GREMLIN Database
DMSC - Putative dimethyl sulfoxide reductase membrane subunit C
UniProt: Q9HR72 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 435 (363)
Sequences: 1359 (982)
Seq/√Len: 51.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_A395_A5.0761.00
28_A32_V4.4061.00
239_V334_F3.8711.00
261_G333_I3.4061.00
63_L345_L3.3381.00
31_L403_I3.2271.00
387_Y393_E3.2021.00
32_V36_G3.1171.00
31_L406_L3.0091.00
27_L402_S2.9951.00
50_G390_T2.8941.00
30_L402_S2.7891.00
235_G337_S2.7611.00
338_V342_F2.6771.00
19_L22_G2.6381.00
239_V337_S2.5771.00
36_G40_Y2.5641.00
112_L121_I2.5631.00
306_F309_W2.5401.00
316_V339_L2.5391.00
220_L275_L2.4321.00
123_Q127_S2.4311.00
41_Q60_Y2.3641.00
305_Y309_W2.3381.00
23_W409_M2.2641.00
242_I334_F2.2091.00
257_L333_I2.1731.00
320_L336_A2.1631.00
320_L326_L2.1591.00
264_L340_A2.1051.00
69_G229_A2.0971.00
25_G29_L2.0881.00
48_E392_V2.0801.00
40_Y44_H2.0631.00
227_A270_F2.0461.00
26_V30_L2.0451.00
329_R332_V2.0261.00
61_I64_F1.9941.00
313_G339_L1.9841.00
72_A196_A1.9581.00
394_I398_V1.9300.99
311_G316_V1.9140.99
32_V35_L1.8750.99
304_V307_W1.8600.99
410_A414_Y1.8530.99
33_I395_A1.8480.99
120_R123_Q1.8210.99
49_T60_Y1.8050.99
44_H47_I1.8040.99
123_Q126_T1.7960.99
231_V340_A1.7950.99
261_G321_L1.7750.99
29_L32_V1.7700.99
95_L241_S1.7590.99
258_T328_R1.7540.99
199_L203_T1.7490.99
39_A43_Q1.7270.99
267_F270_F1.7200.99
218_S354_T1.7150.99
24_L406_L1.7100.99
326_L332_V1.7090.99
325_S328_R1.7050.99
64_F137_D1.6960.99
258_T262_K1.6680.98
22_G26_V1.6620.98
259_S262_K1.6520.98
243_L247_F1.6220.98
272_V314_G1.6200.98
64_F202_V1.5610.98
21_R25_G1.5500.97
312_L315_A1.5390.97
107_A151_Y1.5380.97
235_G341_V1.5380.97
323_T326_L1.5300.97
262_K266_I1.5260.97
106_V404_G1.5000.97
75_L192_A1.4940.97
142_M206_I1.4880.97
322_A325_S1.4790.97
150_W188_T1.4730.97
98_L411_G1.4630.96
305_Y308_L1.4500.96
114_D203_T1.4380.96
46_L49_T1.4340.96
313_G317_P1.4320.96
40_Y392_V1.4320.96
64_F111_I1.4250.96
123_Q128_P1.4150.96
331_A335_T1.4140.96
96_G144_Y1.4120.96
411_G415_L1.4000.95
41_Q46_L1.3910.95
399_G409_M1.3910.95
29_L115_I1.3710.95
144_Y200_H1.3680.95
228_K348_G1.3550.94
137_D141_V1.3460.94
391_A395_A1.3430.94
238_L337_S1.3370.94
265_G272_V1.3320.94
244_A408_V1.3300.94
264_L267_F1.3250.94
26_V398_V1.3200.94
31_L35_L1.3180.94
146_A202_V1.3180.94
140_I148_N1.3140.93
242_I257_L1.3110.93
60_Y64_F1.3110.93
75_L100_S1.2870.93
95_L408_V1.2760.92
317_P343_G1.2750.92
208_A221_V1.2650.92
102_G408_V1.2570.92
205_W222_A1.2550.92
265_G322_A1.2540.92
58_G352_V1.2420.91
234_L263_L1.2420.91
239_V341_V1.2390.91
42_L45_G1.2250.91
238_L333_I1.2170.90
312_L339_L1.2160.90
63_L397_T1.2070.90
333_I405_A1.1950.90
390_T393_E1.1950.90
122_Y125_V1.1930.90
109_L112_L1.1910.90
332_V336_A1.1910.90
22_G25_G1.1850.89
275_L278_A1.1840.89
102_G404_G1.1840.89
62_M353_F1.1760.89
249_A316_V1.1730.89
138_F142_M1.1690.89
