GREMLIN Database
Q9HR56 - Uncharacterized protein
UniProt: Q9HR56 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 344 (314)
Sequences: 885 (614)
Seq/√Len: 34.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_I99_F5.9401.00
32_I97_V5.8871.00
295_D315_K4.4721.00
27_Y55_R4.4441.00
279_I297_F4.3271.00
153_R157_E4.0431.00
59_V63_L3.8561.00
48_F59_V3.5911.00
29_L59_V3.5761.00
335_L338_D3.3191.00
28_E31_R3.3051.00
84_D103_P3.1111.00
60_A72_I3.1051.00
183_Y205_G3.0831.00
63_L70_T3.0541.00
298_V323_Y3.0141.00
43_K94_D2.6571.00
247_A295_D2.5551.00
250_W323_Y2.5051.00
249_Q293_D2.4241.00
247_A296_A2.3540.99
249_Q275_N2.3540.99
141_T149_F2.2790.99
95_V111_I2.1520.99
265_Q324_E2.1220.99
140_V195_Y2.1100.99
42_E94_D2.0680.99
255_C301_G2.0110.98
83_C302_C1.9590.98
294_M297_F1.9420.98
125_M152_M1.8920.97
136_D162_T1.8830.97
39_K95_V1.8050.96
35_E95_V1.7960.96
128_A194_L1.7860.96
236_E311_P1.7800.96
250_W270_V1.7770.96
129_R159_R1.7710.96
251_G292_F1.7700.96
202_H304_R1.7680.96
122_E155_W1.7350.96
123_P223_N1.7270.95
269_I272_N1.7010.95
124_I196_V1.6950.95
48_F99_F1.6870.95
35_E111_I1.6860.95
192_Q214_N1.6740.95
67_L72_I1.6690.95
198_G219_D1.6530.94
287_D290_M1.6350.94
90_M93_T1.6260.94
255_C258_I1.6230.94
273_N277_Y1.6190.94
29_L32_I1.5970.93
116_F147_N1.5520.92
60_A139_L1.5520.92
48_F74_L1.5420.92
237_R322_E1.5380.92
178_V195_Y1.5360.92
197_G301_G1.5210.91
136_D191_D1.5200.91
34_D38_R1.4940.90
154_T158_E1.4830.90
35_E38_R1.4550.89
186_A213_K1.4480.89
176_G181_C1.4460.89
101_H304_R1.4020.87
193_V206_L1.3820.87
254_F263_F1.3770.86
259_G262_R1.3660.86
247_A323_Y1.3660.86
273_N295_D1.3650.86
119_V148_Q1.3630.86
121_V125_M1.3580.86
274_D277_Y1.3450.85
52_L244_A1.3400.85
163_V167_R1.3400.85
140_V197_G1.2990.83
125_M129_R1.2930.83
252_V267_E1.2900.83
43_K71_R1.2830.82
268_E271_E1.2780.82
78_P283_E1.2680.81
266_A327_V1.2660.81
323_Y327_V1.2660.81
201_F304_R1.2600.81
183_Y209_E1.2470.80
138_G190_A1.2440.80
177_Q182_N1.2440.80
248_E274_D1.2310.79
53_K300_T1.2260.79
123_P127_E1.2260.79
36_V95_V1.2130.78
231_E235_K1.2080.78
299_N306_T1.2070.78
148_Q152_M1.2020.78
124_I141_T1.2000.78
252_V263_F1.1950.77
84_D257_K1.1950.77
267_E271_E1.1910.77
214_N227_I1.1900.77
235_K239_A1.1850.77
48_F56_G1.1700.76
86_D288_R1.1680.76
270_V323_Y1.1670.76
101_H201_F1.1630.75
250_W296_A1.1630.75
85_L275_N1.1590.75
154_T159_R1.1580.75
244_A319_T1.1570.75
194_L323_Y1.1310.73
63_L72_I1.1270.73
45_G93_T1.1210.73
123_P218_A1.1190.73
141_T195_Y1.1120.72
40_D292_F1.1110.72
