GREMLIN Database
Q9HR78 - Probable molybdenum cofactor guanylyltransferase
UniProt: Q9HR78 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 233 (185)
Sequences: 6165 (4935)
Seq/√Len: 362.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_R44_A5.2281.00
11_A101_E3.0151.00
13_I95_A2.8901.00
23_F31_A2.8831.00
37_P40_W2.8211.00
29_A109_C2.8151.00
52_S77_A2.5431.00
12_G46_L2.4631.00
12_G50_V2.3711.00
103_V126_R2.3471.00
113_F207_A2.3261.00
31_A204_L2.3121.00
46_L107_T2.1911.00
36_R41_H2.0641.00
11_A52_S1.9801.00
200_T203_E1.9801.00
168_S171_G1.9781.00
13_I104_V1.9471.00
103_V148_V1.8501.00
11_A99_V1.8311.00
133_G176_L1.8231.00
97_N159_D1.8221.00
99_V104_V1.7551.00
126_R134_A1.7361.00
36_R40_W1.6991.00
105_A119_F1.6901.00
81_D90_A1.6761.00
118_F194_S1.6641.00
115_D194_S1.6411.00
198_V207_A1.6351.00
108_A111_M1.5751.00
96_L104_V1.5251.00
33_L38_L1.4971.00
115_D118_F1.4951.00
40_W44_A1.4851.00
157_A175_R1.4631.00
86_Q90_A1.4561.00
14_V43_V1.4471.00
137_V182_P1.4301.00
178_V185_Q1.4211.00
26_R201_P1.4181.00
92_L106_V1.4151.00
126_R150_A1.3951.00
114_I146_H1.3831.00
26_R31_A1.3651.00
54_V79_A1.3631.00
196_M206_A1.3531.00
132_A150_A1.3511.00
204_L208_R1.3491.00
56_N95_A1.3451.00
49_V120_A1.3331.00
107_T114_I1.3321.00
103_V150_A1.3131.00
105_A148_V1.3011.00
157_A176_L1.2781.00
48_T116_P1.2601.00
137_V180_Q1.2541.00
83_D86_Q1.2541.00
172_V176_L1.2201.00
157_A160_A1.2201.00
142_L180_Q1.2191.00
196_M207_A1.2101.00
93_S97_N1.2021.00
23_F201_P1.1941.00
161_A172_V1.1931.00
16_A55_V1.1771.00
180_Q185_Q1.1751.00
10_R123_C1.1681.00
14_V46_L1.1631.00
111_M146_H1.1601.00
9_G102_P1.1591.00
122_L148_V1.1541.00
38_L198_V1.1511.00
11_A54_V1.1491.00
107_T119_F1.1471.00
14_V42_V1.1441.00
32_T35_G1.1381.00
57_C61_Q1.1211.00
47_G75_D1.1191.00
43_V53_V1.1171.00
40_W74_T1.1161.00
60_D64_A1.1131.00
33_L207_A1.1101.00
135_V141_H1.1091.00
23_F26_R1.1061.00
126_R148_V1.0971.00
13_I106_V1.0841.00
92_L169_L1.0781.00
205_A208_R1.0761.00
43_V76_V1.0761.00
37_P41_H1.0661.00
86_Q167_R1.0611.00
10_R103_V1.0601.00
79_A94_T1.0441.00
13_I56_N1.0411.00
20_S26_R1.0371.00
153_P176_L1.0321.00
156_V159_D1.0201.00
90_A93_S1.0161.00
54_V98_A1.0141.00
57_C80_V1.0111.00
149_L158_V1.0101.00
9_G51_D1.0081.00
32_T37_P1.0061.00
170_S174_A0.9951.00
34_G41_H0.9931.00
131_C179_T0.9931.00
57_C78_F0.9891.00
116_P120_A0.9871.00
93_S159_D0.9791.00
41_H45_R0.9751.00
64_A72_T0.9751.00
203_E206_A0.9731.00
198_V204_L0.9691.00
133_G173_V0.9531.00
161_A166_N0.9381.00
77_A98_A0.9351.00
132_A177_P0.9271.00
20_S29_A0.9261.00
19_R85_G0.9201.00
153_P157_A0.9181.00
87_G90_A0.9171.00
45_R116_P0.9161.00
42_V45_R0.9121.00
135_V180_Q0.9001.00
14_V39_L0.8961.00
58_R84_P0.8921.00
54_V99_V0.8751.00
159_D163_A0.8741.00
125_R179_T0.8701.00
125_R128_D0.8681.00
123_C148_V0.8661.00
55_V76_V0.8561.00
171_G174_A0.8451.00
104_V154_T0.8451.00
38_L42_V0.8421.00
81_D94_T0.8401.00
160_A164_A0.8321.00
156_V160_A0.8211.00
27_E30_L0.8171.00
47_G53_V0.8161.00
58_R61_Q0.8151.00
12_G49_V0.8031.00
181_V185_Q0.8021.00
157_A172_V0.8001.00
20_S27_E0.7991.00
90_A94_T0.7961.00
