GREMLIN Database
Q9HR60 - Uncharacterized protein
UniProt: Q9HR60 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 449 (368)
Sequences: 130 (130)
Seq/√Len: 6.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
267_A271_R3.2060.86
271_R283_I3.0910.84
273_D279_D2.7940.77
271_R277_D2.6870.74
280_L284_Q2.6550.73
280_L287_M2.4470.67
271_R276_A2.4320.66
277_D288_G2.4210.66
350_V364_R2.3800.65
73_T86_A2.3780.65
274_A279_D2.3650.64
274_A283_I2.3220.63
419_V433_V2.3210.63
271_R284_Q2.3130.62
279_D288_G2.2930.62
332_L339_L2.2040.58
266_L283_I2.1800.57
279_D283_I2.1500.56
277_D280_L2.1400.56
272_N282_T2.1160.55
350_V357_V2.1090.55
275_V283_I2.0770.54
278_E288_G2.0300.52
273_D277_D2.0290.52
264_A271_R2.0240.52
269_A276_A2.0190.51
93_V97_R1.9840.50
335_D340_E1.9760.50
332_L335_D1.9680.50
97_R103_D1.9640.49
77_V86_A1.9530.49
283_I286_A1.9250.48
367_L405_T1.9240.48
357_V360_A1.9020.47
414_D418_D1.8790.46
272_N276_A1.8630.46
271_R279_D1.8540.45
273_D283_I1.8450.45
96_V104_E1.8360.45
331_D360_A1.8280.44
335_D353_V1.8210.44
269_A279_D1.8140.44
271_R282_T1.7840.43
272_N283_I1.7770.42
353_V361_A1.7700.42
87_G96_V1.7660.42
311_Y314_A1.7610.42
276_A280_L1.7520.41
270_I283_I1.7150.40
269_A284_Q1.7110.40
349_D353_V1.7070.40
72_A81_E1.6590.38
353_V357_V1.6510.38
331_D335_D1.6330.37
74_G88_E1.6280.37
283_I288_G1.6180.37
276_A281_A1.6170.37
306_S309_E1.6130.36
71_T79_R1.5990.36
335_D349_D1.5970.36
253_D279_D1.5840.35
73_T92_T1.5810.35
74_G79_R1.5660.35
181_D185_L1.5640.35
75_D80_F1.5630.35
270_I278_E1.5610.35
167_D174_D1.5590.35
183_A186_T1.5590.35
269_A274_A1.5570.35
277_D283_I1.5450.34
73_T83_E1.5430.34
274_A277_D1.5380.34
264_A277_D1.5370.34
281_A286_A1.5360.34
277_D282_T1.5030.33
335_D356_S1.4900.32
345_T349_D1.4870.32
349_D356_S1.4790.32
271_R278_E1.4760.32
125_P136_A1.4730.32
321_D329_L1.4660.32
271_R280_L1.4600.31
265_A279_D1.4590.31
339_L353_V1.4550.31
312_T316_E1.4530.31
106_P109_S1.4490.31
75_D92_T1.4450.31
345_T359_A1.4440.31
72_A96_V1.4380.31
71_T93_V1.4350.31
278_E283_I1.4280.30
91_T109_S1.4280.30
271_R275_V1.4240.30
69_H82_R1.4210.30
326_Q329_L1.4170.30
342_E356_S1.4080.30
93_V106_P1.4040.30
72_A79_R1.3850.29
113_I301_L1.3730.29
269_A273_D1.3680.28
360_A363_D1.3640.28
266_L273_D1.3590.28
267_A270_I1.3550.28
80_F92_T1.3440.28
349_D361_A1.3430.28
263_V273_D1.3420.28
264_A282_T1.3400.28
270_I282_T1.3400.28
106_P113_I1.3340.27
275_V284_Q1.3340.27
76_G79_R1.3300.27
270_I276_A1.3280.27
356_S361_A1.3240.27
426_V433_V1.3150.27
89_S95_G1.3140.27
276_A283_I1.3050.27
340_E349_D1.2990.26
136_A143_V1.2990.26
396_D420_D1.2950.26
170_T177_E1.2900.26
296_V308_I1.2840.26
79_R83_E1.2820.26
352_G357_V1.2660.25
91_T295_R1.2640.25
349_D357_V1.2600.25
83_E90_F1.2590.25
122_D133_R1.2580.25
356_S369_E1.2560.25
325_A329_L1.2480.25
272_N279_D1.2440.25
362_D365_A1.2410.25
175_D187_D1.2380.25
199_T210_N1.2350.25
76_G83_E1.2320.24
132_V138_G1.2310.24
345_T353_V1.2300.24
