Q9HR63 - HALSA - GREMLIN Contacts

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Q9HR63 - Uncharacterized protein

UniProt:	Q9HR63	Sequences: MNTAPDTGTERATYTWSAGRYPSLAPNLLPAIARLVSACGVDPGNTVLDVGCGTGNAALTARRAGATVTGLDVTRSMLELARDTTQLTDYNDISWVAGDASTLPFPDDAFDVVLSSFGHVFSPAAAEAGREMLRVAQPGGRVAFTAWSPDGLVGALTDVLDDYVGHDDHDPWAHLRWGNPEFVRDHLGDACELTFERRIARFRYVSPEHFWRNFAEEAGPLSPALRALDDPGARSALREDALATLDEWFADNTVRVEYLLARGVVDGAA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	269 (227)
Sequences:	14376 (11113)
Seq/√Len:	737.6

ECOLI - BIOC TAM YJHP SMTA UBIE YAFE UBIG TEHB CMOA CMOB RLMA
BACSU - YCGJ YXBB YODH MENG YRRT YBAJ YRHH YQEM YXJB YDAC
HALSA - Q9HR63 Q9HRX3 Q9HR81 Q9HND6 Q9HMT2 ARSM Q9HSK6 Q9HQ85
SULSO - Q97X57 Q97WT7 Q97ZU8 Q97WH3 Q97XD7 Q7LXN7 Q97YX4 Q97WN4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
46_T	67_T	3.759	1.00
131_E	134_R	3.124	1.00
75_R	97_A	2.937	1.00
67_T	94_S	2.843	1.00
81_A	95_W	2.800	1.00
63_R	88_T	2.699	1.00
78_L	95_W	2.619	1.00
133_L	191_C	2.616	1.00
69_T	110_F	2.605	1.00
69_T	96_V	2.515	1.00
78_L	82_R	2.512	1.00
52_C	70_G	2.502	1.00
58_A	68_V	2.496	1.00
136_A	140_G	2.467	1.00
78_L	97_A	2.465	1.00
75_R	79_E	2.453	1.00
132_M	142_V	2.388	1.00
111_D	137_Q	2.360	1.00
71_L	98_G	2.323	1.00
124_A	127_E	2.301	1.00
80_L	83_D	2.297	1.00
113_V	132_M	2.249	1.00
113_V	136_A	2.245	1.00
45_N	112_V	2.216	1.00
48_L	110_F	2.126	1.00
131_E	135_V	2.104	1.00
105_F	110_F	2.000	1.00
115_S	118_G	1.981	1.00
59_L	84_T	1.947	1.00
59_L	85_T	1.909	1.00
72_D	78_L	1.894	1.00
51_G	118_G	1.874	1.00
42_D	45_N	1.798	1.00
69_T	94_S	1.697	1.00
46_T	69_T	1.679	1.00
46_T	137_Q	1.675	1.00
47_V	61_A	1.671	1.00
126_A	130_R	1.659	1.00
136_A	142_V	1.614	1.00
79_E	82_R	1.566	1.00
25_A	29_L	1.532	1.00
100_A	122_S	1.525	1.00
52_C	58_A	1.521	1.00
34_R	37_S	1.483	1.00
24_L	27_N	1.476	1.00
83_D	87_L	1.473	1.00
127_E	130_R	1.468	1.00
85_T	95_W	1.460	1.00
126_A	189_D	1.453	1.00
60_T	63_R	1.444	1.00
222_S	226_R	1.442	1.00
98_G	104_P	1.431	1.00
50_V	100_A	1.427	1.00
41_V	45_N	1.427	1.00
25_A	28_L	1.424	1.00
58_A	70_G	1.421	1.00
79_E	83_D	1.364	1.00
71_L	103_L	1.363	1.00
24_L	28_L	1.354	1.00
126_A	186_H	1.354	1.00
50_V	132_M	1.352	1.00
122_S	128_A	1.325	1.00
70_G	95_W	1.323	1.00
184_R	188_G	1.312	1.00
