GREMLIN Database
DMSD - Putative dimethyl sulfoxide reductase chaperone
UniProt: Q9HR71 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 192 (161)
Sequences: 1317 (998)
Seq/√Len: 78.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
109_Y133_F3.9281.00
38_W181_T3.3161.00
65_E171_K2.9561.00
106_A124_P2.9181.00
82_E153_H2.5731.00
161_F165_V2.4701.00
162_A181_T2.4591.00
27_T146_L2.4561.00
127_L158_V2.4291.00
166_R182_V2.3851.00
87_D99_G2.3571.00
158_V185_L2.3071.00
27_T188_A2.2531.00
134_A146_L2.2421.00
27_T31_F2.2031.00
39_R128_A2.1281.00
166_R179_N2.1061.00
31_F188_A2.0811.00
112_Y145_T2.0081.00
67_T71_V1.9901.00
85_Y164_R1.8791.00
62_L173_F1.8741.00
82_E130_E1.8521.00
133_F149_F1.8041.00
34_L181_T1.7911.00
148_Q152_E1.7911.00
138_R146_L1.7581.00
82_E86_R1.7421.00
43_D47_A1.7141.00
80_P161_F1.6951.00
38_W177_L1.6941.00
165_V178_L1.6421.00
114_L136_Y1.5911.00
151_T189_D1.5680.99
32_A139_E1.5650.99
158_V162_A1.5620.99
105_V130_E1.5500.99
105_V109_Y1.5410.99
37_C177_L1.5300.99
172_P175_R1.5160.99
31_F184_T1.5140.99
35_A132_E1.5130.99
32_A135_A1.5010.99
82_E105_V1.4790.99
134_A150_L1.4660.99
65_E169_D1.4440.99
135_A139_E1.4360.99
63_R67_T1.3950.99
131_L185_L1.3860.99
159_E182_V1.3820.99
134_A184_T1.3750.99
82_E156_N1.3680.99
31_F146_L1.3600.99
41_P66_Y1.2980.98
73_P76_S1.2740.98
127_L161_F1.2730.98
138_R141_E1.2050.97
182_V186_A1.1980.97
66_Y126_H1.1800.96
138_R188_A1.1750.96
28_A139_E1.1740.96
36_A42_D1.1680.96
130_E133_F1.1550.96
127_L162_A1.1380.96
27_T184_T1.1330.95
111_E148_Q1.1120.95
169_D172_P1.1000.95
163_R182_V1.0830.94
154_P158_V1.0810.94
38_W70_F1.0760.94
102_T124_P1.0760.94
83_S123_P1.0580.93
81_Y122_A1.0570.93
127_L181_T1.0550.93
79_P84_V1.0480.93
85_Y174_Y1.0240.92
177_L181_T1.0130.92
38_W127_L1.0060.92
27_T134_A0.9970.91
42_D48_A0.9950.91
100_S104_A0.9760.90
58_D61_S0.9620.90
131_L181_T0.9560.89
27_T138_R0.9560.89
81_Y98_Y0.9550.89
105_V149_F0.9520.89
40_Q71_V0.9440.89
160_S164_R0.9300.88
102_T106_A0.9260.88
102_T105_V0.9250.88
57_V62_L0.9200.88
37_C173_F0.9190.88
169_D175_R0.9170.87
50_A55_T0.9160.87
157_W161_F0.9070.87
71_V76_S0.9060.87
43_D59_A0.9030.87
176_T180_V0.9000.86
126_H129_T0.8830.85
69_L180_V0.8790.85
72_G76_S0.8680.84
84_V89_E0.8670.84
107_R111_E0.8670.84
130_E149_F0.8520.83
155_R185_L0.8500.83
31_F134_A0.8480.83
36_A62_L0.8470.83
80_P127_L0.8470.83
163_R166_R0.8450.83
104_A152_E0.8420.83
176_T183_D0.8380.82
112_Y133_F0.8330.82
66_Y70_F0.8200.81
41_P45_L0.8120.80
87_D101_S0.8110.80
111_E118_A0.8080.80
111_E145_T0.8030.79
59_A63_R0.7980.79
156_N159_E0.7910.78
109_Y129_T0.7850.78
40_Q67_T0.7790.77
149_F157_W0.7770.77
65_E68_R0.7710.77
109_Y130_E0.7710.77
160_S163_R0.7670.76
153_H156_N0.7570.75
40_Q59_A0.7510.75