315_A319_L1.1680.89
27_L31_L1.1680.89
33_I398_V1.1680.89
313_G343_G1.1670.89
299_L302_D1.1630.88
29_L33_I1.1600.88
51_M60_Y1.1590.88
102_G407_I1.1500.88
108_G112_L1.1470.88
315_A335_T1.1410.87
115_I288_H1.1390.87
136_W140_I1.1390.87
69_G73_G1.1320.87
202_V206_I1.1190.86
48_E395_A1.1170.86
219_P298_F1.1090.86
69_G132_S1.1070.86
231_V267_F1.1070.86
108_G111_I1.1040.86
318_L322_A1.0980.85
76_I100_S1.0910.85
188_T194_P1.0910.85
250_F419_R1.0870.85
134_M206_I1.0870.85
142_M146_A1.0850.85
137_D203_T1.0850.85
78_S96_G1.0790.84
280_R284_A1.0770.84
301_G304_V1.0760.84
69_G72_A1.0730.84
272_V318_L1.0720.84
65_V348_G1.0650.83
312_L325_S1.0630.83
124_F128_P1.0600.83
29_L36_G1.0540.83
321_L336_A1.0540.83
46_L51_M1.0530.83
274_Y278_A1.0500.83
58_G387_Y1.0420.82
106_V110_L1.0360.82
114_D144_Y1.0350.82
27_L406_L1.0350.82
278_A310_T1.0350.82
84_F335_T1.0340.82
70_L103_C1.0330.82
225_F351_L1.0290.81
149_V194_P1.0270.81
36_G43_Q1.0260.81
190_V194_P1.0250.81
37_A392_V1.0230.81
229_A348_G1.0130.80
34_G37_A1.0030.80
25_G31_L1.0000.79
105_I407_I0.9940.79
179_D272_V0.9930.79
258_T327_R0.9890.79
25_G32_V0.9880.79
265_G321_L0.9880.79
71_S233_G0.9830.78
117_R120_R0.9790.78
279_E283_H0.9780.78
303_T309_W0.9740.78
283_H287_H0.9680.77
108_G134_M0.9650.77
70_L73_G0.9650.77
238_L264_L0.9630.77
38_W41_Q0.9620.77
86_S89_Y0.9590.76
68_V107_A0.9560.76
22_G29_L0.9560.76
190_V381_W0.9550.76
106_V403_I0.9510.76
410_A413_R0.9500.76
227_A275_L0.9430.75
144_Y229_A0.9410.75
19_L398_V0.9410.75
307_W320_L0.9400.75
329_R334_F0.9390.75
227_A271_H0.9390.75
21_R24_L0.9310.74
108_G141_V0.9270.74
132_S222_A0.9230.74
19_L25_G0.9160.73
29_L43_Q0.9120.73
325_S332_V0.9110.73
141_V202_V0.9050.72
101_L158_R0.9050.72
93_A402_S0.9050.72
137_D140_I0.9000.72
180_R264_L0.8950.71
228_K341_V0.8920.71
24_L27_L0.8920.71
305_Y350_R0.8910.71
320_L323_T0.8910.71
26_V33_I0.8850.70
74_G96_G0.8830.70
30_L108_G0.8750.70
88_R259_S0.8660.69
92_F232_S0.8660.69
19_L39_A0.8650.69
137_D199_L0.8630.69
122_Y126_T0.8630.69
28_A35_L0.8630.69
46_L60_Y0.8610.68
36_G243_L0.8580.68
317_P340_A0.8520.68
254_R258_T0.8500.67
200_H229_A0.8480.67
64_F110_L0.8410.67
201_S220_L0.8350.66
406_L410_A0.8340.66
176_A179_D0.8330.66
149_V153_W0.8320.66
241_S252_A0.8240.65
107_A144_Y0.8240.65
107_A229_A0.8230.65
22_G386_T0.8200.65
116_G387_Y0.8160.64
94_R351_L0.8130.64
344_T347_E0.8110.64
294_I314_G0.8090.64
262_K338_V0.8070.63
140_I202_V0.8050.63
248_T412_L0.8000.63
320_L332_V0.7980.62
88_R291_F0.7980.62
24_L34_G0.7980.62
29_L35_L0.7970.62
239_V335_T0.7950.62
31_L37_A0.7930.62
41_Q392_V0.7920.62
325_S329_R0.7910.62
121_I127_S0.7870.61
78_S151_Y0.7870.61
41_Q48_E0.7860.61
74_G144_Y0.7860.61
32_V335_T0.7850.61
137_D202_V0.7820.61
84_F209_T0.7780.60
200_H203_T0.7780.60
63_L73_G0.7770.60
305_Y346_F0.7770.60
353_F356_Y0.7750.60
97_V201_S0.7750.60
96_G237_L0.7730.60
115_I125_V0.7730.60