59_L	63_R	1.292	1.00
118_G	122_S	1.292	1.00
99_D	102_T	1.283	1.00
45_N	66_A	1.280	1.00
159_V	163_Y	1.272	1.00
76_S	79_E	1.261	1.00
52_C	81_A	1.250	1.00
128_A	132_M	1.246	1.00
57_A	116_S	1.236	1.00
49_D	70_G	1.231	1.00
57_A	114_L	1.229	1.00
46_T	110_F	1.213	1.00
47_V	112_V	1.205	1.00
84_T	87_L	1.203	1.00
179_N	182_F	1.198	1.00
33_A	60_T	1.195	1.00
107_D	134_R	1.194	1.00
119_H	146_A	1.182	1.00
185_D	189_D	1.178	1.00
85_T	93_I	1.177	1.00
229_D	233_A	1.168	1.00
26_P	29_L	1.167	1.00
106_P	109_A	1.147	1.00
51_G	115_S	1.141	1.00
246_D	249_F	1.135	1.00
104_P	131_E	1.126	1.00
205_V	209_H	1.126	1.00
48_L	113_V	1.119	1.00
59_L	88_T	1.114	1.00
239_E	243_A	1.114	1.00
160_L	164_V	1.110	1.00
238_R	242_L	1.110	1.00
209_H	212_R	1.101	1.00
103_L	135_V	1.096	1.00
130_R	190_A	1.095	1.00
235_S	239_E	1.092	1.00
113_V	135_V	1.091	1.00
17_S	76_S	1.091	1.00
60_T	64_A	1.072	1.00
132_M	136_A	1.072	1.00
103_L	131_E	1.068	1.00
83_D	86_Q	1.068	1.00
34_R	38_A	1.065	1.00
80_L	84_T	1.060	1.00
22_P	54_T	1.042	1.00
96_V	105_F	1.030	1.00
180_P	184_R	1.030	1.00
101_S	122_S	1.028	1.00
234_R	237_L	1.019	1.00
243_A	247_E	1.018	1.00
136_A	191_C	1.013	1.00
221_L	225_L	1.000	1.00
127_E	131_E	0.991	1.00
100_A	118_G	0.990	1.00
210_F	213_N	0.973	1.00
52_C	72_D	0.971	1.00
62_R	92_D	0.971	1.00
73_V	99_D	0.964	1.00
109_A	137_Q	0.957	1.00
208_E	242_L	0.943	1.00
160_L	163_Y	0.933	1.00
206_S	209_H	0.932	1.00
20_R	23_S	0.930	1.00
98_G	103_L	0.922	1.00
30_P	33_A	0.918	1.00
152_L	156_L	0.916	1.00
223_P	226_R	0.911	1.00
158_D	161_D	0.910	1.00
224_A	227_A	0.907	1.00
35_L	143_A	0.906	1.00
37_S	64_A	0.905	1.00
235_S	238_R	0.899	1.00
154_G	158_D	0.898	1.00
133_L	190_A	0.898	1.00
211_W	215_A	0.895	1.00
119_H	144_F	0.894	1.00
48_L	135_V	0.894	1.00
70_G	81_A	0.888	1.00
22_P	84_T	0.888	1.00
24_L	29_L	0.887	1.00
84_T	88_T	0.884	1.00
119_H	122_S	0.882	1.00
213_N	216_E	0.881	1.00
19_G	80_L	0.879	1.00
69_T	105_F	0.877	1.00
49_D	68_V	0.876	1.00
240_D	244_T	0.870	1.00
215_A	239_E	0.868	1.00
224_A	228_L	0.866	1.00
17_S	74_T	0.863	1.00
45_N	111_D	0.856	1.00
225_L	229_D	0.850	1.00
47_V	114_L	0.847	1.00
116_S	145_T	0.843	1.00
244_T	247_E	0.841	1.00
199_I	202_F	0.841	1.00
239_E	242_L	0.841	1.00
46_T	111_D	0.840	1.00
213_N	217_E	0.838	1.00
101_S	127_E	0.824	1.00
