GREMLIN Database
Q9HR62 - Uncharacterized protein
UniProt: Q9HR62 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 491 (388)
Sequences: 460 (390)
Seq/√Len: 19.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
93_V144_V7.2211.00
166_C333_L4.9081.00
102_F134_L4.7141.00
335_G339_Y4.0021.00
29_V104_T3.7721.00
128_M332_L3.5811.00
172_Y251_H3.5171.00
104_T130_F3.3811.00
394_A397_G3.2191.00
168_L271_L3.1991.00
262_V266_V3.1961.00
26_A92_L3.0480.99
91_L104_T3.0320.99
180_L223_L3.0230.99
89_V93_V2.9050.99
90_A93_V2.8430.99
326_T330_V2.8350.99
51_P56_R2.8250.99
125_V171_I2.8130.99
91_L130_F2.6580.98
171_I267_A2.6450.98
414_S418_R2.5870.98
90_A103_A2.5830.98
131_V134_L2.4990.97
109_V127_Q2.4730.97
29_V130_F2.4440.97
37_L50_L2.4190.97
140_E146_A2.3610.96
144_V147_V2.3490.96
63_S69_M2.2780.95
185_W188_G2.1710.94
81_F111_M2.1290.93
164_V174_S2.1030.93
105_G134_L2.0800.92
397_G412_Y2.0730.92
128_M132_W2.0700.92
412_Y416_R2.0440.92
87_A103_A2.0360.91
17_S161_T2.0310.91
82_A318_R2.0280.91
19_A145_D1.9830.90
222_W226_L1.9520.89
83_V382_A1.9500.89
379_W402_W1.9400.89
386_T389_G1.8570.87
254_M368_M1.8440.87
83_V128_M1.8340.86
380_V391_R1.8150.86
73_A80_L1.7900.85
86_V276_P1.7870.85
199_M420_Y1.7750.84
80_L110_S1.7500.83
177_V322_R1.6800.81
139_G145_D1.6710.80
163_G329_F1.6520.80
105_G131_V1.6360.79
100_A103_A1.6330.79
32_D36_R1.6270.79
16_R281_E1.6260.79
238_W241_A1.6240.78
96_R148_D1.6120.78
393_G396_A1.5920.77
226_L369_F1.5870.77
77_Q84_T1.5600.76
335_G351_V1.5560.75
116_P408_V1.5550.75
127_Q364_P1.5460.75
36_R123_D1.5450.75
101_T134_L1.5440.75
296_R299_A1.5220.74
264_P274_F1.5100.73
153_R296_R1.5070.73
27_V92_L1.5060.73
140_E153_R1.4970.72
20_A285_A1.4650.71
172_Y369_F1.4630.71
72_G114_R1.4620.71
171_I205_G1.4550.70
390_G420_Y1.4510.70
99_A385_T1.4360.69
203_G206_H1.4350.69
90_A100_A1.4320.69
214_L217_A1.4150.68
392_I397_G1.4130.68
214_L221_V1.3990.67
90_A249_G1.3980.67
414_S417_W1.3930.67
135_G256_A1.3880.66
221_V277_G1.3730.66
188_G216_V1.3680.65
255_A265_L1.3630.65
120_N185_W1.3560.65
382_A389_G1.3540.64
392_I416_R1.3460.64
83_V326_T1.3380.64
49_V123_D1.3320.63
100_A296_R1.3320.63
122_G342_V1.3300.63
203_G269_V1.3280.63
131_V403_G1.3230.63
151_A390_G1.3170.62
15_T19_A1.3150.62
131_V135_G1.3040.61
69_M72_G1.2900.61
30_L238_W1.2810.60
244_A275_V1.2810.60
172_Y267_A1.2800.60
144_V189_T1.2800.60
29_V91_L1.2800.60
277_G324_A1.2790.60
23_V286_A1.2700.59
214_L253_G1.2470.58
99_A151_A1.2430.58
