Q9HR59 - HALSA - GREMLIN Contacts

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Q9HR59 - Uncharacterized protein

UniProt:	Q9HR59	Sequences: MRGDDIDSSAMTLITSYTCPRAVKCPGRTTERLGRGPPTAGMVHSDWGDWLPAAVAAADPDGIAVWYLGCNGVILKASDGTTLFVDPYLGTGDPPRTVRMIPVPFDPRDVSDADAVLATHEHTDHVHGPSQAPLLADTGCSLYAPEASIAVARDDERWQDDYAVTTDQYRRVAVGDTYDIGSFTVHVTPAHDPDAVQPVSYVFEHDAGTVFHGGDTKPADALAEIGAAHDIDVGILAFGSTGEIPDKQTREPSVTTWYNTETEVVACANALQLDRLVPTHWDMWKGLTADPTALHAHTRSMASPQRLDVVEIGDRIDVS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	319 (251)
Sequences:	2530 (1715)
Seq/√Len:	108.3

ECOLI - ULAG
BACSU - YDDR YTKL
HALSA - Q9HR59 Y1038 Q9HR33
SULSO - Y099

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
187_V	199_V	4.223	1.00
234_G	273_L	3.451	1.00
141_S	170_R	3.427	1.00
262_T	297_H	3.315	1.00
204_E	209_T	3.217	1.00
218_P	270_A	3.147	1.00
184_T	204_E	3.044	1.00
73_V	279_T	3.032	1.00
188_T	202_V	2.963	1.00
156_E	171_R	2.849	1.00
268_A	276_L	2.770	1.00
202_V	231_I	2.748	1.00
202_V	229_H	2.607	1.00
66_W	315_R	2.492	1.00
76_K	82_T	2.441	1.00
83_L	115_A	2.393	1.00
259_N	267_C	2.387	1.00
186_H	204_E	2.304	1.00
188_T	200_S	2.221	1.00
186_H	229_H	2.175	1.00
85_V	119_T	2.077	1.00
119_T	212_H	2.069	1.00
149_I	173_A	2.019	1.00
90_G	127_H	2.016	1.00
232_D	274_D	1.973	1.00
65_V	233_V	1.965	1.00
177_T	184_T	1.954	1.00
156_E	160_D	1.950	1.00
177_T	186_H	1.905	1.00
116_V	142_L	1.834	1.00
223_A	227_A	1.825	1.00
235_I	277_V	1.823	1.00
179_D	184_T	1.798	1.00
210_V	235_I	1.796	1.00
175_G	189_P	1.777	1.00
117_L	203_F	1.758	1.00
311_E	314_D	1.737	1.00
224_E	228_A	1.720	1.00
265_V	301_M	1.645	1.00
213_G	237_A	1.640	1.00
172_V	187_V	1.639	1.00
266_A	270_A	1.630	1.00
64_A	315_R	1.626	1.00
185_V	201_Y	1.619	1.00
292_T	296_A	1.590	1.00
81_T	181_G	1.585	1.00
266_A	269_N	1.582	1.00
106_D	109_D	1.573	1.00
209_T	231_I	1.572	1.00
293_A	297_H	1.557	1.00
234_G	268_A	1.524	1.00
212_H	279_T	1.522	1.00
68_L	89_L	1.519	1.00
64_A	76_K	1.514	1.00
236_L	271_L	1.512	1.00
223_A	270_A	1.509	1.00
175_G	228_A	1.495	1.00
226_G	272_Q	1.482	1.00
143_Y	201_Y	1.481	1.00
142_L	164_V	1.469	1.00
88_Y	93_D	1.451	1.00
121_E	158_W	1.445	1.00
115_A	143_Y	1.444	1.00
108_R	133_P	1.440	1.00
72_G	85_V	1.439	1.00
92_G	97_T	1.426	1.00
115_A	180_I	1.404	1.00
73_V	235_I	1.402	1.00
78_S	205_H	1.351	1.00
143_Y	178_Y	1.342	1.00
179_D	182_S	1.334	1.00
264_V	276_L	1.334	1.00
200_S	213_G	1.326	0.99
175_G	229_H	1.326	0.99
85_V	117_L	1.319	0.99
85_V	212_H	1.318	0.99
