GREMLIN Database
Q9HR79 - Type II secretion system protein
UniProt: Q9HR79 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 561 (475)
Sequences: 3992 (2782)
Seq/√Len: 127.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
473_D494_R5.6921.00
288_Y316_V4.4011.00
479_F490_I4.1861.00
217_V260_F3.9771.00
406_S409_T3.8561.00
291_L431_I3.7571.00
259_A325_K3.6851.00
441_G511_V3.5671.00
324_A374_Y3.4541.00
129_D133_V3.3191.00
289_L319_F3.2921.00
444_R454_I3.2001.00
73_V77_Y3.0041.00
327_L367_A2.8841.00
492_D499_S2.8331.00
501_L515_L2.7891.00
473_D490_I2.7411.00
476_R487_L2.7221.00
233_P356_D2.6841.00
440_V464_L2.6661.00
441_G446_R2.6321.00
433_C469_A2.6201.00
329_I363_L2.5861.00
300_L400_S2.5191.00
90_T116_R2.4981.00
490_I493_E2.4921.00
302_A402_M2.4911.00
255_P333_R2.4801.00
380_V388_L2.4661.00
490_I494_R2.4611.00
292_A316_V2.4251.00
243_S266_S2.3901.00
252_E343_L2.3821.00
192_L213_L2.3811.00
464_L509_K2.3621.00
472_W480_E2.3591.00
285_Q289_L2.3561.00
475_T494_R2.3541.00
500_D504_E2.3411.00
290_W471_E2.2971.00
320_V374_Y2.2331.00
408_Q470_F2.2231.00
171_L216_F2.2171.00
40_G43_V2.2111.00
125_T129_D2.2071.00
283_L497_S2.1681.00
94_H120_I2.1591.00
346_V355_G2.1551.00
259_A341_N2.1531.00
179_H461_T2.1181.00
503_R507_N2.1161.00
86_A113_D2.0911.00
224_S249_L2.0911.00
247_L262_I2.0781.00
39_R44_D2.0601.00
93_Y107_V2.0521.00
120_I125_T2.0161.00
251_E260_F1.9871.00
483_D486_V1.9781.00
204_T207_T1.9531.00
282_S286_M1.9401.00
406_S488_D1.9341.00
411_I429_L1.9211.00
75_A79_F1.9211.00
502_L506_R1.9071.00
41_T123_A1.9001.00
201_D517_E1.8971.00
284_D469_A1.8961.00
121_Y124_T1.8881.00
226_R251_E1.8761.00
49_D56_L1.8751.00
250_G370_H1.8101.00
284_D467_S1.7891.00
359_T362_D1.7811.00
247_L264_K1.7811.00
45_V119_L1.7741.00
191_P207_T1.7601.00
415_E426_I1.7481.00
444_R461_T1.7471.00
254_T341_N1.7451.00
92_Y118_A1.7341.00
107_V115_I1.7301.00
281_F284_D1.7191.00
478_D482_R1.7091.00
321_P326_I1.6891.00
505_L515_L1.6871.00
95_V117_D1.6851.00
85_D92_Y1.6791.00
475_T490_I1.6631.00
343_L367_A1.6091.00
452_A455_E1.6041.00
475_T493_E1.5991.00
294_E430_D1.5861.00
204_T322_P1.5811.00
346_V356_D1.5731.00
125_T133_V1.5681.00
482_R486_V1.5661.00
329_I367_A1.5621.00
220_L249_L1.5621.00
80_V96_V1.5531.00
489_E493_E1.5301.00
71_Y76_P1.5281.00
486_V489_E1.5281.00
470_F496_W1.5141.00
497_S503_R1.5071.00
293_I319_F1.5061.00
101_D105_Q1.4991.00
474_P477_D1.4941.00
363_L367_A1.4811.00
84_F94_H1.4791.00
280_T312_S1.4731.00
442_D452_A1.4731.00
127_P131_E1.4691.00
