Q9HR56 - HALSA - GREMLIN Contacts

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Q9HR56 - Uncharacterized protein

UniProt:	Q9HR56	Sequences: MSNEEARSAGDLRNTGLSLRHDRTWDYELDRIVDEVERKDAEKVGLQFPEGLKRRGPAVADDLRARLDDTRIMLSGQPCYGACDLDTYLMRRTDVFVHFGHSPMKESDSIIYVPLFSNVDVEPIMQEARDELHDGDVGLVTTAQHMNQFEEMRTWLEERGYTVHTRRGDDRLTNEGQVLGCNYASADIDADQVLYVGGGKFHPLGLAMEHPEKNVVIADPVNNAVSIADAEQFLKERYASVHKAMDAEQWGVIFCTKIGQGRFDQAEEIVENNDNAYLITMDEVTPDRLMNFDMDAFVNTGCPRITTDDGPQFHKPMLTPGEYEIAVGNKPLEDLSFDTFHGTW	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	344 (314)
Sequences:	885 (614)
Seq/√Len:	34.6

HALSA - Q9HR56
SULSO - Q980J8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
32_I	99_F	5.940	1.00
32_I	97_V	5.887	1.00
295_D	315_K	4.472	1.00
27_Y	55_R	4.444	1.00
279_I	297_F	4.327	1.00
153_R	157_E	4.043	1.00
59_V	63_L	3.856	1.00
48_F	59_V	3.591	1.00
29_L	59_V	3.576	1.00
335_L	338_D	3.319	1.00
28_E	31_R	3.305	1.00
84_D	103_P	3.111	1.00
60_A	72_I	3.105	1.00
183_Y	205_G	3.083	1.00
63_L	70_T	3.054	1.00
298_V	323_Y	3.014	1.00
43_K	94_D	2.657	1.00
247_A	295_D	2.555	1.00
250_W	323_Y	2.505	1.00
249_Q	293_D	2.424	1.00
247_A	296_A	2.354	0.99
249_Q	275_N	2.354	0.99
141_T	149_F	2.279	0.99
95_V	111_I	2.152	0.99
265_Q	324_E	2.122	0.99
140_V	195_Y	2.110	0.99
42_E	94_D	2.068	0.99
255_C	301_G	2.011	0.98
83_C	302_C	1.959	0.98
294_M	297_F	1.942	0.98
125_M	152_M	1.892	0.97
136_D	162_T	1.883	0.97
39_K	95_V	1.805	0.96
35_E	95_V	1.796	0.96
128_A	194_L	1.786	0.96
236_E	311_P	1.780	0.96
250_W	270_V	1.777	0.96
129_R	159_R	1.771	0.96
251_G	292_F	1.770	0.96
202_H	304_R	1.768	0.96
122_E	155_W	1.735	0.96
123_P	223_N	1.727	0.95
269_I	272_N	1.701	0.95
124_I	196_V	1.695	0.95
48_F	99_F	1.687	0.95
35_E	111_I	1.686	0.95
192_Q	214_N	1.674	0.95
67_L	72_I	1.669	0.95
198_G	219_D	1.653	0.94
287_D	290_M	1.635	0.94
90_M	93_T	1.626	0.94
255_C	258_I	1.623	0.94
273_N	277_Y	1.619	0.94
29_L	32_I	1.597	0.93
116_F	147_N	1.552	0.92
60_A	139_L	1.552	0.92
48_F	74_L	1.542	0.92
237_R	322_E	1.538	0.92
178_V	195_Y	1.536	0.92
197_G	301_G	1.521	0.91
136_D	191_D	1.520	0.91
34_D	38_R	1.494	0.90
154_T	158_E	1.483	0.90
35_E	38_R	1.455	0.89
186_A	213_K	1.448	0.89
176_G	181_C	1.446	0.89
101_H	304_R	1.402	0.87
193_V	206_L	1.382	0.87
254_F	263_F	1.377	0.86
259_G	262_R	1.366	0.86
247_A	323_Y	1.366	0.86
273_N	295_D	1.365	0.86
119_V	148_Q	1.363	0.86
121_V	125_M	1.358	0.86
274_D	277_Y	1.345	0.85