140_V206_L1.1080.72
45_G332_L1.0990.71
305_I308_D1.0980.71
243_K246_D1.0960.71
201_F260_Q1.0960.71
50_E78_P1.0900.71
101_H144_Q1.0880.70
27_Y59_V1.0880.70
173_T181_C1.0820.70
273_N276_A1.0790.70
325_I332_L1.0710.69
201_F305_I1.0690.69
253_I289_L1.0670.69
86_D89_L1.0600.68
271_E276_A1.0530.68
205_G209_E1.0440.67
127_E225_V1.0420.67
38_R227_I1.0370.67
53_K77_Q1.0320.66
24_T62_D1.0270.66
100_G209_E1.0260.66
35_E39_K1.0200.65
160_G163_V1.0170.65
136_D268_E1.0160.65
56_G298_V1.0100.65
132_L194_L1.0090.64
81_G101_H1.0070.64
100_G256_T1.0050.64
159_R165_T1.0020.64
288_R292_F0.9970.64
267_E278_L0.9960.63
265_Q268_E0.9820.62
252_V295_D0.9800.62
330_K333_E0.9800.62
251_G279_I0.9770.62
25_W51_G0.9760.62
125_M155_W0.9640.61
125_M156_L0.9490.60
103_P288_R0.9460.59
59_V64_R0.9420.59
79_C90_M0.9400.59
154_T157_E0.9350.59
79_C286_P0.9330.58
104_M114_P0.9300.58
44_V47_Q0.9280.58
91_R270_V0.9240.58
265_Q272_N0.9220.57
248_E275_N0.9210.57
242_H245_M0.9160.57
172_L177_Q0.9120.57
318_L323_Y0.9110.57
48_F102_S0.9050.56
139_L149_F0.9040.56
201_F303_P0.9040.56
177_Q180_G0.9040.56
186_A193_V0.9010.56
202_H308_D0.9010.56
200_K204_L0.9010.56
130_D135_G0.9000.56
177_Q183_Y0.8990.56
232_Q311_P0.8960.55
201_F204_L0.8950.55
102_S114_P0.8940.55
137_V164_H0.8900.55
96_F110_I0.8900.55
91_R294_M0.8890.55
84_D259_G0.8860.54
270_V280_T0.8840.54
45_G77_Q0.8810.54
260_Q304_R0.8810.54
193_V215_V0.8800.54
49_P52_L0.8800.54
51_G181_C0.8790.54
199_G204_L0.8750.53
42_E157_E0.8700.53
270_V273_N0.8680.53
333_E336_S0.8650.53
245_M326_A0.8610.52
145_H221_V0.8610.52
296_A318_L0.8600.52
86_D103_P0.8580.52
151_E155_W0.8510.51
92_R282_D0.8480.51
282_D288_R0.8450.51
267_E274_D0.8400.50
26_D317_M0.8400.50
39_K56_G0.8390.50
300_T319_T0.8380.50
176_G179_L0.8360.50
252_V276_A0.8360.50
43_K185_S0.8320.50
51_G201_F0.8270.49
79_C280_T0.8250.49
77_Q282_D0.8210.49
172_L182_N0.8180.49
218_A223_N0.8170.49
149_F165_T0.8100.48
148_Q313_F0.8100.48
176_G180_G0.8090.48
250_W274_D0.8090.48
279_I315_K0.8080.48
38_R154_T0.8070.48
84_D302_C0.8060.48
254_F280_T0.8050.48
131_E225_V0.8010.47
53_K262_R0.8010.47
64_R72_I0.8010.47
129_R136_D0.8000.47
299_N305_I0.7980.47
284_V317_M0.7970.47
137_V140_V0.7940.47
95_V99_F0.7920.46
50_E53_K0.7900.46
181_C201_F0.7900.46
101_H179_L0.7890.46
183_Y208_M0.7860.46
103_P302_C0.7850.46
201_F308_D0.7840.46
235_K298_V0.7840.46
77_Q281_M0.7820.46
164_H188_I0.7820.46
128_A161_Y0.7800.45
46_L97_V0.7800.45
51_G81_G0.7790.45
28_E310_G0.7770.45
107_S275_N0.7770.45
247_A264_D0.7750.45