137_G142_T1.2280.24
73_T77_V1.2280.24
227_D251_G1.2280.24
73_T76_G1.2270.24
331_D350_V1.2040.24
253_D282_T1.2010.24
265_A288_G1.1950.23
345_T350_V1.1930.23
331_D359_A1.1900.23
99_E348_D1.1890.23
358_D369_E1.1880.23
349_D364_R1.1880.23
353_V360_A1.1850.23
276_A282_T1.1840.23
227_D236_T1.1720.23
339_L358_D1.1640.23
218_L223_T1.1630.23
279_D282_T1.1500.22
357_V366_A1.1450.22
335_D339_L1.1440.22
72_A83_E1.1330.22
298_L315_L1.1320.22
417_G423_E1.1290.22
363_D371_V1.1290.22
74_G86_A1.1220.21
74_G92_T1.1220.21
265_A273_D1.1210.21
110_A366_A1.1180.21
95_G107_F1.1180.21
300_H316_E1.1050.21
352_G358_D1.1050.21
97_R111_P1.1010.21
266_L269_A1.0980.21
310_A318_F1.0940.21
433_V436_I1.0920.21
350_V360_A1.0910.21
76_G90_F1.0910.21
274_A278_E1.0910.21
164_G176_A1.0900.21
169_D197_D1.0880.21
310_A314_A1.0820.20
139_D144_P1.0810.20
338_D408_D1.0780.20
74_G80_F1.0740.20
271_R287_M1.0740.20
277_D284_Q1.0720.20
318_F323_G1.0660.20
72_A76_G1.0630.20
150_D332_L1.0580.20
345_T363_D1.0570.20
118_P121_E1.0530.20
69_H73_T1.0510.20
79_R86_A1.0480.20
73_T95_G1.0470.20
73_T85_D1.0410.19
275_V280_L1.0410.19
301_L391_L1.0390.19
125_P140_R1.0360.19
113_I395_V1.0330.19
149_E159_V1.0310.19
72_A78_V1.0300.19
72_A95_G1.0290.19
331_D344_S1.0230.19
215_G247_D1.0180.19
284_Q288_G1.0150.19
305_V433_V1.0140.19
74_G81_E1.0110.19
271_R274_A1.0080.19
278_E287_M1.0080.19
312_T318_F1.0060.19
273_D288_G1.0030.19
349_D360_A1.0020.19
319_I345_T1.0020.19
414_D424_A0.9990.19
81_E92_T0.9980.18
312_T319_I0.9980.18
267_A277_D0.9970.18
75_D83_E0.9940.18
261_E279_D0.9920.18
259_G263_V0.9890.18
303_S311_Y0.9890.18
193_P196_T0.9830.18
339_L349_D0.9830.18
79_R88_E0.9820.18
352_G359_A0.9810.18
192_E196_T0.9770.18
187_D240_A0.9750.18
364_R368_H0.9740.18
282_T288_G0.9740.18
93_V275_V0.9700.18
78_V87_G0.9680.18
78_V93_V0.9640.18
339_L357_V0.9640.18
186_T190_G0.9600.18
255_A284_Q0.9560.18
92_T95_G0.9560.18
148_D156_F0.9540.18
334_D352_G0.9530.17
74_G93_V0.9520.17
109_S113_I0.9500.17
270_I279_D0.9470.17
335_D361_A0.9460.17
90_F99_E0.9420.17
300_H307_E0.9410.17
81_E85_D0.9400.17
293_S307_E0.9360.17
349_D363_D0.9350.17
277_D286_A0.9300.17
71_T80_F0.9290.17
212_T376_A0.9280.17
270_I277_D0.9250.17
372_D375_E0.9160.17
97_R132_V0.9150.17
273_D282_T0.9140.17
204_D213_G0.9070.17
245_A277_D0.9040.16
195_D208_A0.9030.16
345_T357_V0.9000.16
272_N286_A0.8950.16
219_E222_A0.8950.16
276_A289_G0.8950.16
278_E286_A0.8930.16
336_V405_T0.8900.16
104_E109_S0.8880.16
72_A84_I0.8880.16
339_L352_G0.8860.16
271_R288_G0.8860.16
72_A90_F0.8850.16
273_D287_M0.8850.16
361_A364_R0.8850.16
357_V370_R0.8830.16
340_E350_V0.8830.16
255_A264_A0.8820.16
73_T79_R0.8790.16
82_R107_F0.8780.16
333_E341_T0.8780.16
87_G283_I0.8780.16
264_A274_A0.8760.16
323_G328_V0.8760.16
340_E360_A0.8760.16
227_D238_T0.8720.16
161_A208_A0.8710.16
345_T364_R0.8710.16
82_R89_S0.8690.16
342_E366_A0.8660.16
330_N335_D0.8660.16
201_P216_A0.8650.16
168_V175_D0.8650.16