286_M290_W1.4591.00
104_E117_D1.4421.00
185_C192_L1.4371.00
464_L504_E1.4351.00
442_D455_E1.4331.00
58_E61_G1.4331.00
128_D133_V1.4231.00
408_Q487_L1.4231.00
283_L287_A1.4211.00
265_Y335_L1.4191.00
259_A327_L1.4171.00
49_D54_G1.4111.00
491_Q495_G1.3981.00
284_D500_D1.3961.00
233_P358_I1.3891.00
284_D287_A1.3881.00
193_F204_T1.3861.00
442_D445_V1.3801.00
201_D439_H1.3561.00
445_V452_A1.3521.00
393_N425_M1.3471.00
361_Y384_E1.3431.00
492_D496_W1.3381.00
84_F118_A1.3301.00
91_H111_L1.3281.00
97_E100_L1.3161.00
299_L397_T1.3091.00
445_V455_E1.3091.00
460_R510_R1.2931.00
299_L431_I1.2921.00
45_V56_L1.2841.00
89_D113_D1.2831.00
287_A471_E1.2751.00
180_I198_D1.2731.00
198_D203_E1.2631.00
129_D132_A1.2611.00
186_D195_Y1.2581.00
46_P56_L1.2511.00
80_V126_D1.2501.00
380_V400_S1.2421.00
291_L469_A1.2321.00
275_L315_A1.2301.00
443_E446_R1.2291.00
320_V399_Y1.2180.99
43_V46_P1.2120.99
466_Y501_L1.1940.99
284_D433_C1.1850.99
196_H205_N1.1840.99
245_A264_K1.1810.99
94_H118_A1.1710.99
128_D131_E1.1610.99
58_E124_T1.1600.99
476_R491_Q1.1510.99
127_P133_V1.1510.99
386_M421_V1.1490.99
48_Y51_Q1.1480.99
201_D323_R1.1410.99
63_A67_E1.1310.99
52_A99_H1.1310.99
250_G261_T1.1280.99
223_Q239_L1.1240.99
70_R86_A1.1160.99
300_L380_V1.1150.99
138_M141_L1.1130.99
504_E509_K1.1090.99
274_T277_D1.1080.99
432_L470_F1.1070.99
408_Q488_D1.1070.99
389_F421_V1.1000.99
71_Y107_V1.0980.99
329_I345_S1.0950.99
80_V122_D1.0930.99
488_D492_D1.0890.99
301_F433_C1.0880.99
276_V285_Q1.0710.99
92_Y116_R1.0700.99
347_T356_D1.0690.99
239_L247_L1.0680.99
171_L220_L1.0640.99
305_T396_H1.0630.99
412_N484_S1.0630.99
278_Y467_S1.0620.99
390_Q416_N1.0620.99
179_H198_D1.0610.99
210_Q213_L1.0590.99
460_R511_V1.0530.98
502_L512_L1.0500.98
41_T121_Y1.0480.98
357_T362_D1.0440.98
281_F503_R1.0400.98
166_E169_E1.0380.98
290_W294_E1.0380.98
429_L432_L1.0370.98
275_L289_L1.0360.98
129_D134_L1.0290.98
305_T372_P1.0280.98
312_S433_C1.0260.98
504_E507_N1.0240.98
244_R267_E1.0220.98
227_H355_G1.0220.98
33_R39_R1.0190.98
441_G447_R1.0180.98
280_T288_Y1.0150.98
298_S398_T1.0090.98
84_F92_Y1.0040.98
364_L387_T1.0030.98
137_Q142_L1.0000.98
367_A375_I1.0000.98
478_D489_E0.9980.98
411_I480_E0.9940.98
158_F161_L0.9940.98
280_T465_D0.9930.98
500_D503_R0.9910.98
415_E423_R0.9840.98
438_T510_R0.9830.98
296_N430_D0.9810.98
375_I391_A0.9810.98
42_A56_L0.9720.97
45_V121_Y0.9660.97
138_M142_L0.9640.97
296_N406_S0.9610.97
41_T45_V0.9600.97
128_D132_A0.9590.97
503_R506_R0.9580.97
327_L343_L0.9580.97
