GREMLIN Database
Q9HR59 - Uncharacterized protein
UniProt: Q9HR59 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 319 (251)
Sequences: 2530 (1715)
Seq/√Len: 108.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
187_V199_V4.2231.00
234_G273_L3.4511.00
141_S170_R3.4271.00
262_T297_H3.3151.00
204_E209_T3.2171.00
218_P270_A3.1471.00
184_T204_E3.0441.00
73_V279_T3.0321.00
188_T202_V2.9631.00
156_E171_R2.8491.00
268_A276_L2.7701.00
202_V231_I2.7481.00
202_V229_H2.6071.00
66_W315_R2.4921.00
76_K82_T2.4411.00
83_L115_A2.3931.00
259_N267_C2.3871.00
186_H204_E2.3041.00
188_T200_S2.2211.00
186_H229_H2.1751.00
85_V119_T2.0771.00
119_T212_H2.0691.00
149_I173_A2.0191.00
90_G127_H2.0161.00
232_D274_D1.9731.00
65_V233_V1.9651.00
177_T184_T1.9541.00
156_E160_D1.9501.00
177_T186_H1.9051.00
116_V142_L1.8341.00
223_A227_A1.8251.00
235_I277_V1.8231.00
179_D184_T1.7981.00
210_V235_I1.7961.00
175_G189_P1.7771.00
117_L203_F1.7581.00
311_E314_D1.7371.00
224_E228_A1.7201.00
265_V301_M1.6451.00
213_G237_A1.6401.00
172_V187_V1.6391.00
266_A270_A1.6301.00
64_A315_R1.6261.00
185_V201_Y1.6191.00
292_T296_A1.5901.00
81_T181_G1.5851.00
266_A269_N1.5821.00
106_D109_D1.5731.00
209_T231_I1.5721.00
293_A297_H1.5571.00
234_G268_A1.5241.00
212_H279_T1.5221.00
68_L89_L1.5191.00
64_A76_K1.5141.00
236_L271_L1.5121.00
223_A270_A1.5091.00
175_G228_A1.4951.00
226_G272_Q1.4821.00
143_Y201_Y1.4811.00
142_L164_V1.4691.00
88_Y93_D1.4511.00
121_E158_W1.4451.00
115_A143_Y1.4441.00
108_R133_P1.4401.00
72_G85_V1.4391.00
92_G97_T1.4261.00
115_A180_I1.4041.00
73_V235_I1.4021.00
78_S205_H1.3511.00
143_Y178_Y1.3421.00
179_D182_S1.3341.00
264_V276_L1.3341.00
200_S213_G1.3260.99
175_G229_H1.3260.99
85_V117_L1.3190.99
85_V212_H1.3180.99
117_L199_V1.3130.99
260_T263_E1.3090.99
143_Y185_V1.3010.99
155_D196_V1.2970.99
49_D53_A1.2870.99
297_H300_S1.2780.99
218_P266_A1.2680.99
145_P201_Y1.2500.99
172_V176_D1.2400.99
49_D54_A1.2320.99
281_W295_H1.2320.99
75_L210_V1.2310.99
233_V277_V1.2280.99
68_L104_P1.2230.99
203_F210_V1.2160.99
226_G231_I1.2110.99
67_Y281_W1.2040.99
268_A273_L1.1990.99
276_L307_L1.1970.99
89_L130_S1.1790.99
191_H219_A1.1610.99
265_V298_T1.1520.99
240_S286_G1.1480.98
222_L270_A1.1460.98
128_G132_A1.1320.98
188_T211_F1.1310.98
302_A307_L1.1220.98
92_G96_R1.1160.98
175_G188_T1.1100.98
65_V73_V1.1030.98
298_T307_L1.1000.98
81_T183_F1.0990.98
213_G236_L1.0950.98
126_V131_Q1.0900.98
277_V308_D1.0830.98
236_L259_N1.0820.98
275_R306_R1.0820.98
190_A216_T1.0670.98
68_L72_G1.0630.98
115_A141_S1.0500.97
107_P133_P1.0470.97
75_L85_V1.0440.97
144_A155_D1.0360.97
65_V235_I1.0260.97
66_W76_K1.0230.97
263_E266_A1.0210.97
236_L267_C1.0170.97
170_R178_Y1.0140.97
51_L54_A1.0130.97
157_R160_D1.0070.97