83_C103_P0.7730.45
91_R241_V0.7710.45
202_H205_G0.7700.45
157_E162_T0.7660.44
74_L95_V0.7650.44
60_A131_E0.7640.44
24_T30_D0.7640.44
284_V301_G0.7610.44
304_R308_D0.7600.44
73_M93_T0.7590.44
87_T258_I0.7560.43
97_V130_D0.7560.43
256_T280_T0.7540.43
284_V304_R0.7530.43
171_R179_L0.7460.43
281_M289_L0.7460.43
199_G305_I0.7440.42
41_A296_A0.7430.42
48_F75_S0.7400.42
100_G175_E0.7390.42
48_F98_H0.7380.42
126_Q224_A0.7380.42
161_Y178_V0.7380.42
151_E294_M0.7370.42
251_G266_A0.7360.42
308_D317_M0.7350.42
135_G152_M0.7350.42
98_H104_M0.7340.42
164_H250_W0.7250.41
311_P317_M0.7250.41
25_W144_Q0.7250.41
112_Y306_T0.7250.41
253_I276_A0.7200.40
132_L225_V0.7200.40
155_W224_A0.7200.40
63_L109_S0.7200.40
102_S245_M0.7170.40
87_T104_M0.7160.40
69_D138_G0.7160.40
44_V63_L0.7150.40
207_A215_V0.7140.40
262_R309_D0.7130.40
25_W31_R0.7120.40
251_G294_M0.7120.40
325_I333_E0.7110.40
30_D66_R0.7100.40
99_F106_E0.7100.40
85_L155_W0.7010.39
88_Y92_R0.7000.39
220_P255_C0.6990.39
265_Q269_I0.6980.39
30_D37_E0.6980.39
126_Q166_R0.6960.38
172_L183_Y0.6940.38
56_G74_L0.6940.38
92_R292_F0.6890.38
172_L180_G0.6870.38
74_L190_A0.6870.38
91_R96_F0.6860.38
144_Q202_H0.6860.38
67_L110_I0.6850.38
92_R288_R0.6840.37
129_R152_M0.6810.37
76_G267_E0.6800.37
138_G193_V0.6800.37
263_F276_A0.6760.37
284_V306_T0.6750.37
87_T285_T0.6740.37
80_Y256_T0.6740.37
172_L181_C0.6730.37
250_W327_V0.6700.36
196_V234_L0.6670.36
33_V40_D0.6640.36
124_I225_V0.6640.36
172_L176_G0.6610.36
200_K205_G0.6590.35
130_D275_N0.6560.35
44_V70_T0.6550.35
238_Y242_H0.6540.35
176_G182_N0.6520.35
103_P257_K0.6520.35
144_Q181_C0.6510.35
42_E224_A0.6500.35
146_M175_E0.6450.34
136_D164_H0.6410.34
251_G277_Y0.6410.34
179_L183_Y0.6400.34
148_Q274_D0.6390.34
67_L262_R0.6380.34
210_H308_D0.6370.34
97_V230_A0.6350.34
179_L182_N0.6320.33
30_D127_E0.6320.33
123_P226_S0.6300.33
40_D158_E0.6290.33
181_C260_Q0.6280.33
220_P301_G0.6280.33
162_T168_G0.6280.33
119_V149_F0.6270.33
100_G330_K0.6240.33
105_K305_I0.6240.33
77_Q258_I0.6220.33
154_T175_E0.6190.32
37_E154_T0.6190.32
51_G304_R0.6180.32
210_H215_V0.6180.32
143_A284_V0.6170.32
290_M314_H0.6160.32
36_V63_L0.6150.32
95_V239_A0.6140.32
42_E189_D0.6110.32
41_A163_V0.6100.32
195_Y266_A0.6100.32
244_A318_L0.6100.32
328_G331_P0.6070.32
51_G176_G0.6070.32
90_M288_R0.6060.31
100_G148_Q0.6050.31
82_A95_V0.6050.31
36_V70_T0.6000.31
162_T191_D0.6000.31
171_R180_G0.5990.31
235_K238_Y0.5990.31
38_R196_V0.5980.31
130_D133_H0.5950.31
288_R291_N0.5930.31
251_G326_A0.5930.31
