Q9HR58 - HALSA - GREMLIN Contacts

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Q9HR58 - Uncharacterized protein

UniProt:	Q9HR58	Sequences: MSVIAELSMSSPRMILYEATTSVPNVTFDVESVDVADGGDTVKTVAWAIGDDLSAFDDAMRADSTTTSVTLLDQLADRRLYSYQNADASEVQMYTEWLDLGAAQLHVESQNGVWFVRVRFPDRDALASFREICTSQGVAFTLHCIYSGVPEADATHQDPLTDAQREAVRVALDVGYLDVPRSASLSAVSEQLGVTEQSASERLRRATRNLAANAVD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	216 (204)
Sequences:	1854 (1470)
Seq/√Len:	102.9

HALSA - Q9HR58 Q9HSR5 Q9HSM9 Q9HPS7 O54637 Q9HQD9 DMSR Q9HQU9
SULSO - Q97YL7 Q97UD7 Q97X87 Q97WR0 Q97Y14 Q97YT8 Q7LXI8 Q97UC0 Q97ZB6 Q97ZX5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
183_A	188_V	4.371	1.00
177_L	207_T	4.320	1.00
170_V	174_V	4.034	1.00
174_V	188_V	3.249	1.00
195_T	198_S	3.214	1.00
167_A	192_L	3.194	1.00
163_A	202_R	3.116	1.00
174_V	191_Q	3.051	1.00
198_S	202_R	3.032	1.00
172_L	212_A	3.024	1.00
178_D	182_S	2.998	1.00
97_W	102_A	2.951	1.00
184_S	187_A	2.869	1.00
170_V	188_V	2.845	1.00
183_A	187_A	2.795	1.00
46_A	83_Y	2.656	1.00
102_A	120_F	2.655	1.00
20_T	112_G	2.331	1.00
163_A	167_A	2.287	1.00
185_L	199_A	2.285	1.00
179_V	200_S	2.176	1.00
163_A	166_E	2.126	1.00
165_R	169_R	2.081	1.00
194_V	199_A	2.039	1.00
57_D	81_Y	1.994	1.00
8_S	113_V	1.986	1.00
168_V	211_A	1.963	1.00
202_R	205_R	1.802	1.00
188_V	199_A	1.783	1.00
196_E	200_S	1.733	1.00
185_L	200_S	1.724	1.00
48_A	56_F	1.716	1.00
19_A	63_D	1.702	1.00
105_L	119_R	1.688	1.00
167_A	202_R	1.674	1.00
122_D	125_A	1.651	1.00
183_A	191_Q	1.567	1.00
52_D	55_A	1.556	1.00
157_Q	214_A	1.547	1.00
70_T	183_A	1.526	1.00
167_A	194_V	1.519	1.00
181_R	204_R	1.459	1.00
190_E	193_G	1.435	1.00
128_S	131_E	1.429	1.00
187_A	190_E	1.423	1.00
202_R	209_N	1.419	1.00
5_A	126_L	1.405	1.00
211_A	214_A	1.392	1.00
179_V	201_E	1.378	1.00
175_G	182_S	1.344	0.99
71_L	81_Y	1.338	0.99
31_E	47_W	1.333	0.99
168_V	177_L	1.323	0.99
8_S	143_H	1.320	0.99
174_V	183_A	1.304	0.99
8_S	141_T	1.293	0.99
66_T	69_V	1.288	0.99
160_L	206_A	1.265	0.99
130_R	140_F	1.255	0.99
49_I	78_R	1.252	0.99
185_L	202_R	1.240	0.99
172_L	177_L	1.217	0.99
189_S	199_A	1.200	0.99
120_F	141_T	1.198	0.99
53_L	79_R	1.196	0.99
192_L	199_A	1.187	0.99
201_E	205_R	1.173	0.98
55_A	58_D	1.149	0.98
208_R	212_A	1.147	0.98
197_Q	201_E	1.145	0.98
86_A	142_L	1.136	0.98
133_C	138_V	1.126	0.98
30_V	33_V	1.113	0.98
176_Y	181_R	1.113	0.98
210_L	214_A	1.111	0.98
198_S	201_E	1.111	0.98
198_S	203_L	1.074	0.97
167_A	188_V	1.074	0.97
198_S	206_A	1.064	0.97
44_T	85_N	1.060	0.97
177_L	203_L	1.053	0.97
104_Q	118_V	1.048	0.97
179_V	197_Q	1.044	0.97
167_A	199_A	1.034	0.97
71_L	79_R	1.033	0.97
203_L	207_T	1.027	0.96
78_R	162_D	1.026	0.96
53_L	57_D	1.026	0.96
80_L	152_A	1.024	0.96