86_A90_F0.8600.16
345_T362_D0.8590.16
354_E357_V0.8530.15
239_V242_D0.8520.15
255_A277_D0.8510.15
352_G356_S0.8500.15
274_A284_Q0.8500.15
70_W107_F0.8490.15
74_G77_V0.8490.15
73_T98_M0.8490.15
342_E345_T0.8460.15
70_W94_Y0.8440.15
275_V282_T0.8410.15
359_A370_R0.8400.15
255_A280_L0.8350.15
256_P283_I0.8350.15
276_A286_A0.8340.15
304_R309_E0.8300.15
75_D95_G0.8300.15
85_D92_T0.8280.15
255_A276_A0.8260.15
124_I129_S0.8260.15
303_S307_E0.8220.15
107_F120_I0.8200.15
297_E427_A0.8190.15
201_P399_D0.8180.15
435_A439_W0.8170.15
394_D433_V0.8150.15
279_D287_M0.8140.15
207_P212_T0.8110.15
86_A95_G0.8100.15
356_S364_R0.8090.15
267_A286_A0.8080.15
277_D287_M0.8020.14
305_V312_T0.8010.14
75_D79_R0.8000.14
76_G86_A0.7990.14
172_V227_D0.7940.14
215_G218_L0.7910.14
265_A271_R0.7890.14
72_A92_T0.7880.14
116_D144_P0.7870.14
156_F159_V0.7860.14
87_G104_E0.7840.14
356_S360_A0.7810.14
97_R106_P0.7810.14
396_D436_I0.7810.14
69_H100_D0.7780.14
83_E94_Y0.7780.14
227_D234_P0.7780.14
71_T95_G0.7770.14
70_W108_L0.7750.14
76_G96_V0.7680.14
259_G269_A0.7680.14
147_E355_Q0.7670.14
70_W110_A0.7670.14
76_G101_D0.7650.14
186_T199_T0.7560.14
91_T102_Q0.7530.14
367_L375_E0.7520.14
270_I273_D0.7470.13
272_N277_D0.7350.13
374_V395_V0.7330.13
339_L361_A0.7290.13
137_G145_G0.7290.13
269_A286_A0.7260.13
91_T111_P0.7250.13
75_D86_A0.7240.13
355_Q372_D0.7240.13
278_E282_T0.7220.13
175_D180_G0.7210.13
434_D439_W0.7180.13
69_H86_A0.7180.13
190_G208_A0.7160.13
296_V300_H0.7160.13
272_N278_E0.7160.13
92_T97_R0.7130.13
269_A283_I0.7120.13
273_D276_A0.7110.13
349_D352_G0.7090.13
243_T248_D0.7070.13
269_A277_D0.7060.13
178_I187_D0.7060.13
109_S304_R0.7050.13
124_I128_S0.7010.13
274_A288_G0.7000.13
350_V363_D0.7000.13
87_G356_S0.7000.13
271_R281_A0.6950.13
435_A438_D0.6930.13
379_G389_D0.6920.13
355_Q408_D0.6910.12
418_D425_D0.6900.12
249_A253_D0.6890.12
276_A279_D0.6880.12
134_E337_A0.6860.12
121_E134_E0.6840.12
215_G223_T0.6840.12
396_D428_E0.6830.12
140_R144_P0.6820.12
158_S185_L0.6780.12
253_D272_N0.6720.12
81_E96_V0.6700.12
111_P318_F0.6680.12
203_T253_D0.6670.12
339_L354_E0.6650.12
340_E363_D0.6640.12
351_A361_A0.6640.12
215_G249_A0.6640.12
349_D354_E0.6610.12
436_I439_W0.6610.12
153_D210_N0.6600.12
151_T157_G0.6590.12
69_H88_E0.6580.12
348_D398_L0.6570.12
282_T286_A0.6570.12
79_R90_F0.6560.12
264_A272_N0.6560.12
374_V378_V0.6560.12
330_N359_A0.6530.12
260_S265_A0.6520.12
279_D286_A0.6520.12
265_A272_N0.6510.12
192_E383_D0.6490.12
335_D359_A0.6480.12
154_H157_G0.6480.12
381_V422_L0.6480.12
267_A273_D0.6450.12
117_G134_E0.6360.12
283_I287_M0.6360.12
269_A297_E0.6330.12
92_T96_V0.6330.12
137_G368_H0.6310.12
71_T74_G0.6310.12
139_D267_A0.6300.12
289_G371_V0.6280.11
346_V355_Q0.6280.11
260_S287_M0.6280.11
160_E234_P0.6270.11
224_T230_A0.6270.11
357_V369_E0.6260.11
272_N275_V0.6250.11
88_E95_G0.6240.11
76_G100_D0.6240.11
81_E93_V0.6240.11
398_L429_L0.6220.11
72_A88_E0.6190.11