117_L	199_V	1.313	0.99
260_T	263_E	1.309	0.99
143_Y	185_V	1.301	0.99
155_D	196_V	1.297	0.99
49_D	53_A	1.287	0.99
297_H	300_S	1.278	0.99
218_P	266_A	1.268	0.99
145_P	201_Y	1.250	0.99
172_V	176_D	1.240	0.99
49_D	54_A	1.232	0.99
281_W	295_H	1.232	0.99
75_L	210_V	1.231	0.99
233_V	277_V	1.228	0.99
68_L	104_P	1.223	0.99
203_F	210_V	1.216	0.99
226_G	231_I	1.211	0.99
67_Y	281_W	1.204	0.99
268_A	273_L	1.199	0.99
276_L	307_L	1.197	0.99
89_L	130_S	1.179	0.99
191_H	219_A	1.161	0.99
265_V	298_T	1.152	0.99
240_S	286_G	1.148	0.98
222_L	270_A	1.146	0.98
128_G	132_A	1.132	0.98
188_T	211_F	1.131	0.98
302_A	307_L	1.122	0.98
92_G	96_R	1.116	0.98
175_G	188_T	1.110	0.98
65_V	73_V	1.103	0.98
298_T	307_L	1.100	0.98
81_T	183_F	1.099	0.98
213_G	236_L	1.095	0.98
126_V	131_Q	1.090	0.98
277_V	308_D	1.083	0.98
236_L	259_N	1.082	0.98
275_R	306_R	1.082	0.98
190_A	216_T	1.067	0.98
68_L	72_G	1.063	0.98
115_A	141_S	1.050	0.97
107_P	133_P	1.047	0.97
75_L	85_V	1.044	0.97
144_A	155_D	1.036	0.97
65_V	235_I	1.026	0.97
66_W	76_K	1.023	0.97
263_E	266_A	1.021	0.97
236_L	267_C	1.017	0.97
170_R	178_Y	1.014	0.97
51_L	54_A	1.013	0.97
157_R	160_D	1.007	0.97
242_G	260_T	1.000	0.96
224_E	227_A	0.993	0.96
120_H	215_D	0.983	0.96
115_A	185_V	0.981	0.96
160_D	166_T	0.976	0.96
211_F	267_C	0.975	0.96
227_A	272_Q	0.974	0.96
81_T	115_A	0.974	0.96
190_A	200_S	0.965	0.96
105_F	109_D	0.960	0.95
135_L	164_V	0.959	0.95
290_D	293_A	0.955	0.95
118_A	159_Q	0.953	0.95
143_Y	172_V	0.944	0.95
72_G	103_V	0.935	0.95
260_T	264_V	0.934	0.95
185_V	203_F	0.932	0.95
77_A	205_H	0.922	0.94
117_L	200_S	0.918	0.94
172_V	178_Y	0.918	0.94
209_T	232_D	0.918	0.94
83_L	185_V	0.917	0.94
121_E	196_V	0.898	0.94
222_L	267_C	0.897	0.93
110_V	113_A	0.894	0.93
120_H	280_H	0.889	0.93
246_D	256_T	0.885	0.93
71_N	237_A	0.883	0.93
234_G	276_L	0.880	0.93
78_S	207_A	0.878	0.93
101_I	312_I	0.874	0.93
85_V	203_F	0.868	0.92
175_G	225_I	0.868	0.92
297_H	301_M	0.866	0.92
107_P	130_S	0.864	0.92
289_A	294_L	0.860	0.92
118_A	126_V	0.857	0.92
226_G	271_L	0.856	0.92
241_T	294_L	0.852	0.92
100_M	285_K	0.846	0.91
308_D	316_I	0.839	0.91
237_A	264_V	0.837	0.91
241_T	286_G	0.837	0.91
235_I	279_T	0.832	0.91
55_V	58_A	0.832	0.91
83_L	183_F	0.829	0.90
215_D	280_H	0.827	0.90
94_P	97_T	0.824	0.90
189_P	225_I	0.823	0.90
91_T	98_V	0.821	0.90
54_A	57_A	0.820	0.90
145_P	199_V	0.820	0.90
211_F	271_L	0.816	0.90
117_L	185_V	0.806	0.89
187_V	201_Y	0.805	0.89
282_D	295_H	0.799	0.89
131_Q	164_V	0.799	0.89
82_T	114_D	0.798	0.89