234_R	238_R	0.824	1.00
20_R	28_L	0.824	1.00
35_L	116_S	0.823	1.00
156_L	160_L	0.822	1.00
21_Y	24_L	0.821	1.00
82_R	86_Q	0.816	1.00
212_R	216_E	0.812	1.00
243_A	246_D	0.807	1.00
244_T	248_W	0.805	1.00
39_C	143_A	0.801	1.00
152_L	155_A	0.801	1.00
126_A	190_A	0.792	1.00
112_V	141_R	0.791	1.00
31_A	34_R	0.789	1.00
38_A	196_E	0.788	1.00
18_A	21_Y	0.788	1.00
182_F	185_D	0.786	1.00
181_E	184_R	0.786	1.00
236_A	240_D	0.785	1.00
46_T	109_A	0.784	1.00
222_S	225_L	0.782	1.00
71_L	96_V	0.780	1.00
125_A	186_H	0.776	1.00
159_V	162_D	0.766	1.00
185_D	188_G	0.761	1.00
20_R	24_L	0.761	1.00
101_S	123_P	0.760	1.00
58_A	93_I	0.755	1.00
159_V	164_V	0.754	1.00
153_V	157_T	0.750	1.00
67_T	92_D	0.747	1.00
107_D	131_E	0.746	1.00
209_H	213_N	0.745	1.00
74_T	77_M	0.745	1.00
73_V	97_A	0.742	1.00
117_F	147_W	0.741	1.00
157_T	161_D	0.738	1.00
52_C	71_L	0.737	1.00
195_F	199_I	0.733	1.00
44_G	66_A	0.730	1.00
82_R	94_S	0.730	1.00
129_G	187_L	0.724	1.00
210_F	214_F	0.724	1.00
200_A	203_R	0.723	1.00
208_E	212_R	0.722	1.00
61_A	114_L	0.722	1.00
187_L	190_A	0.721	1.00
242_L	246_D	0.720	1.00
30_P	34_R	0.703	1.00
47_V	57_A	0.700	1.00
57_A	61_A	0.696	1.00
158_D	162_D	0.696	1.00
54_T	77_M	0.694	1.00
240_D	243_A	0.694	1.00
72_D	77_M	0.693	1.00
233_A	237_L	0.691	1.00
130_R	134_R	0.689	1.00
19_G	23_S	0.686	1.00
41_V	44_G	0.685	1.00
101_S	124_A	0.683	1.00
233_A	236_A	0.683	1.00
152_L	157_T	0.682	1.00
153_V	156_L	0.672	1.00
195_F	198_R	0.669	1.00
70_G	93_I	0.668	1.00
115_S	144_F	0.664	1.00
104_P	135_V	0.662	1.00
33_A	37_S	0.662	1.00
33_A	64_A	0.660	1.00
58_A	95_W	0.659	1.00
72_D	97_A	0.655	1.00
110_F	135_V	0.652	1.00
212_R	215_A	0.652	1.00
157_T	160_L	0.651	1.00
50_V	128_A	0.648	1.00
98_G	102_T	0.647	1.00
226_R	229_D	0.646	1.00
109_A	135_V	0.644	1.00
183_V	186_H	0.639	1.00
62_R	93_I	0.638	1.00
154_G	159_V	0.636	1.00
173_A	176_R	0.633	1.00
228_L	233_A	0.628	1.00
224_A	230_D	0.628	1.00
241_A	245_L	0.628	1.00
236_A	239_E	0.625	1.00
119_H	128_A	0.624	1.00
75_R	82_R	0.624	1.00
222_S	227_A	0.618	1.00
82_R	95_W	0.617	1.00
117_F	145_T	0.612	1.00
45_N	141_R	0.609	1.00
100_A	128_A	0.606	1.00
221_L	224_A	0.606	1.00
36_V	61_A	0.605	1.00
171_P	174_H	0.604	1.00
161_D	164_V	0.603	1.00
225_L	228_L	0.602	1.00
200_A	204_Y	0.598	1.00
