GREMLIN Database
Q9HR55 - Uncharacterized protein
UniProt: Q9HR55 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 89 (82)
Sequences: 136 (97)
Seq/√Len: 10.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_A24_E3.7200.98
37_S79_E2.5450.87
41_V81_F2.3050.81
66_F72_D2.1690.76
64_A72_D2.1550.76
19_L44_F2.1150.74
7_A34_N2.1120.74
36_G79_E2.0590.72
70_T80_L1.9250.67
53_T82_R1.8930.66
62_V70_T1.8740.65
41_V75_V1.8020.62
71_Q74_A1.7910.61
20_A44_F1.7380.59
22_A64_A1.6550.55
46_G51_T1.6540.55
54_H82_R1.5980.52
28_V53_T1.5130.48
34_N83_V1.4940.47
8_Q68_F1.4920.47
61_A65_Q1.3850.42
21_A83_V1.3730.42
61_A64_A1.3630.41
36_G64_A1.3460.40
28_V82_R1.3300.40
16_R32_V1.3050.38
62_V74_A1.2880.38
13_H60_F1.2800.37
19_L83_V1.2480.36
19_L81_F1.2460.36
42_E55_A1.2450.36
31_S44_F1.2440.36
77_D80_L1.2390.36
68_F75_V1.2250.35
7_A37_S1.1780.33
60_F69_H1.1650.32
33_H39_A1.1580.32
28_V44_F1.1540.32
25_V68_F1.1160.30
35_A78_V1.1020.30
13_H49_G1.0840.29
64_A73_R1.0390.27
31_S77_D1.0360.27
29_S85_W1.0210.27
17_A66_F1.0080.26
12_E23_S0.9870.25
76_L83_V0.9810.25
38_K56_F0.9760.25
37_S65_Q0.9580.24
19_L33_H0.9550.24
51_T60_F0.9350.24
27_A81_F0.9190.23
54_H64_A0.9170.23
68_F74_A0.8950.22
62_V71_Q0.8880.22
73_R84_D0.8660.21
20_A48_R0.8660.21
41_V82_R0.8620.21
31_S65_Q0.8550.21
56_F80_L0.8390.21
17_A71_Q0.8290.20
32_V76_L0.8240.20
20_A49_G0.7960.19
26_A42_E0.7800.19
43_S66_F0.7780.19
9_D48_R0.7740.19
38_K62_V0.7700.18
21_A52_V0.7520.18
7_A47_D0.7440.18
12_E60_F0.7410.18
12_E46_G0.7360.18
25_V59_E0.7210.17
72_D80_L0.7180.17
41_V50_G0.7150.17
38_K64_A0.6890.16
75_V81_F0.6850.16
73_R76_L0.6830.16
54_H67_S0.6810.16
34_N76_L0.6770.16
50_G77_D0.6770.16
67_S73_R0.6600.16
61_A70_T0.6600.16
19_L45_A0.6430.15
22_A78_V0.6400.15
39_A78_V0.6330.15
14_A55_A0.6330.15
12_E72_D0.6310.15
12_E45_A0.6270.15
22_A63_P0.6250.15
7_A46_G0.6180.14
59_E75_V0.6180.14
38_K81_F0.6160.14
43_S84_D0.6030.14
24_E71_Q0.5970.14
17_A65_Q0.5950.14
45_A83_V0.5950.14
35_A58_A0.5890.14
48_R60_F0.5870.14
44_F66_F0.5870.14
26_A34_N0.5790.14
32_V79_E0.5760.14
12_E63_P0.5740.13
61_A73_R0.5720.13
34_N60_F0.5720.13
48_R63_P0.5630.13
25_V57_A0.5610.13
19_L79_E0.5490.13
56_F67_S0.5470.13
35_A76_L0.5470.13
39_A54_H0.5450.13
27_A65_Q0.5440.13
14_A49_G0.5400.13
24_E32_V0.5350.13
9_D19_L0.5350.13
13_H31_S0.5320.13
58_A80_L0.5250.12
45_A66_F0.5230.12
29_S55_A0.5170.12
8_Q24_E0.5140.12
69_H78_V0.5130.12
25_V72_D0.5110.12
7_A79_E0.5090.12
13_H74_A0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wy7A 1 0.9775 98.9 0.734 Contact Map
1ne2A 2 0.9551 98.3 0.78 Contact Map
3lkdA 1 0.8989 76.8 0.898 Contact Map
3khkA 1 0.8989 73.3 0.901 Contact Map
3tm4A 1 0.6404 71.8 0.902 Contact Map
3bzbA 1 0.7528 70.1 0.903 Contact Map
2ih2A 1 0.8764 62.7 0.908 Contact Map
3vseA 1 1 62.5 0.908 Contact Map
2ar0A 1 0.8989 60.4 0.91 Contact Map
2oyrA 1 0.6742 52.7 0.913 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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