52_L	244_A	1.340	0.85
163_V	167_R	1.340	0.85
140_V	197_G	1.299	0.83
125_M	129_R	1.293	0.83
252_V	267_E	1.290	0.83
43_K	71_R	1.283	0.82
268_E	271_E	1.278	0.82
78_P	283_E	1.268	0.81
266_A	327_V	1.266	0.81
323_Y	327_V	1.266	0.81
201_F	304_R	1.260	0.81
183_Y	209_E	1.247	0.80
138_G	190_A	1.244	0.80
177_Q	182_N	1.244	0.80
248_E	274_D	1.231	0.79
53_K	300_T	1.226	0.79
123_P	127_E	1.226	0.79
36_V	95_V	1.213	0.78
231_E	235_K	1.208	0.78
299_N	306_T	1.207	0.78
148_Q	152_M	1.202	0.78
124_I	141_T	1.200	0.78
252_V	263_F	1.195	0.77
84_D	257_K	1.195	0.77
267_E	271_E	1.191	0.77
214_N	227_I	1.190	0.77
235_K	239_A	1.185	0.77
48_F	56_G	1.170	0.76
86_D	288_R	1.168	0.76
270_V	323_Y	1.167	0.76
101_H	201_F	1.163	0.75
250_W	296_A	1.163	0.75
85_L	275_N	1.159	0.75
154_T	159_R	1.158	0.75
244_A	319_T	1.157	0.75
194_L	323_Y	1.131	0.73
63_L	72_I	1.127	0.73
45_G	93_T	1.121	0.73
123_P	218_A	1.119	0.73
141_T	195_Y	1.112	0.72
40_D	292_F	1.111	0.72
140_V	206_L	1.108	0.72
45_G	332_L	1.099	0.71
305_I	308_D	1.098	0.71
243_K	246_D	1.096	0.71
201_F	260_Q	1.096	0.71
50_E	78_P	1.090	0.71
101_H	144_Q	1.088	0.70
27_Y	59_V	1.088	0.70
173_T	181_C	1.082	0.70
273_N	276_A	1.079	0.70
325_I	332_L	1.071	0.69
201_F	305_I	1.069	0.69
253_I	289_L	1.067	0.69
86_D	89_L	1.060	0.68
271_E	276_A	1.053	0.68
205_G	209_E	1.044	0.67
127_E	225_V	1.042	0.67
38_R	227_I	1.037	0.67
53_K	77_Q	1.032	0.66
24_T	62_D	1.027	0.66
100_G	209_E	1.026	0.66
35_E	39_K	1.020	0.65
160_G	163_V	1.017	0.65
136_D	268_E	1.016	0.65
56_G	298_V	1.010	0.65
132_L	194_L	1.009	0.64
81_G	101_H	1.007	0.64
100_G	256_T	1.005	0.64
159_R	165_T	1.002	0.64
288_R	292_F	0.997	0.64
267_E	278_L	0.996	0.63
265_Q	268_E	0.982	0.62
252_V	295_D	0.980	0.62
330_K	333_E	0.980	0.62
251_G	279_I	0.977	0.62
25_W	51_G	0.976	0.62
125_M	155_W	0.964	0.61
125_M	156_L	0.949	0.60
103_P	288_R	0.946	0.59
59_V	64_R	0.942	0.59
79_C	90_M	0.940	0.59
154_T	157_E	0.935	0.59
79_C	286_P	0.933	0.58
104_M	114_P	0.930	0.58
44_V	47_Q	0.928	0.58
91_R	270_V	0.924	0.58
265_Q	272_N	0.922	0.57
248_E	275_N	0.921	0.57
242_H	245_M	0.916	0.57
172_L	177_Q	0.912	0.57
318_L	323_Y	0.911	0.57
48_F	102_S	0.905	0.56
139_L	149_F	0.904	0.56
201_F	303_P	0.904	0.56
177_Q	180_G	0.904	0.56
186_A	193_V	0.901	0.56
202_H	308_D	0.901	0.56
200_K	204_L	0.901	0.56
130_D	135_G	0.900	0.56
177_Q	183_Y	0.899	0.56
232_Q	311_P	0.896	0.55
201_F	204_L	0.895	0.55
102_S	114_P	0.894	0.55
137_V	164_H	0.890	0.55
