GREMLIN Database
Q9HR69 - Iron-dependent repressor homolog
UniProt: Q9HR69 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 120 (110)
Sequences: 2469 (1662)
Seq/√Len: 158.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
80_S93_E2.9681.00
66_R70_T2.8591.00
83_F99_L2.8511.00
9_L76_Y2.6671.00
95_E104_D2.5211.00
74_E112_A2.4021.00
52_T60_R2.3251.00
91_T106_T2.1771.00
24_T38_V2.1141.00
4_A48_N2.1121.00
11_I51_V2.0751.00
110_R113_A1.9501.00
40_E44_Q1.8221.00
15_S66_R1.7961.00
42_L51_V1.7911.00
71_E105_P1.7811.00
13_I73_H1.7111.00
37_S41_M1.6491.00
18_D30_R1.5971.00
46_D53_Y1.5891.00
50_L64_A1.5871.00
33_K38_V1.5741.00
86_V114_T1.5661.00
64_A67_E1.5211.00
63_D66_R1.5211.00
9_L97_M1.4881.00
103_I108_T1.4771.00
82_F87_L1.4731.00
42_L59_A1.4211.00
10_A30_R1.3761.00
98_E102_I1.3731.00
15_S22_V1.3681.00
5_D101_S1.3641.00
80_S84_R1.3261.00
79_L103_I1.3261.00
26_Q29_D1.2831.00
97_M101_S1.2681.00
27_L42_L1.2251.00
11_I22_V1.2241.00
89_L107_V1.1991.00
10_A31_L1.1931.00
53_Y56_Y1.1911.00
76_Y93_E1.1721.00
97_M100_A1.1571.00
35_A41_M1.1491.00
51_V59_A1.1461.00
10_A27_L1.1381.00
39_T53_Y1.0991.00
27_L59_A1.0920.99
25_G35_A1.0620.99
5_D100_A1.0430.99
106_T110_R1.0240.99
67_E71_E1.0230.99
5_D72_L1.0160.99
6_Q97_M1.0040.99
13_I30_R1.0010.99
82_F114_T1.0000.99
95_E107_V0.9960.99
21_P58_G0.9660.99
8_L12_Y0.9660.99
82_F111_L0.9540.99
74_E78_T0.9530.99
92_H97_M0.9500.99
72_L75_S0.9470.99
82_F86_V0.9410.98
12_Y73_H0.9370.98
9_L100_A0.9180.98
71_E75_S0.9180.98
89_L95_E0.9030.98
76_Y97_M0.8990.98
6_Q101_S0.8880.98
15_S20_S0.8650.97
91_T95_E0.8650.97
68_R71_E0.8630.97
41_M44_Q0.8630.97
34_A39_T0.8540.97
24_T35_A0.8340.97
52_T62_T0.8280.97
38_V42_L0.8210.96
91_T107_V0.8200.96
12_Y16_H0.8130.96
43_K47_E0.8040.96
84_R92_H0.8020.96
105_P109_D0.7940.96
87_L110_R0.7890.95
8_L68_R0.7830.95
4_A44_Q0.7760.95
6_Q40_E0.7680.95
5_D68_R0.7660.95
75_S105_P0.7660.95
24_T42_L0.7650.95
31_L41_M0.7640.95
79_L107_V0.7600.94
43_K46_D0.7570.94
10_A13_I0.7560.94
77_V80_S0.7500.94
96_A102_I0.7500.94
11_I38_V0.7390.94
21_P60_R0.7290.93
49_G64_A0.7290.93
95_E106_T0.7280.93
81_W111_L0.7270.93
80_S92_H0.7210.93
13_I72_L0.7010.92
33_K36_P0.6990.92
76_Y100_A0.6970.91
6_Q100_A0.6970.91
16_H77_V0.6910.91
14_E22_V0.6840.91
24_T53_Y0.6830.91
12_Y69_A0.6790.90
6_Q9_L0.6720.90
103_I107_V0.6710.90
31_L35_A0.6710.90
82_F115_L0.6700.90
40_E43_K0.6640.89
95_E103_I0.6590.89
64_A68_R0.6570.89
54_T58_G0.6560.89
39_T43_K0.6560.89
24_T39_T0.6540.89
23_P58_G0.6530.89
4_A43_K0.6470.88
9_L13_I0.6450.88
95_E98_E0.6440.88
15_S21_P0.6440.88
70_T74_E0.6430.88
63_D67_E0.6380.87
19_D26_Q0.6360.87
42_L53_Y0.6320.87
75_S108_T0.6280.87
22_V27_L0.6200.86
19_D56_Y0.6110.85
34_A40_E0.6110.85
79_L111_L0.6100.85
4_A41_M0.5970.84
33_K37_S0.5960.84
24_T58_G0.5920.83
73_H77_V0.5900.83
69_A72_L0.5820.82
42_L45_L0.5820.82
84_R93_E0.5790.82
95_E102_I0.5770.82
109_D112_A0.5680.81
27_L31_L0.5600.80
19_D22_V0.5580.79
33_K40_E0.5570.79
4_A37_S0.5570.79
87_L114_T0.5520.79
12_Y66_R0.5450.78
104_D107_V0.5420.77
9_L73_H0.5410.77
94_S98_E0.5370.77
27_L38_V0.5350.77
35_A58_G0.5340.76
43_K53_Y0.5290.76
88_D110_R0.5280.76
57_K60_R0.5270.76
99_L102_I0.5260.75
25_G40_E0.5240.75
45_L50_L0.5180.74
28_A33_K0.5160.74
73_H80_S0.5110.73
78_T115_L0.5050.72
46_D57_K0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1fx7A 4 0.9917 99.9 0.487 Contact Map
4o5vA 2 0.9833 99.9 0.49 Contact Map
2qq9A 2 0.9917 99.8 0.499 Contact Map
3hrsA 2 0.9917 99.8 0.5 Contact Map
1on2A 2 0.9833 99.7 0.569 Contact Map
2p8tA 1 0.9167 99.7 0.57 Contact Map
2h09A 2 0.9583 99.6 0.593 Contact Map
2x4hA 3 0.9833 99.6 0.614 Contact Map
2o0mA 1 0.3667 99.1 0.693 Contact Map
2fxaA 4 0.9583 99.1 0.697 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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