GREMLIN Database
DMSB - Putative dimethyl sulfoxide reductase iron-sulfur subunit B
UniProt: Q9HR73 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 262 (201)
Sequences: 1298 (720)
Seq/√Len: 50.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
160_P163_V4.0381.00
6_L149_F4.0001.00
149_F205_T3.6241.00
26_E152_H3.1321.00
69_T195_L3.0971.00
194_Q197_D3.0691.00
13_C19_C2.7521.00
88_T118_R2.5861.00
13_C16_C2.5261.00
57_G60_G2.5091.00
16_C19_C2.1861.00
95_I154_V2.1631.00
13_C166_C2.1431.00
107_R122_W2.1411.00
77_A90_T2.1091.00
163_V171_R2.0931.00
27_N148_T2.0621.00
82_V108_Y2.0391.00
172_I186_Y2.0081.00
180_D185_K2.0021.00
83_C103_C1.9891.00
182_T185_K1.9580.99
107_R120_F1.9460.99
83_C109_C1.9080.99
153_R164_V1.8430.99
178_D181_S1.8360.99
14_I168_A1.8240.99
103_C109_C1.7920.99
80_V88_T1.7760.99
8_I171_R1.7740.99
11_E190_Y1.7610.99
183_V186_Y1.7430.99
16_C166_C1.7100.99
175_D178_D1.6830.98
22_T161_A1.6500.98
98_I118_R1.6420.98
107_R110_M1.6260.98
194_Q202_D1.6150.98
110_M144_V1.6140.98
3_N204_S1.5910.98
139_R145_E1.5870.98
82_V88_T1.5860.98
195_L201_T1.5830.98
47_D51_G1.5720.98
10_Q68_P1.5650.97
151_S155_E1.5380.97
83_C105_G1.5360.97
5_G176_L1.5310.97
70_A205_T1.5270.97
47_D50_S1.5150.97
57_G61_T1.5040.97
8_I70_A1.4930.97
121_N145_E1.4900.97
91_R97_E1.4730.96
90_T96_V1.4710.96
75_E204_S1.4540.96
89_Y99_D1.4480.96
70_A149_F1.4440.96
105_G109_C1.4300.96
19_C166_C1.4090.95
185_K189_E1.4080.95
22_T165_N1.3940.95
82_V112_A1.3930.95
172_I182_T1.3590.94
88_T98_I1.3520.94
159_D163_V1.3290.94
194_Q206_Y1.2960.93
78_P112_A1.2910.93
194_Q199_K1.2890.93
181_S184_S1.2790.92
27_N152_H1.2780.92
24_K29_V1.2480.91
192_T208_I1.2390.91
26_E161_A1.2220.90
96_V112_A1.2200.90
91_R155_E1.2160.90
7_V183_V1.2130.90
98_I144_V1.2110.90
108_Y111_A1.1900.89
26_E153_R1.1770.89
13_C167_P1.1710.88
46_V50_S1.1640.88
213_S216_R1.1550.88
85_V106_C1.1230.86
37_R73_H1.1170.86
185_K188_A1.1120.86
12_R169_D1.1080.85
85_V104_M1.1080.85
15_G19_C1.1050.85
84_P103_C1.0990.85
181_S185_K1.0920.85
77_A96_V1.0850.84
7_V208_I1.0670.83
84_P109_C1.0660.83
3_N75_E1.0520.82
153_R158_L1.0490.82
80_V90_T1.0380.81
97_E151_S1.0360.81
159_D164_V1.0340.81
120_F142_G1.0270.81
77_A80_V1.0270.81
19_C167_P1.0210.80
184_S188_A1.0210.80
69_T72_Q1.0160.80
48_T51_G1.0000.79
120_F141_Q0.9980.79
203_P207_Y0.9950.79
5_G81_K0.9900.78
7_V186_Y0.9890.78
115_Y201_T0.9860.78
78_P115_Y0.9800.77
37_R92_D0.9730.77
179_D184_S0.9690.77
187_I192_T0.9550.76
182_T186_Y0.9470.75
121_N139_R0.9460.75
18_S25_Q0.9450.75
6_L70_A0.9330.74
4_Y95_I0.9300.74
177_D185_K0.9300.74
8_I68_P0.9230.73
18_S26_E0.9230.73
38_V41_Q0.9210.73
42_G45_H0.9150.72
106_C109_C0.9000.71
76_N81_K0.9000.71
33_Q36_N0.9000.71
68_P207_Y0.8940.71
14_I169_D0.8870.70
106_C112_A0.8710.69
12_R18_S0.8700.69
78_P201_T0.8650.68
196_L199_K0.8630.68
38_V43_G0.8590.68
187_I206_Y0.8560.67
28_N145_E0.8490.67
8_I170_A0.8470.67
186_Y189_E0.8430.66
190_Y208_I0.8410.66
93_D155_E0.8350.65
58_D61_T0.8290.65
84_P105_G0.8240.64
68_P115_Y0.8190.64
26_E164_V0.8180.64
36_N40_T0.8000.62
59_G62_L0.7990.62
5_G184_S0.7960.62
160_P171_R0.7930.61
40_T43_G0.7830.60
17_Q20_S0.7790.60
11_E208_I0.7770.60
7_V187_I0.7720.59
18_S165_N0.7700.59
10_Q69_T0.7680.59
100_Y120_F0.7640.59
139_R142_G0.7590.58
204_S209_N0.7580.58
176_L180_D0.7540.57
