GREMLIN Database
DMSR - Dimethyl sulfoxide reductase transcriptional activator
UniProt: Q9HR76 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 224 (188)
Sequences: 1793 (1405)
Seq/√Len: 102.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
175_Y205_E4.7871.00
181_A186_L4.0791.00
168_A172_K4.0751.00
193_S196_A3.7971.00
172_K186_L3.6971.00
165_A190_L3.6411.00
87_F92_C3.2041.00
172_K189_A3.1621.00
161_K200_R3.1101.00
181_A185_D3.0961.00
170_V210_T3.0121.00
92_C110_L2.9501.00
196_A200_R2.8641.00
168_A186_L2.8631.00
176_A180_G2.8431.00
182_D185_D2.5851.00
177_T198_S2.4421.00
161_K165_A2.4051.00
183_L198_S2.1881.00
161_K164_E2.1401.00
183_L197_V2.0781.00
163_R167_A2.0301.00
200_R203_A1.9801.00
194_K198_S1.9781.00
95_Q109_Y1.8721.00
165_A200_R1.8091.00
186_L197_V1.7811.00
179_R202_S1.7541.00
192_I197_V1.7011.00
166_A209_A1.6891.00
165_A192_I1.6481.00
200_R207_K1.5501.00
177_T199_Q1.5401.00
195_S199_Q1.5341.00
209_A212_A1.5341.00
181_A189_A1.5171.00
185_D188_T1.4781.00
172_K181_A1.4551.00
173_G180_G1.4551.00
208_L212_A1.4491.00
33_P36_E1.4361.00
115_T118_D1.4251.00
110_L131_S1.4191.00
166_A175_Y1.4051.00
170_V175_Y1.3991.00
167_A171_A1.3801.00
158_L204_V1.3570.99
56_D59_V1.2910.99
196_A204_V1.2870.99
112_D115_T1.2780.99
177_T202_S1.2330.99
196_A201_L1.2170.99
76_T84_C1.2140.99
188_T191_G1.2110.99
165_A197_V1.2020.99
109_Y175_Y1.2000.99
190_L197_V1.1640.98
170_V213_F1.1550.98
186_L190_L1.1490.98
143_Q156_F1.1410.98
132_L135_L1.1350.98
120_V130_V1.1320.98
201_L205_E1.1290.98
64_P191_G1.1270.98
91_G112_D1.1160.98
196_A199_Q1.1130.98
35_E102_D1.1100.98
104_I107_E1.1100.98
96_I175_Y1.1030.98
157_K211_S1.1010.98
174_Y179_R1.0920.97
175_Y201_L1.0910.97
199_Q203_A1.0890.97
209_A213_F1.0710.97
58_T197_V1.0610.97
165_A204_V1.0490.97
123_L128_N1.0470.97
183_L200_R1.0390.97
193_S202_S1.0350.97
94_P108_T1.0270.96
177_T195_S1.0160.96
121_A125_A1.0140.96
88_S186_L1.0090.96
155_L212_A0.9970.96
30_A33_P0.9940.96
69_S73_H0.9810.95
47_Q196_A0.9790.95
98_A105_T0.9790.95
170_V209_A0.9760.95
165_A186_L0.9740.95
164_E167_A0.9570.95
187_A197_V0.9570.95
203_A208_L0.9540.95
184_S194_K0.9540.95
69_S74_V0.9520.94
85_C89_D0.9510.94
45_R72_M0.9500.94
118_D121_A0.9460.94
94_P118_D0.9450.94
196_A203_A0.9430.94
57_V76_T0.9350.94
168_A189_A0.9230.93
92_C96_I0.9050.93
19_R190_L0.8980.93
41_V44_V0.8930.92
70_D74_V0.8840.92
77_Q155_L0.8780.92
206_S210_T0.8750.92
204_V209_A0.8580.91
107_E116_L0.8560.91
183_L194_K0.8340.89
43_A46_H0.8330.89
177_T184_S0.8300.89
184_S202_S0.8270.89
172_K197_V0.8200.89
16_R21_V0.8180.89
24_V130_V0.8150.88
161_K199_Q0.8130.88
105_T133_T0.8120.88
154_D203_A0.8030.88
135_L174_Y0.7970.87
23_D131_S0.7960.87
143_Q160_D0.7940.87
30_A134_H0.7940.87
82_C85_C0.7930.87
43_A166_A0.7840.86
177_T206_S0.7820.86
67_D70_D0.7800.86
99_V104_I0.7770.86
91_G122_D0.7720.86
74_V193_S0.7710.85
176_A206_S0.7710.85
203_A206_S0.7580.84
192_I195_S0.7580.84
164_E168_A0.7570.84
16_R116_L0.7570.84
65_D102_D0.7560.84
24_V33_P0.7560.84
34_L80_D0.7550.84
31_A50_G0.7540.84
102_D125_A0.7530.84
116_L134_H0.7530.84
139_A153_L0.7520.84
93_V109_Y0.7510.84
174_Y183_L0.7510.84
48_Y70_D0.7390.83