96_F	110_I	0.890	0.55
91_R	294_M	0.889	0.55
84_D	259_G	0.886	0.54
270_V	280_T	0.884	0.54
45_G	77_Q	0.881	0.54
260_Q	304_R	0.881	0.54
193_V	215_V	0.880	0.54
49_P	52_L	0.880	0.54
51_G	181_C	0.879	0.54
199_G	204_L	0.875	0.53
42_E	157_E	0.870	0.53
270_V	273_N	0.868	0.53
333_E	336_S	0.865	0.53
245_M	326_A	0.861	0.52
145_H	221_V	0.861	0.52
296_A	318_L	0.860	0.52
86_D	103_P	0.858	0.52
151_E	155_W	0.851	0.51
92_R	282_D	0.848	0.51
282_D	288_R	0.845	0.51
267_E	274_D	0.840	0.50
26_D	317_M	0.840	0.50
39_K	56_G	0.839	0.50
300_T	319_T	0.838	0.50
176_G	179_L	0.836	0.50
252_V	276_A	0.836	0.50
43_K	185_S	0.832	0.50
51_G	201_F	0.827	0.49
79_C	280_T	0.825	0.49
77_Q	282_D	0.821	0.49
172_L	182_N	0.818	0.49
218_A	223_N	0.817	0.49
149_F	165_T	0.810	0.48
148_Q	313_F	0.810	0.48
176_G	180_G	0.809	0.48
250_W	274_D	0.809	0.48
279_I	315_K	0.808	0.48
38_R	154_T	0.807	0.48
84_D	302_C	0.806	0.48
254_F	280_T	0.805	0.48
131_E	225_V	0.801	0.47
53_K	262_R	0.801	0.47
64_R	72_I	0.801	0.47
129_R	136_D	0.800	0.47
299_N	305_I	0.798	0.47
284_V	317_M	0.797	0.47
137_V	140_V	0.794	0.47
95_V	99_F	0.792	0.46
50_E	53_K	0.790	0.46
181_C	201_F	0.790	0.46
101_H	179_L	0.789	0.46
183_Y	208_M	0.786	0.46
103_P	302_C	0.785	0.46
201_F	308_D	0.784	0.46
235_K	298_V	0.784	0.46
77_Q	281_M	0.782	0.46
164_H	188_I	0.782	0.46
128_A	161_Y	0.780	0.45
46_L	97_V	0.780	0.45
51_G	81_G	0.779	0.45
28_E	310_G	0.777	0.45
107_S	275_N	0.777	0.45
247_A	264_D	0.775	0.45
83_C	103_P	0.773	0.45
91_R	241_V	0.771	0.45
202_H	205_G	0.770	0.45
157_E	162_T	0.766	0.44
74_L	95_V	0.765	0.44
60_A	131_E	0.764	0.44
24_T	30_D	0.764	0.44
284_V	301_G	0.761	0.44
304_R	308_D	0.760	0.44
73_M	93_T	0.759	0.44
87_T	258_I	0.756	0.43
97_V	130_D	0.756	0.43
256_T	280_T	0.754	0.43
284_V	304_R	0.753	0.43
171_R	179_L	0.746	0.43
281_M	289_L	0.746	0.43
199_G	305_I	0.744	0.42
41_A	296_A	0.743	0.42
48_F	75_S	0.740	0.42
100_G	175_E	0.739	0.42
48_F	98_H	0.738	0.42
126_Q	224_A	0.738	0.42
161_Y	178_V	0.738	0.42
151_E	294_M	0.737	0.42
251_G	266_A	0.736	0.42
308_D	317_M	0.735	0.42
135_G	152_M	0.735	0.42
98_H	104_M	0.734	0.42
164_H	250_W	0.725	0.41
311_P	317_M	0.725	0.41
25_W	144_Q	0.725	0.41
112_Y	306_T	0.725	0.41
253_I	276_A	0.720	0.40
132_L	225_V	0.720	0.40
155_W	224_A	0.720	0.40
63_L	109_S	0.720	0.40
102_S	245_M	0.717	0.40
87_T	104_M	0.716	0.40
69_D	138_G	0.716	0.40
44_V	63_L	0.715	0.40
207_A	215_V	0.714	0.40
262_R	309_D	0.713	0.40
