GREMLIN Database
Q9HR58 - Uncharacterized protein
UniProt: Q9HR58 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 216 (204)
Sequences: 1854 (1470)
Seq/√Len: 102.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
183_A188_V4.3711.00
177_L207_T4.3201.00
170_V174_V4.0341.00
174_V188_V3.2491.00
195_T198_S3.2141.00
167_A192_L3.1941.00
163_A202_R3.1161.00
174_V191_Q3.0511.00
198_S202_R3.0321.00
172_L212_A3.0241.00
178_D182_S2.9981.00
97_W102_A2.9511.00
184_S187_A2.8691.00
170_V188_V2.8451.00
183_A187_A2.7951.00
46_A83_Y2.6561.00
102_A120_F2.6551.00
20_T112_G2.3311.00
163_A167_A2.2871.00
185_L199_A2.2851.00
179_V200_S2.1761.00
163_A166_E2.1261.00
165_R169_R2.0811.00
194_V199_A2.0391.00
57_D81_Y1.9941.00
8_S113_V1.9861.00
168_V211_A1.9631.00
202_R205_R1.8021.00
188_V199_A1.7831.00
196_E200_S1.7331.00
185_L200_S1.7241.00
48_A56_F1.7161.00
19_A63_D1.7021.00
105_L119_R1.6881.00
167_A202_R1.6741.00
122_D125_A1.6511.00
183_A191_Q1.5671.00
52_D55_A1.5561.00
157_Q214_A1.5471.00
70_T183_A1.5261.00
167_A194_V1.5191.00
181_R204_R1.4591.00
190_E193_G1.4351.00
128_S131_E1.4291.00
187_A190_E1.4231.00
202_R209_N1.4191.00
5_A126_L1.4051.00
211_A214_A1.3921.00
179_V201_E1.3781.00
175_G182_S1.3440.99
71_L81_Y1.3380.99
31_E47_W1.3330.99
168_V177_L1.3230.99
8_S143_H1.3200.99
174_V183_A1.3040.99
8_S141_T1.2930.99
66_T69_V1.2880.99
160_L206_A1.2650.99
130_R140_F1.2550.99
49_I78_R1.2520.99
185_L202_R1.2400.99
172_L177_L1.2170.99
189_S199_A1.2000.99
120_F141_T1.1980.99
53_L79_R1.1960.99
192_L199_A1.1870.99
201_E205_R1.1730.98
55_A58_D1.1490.98
208_R212_A1.1470.98
197_Q201_E1.1450.98
86_A142_L1.1360.98
133_C138_V1.1260.98
30_V33_V1.1130.98
176_Y181_R1.1130.98
210_L214_A1.1110.98
198_S201_E1.1110.98
198_S203_L1.0740.97
167_A188_V1.0740.97
198_S206_A1.0640.97
44_T85_N1.0600.97
177_L203_L1.0530.97
104_Q118_V1.0480.97
179_V197_Q1.0440.97
167_A199_A1.0340.97
71_L79_R1.0330.97
203_L207_T1.0270.96
78_R162_D1.0260.96
53_L57_D1.0260.96
80_L152_A1.0240.96
53_L56_F1.0230.96
30_V35_V1.0180.96
169_R173_D1.0160.96
188_V192_L1.0040.96
26_V50_G0.9980.96
14_M20_T0.9830.95
131_E135_S0.9800.95
115_F143_H0.9790.95
125_A128_S0.9730.95
179_V204_R0.9690.95
186_S196_E0.9620.95
14_M17_Y0.9570.95
167_A206_A0.9510.94
119_R177_L0.9490.94
92_Q95_T0.9420.94
63_D66_T0.9390.94
72_L121_P0.9290.94
102_A106_H0.9240.94
101_G122_D0.9210.93
185_L196_E0.9150.93
55_A59_A0.9090.93
177_L185_L0.9090.93
179_V186_S0.9070.93
18_E65_T0.8970.93
195_T204_R0.8940.92
7_L112_G0.8910.92
70_T82_S0.8860.92
68_S71_L0.8810.92
149_V153_D0.8740.92
179_V208_R0.8730.92
127_A130_R0.8720.91
170_V191_Q0.8680.91
65_T161_T0.8630.91
141_T149_V0.8590.91
6_E115_F0.8580.91
28_F48_A0.8550.91
94_Y199_A0.8510.90
48_A79_R0.8510.90
30_V119_R0.8460.90
100_L132_I0.8440.90
176_Y185_L0.8440.90
47_W78_R0.8420.90
56_F148_G0.8370.90
121_P134_T0.8300.89
5_A8_S0.8280.89
43_K113_V0.8270.89
185_L198_S0.8240.89
126_L166_E0.8220.89
72_L80_L0.8190.89
7_L130_R0.8190.89
129_F201_E0.8160.89
166_E170_V0.8140.88
54_S57_D0.8130.88
210_L213_N0.8120.88
101_G132_I0.8060.88
142_L145_I0.7930.87
35_V39_G0.7930.87
30_V123_R0.7820.86
20_T113_V0.7800.86
177_L206_A0.7780.86
7_L118_V0.7740.86
178_D208_R0.7740.86
159_P212_A0.7650.85
145_I197_Q0.7620.85
196_E205_R0.7600.85
163_A201_E0.7580.85
15_I19_A0.7570.85
57_D69_V0.7550.84
179_V202_R0.7510.84
45_V119_R0.7500.84
186_S204_R0.7460.84
