GREMLIN Database
Q9HR64 - Carbonic anhydrase
UniProt: Q9HR64 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 220 (178)
Sequences: 3886 (2316)
Seq/√Len: 173.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
152_V173_G4.8501.00
26_D85_E4.2251.00
156_V173_G3.3081.00
58_G97_A3.2681.00
156_V171_V2.8931.00
28_V75_V2.7131.00
86_T172_V2.6271.00
76_L80_E2.3961.00
57_I74_D2.3871.00
99_T103_R2.3611.00
99_T144_I2.3071.00
93_T175_V2.2791.00
148_V175_V2.2541.00
149_E184_G2.2221.00
23_Q35_S2.1631.00
174_A183_P2.1611.00
33_A52_F2.0501.00
72_S162_S2.0431.00
85_E168_D2.0221.00
7_R45_N1.9811.00
2_L185_S1.9681.00
78_P84_T1.9461.00
3_A7_R1.9141.00
135_P138_L1.8831.00
60_R123_I1.7461.00
6_Q182_Y1.7251.00
6_Q10_A1.7121.00
77_Y81_H1.6661.00
28_V74_D1.6621.00
177_D184_G1.6201.00
15_R18_D1.6071.00
165_V169_V1.5921.00
149_E175_V1.5851.00
160_L171_V1.5681.00
163_D166_D1.5621.00
28_V84_T1.5491.00
43_W51_I1.5441.00
54_C74_D1.5441.00
102_Y147_L1.5361.00
94_G179_Q1.5221.00
150_Y153_D1.5201.00
23_Q96_G1.4801.00
86_T170_S1.4681.00
22_A94_G1.4571.00
16_F19_V1.4431.00
126_R154_Q1.4181.00
177_D180_D1.4101.00
101_A123_I1.3821.00
56_N59_N1.3491.00
98_V123_I1.3281.00
28_V87_A1.3231.00
75_V159_L1.3221.00
7_R11_E1.3181.00
139_S142_A1.3121.00
158_F161_E1.3021.00
59_N151_N1.2831.00
130_G150_Y1.2691.00
152_V156_V1.2631.00
61_V71_V1.2621.00
4_G45_N1.2361.00
121_T124_R1.2351.00
14_S17_D1.2241.00
93_T177_D1.2201.00
145_N149_E1.2181.00
94_G99_T1.2081.00
88_V174_A1.2081.00
164_R167_D1.2071.00
30_V75_V1.1991.00
29_T90_V1.1981.00
141_S145_N1.1811.00
153_D186_R1.1731.00
3_A6_Q1.1691.00
124_R127_L1.1691.00
77_Y96_G1.1571.00
103_R140_E1.1401.00
5_N9_A1.1001.00
33_A82_T1.0891.00
14_S18_D1.0821.00
79_I84_T1.0801.00
4_G8_H1.0541.00
90_V174_A1.0531.00
102_Y144_I1.0511.00
57_I97_A1.0410.99
40_D43_W1.0360.99
144_I148_V1.0250.99
81_H113_P1.0230.99
24_H83_G1.0130.99
129_A150_Y1.0050.99
31_C37_V1.0040.99
46_T51_I1.0030.99
98_V147_L0.9690.99
9_A182_Y0.9680.99
106_T167_D0.9620.99
33_A54_C0.9590.99
153_D173_G0.9460.99
174_A185_S0.9440.99
15_R19_V0.9440.99
185_S188_E0.9410.99
154_Q157_Q0.9400.99
180_D184_G0.9400.99
113_P116_I0.9400.99
40_D46_T0.9140.99
38_L42_L0.9100.99
61_V155_Q0.9060.99
80_E167_D0.8990.98
122_P125_T0.8920.98
124_R128_A0.8890.98
151_N155_Q0.8870.98
91_G152_V0.8850.98
23_Q52_F0.8830.98
137_D140_E0.8820.98
81_H116_I0.8810.98
71_V75_V0.8810.98
143_A147_L0.8720.98
150_Y154_Q0.8700.98
59_N155_Q0.8480.98
142_A146_R0.8460.98
79_I165_V0.8250.97
72_S115_G0.8200.97
27_A85_E0.8180.97
140_E144_I0.8170.97
31_C90_V0.8130.97
63_Q122_P0.8100.97
145_N148_V0.8070.97
96_G116_I0.7990.97
122_P158_F0.7950.97
54_C71_V0.7950.97
104_D124_R0.7930.97
40_D51_I0.7890.96
140_E143_A0.7870.96
22_A35_S0.7840.96
14_S19_V0.7790.96
39_Q53_T0.7790.96
113_P117_A0.7780.96
163_D167_D0.7770.96
2_L183_P0.7730.96
102_Y143_A0.7720.96
52_F96_G0.7670.96
33_A77_Y0.7650.96
146_R150_Y0.7640.96