169_D188_A0.7500.57
45_H48_T0.7490.57
195_L203_P0.7430.56
82_V111_A0.7420.56
172_I179_D0.7420.56
102_K139_R0.7370.56
83_C106_C0.7340.55
106_C110_M0.7330.55
43_G49_P0.7320.55
7_V163_V0.7180.54
36_N41_Q0.7160.54
91_R95_I0.7110.53
4_Y73_H0.7080.53
103_C106_C0.7060.53
203_P213_S0.7010.52
44_D48_T0.7000.52
73_H117_A0.7000.52
15_G166_C0.7000.52
42_G48_T0.6960.52
46_V49_P0.6940.51
95_I151_S0.6880.51
211_E216_R0.6870.51
21_L24_K0.6840.50
15_G68_P0.6840.50
157_G187_I0.6820.50
99_D102_K0.6780.50
35_W43_G0.6780.50
108_Y112_A0.6770.50
5_G204_S0.6770.50
149_F173_F0.6750.49
7_V179_D0.6740.49
27_N170_A0.6690.49
68_P171_R0.6650.48
35_W39_L0.6640.48
34_F41_Q0.6620.48
153_R168_A0.6610.48
38_V45_H0.6570.48
30_P158_L0.6490.47
28_N139_R0.6490.47
174_G178_D0.6490.47
139_R143_V0.6420.46
18_S168_A0.6390.46
43_G47_D0.6390.46
108_Y143_V0.6380.46
49_P77_A0.6290.45
212_M215_G0.6220.44
88_T121_N0.6200.44
106_C144_V0.6140.43
189_E192_T0.6110.43
55_E62_L0.6110.43
49_P69_T0.6040.42
38_V42_G0.6020.42
100_Y143_V0.6000.42
116_N119_V0.5980.42
12_R185_K0.5970.41
100_Y151_S0.5970.41
154_V173_F0.5950.41
120_F144_V0.5950.41
91_R96_V0.5950.41
32_G82_V0.5930.41
121_N142_G0.5910.41
18_S21_L0.5910.41
106_C211_E0.5900.41
147_C162_C0.5900.41
3_N177_D0.5900.41
77_A91_R0.5880.41
120_F200_G0.5860.40
82_V118_R0.5860.40
44_D52_D0.5860.40
183_V206_Y0.5850.40
153_R161_A0.5840.40
115_Y203_P0.5840.40
195_L200_G0.5810.40
8_I205_T0.5800.40
104_M112_A0.5790.40
11_E213_S0.5780.40
6_L205_T0.5770.39
116_N148_T0.5760.39
92_D178_D0.5730.39
4_Y93_D0.5730.39
171_R195_L0.5720.39
37_R42_G0.5710.39
45_H50_S0.5690.39
92_D97_E0.5660.38
14_I34_F0.5640.38
200_G214_P0.5620.38
22_T159_D0.5600.38
76_N86_N0.5590.38
27_N48_T0.5590.38
85_V98_I0.5550.37
192_T205_T0.5530.37
177_D187_I0.5510.37
61_T185_K0.5480.37
176_L184_S0.5480.37
11_E66_Y0.5440.36
38_V88_T0.5440.36
85_V107_R0.5430.36
169_D172_I0.5420.36
69_T207_Y0.5420.36
72_Q194_Q0.5410.36
81_K204_S0.5390.36
45_H51_G0.5390.36
102_K145_E0.5390.36
212_M216_R0.5320.35
98_I171_R0.5320.35
42_G47_D0.5270.35
22_T25_Q0.5270.35
121_N140_P0.5260.35
67_Q78_P0.5260.35
7_V192_T0.5250.34
56_G86_N0.5230.34
7_V65_T0.5220.34
101_D211_E0.5220.34
78_P120_F0.5220.34
4_Y142_G0.5210.34
63_E210_G0.5200.34
10_Q67_Q0.5200.34
152_H161_A0.5190.34
6_L173_F0.5190.34
179_D182_T0.5190.34
39_L42_G0.5180.34
142_G199_K0.5160.34
78_P199_K0.5160.34
75_E176_L0.5150.33
159_D182_T0.5150.33
13_C170_A0.5150.33
88_T144_V0.5130.33
52_D55_E0.5130.33
16_C167_P0.5120.33
80_V144_V0.5120.33
91_R197_D0.5110.33
187_I202_D0.5110.33
5_G181_S0.5100.33
141_Q170_A0.5090.33
9_D208_I0.5090.33
25_Q164_V0.5090.33
3_N176_L0.5090.33
4_Y177_D0.5080.33
176_L204_S0.5080.33
68_P142_G0.5060.33
63_E189_E0.5050.33
163_V187_I0.5040.32
162_C166_C0.5030.32
182_T192_T0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ivfB 1 0.9351 100 0.456 Contact Map
1ti6B 2 0.874 100 0.492 Contact Map
1kqfB 3 0.8893 100 0.502 Contact Map
1h0hB 1 0.7748 100 0.51 Contact Map
2vpzB 2 0.7328 100 0.53 Contact Map
1q16B 2 0.9351 100 0.531 Contact Map
4z3xE 2 0.6374 100 0.679 Contact Map
3mm5B 2 0.8435 99.8 0.774 Contact Map
3gyxB 1 0.5496 99.4 0.837 Contact Map
3i9v9 1 0.5802 99.4 0.838 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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