242_G260_T1.0000.96
224_E227_A0.9930.96
120_H215_D0.9830.96
115_A185_V0.9810.96
160_D166_T0.9760.96
211_F267_C0.9750.96
227_A272_Q0.9740.96
81_T115_A0.9740.96
190_A200_S0.9650.96
105_F109_D0.9600.95
135_L164_V0.9590.95
290_D293_A0.9550.95
118_A159_Q0.9530.95
143_Y172_V0.9440.95
72_G103_V0.9350.95
260_T264_V0.9340.95
185_V203_F0.9320.95
77_A205_H0.9220.94
117_L200_S0.9180.94
172_V178_Y0.9180.94
209_T232_D0.9180.94
83_L185_V0.9170.94
121_E196_V0.8980.94
222_L267_C0.8970.93
110_V113_A0.8940.93
120_H280_H0.8890.93
246_D256_T0.8850.93
71_N237_A0.8830.93
234_G276_L0.8800.93
78_S207_A0.8780.93
101_I312_I0.8740.93
85_V203_F0.8680.92
175_G225_I0.8680.92
297_H301_M0.8660.92
107_P130_S0.8640.92
289_A294_L0.8600.92
118_A126_V0.8570.92
226_G271_L0.8560.92
241_T294_L0.8520.92
100_M285_K0.8460.91
308_D316_I0.8390.91
237_A264_V0.8370.91
241_T286_G0.8370.91
235_I279_T0.8320.91
55_V58_A0.8320.91
83_L183_F0.8290.90
215_D280_H0.8270.90
94_P97_T0.8240.90
189_P225_I0.8230.90
91_T98_V0.8210.90
54_A57_A0.8200.90
145_P199_V0.8200.90
211_F271_L0.8160.90
117_L185_V0.8060.89
187_V201_Y0.8050.89
282_D295_H0.7990.89
131_Q164_V0.7990.89
82_T114_D0.7980.89
200_S271_L0.7970.89
72_G88_Y0.7930.88
135_L139_G0.7910.88
299_R307_L0.7890.88
237_A260_T0.7860.88
265_V302_A0.7850.88
143_Y187_V0.7840.88
134_L140_C0.7830.88
99_R102_P0.7830.88
243_E246_D0.7830.88
67_Y312_I0.7790.88
145_P187_V0.7780.87
99_R283_M0.7780.87
238_F281_W0.7770.87
213_G216_T0.7680.87
52_P55_V0.7670.87
81_T114_D0.7640.87
63_I208_G0.7630.86
173_A176_D0.7600.86
149_I197_Q0.7570.86
121_E155_D0.7560.86
122_H215_D0.7550.86
174_V197_Q0.7470.85
131_Q142_L0.7410.85
273_L276_L0.7370.85
52_P56_A0.7360.84
165_T168_Q0.7360.84
158_W161_D0.7360.84
276_L298_T0.7310.84
234_G271_L0.7310.84
242_G297_H0.7310.84
139_G164_V0.7300.84
240_S289_A0.7250.84
213_G279_T0.7240.83
143_Y170_R0.7240.83
238_F264_V0.7220.83
192_D280_H0.7210.83
159_Q164_V0.7180.83
175_G224_E0.7150.83
155_D159_Q0.7140.83
51_L55_V0.7130.83
76_K113_A0.7130.83
217_K261_E0.7120.82
268_A298_T0.7110.82
158_W162_Y0.7100.82
128_G162_Y0.7080.82
246_D263_E0.6990.81
135_L142_L0.6980.81
220_D224_E0.6980.81
118_A144_A0.6960.81
143_Y180_I0.6950.81
95_P149_I0.6940.81
244_I260_T0.6920.81
63_I77_A0.6910.81
120_H192_D0.6890.80
101_I283_M0.6850.80
240_S285_K0.6820.80
159_Q162_Y0.6800.79
53_A57_A0.6780.79
269_N272_Q0.6780.79
50_W53_A0.6720.79
194_D198_P0.6720.79
144_A201_Y0.6710.79
202_V226_G0.6710.79
172_V199_V0.6710.79
68_L107_P0.6690.78
89_L107_P0.6680.78
241_T287_L0.6660.78
274_D306_R0.6640.78
68_L103_V0.6640.78
241_T261_E0.6640.78
141_S168_Q0.6620.78
216_T222_L0.6600.77
200_S222_L0.6590.77
260_T297_H0.6560.77
74_I110_V0.6560.77
192_D258_Y0.6560.77
142_L201_Y0.6520.77
90_G129_P0.6520.77
174_V198_P0.6500.76