105_F	109_A	0.598	1.00
193_L	197_R	0.596	1.00
105_F	135_V	0.596	1.00
207_P	210_F	0.595	1.00
157_T	163_Y	0.595	1.00
49_D	114_L	0.594	1.00
237_L	240_D	0.590	1.00
155_A	159_V	0.590	1.00
142_V	191_C	0.590	1.00
36_V	60_T	0.586	1.00
223_P	227_A	0.586	1.00
187_L	191_C	0.586	1.00
192_E	195_F	0.586	1.00
38_A	194_T	0.585	1.00
117_F	120_V	0.583	1.00
156_L	163_Y	0.583	1.00
197_R	200_A	0.580	1.00
186_H	190_A	0.579	1.00
154_G	157_T	0.579	1.00
174_H	177_W	0.576	1.00
21_Y	25_A	0.576	1.00
227_A	230_D	0.576	1.00
192_E	198_R	0.574	1.00
227_A	231_P	0.571	1.00
21_Y	29_L	0.570	1.00
49_D	71_L	0.570	1.00
40_G	141_R	0.568	1.00
156_L	164_V	0.567	1.00
183_V	187_L	0.567	1.00
182_F	186_H	0.562	1.00
18_A	28_L	0.561	1.00
102_T	131_E	0.557	1.00
56_N	60_T	0.556	1.00
23_S	28_L	0.556	1.00
215_A	238_R	0.553	1.00
28_L	31_A	0.551	1.00
103_L	110_F	0.550	1.00
36_V	64_A	0.549	1.00
120_V	146_A	0.549	1.00
46_T	108_D	0.548	1.00
21_Y	27_N	0.547	1.00
153_V	160_L	0.547	1.00
57_A	145_T	0.544	1.00
119_H	125_A	0.542	1.00
44_G	47_V	0.541	1.00
87_L	92_D	0.541	1.00
176_R	182_F	0.541	1.00
119_H	129_G	0.541	1.00
59_L	62_R	0.540	1.00
102_T	127_E	0.538	1.00
224_A	229_D	0.536	1.00
153_V	163_Y	0.536	1.00
229_D	234_R	0.535	1.00
22_P	27_N	0.534	1.00
61_A	112_V	0.533	1.00
65_G	68_V	0.531	1.00
101_S	128_A	0.529	1.00
176_R	180_P	0.527	1.00
228_L	231_P	0.524	1.00
192_E	196_E	0.524	1.00
22_P	80_L	0.523	1.00
50_V	71_L	0.521	1.00
184_R	195_F	0.519	1.00
134_R	137_Q	0.517	1.00
225_L	230_D	0.517	1.00
208_E	246_D	0.514	1.00
88_T	91_N	0.514	1.00
51_G	73_V	0.512	1.00
41_V	66_A	0.511	1.00
23_S	26_P	0.511	1.00
27_N	31_A	0.511	1.00
217_E	224_A	0.509	1.00
51_G	122_S	0.504	1.00
156_L	159_V	0.503	1.00
146_A	183_V	0.503	1.00
109_A	134_R	0.500	0.99
174_H	178_G	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2p35A	2	0.8736	100	0.406	Contact Map
2yqzA	1	0.9182	100	0.441	Contact Map
3ccfA	1	0.8662	100	0.447	Contact Map
1vl5A	1	0.8439	100	0.449	Contact Map
4pneA	2	0.9108	100	0.455	Contact Map
4hg2A	1	0.8625	100	0.461	Contact Map
1xxlA	1	0.8587	100	0.463	Contact Map
3ujcA	1	0.8922	100	0.471	Contact Map
2o57A	2	0.9257	100	0.472	Contact Map
4kriA	1	0.9219	100	0.473	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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