27_E60_D0.7951.00
178_V182_P0.7941.00
118_F136_P0.7941.00
61_Q80_V0.7911.00
104_V151_A0.7861.00
132_A152_A0.7831.00
166_N171_G0.7801.00
123_C126_R0.7771.00
39_L43_V0.7721.00
161_A171_G0.7691.00
202_A206_A0.7681.00
150_A153_P0.7631.00
38_L109_C0.7601.00
132_A153_P0.7511.00
52_S101_E0.7511.00
49_V119_F0.7481.00
113_F196_M0.7471.00
183_A195_F0.7441.00
43_V74_T0.7431.00
50_V105_A0.7401.00
92_L108_A0.7381.00
23_F204_L0.7351.00
113_F198_V0.7241.00
20_S204_L0.7231.00
89_A93_S0.7221.00
13_I99_V0.7211.00
52_S100_G0.7211.00
131_C150_A0.7120.99
34_G208_R0.7120.99
141_H145_T0.7100.99
86_Q165_G0.7090.99
40_W73_D0.7080.99
132_A179_T0.7070.99
201_P205_A0.7060.99
206_A209_E0.7050.99
11_A100_G0.7030.99
106_V149_L0.7030.99
108_A149_L0.6990.99
138_V143_Q0.6940.99
120_A123_C0.6910.99
45_R49_V0.6850.99
32_T36_R0.6850.99
102_P151_A0.6830.99
118_F122_L0.6830.99
145_T149_L0.6730.99
81_D91_G0.6730.99
167_R171_G0.6700.99
31_A201_P0.6700.99
10_R148_V0.6620.99
121_W125_R0.6610.99
108_A146_H0.6590.99
13_I54_V0.6570.99
96_L154_T0.6570.99
158_V161_A0.6520.99
153_P156_V0.6510.99
69_V72_T0.6480.99
124_D128_D0.6420.99
202_A205_A0.6410.99
122_L134_A0.6390.99
56_N79_A0.6370.99
88_P91_G0.6330.99
178_V181_V0.6320.99
39_L109_C0.6270.99
83_D90_A0.6270.99
121_W124_D0.6270.99
81_D84_P0.6220.99
133_G149_L0.6220.99
17_G88_P0.6210.99
58_R85_G0.6200.99
54_V77_A0.6200.99
42_V107_T0.6150.98
136_P183_A0.6150.98
27_E59_R0.6130.98
32_T208_R0.5900.98
143_Q147_S0.5890.98
170_S173_V0.5890.98
17_G91_G0.5880.98
89_A158_V0.5880.98
17_G90_A0.5870.98
136_P194_S0.5850.98
105_A123_C0.5820.98
79_A95_A0.5810.98
120_A124_D0.5760.98
29_A38_L0.5760.98
53_V76_V0.5740.98
77_A80_V0.5740.98
108_A143_Q0.5730.98
135_V142_L0.5720.98
92_L149_L0.5720.98
157_A161_A0.5720.98
14_V107_T0.5710.97
23_F198_V0.5690.97
84_P90_A0.5600.97
131_C177_P0.5590.97
33_L204_L0.5560.97
130_G150_A0.5550.97
158_V172_V0.5530.97
11_A102_P0.5520.97
30_L37_P0.5520.97
18_G22_R0.5520.97
82_P97_N0.5520.97
164_A175_R0.5510.97
32_T204_L0.5500.97
147_S173_V0.5480.97
179_T182_P0.5460.97
40_W69_V0.5460.97
137_V142_L0.5450.97
149_L169_L0.5400.96
165_G168_S0.5360.96
132_A136_P0.5350.96
12_G42_V0.5330.96
121_W181_V0.5300.96
31_A208_R0.5300.96
33_L41_H0.5280.96
49_V116_P0.5280.96
135_V173_V0.5260.96
144_V147_S0.5200.96
117_A120_A0.5180.96
43_V47_G0.5140.95
58_R62_R0.5120.95
88_P92_L0.5110.95
125_R134_A0.5090.95
129_A179_T0.5080.95
138_V141_H0.5060.95
45_R48_T0.5040.95
56_N81_D0.5040.95
23_F200_T0.5040.95
132_A178_V0.5040.95
138_V192_R0.5040.95
34_G37_P0.5030.95
38_L207_A0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1e5kA 1 0.8026 100 0.321 Contact Map
2e8bA 1 0.7854 100 0.37 Contact Map
2weeA 1 0.8069 100 0.373 Contact Map
3ngwA 2 0.8326 100 0.38 Contact Map
2wawA 1 0.824 100 0.383 Contact Map
3d5nA 2 0.7511 100 0.412 Contact Map
1i52A 2 0.824 100 0.503 Contact Map
2xmeA 3 0.794 100 0.506 Contact Map
1vpaA 2 0.824 100 0.506 Contact Map
3rsbA 1 0.7425 99.9 0.516 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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