25_W	31_R	0.712	0.40
251_G	294_M	0.712	0.40
325_I	333_E	0.711	0.40
30_D	66_R	0.710	0.40
99_F	106_E	0.710	0.40
85_L	155_W	0.701	0.39
88_Y	92_R	0.700	0.39
220_P	255_C	0.699	0.39
265_Q	269_I	0.698	0.39
30_D	37_E	0.698	0.39
126_Q	166_R	0.696	0.38
172_L	183_Y	0.694	0.38
56_G	74_L	0.694	0.38
92_R	292_F	0.689	0.38
172_L	180_G	0.687	0.38
74_L	190_A	0.687	0.38
91_R	96_F	0.686	0.38
144_Q	202_H	0.686	0.38
67_L	110_I	0.685	0.38
92_R	288_R	0.684	0.37
129_R	152_M	0.681	0.37
76_G	267_E	0.680	0.37
138_G	193_V	0.680	0.37
263_F	276_A	0.676	0.37
284_V	306_T	0.675	0.37
87_T	285_T	0.674	0.37
80_Y	256_T	0.674	0.37
172_L	181_C	0.673	0.37
250_W	327_V	0.670	0.36
196_V	234_L	0.667	0.36
33_V	40_D	0.664	0.36
124_I	225_V	0.664	0.36
172_L	176_G	0.661	0.36
200_K	205_G	0.659	0.35
130_D	275_N	0.656	0.35
44_V	70_T	0.655	0.35
238_Y	242_H	0.654	0.35
176_G	182_N	0.652	0.35
103_P	257_K	0.652	0.35
144_Q	181_C	0.651	0.35
42_E	224_A	0.650	0.35
146_M	175_E	0.645	0.34
136_D	164_H	0.641	0.34
251_G	277_Y	0.641	0.34
179_L	183_Y	0.640	0.34
148_Q	274_D	0.639	0.34
67_L	262_R	0.638	0.34
210_H	308_D	0.637	0.34
97_V	230_A	0.635	0.34
179_L	182_N	0.632	0.33
30_D	127_E	0.632	0.33
123_P	226_S	0.630	0.33
40_D	158_E	0.629	0.33
181_C	260_Q	0.628	0.33
220_P	301_G	0.628	0.33
162_T	168_G	0.628	0.33
119_V	149_F	0.627	0.33
100_G	330_K	0.624	0.33
105_K	305_I	0.624	0.33
77_Q	258_I	0.622	0.33
154_T	175_E	0.619	0.32
37_E	154_T	0.619	0.32
51_G	304_R	0.618	0.32
210_H	215_V	0.618	0.32
143_A	284_V	0.617	0.32
290_M	314_H	0.616	0.32
36_V	63_L	0.615	0.32
95_V	239_A	0.614	0.32
42_E	189_D	0.611	0.32
41_A	163_V	0.610	0.32
195_Y	266_A	0.610	0.32
244_A	318_L	0.610	0.32
328_G	331_P	0.607	0.32
51_G	176_G	0.607	0.32
90_M	288_R	0.606	0.31
100_G	148_Q	0.605	0.31
82_A	95_V	0.605	0.31
36_V	70_T	0.600	0.31
162_T	191_D	0.600	0.31
171_R	180_G	0.599	0.31
235_K	238_Y	0.599	0.31
38_R	196_V	0.598	0.31
130_D	133_H	0.595	0.31
288_R	291_N	0.593	0.31
251_G	326_A	0.593	0.31
97_V	113_V	0.593	0.31
71_R	128_A	0.593	0.31
156_L	275_N	0.592	0.30
155_W	158_E	0.589	0.30
30_D	34_D	0.586	0.30
251_G	297_F	0.585	0.30
204_L	309_D	0.585	0.30
141_T	146_M	0.585	0.30
101_H	303_P	0.583	0.30
248_E	296_A	0.581	0.30
203_P	257_K	0.581	0.30
50_E	79_C	0.580	0.30
115_L	282_D	0.577	0.29
28_E	104_M	0.576	0.29
158_E	163_V	0.575	0.29
27_Y	32_I	0.573	0.29
100_G	287_D	0.571	0.29
120_D	208_M	0.571	0.29
259_G	308_D	0.570	0.29
172_L	179_L	0.568	0.29