260_L402_S0.7720.60
312_L316_V0.7710.60
308_L342_F0.7700.60
35_L43_Q0.7660.59
297_N301_G0.7660.59
405_A409_M0.7640.59
306_F343_G0.7620.59
240_V403_I0.7610.59
27_L36_G0.7600.59
223_P275_L0.7580.58
59_L397_T0.7570.58
31_L38_W0.7550.58
74_G99_V0.7540.58
206_I211_V0.7530.58
244_A259_S0.7530.58
115_I127_S0.7530.58
25_G36_G0.7510.58
100_S152_L0.7500.58
275_L419_R0.7490.58
75_L229_A0.7490.58
314_G317_P0.7480.57
78_S199_L0.7460.57
268_L313_G0.7450.57
109_L402_S0.7440.57
77_L283_H0.7430.57
266_I274_Y0.7410.57
304_V342_F0.7410.57
193_L201_S0.7410.57
91_G262_K0.7390.57
19_L29_L0.7390.57
220_L354_T0.7380.56
182_R185_M0.7370.56
308_L331_A0.7360.56
33_I332_V0.7340.56
19_L24_L0.7310.56
324_P328_R0.7310.56
44_H48_E0.7300.56
214_G290_G0.7300.56
112_L118_P0.7300.56
136_W202_V0.7270.55
296_S300_I0.7270.55
101_L149_V0.7270.55
342_F345_L0.7180.54
230_L260_L0.7150.54
303_T342_F0.7140.54
51_M58_G0.7090.53
160_L184_L0.7080.53
40_Y43_Q0.7060.53
116_G132_S0.7050.53
86_S268_L0.7040.53
243_L295_T0.7010.53
27_L403_I0.6990.52
36_G397_T0.6990.52
255_G262_K0.6990.52
227_A257_L0.6980.52
99_V240_V0.6980.52
300_I304_V0.6970.52
105_I145_G0.6970.52
141_V232_S0.6970.52
204_G356_Y0.6960.52
75_L347_E0.6960.52
134_M137_D0.6940.52
132_S387_Y0.6910.52
75_L203_T0.6880.51
38_W42_L0.6860.51
334_F398_V0.6850.51
25_G28_A0.6810.51
53_N355_G0.6810.51
28_A36_G0.6780.50
49_T114_D0.6780.50
94_R97_V0.6780.50
307_W310_T0.6760.50
410_A415_L0.6760.50
24_L28_A0.6730.50
387_Y390_T0.6730.50
101_L399_G0.6730.50
81_P89_Y0.6700.49
143_L207_F0.6660.49
79_S345_L0.6660.49
26_V32_V0.6660.49
34_G84_F0.6650.49
81_P93_A0.6650.49
57_W207_F0.6640.49
72_A204_G0.6640.49
71_S116_G0.6630.49
307_W399_G0.6620.49
316_V342_F0.6610.48
238_L261_G0.6600.48
35_L403_I0.6580.48
31_L43_Q0.6580.48
62_M349_I0.6570.48
109_L403_I0.6550.48
35_L300_I0.6540.48
101_L411_G0.6530.48
133_P138_F0.6520.48
69_G348_G0.6510.47
149_V329_R0.6490.47
277_A281_L0.6440.47
60_Y110_L0.6440.47
92_F236_L0.6430.47
357_Q393_E0.6430.47
231_V242_I0.6430.47
115_I197_V0.6420.46
220_L227_A0.6400.46
77_L237_L0.6390.46
69_G196_A0.6380.46
238_L260_L0.6350.46
201_S274_Y0.6330.46
45_G53_N0.6320.45
92_F193_L0.6310.45
72_A100_S0.6300.45
297_N302_D0.6300.45
74_G107_A0.6280.45
69_G77_L0.6280.45
89_Y259_S0.6260.45
71_S236_L0.6250.45
235_G408_V0.6240.45
133_P142_M0.6240.45
73_G401_I0.6230.45
87_Q90_E0.6230.45
238_L242_I0.6210.44
63_L343_G0.6180.44
35_L405_A0.6160.44
271_H276_L0.6160.44
150_W199_L0.6140.44
125_V138_F0.6130.44
311_G335_T0.6100.43
240_V415_L0.6100.43
139_G142_M0.6090.43
28_A406_L0.6090.43
51_M61_I0.6080.43
277_A310_T0.6080.43
228_K271_H0.6060.43
224_V337_S0.6060.43
224_V317_P0.6040.43
61_I144_Y0.6040.43
213_R355_G0.6030.42
278_A314_G0.6020.42
255_G398_V0.6020.42
79_S193_L0.6020.42
208_A282_P0.5990.42
152_L182_R0.5980.42
78_S144_Y0.5970.42
24_L32_V0.5970.42
42_L134_M0.5970.42
218_S279_E0.5950.42