81_Y123_P0.7490.75
86_R156_N0.7430.74
65_E175_R0.7400.74
130_E154_P0.7310.73
70_F165_V0.7250.72
98_Y123_P0.7250.72
35_A81_Y0.7210.72
64_A67_T0.7210.72
146_L188_A0.7180.71
130_E141_E0.7170.71
30_R36_A0.7160.71
78_S84_V0.7150.71
54_D58_D0.7150.71
73_P81_Y0.7120.71
144_E148_Q0.7110.71
61_S141_E0.7090.70
134_A188_A0.7030.70
184_T188_A0.7020.70
39_R129_T0.7010.70
78_S165_V0.6990.69
37_C97_V0.6980.69
83_S97_V0.6900.68
105_V133_F0.6870.68
150_L155_R0.6850.68
60_Q64_A0.6790.67
35_A135_A0.6720.66
41_P174_Y0.6680.66
40_Q99_G0.6670.66
34_L184_T0.6640.65
162_A178_L0.6640.65
108_W149_F0.6600.65
69_L168_A0.6550.64
167_D179_N0.6490.64
72_G123_P0.6450.63
78_S85_Y0.6450.63
37_C180_V0.6410.63
178_L181_T0.6410.63
154_P177_L0.6400.63
30_R53_T0.6390.62
47_A54_D0.6380.62
25_P29_A0.6350.62
85_Y160_S0.6340.62
108_W112_Y0.6340.62
150_L188_A0.6290.61
83_S101_S0.6230.60
65_E77_Q0.6160.60
164_R167_D0.6140.59
136_Y139_E0.6120.59
47_A59_A0.6100.59
149_F153_H0.6080.59
73_P102_T0.6060.58
24_G141_E0.6050.58
51_A170_P0.6040.58
179_N186_A0.6030.58
24_G28_A0.6010.58
32_A132_E0.5960.57
130_E153_H0.5940.57
51_A177_L0.5940.57
28_A135_A0.5940.57
98_Y102_T0.5910.57
109_Y149_F0.5890.56
166_R175_R0.5880.56
132_E136_Y0.5870.56
40_Q62_L0.5830.55
71_V126_H0.5830.55
108_W148_Q0.5790.55
112_Y137_L0.5780.55
77_Q168_A0.5770.55
49_L182_V0.5750.54
136_Y140_H0.5730.54
131_L159_E0.5710.54
135_A167_D0.5710.54
170_P186_A0.5640.53
126_H161_F0.5620.53
114_L139_E0.5560.52
50_A54_D0.5540.52
82_E99_G0.5530.52
86_R101_S0.5500.51
109_Y124_P0.5500.51
65_E165_V0.5500.51
36_A39_R0.5490.51
103_Q124_P0.5480.51
80_P123_P0.5440.50
33_A49_L0.5390.50
30_R147_E0.5370.50
33_A37_C0.5360.49
61_S82_E0.5340.49
118_A121_S0.5320.49
78_S158_V0.5310.49
155_R188_A0.5300.49
162_A182_V0.5280.48
59_A62_L0.5280.48
28_A142_G0.5260.48
81_Y102_T0.5250.48
82_E101_S0.5240.48
67_T105_V0.5230.48
37_C60_Q0.5210.48
84_V102_T0.5200.47
30_R184_T0.5180.47
52_E75_P0.5170.47
71_V80_P0.5170.47
143_A158_V0.5170.47
105_V138_R0.5160.47
44_D48_A0.5160.47
72_G83_S0.5160.47
25_P47_A0.5150.47
97_V102_T0.5140.47
68_R161_F0.5140.47
143_A147_E0.5100.46
62_L174_Y0.5090.46
111_E170_P0.5090.46
162_A166_R0.5050.45
65_E108_W0.5020.45
73_P98_Y0.5020.45
31_F132_E0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1n1cA 2 0.8385 100 0.265 Contact Map
1s9uA 1 0.8698 100 0.28 Contact Map
2o9xA 2 0.7812 100 0.377 Contact Map
2xolA 2 0.7135 100 0.437 Contact Map
2hlyA 1 0.5365 4.2 0.955 Contact Map
3wurA 2 0.7604 3.2 0.957 Contact Map
2dgwA 1 0.4635 2.7 0.959 Contact Map
3q0wA 2 0.474 2.7 0.959 Contact Map
4cv5B 1 0.7083 2.6 0.959 Contact Map
4jzaA 2 0.4427 2.3 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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