426_I429_L0.9570.97
276_V289_L0.9560.97
250_G366_S0.9550.97
72_W75_A0.9540.97
408_Q484_S0.9530.97
347_T359_T0.9470.97
174_V194_V0.9460.97
79_F103_F0.9440.97
57_V84_F0.9420.97
292_A399_Y0.9410.97
174_V183_V0.9300.97
125_T128_D0.9290.97
501_L504_E0.9280.97
379_E403_H0.9260.97
245_A266_S0.9240.96
70_R76_P0.9230.96
302_A404_A0.9230.96
288_Y469_A0.9210.96
292_A299_L0.9200.96
491_Q496_W0.9190.96
259_A370_H0.9170.96
470_F487_L0.9170.96
280_T467_S0.9130.96
321_P339_H0.9110.96
476_R490_I0.9090.96
103_F107_V0.9090.96
390_Q393_N0.9070.96
448_S451_I0.9050.96
472_W476_R0.9030.96
226_R250_G0.8990.96
408_Q496_W0.8980.96
178_P203_E0.8970.96
367_A377_V0.8960.96
43_V47_P0.8950.96
107_V111_L0.8940.96
219_R223_Q0.8940.96
81_F93_Y0.8930.96
224_S239_L0.8930.96
153_A156_R0.8910.96
226_R260_F0.8890.96
287_A290_W0.8830.95
155_H159_Y0.8820.95
45_V49_D0.8800.95
301_F312_S0.8750.95
343_L363_L0.8740.95
359_T384_E0.8720.95
108_L114_D0.8670.95
327_L341_N0.8670.95
506_R509_K0.8660.95
152_N155_H0.8660.95
67_E70_R0.8640.95
369_R381_R0.8620.95
106_T109_D0.8610.95
81_F103_F0.8590.95
39_R47_P0.8580.95
439_H514_Y0.8570.95
71_Y83_G0.8560.95
155_H158_F0.8550.95
188_Y193_F0.8540.95
402_M410_V0.8540.95
380_V386_M0.8530.95
512_L516_V0.8530.95
191_P338_Y0.8500.94
441_G448_S0.8500.94
175_M183_V0.8440.94
139_Q142_L0.8440.94
452_A459_Q0.8430.94
198_D205_N0.8400.94
502_L505_L0.8390.94
155_H160_Y0.8380.94
46_P50_P0.8380.94
68_V132_A0.8370.94
96_V125_T0.8350.94
175_M247_L0.8340.94
111_L114_D0.8310.94
90_T114_D0.8290.94
168_F172_D0.8270.94
238_T246_E0.8230.93
305_T394_T0.8220.93
281_F507_N0.8190.93
410_V432_L0.8180.93
40_G47_P0.8170.93
39_R43_V0.8160.93
142_L145_Y0.8160.93
291_L430_D0.8150.93
347_T358_I0.8130.93
95_V100_L0.8120.93
472_W477_D0.8120.93
511_V514_Y0.8110.93
153_A157_L0.8090.93
42_A46_P0.8090.93
137_Q140_R0.8080.93
81_F95_V0.8060.93
156_R160_Y0.8030.93
365_R384_E0.7990.92
310_T335_L0.7990.92
181_E261_T0.7980.92
299_L430_D0.7950.92
404_A407_V0.7920.92
170_K174_V0.7920.92
104_E108_L0.7890.92
270_F274_T0.7860.92
505_L512_L0.7840.92
334_E403_H0.7830.92
34_I44_D0.7800.91
125_T131_E0.7790.91
82_I125_T0.7790.91
325_K370_H0.7780.91
369_R403_H0.7760.91
83_G86_A0.7760.91
291_L299_L0.7760.91
105_Q108_L0.7740.91
49_D55_P0.7710.91
233_P362_D0.7700.91
317_S340_D0.7680.91
281_F500_D0.7680.91
249_L262_I0.7670.91
190_L338_Y0.7670.91
66_E69_D0.7670.91
218_V228_I0.7670.91
378_G403_H0.7660.91
79_F106_T0.7570.90
191_P204_T0.7560.90
281_F504_E0.7560.90
447_R451_I0.7540.90
