Q9HR69 - HALSA - GREMLIN Contacts

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Q9HR69 - Iron-dependent repressor homolog

UniProt:	Q9HR69	Sequences: MSGADQYLLAIYIESHRDDSPVPTGQLADRLEKAAPSVTEMLKQLDENGLVTYTPYKGARLTDAGRERATELHESYVTLSWFFRSVLDLETHESEAMELASIIDPTVTDRLAATLPDDDR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	120 (110)
Sequences:	2469 (1662)
Seq/√Len:	158.4

ECOLI - MNTR
BACSU - MNTR
HALSA - Q9HR69 Q9HRV3 Q9HME7 Q9HRU8
SULSO - Q7LXP0 Q97WF3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
80_S	93_E	2.968	1.00
66_R	70_T	2.859	1.00
83_F	99_L	2.851	1.00
9_L	76_Y	2.667	1.00
95_E	104_D	2.521	1.00
74_E	112_A	2.402	1.00
52_T	60_R	2.325	1.00
91_T	106_T	2.177	1.00
24_T	38_V	2.114	1.00
4_A	48_N	2.112	1.00
11_I	51_V	2.075	1.00
110_R	113_A	1.950	1.00
40_E	44_Q	1.822	1.00
15_S	66_R	1.796	1.00
42_L	51_V	1.791	1.00
71_E	105_P	1.781	1.00
13_I	73_H	1.711	1.00
37_S	41_M	1.649	1.00
18_D	30_R	1.597	1.00
46_D	53_Y	1.589	1.00
50_L	64_A	1.587	1.00
33_K	38_V	1.574	1.00
86_V	114_T	1.566	1.00
64_A	67_E	1.521	1.00
63_D	66_R	1.521	1.00
9_L	97_M	1.488	1.00
103_I	108_T	1.477	1.00
82_F	87_L	1.473	1.00
42_L	59_A	1.421	1.00
10_A	30_R	1.376	1.00
98_E	102_I	1.373	1.00
15_S	22_V	1.368	1.00
5_D	101_S	1.364	1.00
80_S	84_R	1.326	1.00
79_L	103_I	1.326	1.00
26_Q	29_D	1.283	1.00
97_M	101_S	1.268	1.00
27_L	42_L	1.225	1.00
11_I	22_V	1.224	1.00
89_L	107_V	1.199	1.00
10_A	31_L	1.193	1.00
53_Y	56_Y	1.191	1.00
76_Y	93_E	1.172	1.00
97_M	100_A	1.157	1.00
35_A	41_M	1.149	1.00
51_V	59_A	1.146	1.00
10_A	27_L	1.138	1.00
39_T	53_Y	1.099	1.00
27_L	59_A	1.092	0.99
25_G	35_A	1.062	0.99
5_D	100_A	1.043	0.99
106_T	110_R	1.024	0.99
67_E	71_E	1.023	0.99
5_D	72_L	1.016	0.99
6_Q	97_M	1.004	0.99
13_I	30_R	1.001	0.99
82_F	114_T	1.000	0.99
95_E	107_V	0.996	0.99
21_P	58_G	0.966	0.99
8_L	12_Y	0.966	0.99
82_F	111_L	0.954	0.99
74_E	78_T	0.953	0.99
92_H	97_M	0.950	0.99
72_L	75_S	0.947	0.99
82_F	86_V	0.941	0.98
12_Y	73_H	0.937	0.98
9_L	100_A	0.918	0.98
71_E	75_S	0.918	0.98
89_L	95_E	0.903	0.98
76_Y	97_M	0.899	0.98
6_Q	101_S	0.888	0.98
15_S	20_S	0.865	0.97
91_T	95_E	0.865	0.97
68_R	71_E	0.863	0.97
41_M	44_Q	0.863	0.97
34_A	39_T	0.854	0.97
24_T	35_A	0.834	0.97
52_T	62_T	0.828	0.97
38_V	42_L	0.821	0.96
91_T	107_V	0.820	0.96
12_Y	16_H	0.813	0.96
43_K	47_E	0.804	0.96
84_R	92_H	0.802	0.96
