GREMLIN Database
Q9HR63 - Uncharacterized protein
UniProt: Q9HR63 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 269 (227)
Sequences: 14376 (11113)
Seq/√Len: 737.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_T67_T3.7591.00
131_E134_R3.1241.00
75_R97_A2.9371.00
67_T94_S2.8431.00
81_A95_W2.8001.00
63_R88_T2.6991.00
78_L95_W2.6191.00
133_L191_C2.6161.00
69_T110_F2.6051.00
69_T96_V2.5151.00
78_L82_R2.5121.00
52_C70_G2.5021.00
58_A68_V2.4961.00
136_A140_G2.4671.00
78_L97_A2.4651.00
75_R79_E2.4531.00
132_M142_V2.3881.00
111_D137_Q2.3601.00
71_L98_G2.3231.00
124_A127_E2.3011.00
80_L83_D2.2971.00
113_V132_M2.2491.00
113_V136_A2.2451.00
45_N112_V2.2161.00
48_L110_F2.1261.00
131_E135_V2.1041.00
105_F110_F2.0001.00
115_S118_G1.9811.00
59_L84_T1.9471.00
59_L85_T1.9091.00
72_D78_L1.8941.00
51_G118_G1.8741.00
42_D45_N1.7981.00
69_T94_S1.6971.00
46_T69_T1.6791.00
46_T137_Q1.6751.00
47_V61_A1.6711.00
126_A130_R1.6591.00
136_A142_V1.6141.00
79_E82_R1.5661.00
25_A29_L1.5321.00
100_A122_S1.5251.00
52_C58_A1.5211.00
34_R37_S1.4831.00
24_L27_N1.4761.00
83_D87_L1.4731.00
127_E130_R1.4681.00
85_T95_W1.4601.00
126_A189_D1.4531.00
60_T63_R1.4441.00
222_S226_R1.4421.00
98_G104_P1.4311.00
50_V100_A1.4271.00
41_V45_N1.4271.00
25_A28_L1.4241.00
58_A70_G1.4211.00
79_E83_D1.3641.00
71_L103_L1.3631.00
24_L28_L1.3541.00
126_A186_H1.3541.00
50_V132_M1.3521.00
122_S128_A1.3251.00
70_G95_W1.3231.00
184_R188_G1.3121.00
59_L63_R1.2921.00
118_G122_S1.2921.00
99_D102_T1.2831.00
45_N66_A1.2801.00
159_V163_Y1.2721.00
76_S79_E1.2611.00
52_C81_A1.2501.00
128_A132_M1.2461.00
57_A116_S1.2361.00
49_D70_G1.2311.00
57_A114_L1.2291.00
46_T110_F1.2131.00
47_V112_V1.2051.00
84_T87_L1.2031.00
179_N182_F1.1981.00
33_A60_T1.1951.00
107_D134_R1.1941.00
119_H146_A1.1821.00
185_D189_D1.1781.00
85_T93_I1.1771.00
229_D233_A1.1681.00
26_P29_L1.1671.00
106_P109_A1.1471.00
51_G115_S1.1411.00
246_D249_F1.1351.00
104_P131_E1.1261.00
205_V209_H1.1261.00
48_L113_V1.1191.00
59_L88_T1.1141.00
239_E243_A1.1141.00
160_L164_V1.1101.00
238_R242_L1.1101.00
209_H212_R1.1011.00
103_L135_V1.0961.00
130_R190_A1.0951.00
235_S239_E1.0921.00
113_V135_V1.0911.00
17_S76_S1.0911.00
60_T64_A1.0721.00
132_M136_A1.0721.00
103_L131_E1.0681.00
83_D86_Q1.0681.00
34_R38_A1.0651.00
80_L84_T1.0601.00
22_P54_T1.0421.00
96_V105_F1.0301.00
180_P184_R1.0301.00
101_S122_S1.0281.00
234_R237_L1.0191.00
243_A247_E1.0181.00
136_A191_C1.0131.00