20_Q94_G0.7620.96
76_L181_V0.7540.95
11_E45_N0.7540.95
79_I87_A0.7520.95
152_V175_V0.7510.95
159_L171_V0.7500.95
123_I126_R0.7460.95
142_A145_N0.7450.95
27_A86_T0.7420.95
98_V148_V0.7410.95
62_I71_V0.7410.95
63_Q115_G0.7360.95
18_D47_D0.7350.95
63_Q118_H0.7350.95
13_Q16_F0.7320.95
129_A157_Q0.7320.95
145_N175_V0.7300.95
38_L53_T0.7200.94
77_Y82_T0.7140.94
129_A154_Q0.7100.94
43_W174_A0.7070.94
40_D53_T0.7050.94
19_V48_P0.7010.93
175_V184_G0.7010.93
127_L147_L0.6990.93
157_Q160_L0.6990.93
146_R149_E0.6970.93
12_F47_D0.6940.93
128_A131_V0.6890.93
141_S146_R0.6860.93
27_A88_V0.6830.92
3_A132_D0.6800.92
145_N177_D0.6780.92
35_S96_G0.6740.92
61_V72_S0.6640.91
99_T102_Y0.6630.91
4_G7_R0.6630.91
114_P117_A0.6590.91
72_S159_L0.6550.91
37_V42_L0.6540.91
79_I166_D0.6540.91
59_N91_G0.6530.91
43_W90_V0.6510.91
96_G100_A0.6480.90
83_G168_D0.6470.90
2_L88_V0.6440.90
56_N119_S0.6420.90
137_D143_A0.6410.90
76_L115_G0.6400.90
16_F48_P0.6270.89
20_Q179_Q0.6220.88
20_Q178_F0.6200.88
98_V151_N0.6200.88
160_L166_D0.6130.88
39_Q48_P0.6110.88
123_I127_L0.6100.88
64_Q163_D0.6090.87
132_D136_A0.6090.87
156_V160_L0.6080.87
30_V60_R0.6060.87
118_H121_T0.6040.87
18_D89_V0.6010.87
98_V101_A0.5990.87
122_P154_Q0.5990.87
87_A166_D0.5980.86
78_P87_A0.5970.86
131_V143_A0.5900.86
171_V188_E0.5880.86
126_R150_Y0.5860.85
29_T39_Q0.5860.85
122_P126_R0.5850.85
94_G141_S0.5800.85
39_Q51_I0.5800.85
46_T50_S0.5780.85
29_T178_F0.5770.85
31_C75_V0.5760.84
29_T43_W0.5750.84
118_H122_P0.5740.84
51_I106_T0.5710.84
67_D74_D0.5670.83
103_R106_T0.5650.83
29_T51_I0.5650.83
101_A127_L0.5620.83
27_A76_L0.5560.82
16_F20_Q0.5560.82
158_F162_S0.5550.82
101_A139_S0.5520.82
100_A116_I0.5520.82
62_I120_L0.5520.82
115_G118_H0.5490.81
102_Y127_L0.5440.81
39_Q93_T0.5430.81
118_H163_D0.5400.80
27_A51_I0.5390.80
32_C95_C0.5380.80
61_V158_F0.5380.80
52_F78_P0.5370.80
31_C38_L0.5350.80
105_L161_E0.5310.79
15_R47_D0.5310.79
42_L53_T0.5310.79
4_G9_A0.5300.79
57_I73_G0.5230.78
128_A154_Q0.5220.78
125_T128_A0.5210.78
126_R130_G0.5210.78
62_I158_F0.5200.78
61_V75_V0.5190.78
31_C39_Q0.5180.78
106_T117_A0.5160.77
30_V61_V0.5150.77
138_L141_S0.5140.77
56_N71_V0.5130.77
28_V79_I0.5130.77
5_N183_P0.5120.77
77_Y116_I0.5120.77
77_Y99_T0.5120.77
106_T111_A0.5110.77
62_I122_P0.5110.77
28_V78_P0.5070.76
27_A50_S0.5060.76
16_F176_Y0.5050.76
4_G188_E0.5050.76
32_C96_G0.5050.76
99_T141_S0.5020.75
90_V176_Y0.5010.75
14_S21_N0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4o1kA 4 0.8773 100 0.228 Contact Map
1ddzA 2 0.9545 100 0.233 Contact Map
4rxyA 4 0.8864 100 0.237 Contact Map
3qy1A 4 0.9091 100 0.245 Contact Map
3e3iA 6 0.8864 100 0.245 Contact Map
2w3qA 2 0.8091 100 0.246 Contact Map
3ucjA 4 0.9045 100 0.249 Contact Map
1ekjA 5 0.8864 100 0.25 Contact Map
3eyxA 2 0.8318 100 0.252 Contact Map
4o1jA 4 0.8273 100 0.257 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0074 seconds.