81_F107_V0.7510.90
50_P53_H0.7490.90
368_L391_A0.7480.90
318_M321_P0.7470.90
208_Y216_F0.7460.90
440_V509_K0.7430.89
275_L285_Q0.7410.89
95_V103_F0.7400.89
34_I37_V0.7400.89
189_G256_R0.7390.89
221_A258_S0.7370.89
431_I469_A0.7370.89
263_R403_H0.7370.89
362_D366_S0.7360.89
369_R379_E0.7360.89
96_V122_D0.7350.89
358_I363_L0.7350.89
314_N337_L0.7330.89
460_R513_Q0.7280.88
135_I139_Q0.7280.88
304_G436_T0.7270.88
199_Y439_H0.7260.88
213_L217_V0.7260.88
266_S270_F0.7250.88
470_F476_R0.7210.88
47_P51_Q0.7200.88
73_V76_P0.7190.88
87_E92_Y0.7180.88
287_A469_A0.7180.88
170_K216_F0.7170.88
56_L59_F0.7170.88
64_D85_D0.7160.88
309_K379_E0.7130.87
475_T479_F0.7100.87
126_D130_R0.7100.87
246_E267_E0.7090.87
333_R344_S0.7090.87
47_P50_P0.7080.87
294_E474_P0.7080.87
266_S314_N0.7060.87
282_S285_Q0.7040.87
453_E457_I0.7040.87
168_F219_R0.7030.87
263_R379_E0.7020.87
64_D67_E0.7020.87
325_K341_N0.7020.87
267_E335_L0.7000.86
243_S268_E0.6980.86
455_E459_Q0.6950.86
178_P456_G0.6950.86
485_N489_E0.6940.86
409_T484_S0.6940.86
177_D241_D0.6930.86
514_Y517_E0.6930.86
163_R368_L0.6930.86
316_V329_I0.6930.86
389_F425_M0.6920.86
95_V104_E0.6920.86
37_V41_T0.6910.86
283_L286_M0.6910.86
498_R501_L0.6900.86
42_A58_E0.6900.86
484_S488_D0.6900.86
88_S116_R0.6880.85
470_F491_Q0.6870.85
369_R413_R0.6860.85
329_I387_T0.6860.85
487_L490_I0.6850.85
88_S113_D0.6850.85
334_E379_E0.6840.85
71_Y81_F0.6830.85
45_V54_G0.6830.85
45_V52_A0.6830.85
252_E367_A0.6830.85
56_L121_Y0.6820.85
154_F158_F0.6790.85
305_T381_R0.6780.85
298_S392_M0.6780.85
298_S390_Q0.6770.85
67_E82_I0.6760.84
452_A468_T0.6760.84
475_T478_D0.6750.84
320_V324_A0.6750.84
320_V326_I0.6740.84
367_A477_D0.6730.84
220_L260_F0.6720.84
305_T369_R0.6710.84
168_F171_L0.6700.84
479_F486_V0.6690.84
236_E250_G0.6680.84
274_T319_F0.6670.84
310_T337_L0.6670.84
42_A121_Y0.6670.84
222_Q228_I0.6660.84
283_L503_R0.6640.83
82_I128_D0.6630.83
329_I343_L0.6610.83
263_R334_E0.6580.83
474_P489_E0.6580.83
49_D119_L0.6560.83
186_D231_G0.6550.83
126_D129_D0.6520.82
309_K403_H0.6520.82
331_D344_S0.6510.82
356_D362_D0.6510.82
130_R478_D0.6500.82
487_L491_Q0.6500.82
393_N428_S0.6470.82
299_L433_C0.6470.82
341_N370_H0.6470.82
100_L103_F0.6470.82
220_L262_I0.6460.82
510_R514_Y0.6460.82
215_S222_Q0.6460.82
310_T314_N0.6450.82
175_M239_L0.6450.82
153_A160_Y0.6440.81
67_E86_A0.6440.81
298_S429_L0.6420.81
416_N481_Q0.6420.81
225_G292_A0.6420.81
94_H125_T0.6400.81
372_P396_H0.6390.81
471_E494_R0.6380.81
296_N311_T0.6380.81