221_L225_L1.0001.00
127_E131_E0.9911.00
100_A118_G0.9901.00
210_F213_N0.9731.00
52_C72_D0.9711.00
62_R92_D0.9711.00
73_V99_D0.9641.00
109_A137_Q0.9571.00
208_E242_L0.9431.00
160_L163_Y0.9331.00
206_S209_H0.9321.00
20_R23_S0.9301.00
98_G103_L0.9221.00
30_P33_A0.9181.00
152_L156_L0.9161.00
223_P226_R0.9111.00
158_D161_D0.9101.00
224_A227_A0.9071.00
35_L143_A0.9061.00
37_S64_A0.9051.00
235_S238_R0.8991.00
154_G158_D0.8981.00
133_L190_A0.8981.00
211_W215_A0.8951.00
119_H144_F0.8941.00
48_L135_V0.8941.00
70_G81_A0.8881.00
22_P84_T0.8881.00
24_L29_L0.8871.00
84_T88_T0.8841.00
119_H122_S0.8821.00
213_N216_E0.8811.00
19_G80_L0.8791.00
69_T105_F0.8771.00
49_D68_V0.8761.00
240_D244_T0.8701.00
215_A239_E0.8681.00
224_A228_L0.8661.00
17_S74_T0.8631.00
45_N111_D0.8561.00
225_L229_D0.8501.00
47_V114_L0.8471.00
116_S145_T0.8431.00
244_T247_E0.8411.00
199_I202_F0.8411.00
239_E242_L0.8411.00
46_T111_D0.8401.00
213_N217_E0.8381.00
101_S127_E0.8241.00
234_R238_R0.8241.00
20_R28_L0.8241.00
35_L116_S0.8231.00
156_L160_L0.8221.00
21_Y24_L0.8211.00
82_R86_Q0.8161.00
212_R216_E0.8121.00
243_A246_D0.8071.00
244_T248_W0.8051.00
39_C143_A0.8011.00
152_L155_A0.8011.00
126_A190_A0.7921.00
112_V141_R0.7911.00
31_A34_R0.7891.00
38_A196_E0.7881.00
18_A21_Y0.7881.00
182_F185_D0.7861.00
181_E184_R0.7861.00
236_A240_D0.7851.00
46_T109_A0.7841.00
222_S225_L0.7821.00
71_L96_V0.7801.00
125_A186_H0.7761.00
159_V162_D0.7661.00
185_D188_G0.7611.00
20_R24_L0.7611.00
101_S123_P0.7601.00
58_A93_I0.7551.00
159_V164_V0.7541.00
153_V157_T0.7501.00
67_T92_D0.7471.00
107_D131_E0.7461.00
209_H213_N0.7451.00
74_T77_M0.7451.00
73_V97_A0.7421.00
117_F147_W0.7411.00
157_T161_D0.7381.00
52_C71_L0.7371.00
195_F199_I0.7331.00
44_G66_A0.7301.00
82_R94_S0.7301.00
129_G187_L0.7241.00
210_F214_F0.7241.00
200_A203_R0.7231.00
208_E212_R0.7221.00
61_A114_L0.7221.00
187_L190_A0.7211.00
242_L246_D0.7201.00
30_P34_R0.7031.00
47_V57_A0.7001.00
57_A61_A0.6961.00
158_D162_D0.6961.00
54_T77_M0.6941.00
240_D243_A0.6941.00
72_D77_M0.6931.00
233_A237_L0.6911.00
130_R134_R0.6891.00
19_G23_S0.6861.00
41_V44_G0.6851.00
101_S124_A0.6831.00
233_A236_A0.6831.00
152_L157_T0.6821.00
153_V156_L0.6721.00
195_F198_R0.6691.00
70_G93_I0.6681.00
115_S144_F0.6641.00
104_P135_V0.6621.00
33_A37_S0.6621.00
33_A64_A0.6601.00
58_A95_W0.6591.00
72_D97_A0.6551.00
110_F135_V0.6521.00
212_R215_A0.6521.00
157_T160_L0.6511.00
50_V128_A0.6481.00
98_G102_T0.6471.00