97_V113_V0.5930.31
71_R128_A0.5930.31
156_L275_N0.5920.30
155_W158_E0.5890.30
30_D34_D0.5860.30
251_G297_F0.5850.30
204_L309_D0.5850.30
141_T146_M0.5850.30
101_H303_P0.5830.30
248_E296_A0.5810.30
203_P257_K0.5810.30
50_E79_C0.5800.30
115_L282_D0.5770.29
28_E104_M0.5760.29
158_E163_V0.5750.29
27_Y32_I0.5730.29
100_G287_D0.5710.29
120_D208_M0.5710.29
259_G308_D0.5700.29
172_L179_L0.5680.29
125_M159_R0.5670.29
43_K162_T0.5660.29
30_D126_Q0.5660.29
220_P223_N0.5650.29
42_E279_I0.5630.28
136_D241_V0.5610.28
199_G309_D0.5600.28
105_K259_G0.5560.28
150_E298_V0.5550.28
120_D157_E0.5540.28
109_S121_V0.5530.28
155_W159_R0.5530.28
102_S116_F0.5530.28
85_L89_L0.5520.28
118_N154_T0.5520.28
241_V325_I0.5520.28
103_P112_Y0.5510.28
73_M273_N0.5510.28
173_T309_D0.5500.27
76_G79_C0.5490.27
45_G89_L0.5480.27
234_L287_D0.5480.27
253_I269_I0.5470.27
197_G217_I0.5470.27
48_F97_V0.5450.27
162_T175_E0.5450.27
103_P114_P0.5440.27
228_A258_I0.5430.27
127_E131_E0.5430.27
50_E75_S0.5420.27
156_L160_G0.5410.27
56_G59_V0.5400.27
282_D290_M0.5390.27
25_W28_E0.5360.27
96_F328_G0.5350.26
275_N319_T0.5350.26
101_H260_Q0.5340.26
51_G260_Q0.5340.26
125_M297_F0.5340.26
285_T291_N0.5320.26
122_E126_Q0.5320.26
194_L268_E0.5310.26
310_G325_I0.5300.26
106_E260_Q0.5290.26
234_L238_Y0.5280.26
98_H112_Y0.5280.26
64_R68_D0.5280.26
259_G309_D0.5280.26
264_D275_N0.5270.26
290_M293_D0.5270.26
233_F279_I0.5260.26
50_E54_R0.5220.26
297_F336_S0.5220.26
69_D334_D0.5210.26
266_A320_P0.5190.25
52_L308_D0.5190.25
242_H328_G0.5190.25
39_K241_V0.5190.25
101_H308_D0.5180.25
151_E277_Y0.5180.25
284_V329_N0.5180.25
62_D66_R0.5170.25
267_E286_P0.5170.25
123_P228_A0.5160.25
180_G201_F0.5160.25
72_I300_T0.5150.25
61_D97_V0.5140.25
301_G306_T0.5130.25
163_V273_N0.5130.25
255_C299_N0.5120.25
248_E295_D0.5080.25
89_L288_R0.5060.25
109_S312_Q0.5060.25
209_E215_V0.5050.25
210_H296_A0.5030.24
38_R119_V0.5030.24
77_Q89_L0.5020.24
263_F275_N0.5010.24
237_R320_P0.5010.24
121_V196_V0.5010.24
81_G258_I0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lzdA 2 0.9186 100 0.136 Contact Map
2uvpA 3 0.4651 39.4 0.969 Contact Map
4xxhA 2 0.2703 26.5 0.971 Contact Map
1ibxB 1 0.2587 24.8 0.972 Contact Map
2bpoA 1 0.3052 18.2 0.973 Contact Map
2w3zA 1 0.5407 18.2 0.973 Contact Map
1ytlA 1 0.3517 15.5 0.974 Contact Map
4f67A 1 0.3924 15.2 0.974 Contact Map
2vnlA 3 0.3605 14.8 0.975 Contact Map
4rweA 1 0.2762 14.3 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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