312_S435_Q0.6380.81
170_K208_Y0.6370.81
414_L426_I0.6330.80
96_V99_H0.6330.80
375_I495_G0.6320.80
162_H168_F0.6310.80
91_H115_I0.6290.80
87_E90_T0.6280.80
313_M376_I0.6280.80
383_E420_N0.6280.80
291_L471_E0.6260.80
130_R133_V0.6260.80
113_D117_D0.6250.80
33_R44_D0.6250.80
337_L340_D0.6250.80
172_D176_Q0.6240.79
212_E216_F0.6230.79
154_F157_L0.6230.79
343_L358_I0.6220.79
127_P132_A0.6220.79
76_P81_F0.6210.79
261_T325_K0.6190.79
146_S150_T0.6180.79
369_R378_G0.6160.79
295_S405_D0.6160.79
392_M428_S0.6150.78
89_D92_Y0.6140.78
284_D497_S0.6130.78
302_A410_V0.6130.78
40_G46_P0.6120.78
474_P485_N0.6120.78
381_R413_R0.6110.78
381_R403_H0.6110.78
438_T501_L0.6100.78
182_D369_R0.6100.78
288_Y299_L0.6100.78
246_E335_L0.6090.78
466_Y504_E0.6090.78
76_P133_V0.6080.78
122_D126_D0.6070.78
261_T370_H0.6070.78
256_R336_A0.6070.78
430_D477_D0.6070.78
150_T155_H0.6060.77
438_T464_L0.6060.77
234_V385_A0.6060.77
479_F487_L0.6060.77
79_F100_L0.6020.77
321_P324_A0.6010.77
44_D48_Y0.6000.77
44_D47_P0.6000.77
389_F393_N0.5990.77
187_G414_L0.5990.77
373_E430_D0.5990.77
134_L138_M0.5990.77
75_A110_Q0.5970.76
492_D495_G0.5970.76
102_D465_D0.5960.76
370_H390_Q0.5960.76
409_T412_N0.5930.76
136_A139_Q0.5910.76
410_V425_M0.5900.76
91_H113_D0.5900.76
356_D359_T0.5890.75
371_R463_D0.5880.75
305_T403_H0.5880.75
327_L335_L0.5860.75
67_E83_G0.5860.75
169_E355_G0.5850.75
402_M414_L0.5850.75
404_A410_V0.5850.75
438_T515_L0.5840.75
417_D467_S0.5830.75
57_V120_I0.5830.75
438_T466_Y0.5830.75
157_L160_Y0.5820.75
182_D403_H0.5820.75
203_E456_G0.5820.75
136_A140_R0.5790.74
255_P336_A0.5770.74
157_L161_L0.5770.74
240_P247_L0.5770.74
301_F313_M0.5770.74
185_C213_L0.5770.74
128_D134_L0.5760.74
240_P244_R0.5760.74
298_S389_F0.5760.74
305_T379_E0.5760.74
452_A463_D0.5750.74
298_S368_L0.5750.74
366_S370_H0.5750.74
187_G370_H0.5730.73
378_G381_R0.5720.73
361_Y366_S0.5710.73
52_A119_L0.5710.73
246_E328_T0.5710.73
236_E369_R0.5700.73
409_T425_M0.5680.73
57_V118_A0.5670.73
192_L216_F0.5670.73
76_P83_G0.5670.73
63_A68_V0.5660.73
139_Q143_S0.5650.72
127_P130_R0.5630.72
125_T132_A0.5630.72
468_T496_W0.5630.72
298_S431_I0.5630.72
153_A161_L0.5610.72
100_L104_E0.5610.72
269_P274_T0.5600.72
87_E116_R0.5570.71
184_S332_T0.5570.71
33_R36_E0.5570.71
35_V43_V0.5550.71
93_Y117_D0.5550.71
302_A434_V0.5540.71
494_R497_S0.5540.71
415_E495_G0.5530.71
155_H161_L0.5530.71
499_S503_R0.5530.71
252_E366_S0.5530.71
311_T335_L0.5520.71
390_Q431_I0.5520.71
125_T130_R0.5510.71
381_R396_H0.5500.70