29_L398_V0.5940.42
55_F78_S0.5930.41
307_W313_G0.5920.41
120_R124_F0.5920.41
111_I115_I0.5910.41
69_G144_Y0.5900.41
270_F275_L0.5890.41
31_L40_Y0.5890.41
38_W113_P0.5890.41
185_M188_T0.5880.41
58_G62_M0.5870.41
57_W132_S0.5850.41
397_T400_V0.5850.41
112_L141_V0.5830.40
19_L40_Y0.5820.40
196_A200_H0.5820.40
190_V193_L0.5810.40
69_G200_H0.5800.40
148_N151_Y0.5780.40
134_M250_F0.5780.40
65_V203_T0.5770.40
285_W291_F0.5760.40
301_G307_W0.5760.40
33_I36_G0.5740.40
183_T186_F0.5740.40
106_V153_W0.5700.39
23_W316_V0.5690.39
397_T405_A0.5690.39
55_F353_F0.5690.39
73_G357_Q0.5670.39
116_G393_E0.5650.39
268_L311_G0.5650.39
75_L344_T0.5650.39
255_G267_F0.5630.38
62_M352_V0.5620.38
58_G211_V0.5620.38
65_V77_L0.5610.38
60_Y205_W0.5610.38
24_L39_A0.5590.38
58_G393_E0.5590.38
193_L226_I0.5580.38
58_G233_G0.5560.38
34_G53_N0.5560.38
396_V403_I0.5550.38
408_V418_Q0.5530.37
55_F121_I0.5520.37
75_L148_N0.5500.37
177_G181_D0.5480.37
20_G23_W0.5470.37
135_V211_V0.5460.37
141_V145_G0.5460.37
24_L31_L0.5450.37
262_K288_H0.5440.37
94_R416_P0.5440.37
74_G233_G0.5420.36
20_G24_L0.5400.36
218_S282_P0.5390.36
215_D223_P0.5380.36
281_L295_T0.5380.36
77_L188_T0.5380.36
389_P393_E0.5380.36
386_T394_I0.5360.36
136_W148_N0.5350.36
187_W191_C0.5340.36
82_K93_A0.5340.36
184_L189_A0.5320.35
392_V395_A0.5320.35
276_L313_G0.5300.35
254_R260_L0.5300.35
144_Y348_G0.5290.35
315_A414_Y0.5290.35
82_K222_A0.5290.35
80_A230_L0.5290.35
151_Y203_T0.5280.35
221_V351_L0.5270.35
100_S233_G0.5260.35
197_V295_T0.5260.35
25_G342_F0.5250.35
26_V293_A0.5230.35
284_A340_A0.5230.35
32_V329_R0.5220.35
118_P132_S0.5210.34
116_G396_V0.5200.34
80_A214_G0.5180.34
25_G39_A0.5180.34
265_G286_A0.5170.34
394_I397_T0.5170.34
152_L411_G0.5160.34
228_K347_E0.5160.34
58_G343_G0.5160.34
58_G132_S0.5160.34
312_L335_T0.5150.34
78_S100_S0.5150.34
66_L345_L0.5140.34
293_A297_N0.5140.34
102_G199_L0.5130.34
217_F230_L0.5130.34
36_G235_G0.5120.34
25_G315_A0.5110.33
101_L204_G0.5110.33
191_C198_A0.5110.33
65_V111_I0.5110.33
71_S199_L0.5100.33
287_H292_W0.5090.33
275_L282_P0.5070.33
147_L195_A0.5070.33
45_G116_G0.5070.33
137_D151_Y0.5060.33
110_L403_I0.5050.33
156_T159_D0.5050.33
121_I197_V0.5040.33
26_V39_A0.5040.33
118_P121_I0.5040.33
48_E391_A0.5030.33
122_Y127_S0.5030.33
262_K278_A0.5020.33
239_V264_L0.5020.33
97_V161_A0.5010.33
187_W342_F0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vpzC 2 0.5678 100 0.668 Contact Map
4o6yA 2 0.469 81.8 0.953 Contact Map
4ev6A 3 0.1816 40.3 0.964 Contact Map
4i0uA 4 0.1793 32.1 0.966 Contact Map
4humA 1 0.8437 30.3 0.967 Contact Map
3l1lA 2 0.7793 27.9 0.967 Contact Map
2wswA 3 0.954 23.4 0.969 Contact Map
4c7rA 3 0.9149 23.3 0.969 Contact Map
2l8sA 1 0.1057 20.3 0.969 Contact Map
4fc4A 3 0.5264 17.4 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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