125_M	159_R	0.567	0.29
43_K	162_T	0.566	0.29
30_D	126_Q	0.566	0.29
220_P	223_N	0.565	0.29
42_E	279_I	0.563	0.28
136_D	241_V	0.561	0.28
199_G	309_D	0.560	0.28
105_K	259_G	0.556	0.28
150_E	298_V	0.555	0.28
120_D	157_E	0.554	0.28
109_S	121_V	0.553	0.28
155_W	159_R	0.553	0.28
102_S	116_F	0.553	0.28
85_L	89_L	0.552	0.28
118_N	154_T	0.552	0.28
241_V	325_I	0.552	0.28
103_P	112_Y	0.551	0.28
73_M	273_N	0.551	0.28
173_T	309_D	0.550	0.27
76_G	79_C	0.549	0.27
45_G	89_L	0.548	0.27
234_L	287_D	0.548	0.27
253_I	269_I	0.547	0.27
197_G	217_I	0.547	0.27
48_F	97_V	0.545	0.27
162_T	175_E	0.545	0.27
103_P	114_P	0.544	0.27
228_A	258_I	0.543	0.27
127_E	131_E	0.543	0.27
50_E	75_S	0.542	0.27
156_L	160_G	0.541	0.27
56_G	59_V	0.540	0.27
282_D	290_M	0.539	0.27
25_W	28_E	0.536	0.27
96_F	328_G	0.535	0.26
275_N	319_T	0.535	0.26
101_H	260_Q	0.534	0.26
51_G	260_Q	0.534	0.26
125_M	297_F	0.534	0.26
285_T	291_N	0.532	0.26
122_E	126_Q	0.532	0.26
194_L	268_E	0.531	0.26
310_G	325_I	0.530	0.26
106_E	260_Q	0.529	0.26
234_L	238_Y	0.528	0.26
98_H	112_Y	0.528	0.26
64_R	68_D	0.528	0.26
259_G	309_D	0.528	0.26
264_D	275_N	0.527	0.26
290_M	293_D	0.527	0.26
233_F	279_I	0.526	0.26
50_E	54_R	0.522	0.26
297_F	336_S	0.522	0.26
69_D	334_D	0.521	0.26
266_A	320_P	0.519	0.25
52_L	308_D	0.519	0.25
242_H	328_G	0.519	0.25
39_K	241_V	0.519	0.25
101_H	308_D	0.518	0.25
151_E	277_Y	0.518	0.25
284_V	329_N	0.518	0.25
62_D	66_R	0.517	0.25
267_E	286_P	0.517	0.25
123_P	228_A	0.516	0.25
180_G	201_F	0.516	0.25
72_I	300_T	0.515	0.25
61_D	97_V	0.514	0.25
301_G	306_T	0.513	0.25
163_V	273_N	0.513	0.25
255_C	299_N	0.512	0.25
248_E	295_D	0.508	0.25
89_L	288_R	0.506	0.25
109_S	312_Q	0.506	0.25
209_E	215_V	0.505	0.25
210_H	296_A	0.503	0.24
38_R	119_V	0.503	0.24
77_Q	89_L	0.502	0.24
263_F	275_N	0.501	0.24
237_R	320_P	0.501	0.24
121_V	196_V	0.501	0.24
81_G	258_I	0.500	0.24

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3lzdA	2	0.9186	100	0.136	Contact Map
2uvpA	3	0.4651	39.4	0.969	Contact Map
4xxhA	2	0.2703	26.5	0.971	Contact Map
1ibxB	1	0.2587	24.8	0.972	Contact Map
2bpoA	1	0.3052	18.2	0.973	Contact Map
2w3zA	1	0.5407	18.2	0.973	Contact Map
1ytlA	1	0.3517	15.5	0.974	Contact Map
4f67A	1	0.3924	15.2	0.974	Contact Map
2vnlA	3	0.3605	14.8	0.975	Contact Map
4rweA	1	0.2762	14.3	0.975	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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