81_F84_T1.2430.58
356_L407_D1.2420.58
226_L250_M1.2390.57
318_R330_V1.2330.57
14_D281_E1.2270.57
158_S162_V1.2260.57
139_G246_V1.2130.56
82_A350_P1.2080.55
129_L167_Q1.2040.55
168_L416_R1.2040.55
192_R196_S1.2030.55
140_E144_V1.1990.55
226_L229_S1.1950.55
110_S114_R1.1920.54
182_G185_W1.1900.54
132_W335_G1.1870.54
72_G76_A1.1820.54
61_V355_P1.1690.53
179_K263_F1.1670.53
136_L163_G1.1610.52
236_T239_W1.1570.52
185_W254_M1.1530.52
129_L266_V1.1520.52
175_N226_L1.1520.52
95_Y144_V1.1510.52
36_R115_N1.1490.52
30_L33_L1.1450.51
79_A135_G1.1430.51
142_W379_W1.1330.51
28_V269_V1.1310.51
93_V187_S1.1300.50
142_W281_E1.1290.50
175_N222_W1.1280.50
100_A412_Y1.1260.50
382_A390_G1.1250.50
17_S280_W1.1240.50
401_S408_V1.1220.50
32_D371_P1.1190.50
232_L246_V1.1180.50
108_V120_N1.1150.50
33_L208_L1.1140.49
216_V220_R1.1050.49
128_M197_L1.1020.49
83_V388_G1.0980.48
226_L258_M1.0940.48
85_A238_W1.0940.48
177_V337_A1.0850.48
136_L232_L1.0810.47
67_L113_A1.0800.47
99_A102_F1.0760.47
160_A169_V1.0700.47
242_A392_I1.0680.46
218_F253_G1.0650.46
23_V315_R1.0640.46
93_V134_L1.0620.46
221_V246_V1.0600.46
190_A194_V1.0570.46
32_D88_A1.0570.46
15_T140_E1.0520.45
373_P405_P1.0480.45
106_V143_S1.0470.45
120_N194_V1.0460.45
91_L101_T1.0440.45
248_A328_V1.0410.45
176_A191_V1.0400.45
166_C326_T1.0400.45
235_L250_M1.0380.45
83_V330_V1.0370.45
24_G269_V1.0370.45
63_S68_H1.0300.44
188_G405_P1.0280.44
111_M276_P1.0260.44
109_V113_A1.0230.44
321_A324_A1.0230.44
146_A327_G1.0180.43
252_L255_A1.0150.43
206_H209_S1.0140.43
377_D403_G1.0130.43
106_V129_L1.0050.42
139_G322_R1.0020.42
29_V191_V1.0010.42
26_A264_P1.0010.42
112_H123_D0.9990.42
99_A238_W0.9990.42
110_S115_N0.9980.42
35_L267_A0.9860.41
21_F274_F0.9830.41
30_L130_F0.9820.41
89_V325_V0.9810.41
360_D371_P0.9800.41
193_T232_L0.9800.41
84_T107_L0.9770.41
89_V106_V0.9750.41
29_V176_A0.9730.40
116_P339_Y0.9700.40
30_L160_A0.9680.40
65_A376_V0.9660.40
33_L50_L0.9620.40
383_P386_T0.9560.39
254_M360_D0.9530.39
247_F259_Q0.9420.39
299_A321_A0.9410.39
33_L111_M0.9390.38
188_G191_V0.9370.38
89_V334_V0.9310.38
183_D405_P0.9290.38
14_D22_R0.9270.38
120_N254_M0.9230.37
30_L89_V0.9140.37
19_A147_V0.9130.37
171_I223_L0.9120.37
30_L34_A0.9100.37
340_T407_D0.9100.37
167_Q332_L0.9100.37
100_A182_G0.9040.36
28_V420_Y0.9030.36
290_R316_S0.9000.36
107_L110_S0.9000.36
97_S145_D0.8970.36
171_I270_G0.8950.36
86_V164_V0.8940.36
33_L37_L0.8900.35
23_V327_G0.8870.35