226_R229_D0.6461.00
109_A135_V0.6441.00
183_V186_H0.6391.00
62_R93_I0.6381.00
154_G159_V0.6361.00
173_A176_R0.6331.00
228_L233_A0.6281.00
224_A230_D0.6281.00
241_A245_L0.6281.00
236_A239_E0.6251.00
119_H128_A0.6241.00
75_R82_R0.6241.00
222_S227_A0.6181.00
82_R95_W0.6171.00
117_F145_T0.6121.00
45_N141_R0.6091.00
100_A128_A0.6061.00
221_L224_A0.6061.00
36_V61_A0.6051.00
171_P174_H0.6041.00
161_D164_V0.6031.00
225_L228_L0.6021.00
200_A204_Y0.5981.00
105_F109_A0.5981.00
193_L197_R0.5961.00
105_F135_V0.5961.00
207_P210_F0.5951.00
157_T163_Y0.5951.00
49_D114_L0.5941.00
237_L240_D0.5901.00
155_A159_V0.5901.00
142_V191_C0.5901.00
36_V60_T0.5861.00
223_P227_A0.5861.00
187_L191_C0.5861.00
192_E195_F0.5861.00
38_A194_T0.5851.00
117_F120_V0.5831.00
156_L163_Y0.5831.00
197_R200_A0.5801.00
186_H190_A0.5791.00
154_G157_T0.5791.00
174_H177_W0.5761.00
21_Y25_A0.5761.00
227_A230_D0.5761.00
192_E198_R0.5741.00
227_A231_P0.5711.00
21_Y29_L0.5701.00
49_D71_L0.5701.00
40_G141_R0.5681.00
156_L164_V0.5671.00
183_V187_L0.5671.00
182_F186_H0.5621.00
18_A28_L0.5611.00
102_T131_E0.5571.00
56_N60_T0.5561.00
23_S28_L0.5561.00
215_A238_R0.5531.00
28_L31_A0.5511.00
103_L110_F0.5501.00
36_V64_A0.5491.00
120_V146_A0.5491.00
46_T108_D0.5481.00
21_Y27_N0.5471.00
153_V160_L0.5471.00
57_A145_T0.5441.00
119_H125_A0.5421.00
44_G47_V0.5411.00
87_L92_D0.5411.00
176_R182_F0.5411.00
119_H129_G0.5411.00
59_L62_R0.5401.00
102_T127_E0.5381.00
224_A229_D0.5361.00
153_V163_Y0.5361.00
229_D234_R0.5351.00
22_P27_N0.5341.00
61_A112_V0.5331.00
65_G68_V0.5311.00
101_S128_A0.5291.00
176_R180_P0.5271.00
228_L231_P0.5241.00
192_E196_E0.5241.00
22_P80_L0.5231.00
50_V71_L0.5211.00
184_R195_F0.5191.00
134_R137_Q0.5171.00
225_L230_D0.5171.00
208_E246_D0.5141.00
88_T91_N0.5141.00
51_G73_V0.5121.00
41_V66_A0.5111.00
23_S26_P0.5111.00
27_N31_A0.5111.00
217_E224_A0.5091.00
51_G122_S0.5041.00
156_L159_V0.5031.00
146_A183_V0.5031.00
109_A134_R0.5000.99
174_H178_G0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2p35A 2 0.8736 100 0.406 Contact Map
2yqzA 1 0.9182 100 0.441 Contact Map
3ccfA 1 0.8662 100 0.447 Contact Map
1vl5A 1 0.8439 100 0.449 Contact Map
4pneA 2 0.9108 100 0.455 Contact Map
4hg2A 1 0.8625 100 0.461 Contact Map
1xxlA 1 0.8587 100 0.463 Contact Map
3ujcA 1 0.8922 100 0.471 Contact Map
2o57A 2 0.9257 100 0.472 Contact Map
4kriA 1 0.9219 100 0.473 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0092 seconds.