342_E357_V0.6180.11
264_A278_E0.6170.11
425_D433_V0.6150.11
266_L282_T0.6140.11
418_D434_D0.6130.11
360_A369_E0.6120.11
166_A250_A0.6120.11
91_T98_M0.6120.11
364_R369_E0.6100.11
89_S111_P0.6070.11
153_D159_V0.6070.11
331_D357_V0.6070.11
350_V359_A0.6060.11
159_V216_A0.6040.11
106_P112_E0.6020.11
153_D200_S0.6010.11
400_E417_G0.6000.11
87_G101_D0.5990.11
340_E356_S0.5990.11
183_A189_G0.5980.11
266_L271_R0.5970.11
338_D345_T0.5970.11
422_L428_E0.5960.11
274_A287_M0.5940.11
344_S422_L0.5940.11
338_D387_S0.5920.11
205_G211_T0.5890.11
302_Q311_Y0.5880.11
95_G100_D0.5880.11
91_T96_V0.5880.11
105_T109_S0.5880.11
269_A282_T0.5870.11
71_T88_E0.5860.11
335_D368_H0.5860.11
349_D370_R0.5850.11
157_G161_A0.5840.11
335_D352_G0.5840.11
335_D420_D0.5840.11
98_M109_S0.5820.11
276_A284_Q0.5820.11
232_A239_V0.5790.11
79_R112_E0.5790.11
75_D85_D0.5780.11
76_G92_T0.5760.11
169_D174_D0.5760.11
335_D360_A0.5750.11
204_D208_A0.5740.11
285_D294_T0.5740.11
421_A427_A0.5730.11
70_W80_F0.5700.11
181_D184_G0.5700.11
339_L347_R0.5690.11
348_D409_V0.5690.11
265_A278_E0.5690.11
338_D348_D0.5690.11
79_R93_V0.5650.11
345_T354_E0.5640.11
93_V111_P0.5560.10
271_R286_A0.5540.10
160_E163_V0.5540.10
423_E427_A0.5540.10
222_A228_D0.5540.10
222_A225_D0.5530.10
75_D89_S0.5520.10
87_G369_E0.5500.10
256_P276_A0.5500.10
82_R88_E0.5490.10
128_S134_E0.5470.10
79_R95_G0.5470.10
340_E345_T0.5450.10
278_E396_D0.5440.10
266_L277_D0.5430.10
90_F95_G0.5430.10
335_D345_T0.5420.10
109_S360_A0.5420.10
74_G78_V0.5400.10
356_S359_A0.5390.10
193_P429_L0.5370.10
295_R298_L0.5370.10
366_A371_V0.5350.10
134_E321_D0.5350.10
128_S142_T0.5350.10
395_V405_T0.5330.10
94_Y335_D0.5330.10
78_V88_E0.5320.10
357_V363_D0.5310.10
426_V429_L0.5300.10
107_F133_R0.5300.10
367_L419_V0.5290.10
404_D408_D0.5260.10
294_T306_S0.5250.10
166_A215_G0.5220.10
369_E374_V0.5210.10
221_T225_D0.5210.10
182_D187_D0.5210.10
410_L426_V0.5210.10
150_D166_A0.5200.10
94_Y101_D0.5180.10
355_Q401_R0.5160.10
419_V436_I0.5160.10
69_H72_A0.5150.10
72_A104_E0.5150.10
83_E91_T0.5150.10
339_L345_T0.5140.10
267_A283_I0.5130.10
274_A281_A0.5130.10
220_A225_D0.5120.10
363_D370_R0.5120.10
388_L398_L0.5110.10
70_W109_S0.5110.10
403_A431_E0.5090.10
298_L428_E0.5090.10
253_D276_A0.5070.10
333_E346_V0.5050.10
187_D217_A0.5040.10
90_F111_P0.5040.10
101_D104_E0.5040.10
353_V367_L0.5020.10
80_F139_D0.5020.10
75_D88_E0.5000.10
297_E320_D0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1c1gA 2 0.4187 98.7 0.901 Contact Map
4linA 5 0.4276 98.5 0.907 Contact Map
4iloA 3 0.3831 98.3 0.912 Contact Map
1i84S 2 0.4477 98.1 0.917 Contact Map
4cgkA 3 0.4009 98.1 0.918 Contact Map
4ll8A 1 0.1002 97.9 0.92 Contact Map
2v71A 3 0.3563 97.8 0.922 Contact Map
3na7A 1 0.3764 97.8 0.923 Contact Map
4q4gX 1 0 97.8 0.923 Contact Map
4rsiB 1 0.314 97.3 0.93 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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