205_G209_S0.8860.35
211_T322_R0.8850.35
71_S76_A0.8820.35
120_N368_M0.8820.35
144_V324_A0.8810.35
122_G133_A0.8790.35
321_A325_V0.8760.35
108_V112_H0.8750.35
191_V194_V0.8720.34
224_V283_A0.8660.34
183_D281_E0.8650.34
63_S114_R0.8650.34
294_P298_I0.8640.34
91_L139_G0.8600.34
214_L327_G0.8530.33
296_R300_D0.8480.33
353_V368_M0.8460.33
106_V295_V0.8450.33
23_V376_V0.8450.33
33_L88_A0.8440.33
379_W386_T0.8380.32
164_V273_P0.8380.32
164_V227_A0.8350.32
112_H368_M0.8350.32
163_G170_I0.8350.32
23_V392_I0.8340.32
247_F373_P0.8320.32
79_A95_Y0.8320.32
19_A418_R0.8320.32
241_A245_A0.8310.32
71_S114_R0.8300.32
110_S113_A0.8260.32
94_G366_W0.8250.32
186_V333_L0.8250.32
79_A390_G0.8230.32
184_A231_C0.8220.32
122_G250_M0.8200.31
139_G143_S0.8190.31
36_R110_S0.8160.31
222_W229_S0.8160.31
93_V153_R0.8150.31
98_T215_L0.8120.31
84_T111_M0.8070.31
242_A328_V0.8060.31
17_S20_A0.8060.31
324_A335_G0.8040.31
237_G241_A0.8020.30
19_A80_L0.7990.30
167_Q288_P0.7970.30
158_S392_I0.7950.30
324_A327_G0.7920.30
286_A315_R0.7890.30
123_D369_F0.7890.30
76_A273_P0.7870.30
30_L91_L0.7860.30
25_L130_F0.7860.30
145_D368_M0.7840.29
325_V330_V0.7820.29
419_K423_N0.7820.29
229_S369_F0.7800.29
20_A214_L0.7800.29
251_H260_L0.7770.29
279_V283_A0.7760.29
149_R392_I0.7750.29
245_A392_I0.7720.29
123_D405_P0.7720.29
140_E149_R0.7690.29
140_E150_G0.7680.29
128_M411_Q0.7680.29
17_S337_A0.7670.29
410_A414_S0.7590.28
27_V316_S0.7580.28
79_A220_R0.7540.28
140_E318_R0.7530.28
105_G335_G0.7510.28
35_L120_N0.7480.28
25_L29_V0.7440.27
110_S280_W0.7420.27
173_T230_V0.7410.27
121_G260_L0.7410.27
179_K251_H0.7400.27
342_V355_P0.7400.27
22_R94_G0.7400.27
334_V384_A0.7390.27
221_V396_A0.7380.27
317_V422_V0.7380.27
107_L258_M0.7340.27
169_V269_V0.7340.27
92_L217_A0.7320.27
229_S247_F0.7300.27
188_G215_L0.7270.26
81_F85_A0.7250.26
399_A403_G0.7250.26
188_G401_S0.7240.26
204_L256_A0.7230.26
321_A381_K0.7220.26
20_A174_S0.7180.26
260_L378_H0.7170.26
29_V88_A0.7160.26
48_G123_D0.7140.26
139_G153_R0.7140.26
199_M374_L0.7140.26
26_A124_L0.7130.26
125_V129_L0.7120.26
316_S330_V0.7100.26
168_L180_L0.7040.25
23_V234_V0.7040.25
27_V385_T0.7030.25
166_C229_S0.7020.25
198_E201_V0.7010.25
190_A405_P0.7000.25
91_L318_R0.7000.25
126_L262_V0.7000.25
49_V57_A0.6990.25
21_F178_L0.6980.25
121_G368_M0.6980.25
19_A146_A0.6960.25
19_A266_V0.6940.25
129_L271_L0.6940.25
165_L273_P0.6920.25
254_M280_W0.6910.25
221_V232_L0.6890.25
158_S281_E0.6890.25
279_V282_A0.6880.25