53_L	56_F	1.023	0.96
30_V	35_V	1.018	0.96
169_R	173_D	1.016	0.96
188_V	192_L	1.004	0.96
26_V	50_G	0.998	0.96
14_M	20_T	0.983	0.95
131_E	135_S	0.980	0.95
115_F	143_H	0.979	0.95
125_A	128_S	0.973	0.95
179_V	204_R	0.969	0.95
186_S	196_E	0.962	0.95
14_M	17_Y	0.957	0.95
167_A	206_A	0.951	0.94
119_R	177_L	0.949	0.94
92_Q	95_T	0.942	0.94
63_D	66_T	0.939	0.94
72_L	121_P	0.929	0.94
102_A	106_H	0.924	0.94
101_G	122_D	0.921	0.93
185_L	196_E	0.915	0.93
55_A	59_A	0.909	0.93
177_L	185_L	0.909	0.93
179_V	186_S	0.907	0.93
18_E	65_T	0.897	0.93
195_T	204_R	0.894	0.92
7_L	112_G	0.891	0.92
70_T	82_S	0.886	0.92
68_S	71_L	0.881	0.92
149_V	153_D	0.874	0.92
179_V	208_R	0.873	0.92
127_A	130_R	0.872	0.91
170_V	191_Q	0.868	0.91
65_T	161_T	0.863	0.91
141_T	149_V	0.859	0.91
6_E	115_F	0.858	0.91
28_F	48_A	0.855	0.91
94_Y	199_A	0.851	0.90
48_A	79_R	0.851	0.90
30_V	119_R	0.846	0.90
100_L	132_I	0.844	0.90
176_Y	185_L	0.844	0.90
47_W	78_R	0.842	0.90
56_F	148_G	0.837	0.90
121_P	134_T	0.830	0.89
5_A	8_S	0.828	0.89
43_K	113_V	0.827	0.89
185_L	198_S	0.824	0.89
126_L	166_E	0.822	0.89
72_L	80_L	0.819	0.89
7_L	130_R	0.819	0.89
129_F	201_E	0.816	0.89
166_E	170_V	0.814	0.88
54_S	57_D	0.813	0.88
210_L	213_N	0.812	0.88
101_G	132_I	0.806	0.88
142_L	145_I	0.793	0.87
35_V	39_G	0.793	0.87
30_V	123_R	0.782	0.86
20_T	113_V	0.780	0.86
177_L	206_A	0.778	0.86
7_L	118_V	0.774	0.86
178_D	208_R	0.774	0.86
159_P	212_A	0.765	0.85
145_I	197_Q	0.762	0.85
196_E	205_R	0.760	0.85
163_A	201_E	0.758	0.85
15_I	19_A	0.757	0.85
57_D	69_V	0.755	0.84
179_V	202_R	0.751	0.84
45_V	119_R	0.750	0.84
186_S	204_R	0.746	0.84
159_P	213_N	0.744	0.84
145_I	176_Y	0.744	0.84
194_V	197_Q	0.740	0.83
30_V	46_A	0.740	0.83
181_R	210_L	0.726	0.82
106_H	177_L	0.724	0.82
72_L	109_S	0.719	0.81
176_Y	203_L	0.713	0.81
165_R	213_N	0.712	0.81
21_T	112_G	0.710	0.81
82_S	177_L	0.705	0.80
103_A	119_R	0.704	0.80
40_D	178_D	0.701	0.80
20_T	26_V	0.698	0.79
166_E	169_R	0.695	0.79
54_S	67_T	0.694	0.79
61_R	107_V	0.687	0.78
17_Y	66_T	0.686	0.78
10_S	209_N	0.685	0.78
23_V	50_G	0.684	0.78
206_A	211_A	0.679	0.78
31_E	80_L	0.678	0.77
67_T	135_S	0.672	0.77
40_D	62_A	0.667	0.76
85_N	94_Y	0.665	0.76
170_V	192_L	0.658	0.75
166_E	199_A	0.657	0.75
144_C	188_V	0.657	0.75
102_A	107_V	0.655	0.75
205_R	208_R	0.653	0.75
194_V	202_R	0.651	0.75
43_K	143_H	0.651	0.75
11_S	114_W	0.650	0.74
23_V	26_V	0.650	0.74
175_G	200_S	0.648	0.74
139_A	158_D	0.647	0.74
129_F	196_E	0.647	0.74
28_F	38_G	0.647	0.74
10_S	112_G	0.645	0.74
198_S	205_R	0.645	0.74
185_L	206_A	0.645	0.74
66_T	71_L	0.644	0.74
120_F	177_L	0.642	0.74
84_Q	196_E	0.634	0.73
33_V	209_N	0.634	0.73
183_A	199_A	0.633	0.72
100_L	161_T	0.632	0.72
104_Q	157_Q	0.631	0.72
57_D	126_L	0.630	0.72