271_T274_T0.5490.70
509_K515_L0.5470.70
298_S388_L0.5470.70
423_R480_E0.5460.70
459_Q463_D0.5450.70
239_L249_L0.5450.70
192_L217_V0.5450.70
151_P157_L0.5440.70
102_D106_T0.5430.69
186_D230_I0.5430.69
416_N425_M0.5430.69
248_A382_G0.5420.69
233_P357_T0.5420.69
130_R134_L0.5410.69
436_T463_D0.5410.69
156_R159_Y0.5400.69
266_S335_L0.5400.69
499_S502_L0.5390.69
238_T390_Q0.5380.69
171_L196_H0.5360.68
236_E378_G0.5360.68
76_P363_L0.5350.68
195_Y370_H0.5340.68
222_Q259_A0.5340.68
135_I138_M0.5340.68
369_R401_T0.5340.68
46_P49_D0.5330.68
290_W293_I0.5330.68
369_R396_H0.5320.68
252_E370_H0.5310.68
95_V101_D0.5300.68
184_S463_D0.5290.67
96_V120_I0.5290.67
359_T480_E0.5290.67
238_T374_Y0.5280.67
263_R369_R0.5280.67
486_V490_I0.5280.67
60_D124_T0.5270.67
280_T284_D0.5260.67
205_N244_R0.5260.67
477_D481_Q0.5250.67
376_I424_A0.5250.67
65_Y69_D0.5250.67
440_V444_R0.5250.67
510_R515_L0.5250.67
171_L310_T0.5250.67
382_G385_A0.5240.67
302_A392_M0.5240.67
292_A295_S0.5240.67
188_Y259_A0.5240.67
102_D105_Q0.5230.67
49_D52_A0.5230.67
334_E369_R0.5230.67
156_R161_L0.5230.67
442_D459_Q0.5220.66
131_E134_L0.5220.66
314_N340_D0.5220.66
54_G95_V0.5210.66
145_Y456_G0.5200.66
276_V282_S0.5180.66
124_T127_P0.5180.66
100_L106_T0.5180.66
364_L367_A0.5170.66
134_L137_Q0.5160.66
129_D138_M0.5150.65
267_E270_F0.5150.65
34_I39_R0.5150.65
133_V138_M0.5150.65
498_R502_L0.5140.65
129_D135_I0.5140.65
162_H215_S0.5140.65
95_V99_H0.5140.65
140_R143_S0.5130.65
298_S430_D0.5120.65
193_F207_T0.5120.65
288_Y433_C0.5110.65
232_D356_D0.5100.65
39_R56_L0.5100.65
455_E462_G0.5090.65
56_L124_T0.5090.65
263_R309_K0.5090.65
226_R331_D0.5080.64
182_D379_E0.5080.64
194_V375_I0.5080.64
35_V50_P0.5070.64
108_L115_I0.5070.64
52_A95_V0.5060.64
446_R511_V0.5050.64
186_D370_H0.5050.64
182_D263_R0.5040.64
299_L470_F0.5030.64
160_Y163_R0.5030.64
86_A89_D0.5020.63
239_L411_I0.5020.63
37_V421_V0.5010.63
399_Y427_Q0.5010.63
401_T411_I0.5010.63
292_A498_R0.5010.63
270_F310_T0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4phtA 1 0.7291 100 0.449 Contact Map
2oap1 3 0.8966 100 0.486 Contact Map
4ksrA 3 0.6471 100 0.525 Contact Map
4ihqA 3 0.877 100 0.538 Contact Map
1p9rA 1 0.6239 100 0.544 Contact Map
2ewvA 3 0.5829 100 0.652 Contact Map
3jvvA 3 0.5615 100 0.659 Contact Map
2gzaA 3 0.5383 100 0.738 Contact Map
2eyuA 1 0.4064 100 0.753 Contact Map
4bloA 4 0.451 100 0.776 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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