200_S	271_L	0.797	0.89
72_G	88_Y	0.793	0.88
135_L	139_G	0.791	0.88
299_R	307_L	0.789	0.88
237_A	260_T	0.786	0.88
265_V	302_A	0.785	0.88
143_Y	187_V	0.784	0.88
134_L	140_C	0.783	0.88
99_R	102_P	0.783	0.88
243_E	246_D	0.783	0.88
67_Y	312_I	0.779	0.88
145_P	187_V	0.778	0.87
99_R	283_M	0.778	0.87
238_F	281_W	0.777	0.87
213_G	216_T	0.768	0.87
52_P	55_V	0.767	0.87
81_T	114_D	0.764	0.87
63_I	208_G	0.763	0.86
173_A	176_D	0.760	0.86
149_I	197_Q	0.757	0.86
121_E	155_D	0.756	0.86
122_H	215_D	0.755	0.86
174_V	197_Q	0.747	0.85
131_Q	142_L	0.741	0.85
273_L	276_L	0.737	0.85
52_P	56_A	0.736	0.84
165_T	168_Q	0.736	0.84
158_W	161_D	0.736	0.84
276_L	298_T	0.731	0.84
234_G	271_L	0.731	0.84
242_G	297_H	0.731	0.84
139_G	164_V	0.730	0.84
240_S	289_A	0.725	0.84
213_G	279_T	0.724	0.83
143_Y	170_R	0.724	0.83
238_F	264_V	0.722	0.83
192_D	280_H	0.721	0.83
159_Q	164_V	0.718	0.83
175_G	224_E	0.715	0.83
155_D	159_Q	0.714	0.83
51_L	55_V	0.713	0.83
76_K	113_A	0.713	0.83
217_K	261_E	0.712	0.82
268_A	298_T	0.711	0.82
158_W	162_Y	0.710	0.82
128_G	162_Y	0.708	0.82
246_D	263_E	0.699	0.81
135_L	142_L	0.698	0.81
220_D	224_E	0.698	0.81
118_A	144_A	0.696	0.81
143_Y	180_I	0.695	0.81
95_P	149_I	0.694	0.81
244_I	260_T	0.692	0.81
63_I	77_A	0.691	0.81
120_H	192_D	0.689	0.80
101_I	283_M	0.685	0.80
240_S	285_K	0.682	0.80
159_Q	162_Y	0.680	0.79
53_A	57_A	0.678	0.79
269_N	272_Q	0.678	0.79
50_W	53_A	0.672	0.79
194_D	198_P	0.672	0.79
144_A	201_Y	0.671	0.79
202_V	226_G	0.671	0.79
172_V	199_V	0.671	0.79
68_L	107_P	0.669	0.78
89_L	107_P	0.668	0.78
241_T	287_L	0.666	0.78
274_D	306_R	0.664	0.78
68_L	103_V	0.664	0.78
241_T	261_E	0.664	0.78
141_S	168_Q	0.662	0.78
216_T	222_L	0.660	0.77
200_S	222_L	0.659	0.77
260_T	297_H	0.656	0.77
74_I	110_V	0.656	0.77
192_D	258_Y	0.656	0.77
142_L	201_Y	0.652	0.77
90_G	129_P	0.652	0.77
174_V	198_P	0.650	0.76
90_G	284_W	0.648	0.76
65_V	277_V	0.645	0.76
122_H	280_H	0.637	0.75
188_T	228_A	0.636	0.75
242_G	288_T	0.635	0.75
132_A	164_V	0.634	0.75
113_A	116_V	0.629	0.74
120_H	124_D	0.629	0.74
275_R	308_D	0.625	0.74
240_S	283_M	0.625	0.74
241_T	293_A	0.623	0.73
264_V	298_T	0.622	0.73
75_L	83_L	0.619	0.73
50_W	54_A	0.619	0.73
192_D	215_D	0.617	0.73
188_T	231_I	0.616	0.72
70_C	258_Y	0.611	0.72
90_G	93_D	0.607	0.71
225_I	271_L	0.607	0.71
82_T	113_A	0.604	0.71
216_T	270_A	0.597	0.70
243_E	260_T	0.597	0.70
238_F	283_M	0.595	0.70
261_E	287_L	0.594	0.70
244_I	288_T	0.594	0.70
226_G	270_A	0.592	0.69
63_I	78_S	0.590	0.69