87_F108_T0.7340.83
194_K209_A0.7330.82
75_A81_S0.7290.82
90_H122_D0.7290.82
183_L196_A0.7250.82
86_V182_D0.7240.82
117_T120_V0.7200.81
97_T106_V0.7180.81
51_D54_H0.7140.81
33_P106_V0.7140.81
119_L194_K0.7140.81
208_L211_S0.7130.81
38_D42_T0.7110.81
166_A204_V0.7040.80
34_L87_F0.6950.79
25_A32_C0.6930.79
46_H78_T0.6930.79
157_K210_T0.6910.79
34_L97_T0.6900.78
183_L204_V0.6900.78
92_C95_Q0.6880.78
96_I205_E0.6860.78
108_T119_L0.6850.78
168_A190_L0.6790.77
132_L159_T0.6790.77
194_K203_A0.6780.77
41_V59_V0.6750.77
52_D55_A0.6740.77
55_A77_Q0.6740.77
69_S184_S0.6720.77
132_L192_I0.6720.77
153_L191_G0.6700.76
111_A124_K0.6700.76
32_C36_E0.6680.76
31_A35_E0.6660.76
177_T200_R0.6590.75
32_C38_D0.6580.75
54_H60_A0.6570.75
33_P37_I0.6550.75
155_L163_R0.6360.73
173_G198_S0.6310.72
51_D111_A0.6280.72
119_L199_Q0.6250.71
131_S139_A0.6250.71
135_L195_S0.6240.71
96_I111_A0.6220.71
107_E194_K0.6210.71
59_V65_D0.6200.71
154_D157_K0.6160.70
94_P155_L0.6140.70
30_A34_L0.6140.70
163_R212_A0.6110.70
112_D163_R0.6100.70
113_R135_L0.6100.70
143_Q153_L0.6090.69
81_S182_D0.6070.69
190_L198_S0.6040.69
166_A213_F0.6020.69
53_C60_A0.5970.68
117_T196_A0.5960.68
120_V196_A0.5950.68
173_G176_A0.5930.67
133_T141_D0.5920.67
48_Y141_D0.5900.67
192_I200_R0.5880.67
116_L188_T0.5870.67
39_G42_T0.5860.66
69_S72_M0.5850.66
127_A160_D0.5850.66
15_R212_A0.5840.66
92_C97_T0.5830.66
90_H159_T0.5830.66
87_F94_P0.5820.66
20_V23_D0.5820.66
137_R157_K0.5810.66
129_T156_F0.5800.66
164_E192_I0.5800.66
55_A58_T0.5770.65
60_A64_P0.5760.65
46_H137_R0.5740.65
83_L106_V0.5740.65
167_A213_F0.5730.65
118_D180_G0.5720.65
44_V47_Q0.5720.65
50_G142_D0.5690.64
60_A189_A0.5680.64
142_D196_A0.5660.64
41_V70_D0.5590.63
175_Y209_A0.5570.63
86_V126_V0.5570.63
22_L32_C0.5570.63
116_L164_E0.5560.62
70_D167_A0.5550.62
72_M96_I0.5550.62
160_D170_V0.5540.62
168_A181_A0.5510.62
33_P104_I0.5480.61
119_L195_S0.5440.61
196_A208_L0.5440.61
65_D69_S0.5440.61
182_D212_A0.5420.60
100_A141_D0.5390.60
123_L127_A0.5380.60
37_I41_V0.5370.60
95_Q182_D0.5370.60
175_Y204_V0.5330.59
39_G172_K0.5310.59
22_L26_L0.5290.59
139_A142_D0.5280.59
102_D114_T0.5250.58
130_V198_S0.5240.58
70_D73_H0.5230.58
37_I191_G0.5210.58
44_V48_Y0.5180.57
124_K192_I0.5150.57
108_T115_T0.5150.57
108_T112_D0.5150.57
185_D190_L0.5150.57
124_K188_T0.5140.56
163_R215_E0.5120.56
76_T88_S0.5110.56
86_V89_D0.5100.56
166_A205_E0.5090.56
51_D65_D0.5090.56
105_T211_S0.5080.56
25_A94_P0.5070.55
71_V87_F0.5060.55
15_R175_Y0.5060.55
19_R22_L0.5050.55
73_H170_V0.5040.55
44_V67_D0.5040.55
116_L135_L0.5040.55
30_A190_L0.5030.55
96_I171_A0.5030.55
108_T207_K0.5020.55
110_L175_Y0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1je8A 2 0.2902 97.3 0.85 Contact Map
1s7oA 3 0.3438 97.3 0.851 Contact Map
1ku3A 1 0.2723 97.2 0.852 Contact Map
1xsvA 2 0.3438 97.1 0.854 Contact Map
3hugA 3 0.3571 97.1 0.854 Contact Map
4wszA 2 0.2545 97.1 0.855 Contact Map
2o8xA 7 0.2723 97 0.856 Contact Map
1ttyA 1 0.3527 96.8 0.861 Contact Map
3c57A 2 0.2143 96.7 0.862 Contact Map
2rnjA 1 0.2545 96.7 0.863 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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