15_T146_A0.6860.24
380_V389_G0.6850.24
115_N176_A0.6850.24
131_V329_F0.6850.24
93_V399_A0.6840.24
151_A286_A0.6820.24
13_V273_P0.6810.24
164_V248_A0.6810.24
51_P386_T0.6800.24
211_T228_G0.6800.24
226_L254_M0.6790.24
27_V394_A0.6790.24
93_V314_P0.6790.24
266_V416_R0.6780.24
99_A384_A0.6760.24
117_L197_L0.6760.24
141_R283_A0.6740.24
100_A269_V0.6740.24
57_A60_P0.6730.24
251_H254_M0.6730.24
27_V298_I0.6690.24
111_M182_G0.6690.24
327_G335_G0.6680.24
163_G333_L0.6670.24
99_A150_G0.6660.24
249_G253_G0.6640.23
92_L118_V0.6630.23
124_L369_F0.6630.23
16_R130_F0.6620.23
159_V250_M0.6610.23
95_Y135_G0.6610.23
14_D18_L0.6610.23
78_A82_A0.6600.23
283_A341_V0.6570.23
301_Q318_R0.6570.23
56_R339_Y0.6540.23
11_L83_V0.6530.23
136_L332_L0.6490.23
27_V99_A0.6470.23
232_L390_G0.6470.23
36_R53_A0.6470.23
92_L365_R0.6430.22
106_V134_L0.6420.22
17_S314_P0.6420.22
184_A254_M0.6400.22
27_V271_L0.6380.22
218_F341_V0.6370.22
110_S176_A0.6350.22
124_L340_T0.6340.22
66_S69_M0.6320.22
130_F408_V0.6310.22
223_L228_G0.6300.22
23_V214_L0.6300.22
95_Y293_H0.6280.22
139_G350_P0.6280.22
144_V328_V0.6280.22
191_V260_L0.6280.22
240_R263_F0.6270.22
22_R366_W0.6260.22
320_R327_G0.6250.22
295_V298_I0.6250.22
97_S370_A0.6240.22
289_Q295_V0.6230.22
76_A165_L0.6230.22
292_V295_V0.6220.22
31_V415_A0.6210.22
201_V205_G0.6200.21
112_H254_M0.6200.21
185_W405_P0.6200.21
23_V242_A0.6200.21
20_A23_V0.6170.21
17_S279_V0.6170.21
99_A152_W0.6170.21
166_C170_I0.6170.21
154_D298_I0.6150.21
222_W250_M0.6150.21
32_D185_W0.6140.21
188_G198_E0.6130.21
35_L184_A0.6130.21
108_V194_V0.6130.21
86_V173_T0.6120.21
187_S252_L0.6110.21
95_Y139_G0.6110.21
195_F272_V0.6100.21
214_L395_F0.6090.21
75_W79_A0.6090.21
288_P293_H0.6080.21
327_G333_L0.6070.21
20_A272_V0.6030.21
131_V388_G0.6020.21
132_W382_A0.6020.21
176_A190_A0.6000.21
353_V356_L0.5990.21
291_T331_V0.5980.21
102_F324_A0.5980.21
205_G252_L0.5970.20
132_W163_G0.5960.20
96_R136_L0.5960.20
136_L383_P0.5940.20
217_A283_A0.5940.20
275_V379_W0.5930.20
17_S129_L0.5930.20
33_L84_T0.5920.20
83_V324_A0.5910.20
134_L173_T0.5890.20
250_M368_M0.5870.20
89_V322_R0.5850.20
113_A122_G0.5800.20
385_T388_G0.5790.20
95_Y384_A0.5790.20
80_L284_A0.5790.20
172_Y366_W0.5770.20
187_S262_V0.5760.20
30_L373_P0.5760.20
224_V245_A0.5750.20
14_D293_H0.5750.20
137_P205_G0.5740.20
338_A394_A0.5740.20
294_P330_V0.5740.20
11_L409_S0.5740.20
21_F136_L0.5730.20
96_R215_L0.5730.20
20_A327_G0.5720.19
166_C242_A0.5710.19