105_L	184_S	0.626	0.72
164_Q	209_N	0.624	0.71
10_S	17_Y	0.623	0.71
74_Q	212_A	0.623	0.71
73_D	192_L	0.622	0.71
13_R	194_V	0.622	0.71
13_R	46_A	0.621	0.71
45_V	167_A	0.621	0.71
96_E	129_F	0.618	0.71
107_V	116_V	0.617	0.71
163_A	207_T	0.617	0.71
123_R	145_I	0.616	0.70
130_R	198_S	0.615	0.70
128_S	182_S	0.614	0.70
54_S	58_D	0.613	0.70
22_S	135_S	0.612	0.70
106_H	192_L	0.611	0.70
127_A	131_E	0.608	0.69
62_A	174_V	0.606	0.69
69_V	193_G	0.605	0.69
108_E	115_F	0.605	0.69
95_T	101_G	0.604	0.69
152_A	165_R	0.603	0.69
174_V	199_A	0.602	0.69
95_T	99_D	0.602	0.69
168_V	206_A	0.599	0.68
21_T	153_D	0.598	0.68
5_A	145_I	0.598	0.68
134_T	194_V	0.597	0.68
43_K	116_V	0.595	0.68
28_F	123_R	0.593	0.68
114_W	117_R	0.589	0.67
29_D	135_S	0.588	0.67
15_I	32_S	0.588	0.67
11_S	14_M	0.588	0.67
65_T	105_L	0.585	0.67
7_L	116_V	0.584	0.66
32_S	109_S	0.584	0.66
59_A	66_T	0.579	0.66
166_E	194_V	0.579	0.66
126_L	144_C	0.577	0.65
25_N	137_G	0.576	0.65
14_M	85_N	0.576	0.65
122_D	165_R	0.576	0.65
60_M	69_V	0.574	0.65
181_R	184_S	0.572	0.65
35_V	116_V	0.572	0.65
177_L	189_S	0.569	0.64
97_W	118_V	0.565	0.64
5_A	11_S	0.562	0.63
47_W	80_L	0.560	0.63
104_Q	128_S	0.560	0.63
109_S	114_W	0.560	0.63
74_Q	79_R	0.559	0.63
78_R	210_L	0.558	0.63
192_L	200_S	0.558	0.63
27_T	166_E	0.553	0.62
43_K	103_A	0.551	0.62
156_H	159_P	0.548	0.62
20_T	109_S	0.548	0.62
19_A	23_V	0.546	0.61
25_N	111_N	0.546	0.61
25_N	51_D	0.545	0.61
137_G	191_Q	0.544	0.61
23_V	51_D	0.544	0.61
97_W	104_Q	0.543	0.61
180_P	204_R	0.542	0.61
165_R	214_A	0.540	0.60
7_L	140_F	0.537	0.60
14_M	114_W	0.537	0.60
23_V	81_Y	0.533	0.59
14_M	116_V	0.533	0.59
175_G	178_D	0.532	0.59
127_A	198_S	0.532	0.59
5_A	9_M	0.531	0.59
172_L	211_A	0.531	0.59
186_S	190_E	0.529	0.59
17_Y	211_A	0.528	0.59
72_L	86_A	0.525	0.58
112_G	135_S	0.524	0.58
139_A	173_D	0.524	0.58
8_S	27_T	0.524	0.58
9_M	14_M	0.518	0.57
84_Q	88_A	0.517	0.57
96_E	184_S	0.514	0.57
126_L	145_I	0.512	0.56
170_V	183_A	0.511	0.56
59_A	86_A	0.510	0.56
27_T	145_I	0.506	0.56
18_E	93_M	0.505	0.55
88_A	101_G	0.504	0.55
125_A	154_A	0.504	0.55
18_E	21_T	0.504	0.55
118_V	129_F	0.502	0.55
74_Q	84_Q	0.502	0.55
51_D	62_A	0.501	0.55
44_T	83_Y	0.500	0.55

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1s7oA	3	0.3148	97.7	0.839	Contact Map
1ku3A	1	0.2731	97.6	0.841	Contact Map
4wszA	2	0.25	97.6	0.843	Contact Map
1je8A	2	0.2546	97.4	0.847	Contact Map
3c57A	2	0.2176	97.4	0.847	Contact Map
1xsvA	2	0.3102	97.4	0.848	Contact Map
2o8xA	7	0.2824	97.3	0.849	Contact Map
3hugA	3	0.3472	97.2	0.853	Contact Map
1x3uA	1	0.3009	97.2	0.853	Contact Map
1fseA	2	0.2593	97.1	0.855	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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