105_P	109_D	0.794	0.96
87_L	110_R	0.789	0.95
8_L	68_R	0.783	0.95
4_A	44_Q	0.776	0.95
6_Q	40_E	0.768	0.95
5_D	68_R	0.766	0.95
75_S	105_P	0.766	0.95
24_T	42_L	0.765	0.95
31_L	41_M	0.764	0.95
79_L	107_V	0.760	0.94
43_K	46_D	0.757	0.94
10_A	13_I	0.756	0.94
77_V	80_S	0.750	0.94
96_A	102_I	0.750	0.94
11_I	38_V	0.739	0.94
21_P	60_R	0.729	0.93
49_G	64_A	0.729	0.93
95_E	106_T	0.728	0.93
81_W	111_L	0.727	0.93
80_S	92_H	0.721	0.93
13_I	72_L	0.701	0.92
33_K	36_P	0.699	0.92
76_Y	100_A	0.697	0.91
6_Q	100_A	0.697	0.91
16_H	77_V	0.691	0.91
14_E	22_V	0.684	0.91
24_T	53_Y	0.683	0.91
12_Y	69_A	0.679	0.90
6_Q	9_L	0.672	0.90
103_I	107_V	0.671	0.90
31_L	35_A	0.671	0.90
82_F	115_L	0.670	0.90
40_E	43_K	0.664	0.89
95_E	103_I	0.659	0.89
64_A	68_R	0.657	0.89
54_T	58_G	0.656	0.89
39_T	43_K	0.656	0.89
24_T	39_T	0.654	0.89
23_P	58_G	0.653	0.89
4_A	43_K	0.647	0.88
9_L	13_I	0.645	0.88
95_E	98_E	0.644	0.88
15_S	21_P	0.644	0.88
70_T	74_E	0.643	0.88
63_D	67_E	0.638	0.87
19_D	26_Q	0.636	0.87
42_L	53_Y	0.632	0.87
75_S	108_T	0.628	0.87
22_V	27_L	0.620	0.86
19_D	56_Y	0.611	0.85
34_A	40_E	0.611	0.85
79_L	111_L	0.610	0.85
4_A	41_M	0.597	0.84
33_K	37_S	0.596	0.84
24_T	58_G	0.592	0.83
73_H	77_V	0.590	0.83
69_A	72_L	0.582	0.82
42_L	45_L	0.582	0.82
84_R	93_E	0.579	0.82
95_E	102_I	0.577	0.82
109_D	112_A	0.568	0.81
27_L	31_L	0.560	0.80
19_D	22_V	0.558	0.79
33_K	40_E	0.557	0.79
4_A	37_S	0.557	0.79
87_L	114_T	0.552	0.79
12_Y	66_R	0.545	0.78
104_D	107_V	0.542	0.77
9_L	73_H	0.541	0.77
94_S	98_E	0.537	0.77
27_L	38_V	0.535	0.77
35_A	58_G	0.534	0.76
43_K	53_Y	0.529	0.76
88_D	110_R	0.528	0.76
57_K	60_R	0.527	0.76
99_L	102_I	0.526	0.75
25_G	40_E	0.524	0.75
45_L	50_L	0.518	0.74
28_A	33_K	0.516	0.74
73_H	80_S	0.511	0.73
78_T	115_L	0.505	0.72
46_D	57_K	0.500	0.72

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1fx7A	4	0.9917	99.9	0.487	Contact Map
4o5vA	2	0.9833	99.9	0.49	Contact Map
2qq9A	2	0.9917	99.8	0.499	Contact Map
3hrsA	2	0.9917	99.8	0.5	Contact Map
1on2A	2	0.9833	99.7	0.569	Contact Map
2p8tA	1	0.9167	99.7	0.57	Contact Map
2h09A	2	0.9583	99.6	0.593	Contact Map
2x4hA	3	0.9833	99.6	0.614	Contact Map
2o0mA	1	0.3667	99.1	0.693	Contact Map
2fxaA	4	0.9583	99.1	0.697	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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