159_P213_N0.7440.84
145_I176_Y0.7440.84
194_V197_Q0.7400.83
30_V46_A0.7400.83
181_R210_L0.7260.82
106_H177_L0.7240.82
72_L109_S0.7190.81
176_Y203_L0.7130.81
165_R213_N0.7120.81
21_T112_G0.7100.81
82_S177_L0.7050.80
103_A119_R0.7040.80
40_D178_D0.7010.80
20_T26_V0.6980.79
166_E169_R0.6950.79
54_S67_T0.6940.79
61_R107_V0.6870.78
17_Y66_T0.6860.78
10_S209_N0.6850.78
23_V50_G0.6840.78
206_A211_A0.6790.78
31_E80_L0.6780.77
67_T135_S0.6720.77
40_D62_A0.6670.76
85_N94_Y0.6650.76
170_V192_L0.6580.75
166_E199_A0.6570.75
144_C188_V0.6570.75
102_A107_V0.6550.75
205_R208_R0.6530.75
194_V202_R0.6510.75
43_K143_H0.6510.75
11_S114_W0.6500.74
23_V26_V0.6500.74
175_G200_S0.6480.74
139_A158_D0.6470.74
129_F196_E0.6470.74
28_F38_G0.6470.74
10_S112_G0.6450.74
198_S205_R0.6450.74
185_L206_A0.6450.74
66_T71_L0.6440.74
120_F177_L0.6420.74
84_Q196_E0.6340.73
33_V209_N0.6340.73
183_A199_A0.6330.72
100_L161_T0.6320.72
104_Q157_Q0.6310.72
57_D126_L0.6300.72
105_L184_S0.6260.72
164_Q209_N0.6240.71
10_S17_Y0.6230.71
74_Q212_A0.6230.71
73_D192_L0.6220.71
13_R194_V0.6220.71
13_R46_A0.6210.71
45_V167_A0.6210.71
96_E129_F0.6180.71
107_V116_V0.6170.71
163_A207_T0.6170.71
123_R145_I0.6160.70
130_R198_S0.6150.70
128_S182_S0.6140.70
54_S58_D0.6130.70
22_S135_S0.6120.70
106_H192_L0.6110.70
127_A131_E0.6080.69
62_A174_V0.6060.69
69_V193_G0.6050.69
108_E115_F0.6050.69
95_T101_G0.6040.69
152_A165_R0.6030.69
174_V199_A0.6020.69
95_T99_D0.6020.69
168_V206_A0.5990.68
21_T153_D0.5980.68
5_A145_I0.5980.68
134_T194_V0.5970.68
43_K116_V0.5950.68
28_F123_R0.5930.68
114_W117_R0.5890.67
29_D135_S0.5880.67
15_I32_S0.5880.67
11_S14_M0.5880.67
65_T105_L0.5850.67
7_L116_V0.5840.66
32_S109_S0.5840.66
59_A66_T0.5790.66
166_E194_V0.5790.66
126_L144_C0.5770.65
25_N137_G0.5760.65
14_M85_N0.5760.65
122_D165_R0.5760.65
60_M69_V0.5740.65
181_R184_S0.5720.65
35_V116_V0.5720.65
177_L189_S0.5690.64
97_W118_V0.5650.64
5_A11_S0.5620.63
47_W80_L0.5600.63
104_Q128_S0.5600.63
109_S114_W0.5600.63
74_Q79_R0.5590.63
78_R210_L0.5580.63
192_L200_S0.5580.63
27_T166_E0.5530.62
43_K103_A0.5510.62
156_H159_P0.5480.62
20_T109_S0.5480.62
19_A23_V0.5460.61
25_N111_N0.5460.61
25_N51_D0.5450.61
137_G191_Q0.5440.61
23_V51_D0.5440.61
97_W104_Q0.5430.61
180_P204_R0.5420.61
165_R214_A0.5400.60
7_L140_F0.5370.60
14_M114_W0.5370.60
23_V81_Y0.5330.59
14_M116_V0.5330.59
175_G178_D0.5320.59
127_A198_S0.5320.59
5_A9_M0.5310.59
172_L211_A0.5310.59
186_S190_E0.5290.59
17_Y211_A0.5280.59
72_L86_A0.5250.58
112_G135_S0.5240.58
139_A173_D0.5240.58
8_S27_T0.5240.58
9_M14_M0.5180.57
84_Q88_A0.5170.57
96_E184_S0.5140.57
126_L145_I0.5120.56
170_V183_A0.5110.56
59_A86_A0.5100.56
27_T145_I0.5060.56
18_E93_M0.5050.55
88_A101_G0.5040.55
125_A154_A0.5040.55
18_E21_T0.5040.55
118_V129_F0.5020.55
74_Q84_Q0.5020.55
51_D62_A0.5010.55
44_T83_Y0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1s7oA 3 0.3148 97.7 0.839 Contact Map
1ku3A 1 0.2731 97.6 0.841 Contact Map
4wszA 2 0.25 97.6 0.843 Contact Map
1je8A 2 0.2546 97.4 0.847 Contact Map
3c57A 2 0.2176 97.4 0.847 Contact Map
1xsvA 2 0.3102 97.4 0.848 Contact Map
2o8xA 7 0.2824 97.3 0.849 Contact Map
3hugA 3 0.3472 97.2 0.853 Contact Map
1x3uA 1 0.3009 97.2 0.853 Contact Map
1fseA 2 0.2593 97.1 0.855 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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