_Y	0.700	0.68
190_D	197_D	0.700	0.68
16_Y	150_W	0.699	0.68
130_A	133_T	0.697	0.68
16_Y	27_R	0.694	0.68
59_A	93_A	0.692	0.67
55_N	150_W	0.688	0.67
49_L	203_S	0.685	0.67
58_H	114_V	0.682	0.66
58_H	151_S	0.682	0.66
59_A	71_C	0.679	0.66
118_T	131_S	0.678	0.66
59_A	124_D	0.675	0.66
70_V	96_V	0.673	0.65
117_A	148_S	0.671	0.65
31_W	37_F	0.670	0.65
53_C	79_L	0.667	0.65
49_L	135_L	0.663	0.64
149_A	181_Y	0.659	0.64
75_S	117_A	0.654	0.63
80_S	140_A	0.652	0.63
47_V	70_V	0.650	0.63
158_D	172_P	0.645	0.62
104_P	138_V	0.644	0.62
57_R	151_S	0.639	0.61
66_A	69_V	0.630	0.60
80_S	84_D	0.629	0.60
117_A	181_Y	0.629	0.60
195_A	201_V	0.629	0.60
111_D	140_A	0.628	0.60
83_R	94_T	0.621	0.59
19_I	23_F	0.618	0.59
79_L	93_A	0.617	0.59
103_V	107_S	0.611	0.58
80_S	202_S	0.605	0.57
132_L	136_A	0.605	0.57
13_Q	24_A	0.605	0.57
174_G	199_R	0.604	0.57
23_F	55_N	0.601	0.57
82_A	93_A	0.600	0.56
104_P	184_Y	0.599	0.56
57_R	119_L	0.595	0.56
16_Y	117_A	0.595	0.56
47_V	91_F	0.594	0.56
34_V	37_F	0.594	0.56
57_R	78_L	0.592	0.55
37_F	146_L	0.591	0.55
26_T	121_H	0.591	0.55
191_A	199_R	0.590	0.55
158_D	161_T	0.589	0.55
167_V	171_L	0.586	0.55
109_T	114_V	0.586	0.55
193_L	199_R	0.584	0.54
175_E	178_P	0.583	0.54
16_Y	26_T	0.580	0.54
58_H	148_S	0.577	0.54
154_H	167_V	0.576	0.53
48_A	69_V	0.569	0.53
58_H	154_H	0.568	0.52
119_L	147_V	0.568	0.52
26_T	55_N	0.567	0.52
118_T	148_S	0.566	0.52
149_A	184_Y	0.565	0.52
77_G	81_E	0.565	0.52
60_E	93_A	0.564	0.52
36_S	199_R	0.563	0.52
144_T	147_V	0.563	0.52
115_Y	121_H	0.563	0.52
109_T	140_A	0.562	0.52
108_G	140_A	0.562	0.52
113_A	135_L	0.561	0.52
19_I	22_H	0.559	0.51
72_V	103_V	0.559	0.51
107_S	140_A	0.558	0.51
46_A	84_D	0.558	0.51
80_S	195_A	0.547	0.50
42_C	144_T	0.543	0.49
73_D	78_L	0.540	0.49
120_H	148_S	0.538	0.49
123_R	190_D	0.538	0.49
148_S	178_P	0.538	0.49
64_A	140_A	0.537	0.49
195_A	202_S	0.535	0.48
74_A	99_D	0.534	0.48
84_D	173_G	0.533	0.48
57_R	121_H	0.532	0.48
57_R	120_H	0.531	0.48
164_D	169_W	0.531	0.48
78_L	120_H	0.531	0.48
35_E	39_D	0.530	0.48
116_V	181_Y	0.527	0.47
75_S	150_W	0.526	0.47
26_T	117_A	0.524	0.47
42_C	133_T	0.524	0.47
133_T	191_A	0.522	0.47
157_F	166_T	0.520	0.46
49_L	103_V	0.519	0.46
55_N	120_H	0.518	0.46
167_V	170_T	0.517	0.46
71_C	79_L	0.517	0.46
52_G	56_G	0.513	0.46
108_G	141_P	0.513	0.46
52_G	121_H	0.512	0.45
14_R	80_S	0.510	0.45
80_S	109_T	0.509	0.45
148_S	193_L	0.509	0.45
133_T	202_S	0.508	0.45
81_E	84_D	0.508	0.45
194_A	200_V	0.506	0.45
199_R	203_S	0.506	0.45
141_P	197_D	0.506	0.45
26_T	120_H	0.504	0.44
33_E	146_L	0.503	0.44
121_H	148_S	0.502	0.44
107_S	195_A	0.501	0.44
121_H	179_R	0.500	0.44
117_A	131_S	0.500	0.44
84_D	133_T	0.500	0.44

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4obxA	2	0.9078	100	0.455	Contact Map
1y8cA	1	0.9355	100	0.466	Contact Map
1wznA	4	0.9032	100	0.475	Contact Map
3dtnA	2	0.9447	100	0.475	Contact Map
3bxoA	2	0.9078	100	0.475	Contact Map
2yqzA	1	0.9124	100	0.475	Contact Map
4hgzA	4	0.8894	100	0.477	Contact Map
4pneA	2	0.9124	100	0.477	Contact Map
3ou2A	1	0.8986	100	0.478	Contact Map
4kdcA	1	0.8848	100	0.479	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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