GREMLIN Database
Q9HR77 - Uncharacterized protein
UniProt: Q9HR77 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 148 (128)
Sequences: 1407 (1015)
Seq/√Len: 89.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_A52_R6.1941.00
33_T53_H4.7531.00
10_S48_K3.8141.00
32_A90_H3.4241.00
26_A59_S3.3121.00
127_L130_D2.9741.00
24_R28_R2.6991.00
8_G12_S2.6811.00
32_A86_F2.5211.00
51_A55_A2.3581.00
22_A33_T2.3201.00
5_T103_L2.2911.00
18_V53_H2.2851.00
126_A130_D2.1961.00
5_T95_V1.9971.00
95_V103_L1.9571.00
3_V83_L1.9031.00
43_I72_G1.8271.00
127_L131_A1.7881.00
78_D81_A1.7591.00
50_T63_G1.7571.00
37_L41_P1.6991.00
69_S73_T1.6141.00
83_L93_A1.5931.00
24_R27_A1.5271.00
70_W73_T1.5191.00
12_S108_L1.4841.00
41_P65_T1.4580.99
19_A56_G1.4300.99
18_V23_E1.3750.99
99_S105_K1.3660.99
18_V94_L1.3220.99
62_I71_F1.3150.99
60_R73_T1.3040.99
44_D47_G1.3040.99
34_V79_L1.2990.99
126_A129_L1.2910.99
44_D51_A1.2670.99
34_V93_A1.2460.98
98_F101_S1.2150.98
6_V21_L1.2070.98
47_G51_A1.1980.98
33_T58_A1.1960.98
4_L106_V1.1900.98
64_L82_V1.1710.98
19_A55_A1.1360.97
62_I82_V1.1040.96
40_E67_D1.0920.96
9_P99_S1.0510.95
54_R68_G1.0420.95
128_D131_A1.0410.95
41_P70_W1.0390.95
8_G61_T0.9810.93
118_A124_A0.9680.93
50_T53_H0.9670.93
32_A60_R0.9610.93
41_P63_G0.9600.92
3_V93_A0.9500.92
120_T123_S0.9470.92
119_V122_A0.9360.91
31_V92_Y0.9300.91
66_D76_S0.9290.91
60_R87_A0.9260.91
80_S101_S0.9250.91
37_L63_G0.9220.91
73_T87_A0.9210.91
18_V22_A0.8640.88
124_A127_L0.8600.88
6_V106_V0.8550.87
6_V20_R0.8550.87
11_D48_K0.8510.87
86_F90_H0.8450.87
84_G112_D0.8450.87
4_L94_L0.8430.87
63_G68_G0.8360.86
106_V126_A0.8350.86
38_T64_L0.8310.86
107_V119_V0.8260.85
4_L18_V0.8250.85
41_P72_G0.8230.85
43_I70_W0.8200.85
9_P105_K0.8180.85
116_P119_V0.8010.84
78_D101_S0.8000.84
8_G97_G0.7920.83
37_L53_H0.7920.83
42_D68_G0.7880.83
8_G108_L0.7850.82
21_L25_L0.7850.82
6_V124_A0.7580.80
53_H56_G0.7550.80
109_G117_V0.7470.79
36_H65_T0.7400.79
111_R131_A0.7400.79
8_G53_H0.7360.78
60_R85_S0.7340.78
22_A61_T0.7340.78
38_T50_T0.7310.78
37_L65_T0.7270.77
52_R56_G0.7260.77
20_R67_D0.7260.77
25_L94_L0.7260.77
37_L42_D0.7240.77
16_T25_L0.7240.77
32_A53_H0.7220.77
18_V33_T0.7140.76
80_S102_A0.7050.75
125_D129_L0.6950.74
12_S117_V0.6950.74
40_E100_D0.6920.74
46_E55_A0.6810.73
109_G114_A0.6810.73
55_A61_T0.6800.72
3_V103_L0.6800.72
37_L40_E0.6720.72
60_R86_F0.6720.72
60_R90_H0.6710.71
36_H97_G0.6660.71
10_S108_L0.6630.71
81_A84_G0.6580.70
95_V98_F0.6540.70
53_H61_T0.6530.69
124_A130_D0.6520.69
40_E66_D0.6490.69
84_G87_A0.6420.68
17_V106_V0.6400.68
50_T92_Y0.6400.68
41_P44_D0.6350.67
82_V86_F0.6310.67
100_D118_A0.6300.67
75_D84_G0.6290.67
79_L101_S0.6270.66
75_D81_A0.6250.66
34_V82_V0.6240.66
5_T101_S0.6220.66
82_V98_F0.6210.66
37_L99_S0.6190.65
16_T20_R0.6190.65
31_V59_S0.6180.65
65_T68_G0.6160.65
62_I86_F0.6050.64
46_E110_G0.6050.64
42_D72_G0.6020.63
37_L67_D0.6020.63
44_D48_K0.5940.62
52_R55_A0.5930.62
42_D70_W0.5830.61
34_V62_I0.5830.61
47_G54_R0.5790.60
124_A129_L0.5760.60
7_V107_V0.5740.60
24_R111_R0.5710.59
107_V122_A0.5710.59
66_D90_H0.5690.59
55_A108_L0.5690.59
28_R31_V0.5640.58
12_S104_P0.5580.57
107_V114_A0.5470.56
121_A124_A0.5460.56
30_P59_S0.5450.56
8_G14_K0.5440.56
63_G70_W0.5440.56
67_D74_G0.5430.55
46_E51_A0.5420.55
42_D54_R0.5410.55
36_H49_D0.5390.55
8_G13_G0.5370.55
79_L92_Y0.5370.55
69_S72_G0.5370.55
4_L105_K0.5340.54
43_I65_T0.5310.54
79_L118_A0.5310.54
45_T51_A0.5300.54
123_S130_D0.5290.53
9_P109_G0.5260.53
41_P66_D0.5250.53
23_E26_A0.5220.53
123_S126_A0.5160.52
14_K96_E0.5160.52
111_R114_A0.5140.51
117_V120_T0.5140.51
107_V110_G0.5130.51
34_V73_T0.5120.51
107_V120_T0.5120.51
22_A56_G0.5110.51
4_L8_G0.5110.51
10_S18_V0.5090.51
38_T66_D0.5080.51
34_V100_D0.5080.51
22_A53_H0.5060.50
116_P121_A0.5010.50
65_T70_W0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4nkrA 2 0.9797 100 0.418 Contact Map
1xjcA 2 0.8649 100 0.466 Contact Map
1np6A 2 0.9797 99.6 0.663 Contact Map
2f1rA 2 0.9189 99.5 0.688 Contact Map
4ehxA 1 0.9527 99.2 0.741 Contact Map
2wsmA 2 0.9324 98.8 0.776 Contact Map
3fgnA 2 0.9797 98.5 0.797 Contact Map
2hf9A 2 0.9392 98.3 0.805 Contact Map
4a0gA 2 0.9797 98.3 0.806 Contact Map
3of5A 2 0.9865 98.2 0.814 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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