90_G284_W0.6480.76
65_V277_V0.6450.76
122_H280_H0.6370.75
188_T228_A0.6360.75
242_G288_T0.6350.75
132_A164_V0.6340.75
113_A116_V0.6290.74
120_H124_D0.6290.74
275_R308_D0.6250.74
240_S283_M0.6250.74
241_T293_A0.6230.73
264_V298_T0.6220.73
75_L83_L0.6190.73
50_W54_A0.6190.73
192_D215_D0.6170.73
188_T231_I0.6160.72
70_C258_Y0.6110.72
90_G93_D0.6070.71
225_I271_L0.6070.71
82_T113_A0.6040.71
216_T270_A0.5970.70
243_E260_T0.5970.70
238_F283_M0.5950.70
261_E287_L0.5940.70
244_I288_T0.5940.70
226_G270_A0.5920.69
63_I78_S0.5900.69
191_H217_K0.5890.69
136_A139_G0.5860.69
212_H235_I0.5860.69
205_H208_G0.5850.69
275_R278_P0.5840.68
58_A62_G0.5840.68
296_A300_S0.5750.67
120_H125_H0.5750.67
211_F256_T0.5730.67
73_V277_V0.5700.67
300_S303_S0.5700.67
84_F89_L0.5690.66
88_Y284_W0.5690.66
72_G89_L0.5650.66
72_G118_A0.5620.65
104_P283_M0.5590.65
90_G94_P0.5580.65
110_V116_V0.5580.65
269_N306_R0.5570.65
257_W287_L0.5560.65
265_V305_Q0.5560.65
49_D52_P0.5560.65
84_F113_A0.5560.65
242_G246_D0.5520.64
219_A226_G0.5510.64
172_V177_T0.5510.64
139_G168_Q0.5510.64
70_C217_K0.5500.64
121_E197_Q0.5500.64
267_C271_L0.5460.63
160_D169_Y0.5450.63
156_E169_Y0.5450.63
297_H302_A0.5440.63
286_G294_L0.5430.63
95_P123_T0.5430.63
51_L57_A0.5410.63
62_G317_D0.5400.62
242_G293_A0.5400.62
310_V316_I0.5390.62
74_I82_T0.5370.62
186_H202_V0.5370.62
103_V107_P0.5370.62
126_V155_D0.5360.62
69_G281_W0.5340.62
77_A83_L0.5320.61
132_A157_R0.5310.61
305_Q310_V0.5300.61
258_Y294_L0.5300.61
100_M291_P0.5300.61
54_A58_A0.5290.61
116_V140_C0.5280.61
81_T85_V0.5280.61
295_H309_V0.5260.60
218_P222_L0.5260.60
57_A109_D0.5250.60
242_G245_P0.5240.60
135_L140_C0.5240.60
99_R104_P0.5240.60
125_H215_D0.5230.60
77_A183_F0.5230.60
144_A171_R0.5230.60
202_V211_F0.5160.59
298_T302_A0.5150.59
221_A267_C0.5150.59
90_G97_T0.5150.59
262_T301_M0.5140.59
127_H130_S0.5110.58
51_L56_A0.5110.58
91_T119_T0.5100.58
236_L264_V0.5100.58
117_L210_V0.5100.58
128_G131_Q0.5100.58
49_D55_V0.5090.58
150_A217_K0.5090.58
66_W82_T0.5060.57
205_H210_V0.5050.57
241_T245_P0.5050.57
216_T259_N0.5030.57
79_D239_G0.5030.57
122_H125_H0.5020.57
159_Q169_Y0.5020.57
217_K245_P0.5010.57
69_G312_I0.5010.57
117_L187_V0.5000.57
293_A296_A0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qn9A 2 0.8934 100 0.409 Contact Map
3rpcA 2 0.7461 100 0.551 Contact Map
3bv6A 5 0.8589 100 0.556 Contact Map
2wylA 5 0.8558 100 0.591 Contact Map
4jo0A 2 0.9248 100 0.612 Contact Map
3kl7A 1 0.6614 100 0.671 Contact Map
3zwfA 2 0.6646 100 0.688 Contact Map
2cbnA 2 0.7179 100 0.689 Contact Map
1zkpA 2 0.7241 100 0.69 Contact Map
1y44A 2 0.7179 100 0.702 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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