191_H	217_K	0.589	0.69
136_A	139_G	0.586	0.69
212_H	235_I	0.586	0.69
205_H	208_G	0.585	0.69
275_R	278_P	0.584	0.68
58_A	62_G	0.584	0.68
296_A	300_S	0.575	0.67
120_H	125_H	0.575	0.67
211_F	256_T	0.573	0.67
73_V	277_V	0.570	0.67
300_S	303_S	0.570	0.67
84_F	89_L	0.569	0.66
88_Y	284_W	0.569	0.66
72_G	89_L	0.565	0.66
72_G	118_A	0.562	0.65
104_P	283_M	0.559	0.65
90_G	94_P	0.558	0.65
110_V	116_V	0.558	0.65
269_N	306_R	0.557	0.65
257_W	287_L	0.556	0.65
265_V	305_Q	0.556	0.65
49_D	52_P	0.556	0.65
84_F	113_A	0.556	0.65
242_G	246_D	0.552	0.64
219_A	226_G	0.551	0.64
172_V	177_T	0.551	0.64
139_G	168_Q	0.551	0.64
70_C	217_K	0.550	0.64
121_E	197_Q	0.550	0.64
267_C	271_L	0.546	0.63
160_D	169_Y	0.545	0.63
156_E	169_Y	0.545	0.63
297_H	302_A	0.544	0.63
286_G	294_L	0.543	0.63
95_P	123_T	0.543	0.63
51_L	57_A	0.541	0.63
62_G	317_D	0.540	0.62
242_G	293_A	0.540	0.62
310_V	316_I	0.539	0.62
74_I	82_T	0.537	0.62
186_H	202_V	0.537	0.62
103_V	107_P	0.537	0.62
126_V	155_D	0.536	0.62
69_G	281_W	0.534	0.62
77_A	83_L	0.532	0.61
132_A	157_R	0.531	0.61
305_Q	310_V	0.530	0.61
258_Y	294_L	0.530	0.61
100_M	291_P	0.530	0.61
54_A	58_A	0.529	0.61
116_V	140_C	0.528	0.61
81_T	85_V	0.528	0.61
295_H	309_V	0.526	0.60
218_P	222_L	0.526	0.60
57_A	109_D	0.525	0.60
242_G	245_P	0.524	0.60
135_L	140_C	0.524	0.60
99_R	104_P	0.524	0.60
125_H	215_D	0.523	0.60
77_A	183_F	0.523	0.60
144_A	171_R	0.523	0.60
202_V	211_F	0.516	0.59
298_T	302_A	0.515	0.59
221_A	267_C	0.515	0.59
90_G	97_T	0.515	0.59
262_T	301_M	0.514	0.59
127_H	130_S	0.511	0.58
51_L	56_A	0.511	0.58
91_T	119_T	0.510	0.58
236_L	264_V	0.510	0.58
117_L	210_V	0.510	0.58
128_G	131_Q	0.510	0.58
49_D	55_V	0.509	0.58
150_A	217_K	0.509	0.58
66_W	82_T	0.506	0.57
205_H	210_V	0.505	0.57
241_T	245_P	0.505	0.57
216_T	259_N	0.503	0.57
79_D	239_G	0.503	0.57
122_H	125_H	0.502	0.57
159_Q	169_Y	0.502	0.57
217_K	245_P	0.501	0.57
69_G	312_I	0.501	0.57
117_L	187_V	0.500	0.57
293_A	296_A	0.500	0.57

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4qn9A	2	0.8934	100	0.409	Contact Map
3rpcA	2	0.7461	100	0.551	Contact Map
3bv6A	5	0.8589	100	0.556	Contact Map
2wylA	5	0.8558	100	0.591	Contact Map
4jo0A	2	0.9248	100	0.612	Contact Map
3kl7A	1	0.6614	100	0.671	Contact Map
3zwfA	2	0.6646	100	0.688	Contact Map
2cbnA	2	0.7179	100	0.689	Contact Map
1zkpA	2	0.7241	100	0.69	Contact Map
1y44A	2	0.7179	100	0.702	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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