23_V180_L0.5700.19
19_A79_A0.5690.19
162_V165_L0.5680.19
284_A381_K0.5670.19
17_S106_V0.5660.19
18_L22_R0.5660.19
177_V262_V0.5650.19
127_Q368_M0.5650.19
184_A194_V0.5650.19
251_H274_F0.5650.19
56_R81_F0.5640.19
144_V246_V0.5620.19
277_G332_L0.5600.19
314_P318_R0.5590.19
71_S77_Q0.5590.19
70_L272_V0.5560.19
66_S363_P0.5550.19
102_F419_K0.5540.19
163_G418_R0.5540.19
150_G153_R0.5540.19
99_A132_W0.5520.19
16_R160_A0.5510.19
401_S405_P0.5500.19
292_V296_R0.5490.19
19_A23_V0.5490.19
384_A393_G0.5480.19
89_V282_A0.5480.19
121_G369_F0.5480.19
112_H273_P0.5470.18
88_A329_F0.5460.18
401_S404_K0.5460.18
131_V400_F0.5460.18
205_G248_A0.5450.18
382_A391_R0.5450.18
144_V153_R0.5450.18
290_R396_A0.5440.18
389_G394_A0.5430.18
31_V92_L0.5420.18
26_A359_G0.5420.18
250_M359_G0.5420.18
82_A315_R0.5410.18
55_M387_P0.5380.18
287_R385_T0.5380.18
333_L380_V0.5370.18
68_H72_G0.5370.18
74_A231_C0.5360.18
299_A328_V0.5350.18
83_V296_R0.5350.18
188_G260_L0.5340.18
68_H253_G0.5340.18
84_T205_G0.5330.18
292_V316_S0.5330.18
208_L235_L0.5330.18
163_G389_G0.5320.18
120_N191_V0.5320.18
178_L367_Y0.5300.18
14_D420_Y0.5290.18
125_V368_M0.5280.18
83_V149_R0.5280.18
32_D254_M0.5270.18
69_M191_V0.5270.18
290_R395_F0.5270.18
330_V334_V0.5260.18
30_L38_Q0.5260.18
77_Q111_M0.5250.18
207_V277_G0.5240.18
356_L360_D0.5240.18
155_R385_T0.5220.18
269_V412_Y0.5210.17
373_P403_G0.5210.17
297_W301_Q0.5190.17
32_D247_F0.5190.17
392_I412_Y0.5190.17
254_M371_P0.5180.17
100_A235_L0.5170.17
73_A76_A0.5160.17
124_L365_R0.5160.17
75_W93_V0.5140.17
209_S215_L0.5130.17
155_R388_G0.5130.17
128_M171_I0.5120.17
36_R368_M0.5110.17
198_E333_L0.5100.17
17_S23_V0.5100.17
342_V413_P0.5090.17
36_R108_V0.5080.17
258_M340_T0.5080.17
342_V398_G0.5080.17
53_A381_K0.5080.17
115_N405_P0.5070.17
267_A368_M0.5070.17
50_L413_P0.5060.17
132_W318_R0.5030.17
219_D368_M0.5030.17
102_F152_W0.5030.17
61_V342_V0.5010.17
91_L138_L0.5000.17
60_P63_S0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2aydA 1 0.1405 11.6 0.981 Contact Map
1ikoP 1 0.1629 9.6 0.982 Contact Map
3d12B 2 0.1609 9 0.982 Contact Map
3fdbA 2 0.2281 6.3 0.983 Contact Map
3q0hA 1 0.2037 5.2 0.984 Contact Map
2dltA 1 0.1853 4.1 0.985 Contact Map
2c4mA 4 0.1772 4 0.985 Contact Map
4uf7C 1 0.1548 4 0.985 Contact Map
2z61A 2 0.2403 3.8 0.985 Contact Map
3ezsA 2 0.2342 3.6 0.985 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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